Around 67 million pets are owned by households in the United Kingdom, and an increasing number of these are exotic animals. Approximately a third of pets are purchased through retail outlets or direct from breeders. A wide range of infections can be associated with companion animals.
This study uses a systematic literature review to describe the transmission of zoonotic disease in humans associated with a pet shop or other location selling pets (incidents of rabies tracebacks and zoonoses from pet food were excluded).
PubMed and EMBASE.
Fifty seven separate case reports or incidents were described in the 82 papers that were identified by the systematic review. Summary information on each incident is included in this manuscript. The infections include bacterial, viral and fungal diseases and range in severity from mild to life threatening. Infections associated with birds and rodents were the most commonly reported. Over half of the reports describe incidents in the Americas, and three of these were outbreaks involving more than 50 cases. Many of the incidents identified relate to infections in pet shop employees.
This review may have been subject to publication bias, where unusual and unexpected zoonotic infections may be over-represented in peer-reviewed publications. It was also restricted to English-language articles so that pathogens that are more common in non-Western countries, or in more exotic animals not common in Europe and the Americas, may have been under-represented.
A wide spectrum of zoonotic infections are acquired from pet shops. Salmonellosis and psittacosis were the most commonly documented diseases, however more unusual infections such as tularemia also appeared in the review. Given their potential to spread zoonotic infection, it is important that pet shops act to minimise the risk as far as possible.
Citation: Halsby KD, Walsh AL, Campbell C, Hewitt K, Morgan D (2014) Healthy Animals, Healthy People: Zoonosis Risk from Animal Contact in Pet Shops, a Systematic Review of the Literature. PLoS ONE 9(2): e89309. doi:10.1371/journal.pone.0089309
Editor: Martyn Kirk, The Australian National University, Australia
Received: April 26, 2013; Accepted: January 22, 2014; Published: February 26, 2014
Copyright: © 2014 Halsby et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: The authors have no support or funding to report.
Competing interests: The authors have declared that no competing interests exist.
Rising numbers of household pets, in particular exotic species, means that an increasing number of people are exposed to the risk of acquiring zoonotic disease from companion animals. Around 67 million pets are now owned by UK households, with 13 million households in the UK (48%) owning at least one pet in 2012 . Traditional pets such as dogs and cats remain the most popular (23% of UK households own a dog and 19% of UK households own a cat) , however there has been an increased ownership of exotic pets in recent years, though accurate figures are difficult to obtain. This increase is due in part to the 2007 modification to The Dangerous Wild Animals Act 1976 . This act lists animals for which licenses are required in the UK in order to keep the animal as a pet, whilst the modification to the act removed some exotic animals from the list.
A wide range of infections can be associated with companion animals, including parasitic, bacterial, fungal and viral diseases –. Of those transmitted by bites and scratches, pasteurellosis, cat-scratch disease, and various aerobic and anaerobic infections are predominant. Other common infections are gastrointestinal (e.g. campylobacter, salmonella), dermatologic (e.g. dermatophytoses, scabies), respiratory (e.g. psittacosis) and multisystemic (e.g. toxoplasmosis, leishmaniasis) .
The top five sources for acquiring a pet are: friend/acquaintance, rescue centre, pet shop, recommended breeder, and private advertisement . There are studies in the literature examining animal infections in pet shops and other retail outlets –, but little exploration of human infections arising from these facilities. Whilst owning a pet will always result in a small risk of zoonotic illness to the owners and those that the pet comes into contact with, a sick animal in a pet shop can potentially spread the illness to other animals within the shop, and to a large number of geographically distributed owners as newly purchased pets are taken home. Pet shops can therefore act as a nexus point for zoonotic disease.
In September 2012, a systematic literature review was performed in order to identify any reports of human infection acquired (or where the report’s authors inferred that it had been acquired) from a pet shop or other location selling pets, or an animal reported to have been acquired from such a premises.
Search Strategy and Selection Criteria
Data for this review were identified by searches of PubMed and EMBASE, and through the references of papers identified by the review (references at all stages of publication were considered). We used the following Boolean search statement: (“pet shop” OR “pet store” OR “pet” OR “companion animal”) AND (“zoonoses” OR “zoonosis” OR “Human infection” OR “Human case”). Articles in English were selected (although foreign language publications were accepted where an English abstract was available and contained sufficient information to fulfill the inclusion criteria), and no date restrictions were applied to the searches. (The main PubMed database contains manuscripts dating back to 1966, whilst EMBASE covers manuscripts from 1974 onwards.).
The abstracts of the articles were examined and retained if they referred to: i) human cases of zoonotic infection, with ii) a link to a pet or companion animal. The full text was then examined and retained if reference was made to: i) human cases of zoonotic infection, ii) which came from a pet (or a potential pet), and iii) where the animal had a link to a pet shop or other location that sells or distributes companion animals. The following information was extracted from the articles: zoonosis/agent, country (of infection or report if not known), year of infection (or report if not known), type of animal, setting (e.g. pet store, pet distributor), number of human cases associated with pet shop (or other location selling/distributing companion animals), age of human cases, method of transmission (e.g. bite or scratch), and type of contact (e.g. domestic or occupational). The information was extracted by the principal investigator and reviewed by a co-author.
A number of articles considered during the systematic review described rabid animals which had been sold in pet shops, and the extensive contact tracing for postexposure prophylaxis (PEP) which had to be conducted as a result. These were not included in this review since none of the articles documented a human case of rabies that had arisen from such animals. Further articles considered by the systematic review described cases of zoonotic infection associated with pet food and treats, purchased in pet shops. These were also not included in the review since the inclusion criteria required the pet itself to have a link to the pet shop.
One thousand and eighty seven papers were identified by the initial systematic literature review. Nine hundred and forty five of these were English-language articles, of which 265 were retained based on abstracts, and 66 met the full text inclusion criteria. The original search also identified 142 foreign language papers, of which five had sufficient information in the English abstract to include the paper in the final review. In addition, twelve potential articles were identified through the references of included papers, of which eleven met the inclusion criteria themselves.
A total of 82 papers fulfilled the criteria of the systematic review.
The results of the literature review are presented in Table 1 (where a particular incident was described by more than one paper in the review, only primary paper(s) are included in the table; articles which discussed the incident only by reference to the primary paper(s) were not included). If the country of the incident was not stated, it was assumed to be the authors’ country. If a year of incident was not given, the year of publication of the paper was used as a proxy. The number of infections refers to the human cases linked to pet shops in each article, not the total number of human cases discussed.
Table 1 therefore summarises the cases of disease associated with a pet shop that were identified by the literature review. Fifty seven cases of disease or incidents associated with pet shops or other facilities distributing companion animals were included. Bacterial, viral and fungal diseases were all identified, and ranged in severity from mild to life threatening. For example, infection with ringworm (Dermatophytosis) was noted in several articles, with four separate examples in Japanese pet shop employees and customers –. Zoophilic dermatophyte infections are rarely serious, generally self-limiting and respond well to treatment . In contrast, two articles describing infection with rat bite fever (Streptobacillus moniliformis or Spirillum minus) were identified by the review , , one of which occurred in a pet shop employee and resulted in his death. Rat bite fever has a mortality rate of up to 13% in untreated cases .
The infection described most often was psittacosis (n = 18), followed by salmonellosis (n = 12) (Table 2). All of the psittacosis infections were associated with birds (where the putative animal source was identified), and no other avian infection was recorded in the review. The next group of animals most commonly referenced were rodents (n = 11), including rats, mice and prairie dogs. Four papers reported that the infections occurred through scratches or bites, two through oral transmission, one through a wound from a rat cage, and seven through other direct contact (including one paper with cases infected by a mixture of bites and direct contact). The review also included one paper (detailing a salmonellosis infection) which specified that the case had had no direct contact with the pet. In the remaining papers the method of transmission was not specified for some or all of the cases (n = 42). This includes 17 of the 18 papers reporting psittacosis incidents; it is likely that many of these infections occurred via airborne transmission.
Thirty of the papers referenced incidents in the Americas, nineteen referenced incidents in Europe, and eight referenced incidents in South East Asia. The majority of the papers described individual case reports or outbreaks of fewer than ten cases associated with pet shops (or other locations selling/distributing companion animals) (n = 42), with only three describing outbreaks with 50 cases or more (an outbreak of lymphocytic choriomeningitis virus in hamsters, an outbreak of monkeypox in prairie dogs, and an outbreak of salmonellosis in African dwarf frogs). Twenty-two of the incidents involved adults only, three involved children only, 11 involved both adults and children, and 21 did not specify the age of some or all of the cases.
Thirty-five papers described an incident associated with a pet shop, eight were associated with a breeder or distributor, five with some other facility (an animal shelter, an educational organization, two rescue centres, and a zoo; all of which sold or distributed animals to members of the public), and the remaining nine incidents involved more than one type of facility (most commonly involving both a distributor and pet shop). Twenty-five of the papers involved infections occurring in a domestic setting, fourteen in an occupational setting and three described infections occurring after a visit to a pet shop. Fifteen papers covered outbreaks where the cases fell into more than one category or where the setting was unspecified.
Pet shops can play an important role in the control of zoonotic infections from companion animals. They are the initial point at which members of the public can access information and advice on the risks associated with their newly purchased pets. Unfortunately, there is evidence to suggest that pet shop employees do not adequately understand or control the risks. A 2003 poll (commissioned by The Royal Society for the Prevention of Cruelty to Animals) of 300 pet shops which reported trading in exotic pets, asked pet shops whether any illnesses contracted by a client’s prospective pet could be passed onto humans; 36% answered “No, not at all” . It is important that zoonotic risks are recognized and addressed because the consequences of these infections can be very serious.
The systematic literature review described in this manuscript identified 82 papers covering 57 separate human infections, outbreaks or incidents believed to have been associated with pet shops. Although the review was conducted in a systematic manner, the authors acknowledge that this list is not comprehensive; in order to be comprehensive, individual searches would have to be conducted for each potential zoonotic disease, and zoonotic incidents are often not written up in peer-reviewed journals. However, the review does present a representative sample of papers derived from a well-defined set of search criteria.
A wide spectrum of infections acquired from pet shops was identified by the review. Salmonellosis and psittacosis were the most commonly documented diseases, however more unusual infections such as tularemia were also identified. Many of the references relate to infections in pet shop employees, where often the precise source of infection was undetermined but the pet shop was assumed to be involved. The animals involved in the transmission of these infections were varied, including birds, mammals and rodents, and cover both common household pets, such as dogs and cats, and more exotic creatures, such as iguanas and prairie dogs. Some zoonotic infections were associated with a variety of different companion animals (e.g. salmonellosis), whereas others were associated with only a narrow range of species (e.g. psittacosis). Whilst some of the pathogens identified in Table 1 are commonly foodborne (e.g. Salmonella), or transmitted by other established routes of zoonotic infection, e.g. bites and scratches, this review demonstrates that more unexpected routes exist, and that transmission through animal contact should be considered when defining strategies to prevent disease in the population.
There are other organisms which have been identified in pet shop animals, and which have the potential to cause human infection, but which were not identified in this literature review. For example, infections caused by Yersinia pseudotuberculosis and Y. enterocolitica may be contracted from pet rodents, however this is uncommon because the usual serotypes found in rodents do not affect humans. The lack of clinical signs in animals affected by these infections may increase the likelihood of transmission of the organism from pet to human; guinea pigs are commonly infected with Y. pseudotuberculosis and clinical signs are usually subacute, similarly Y. enterocolitica is usually asymptomatic in rodents . It is also likely that other zoonotic organisms may have passed from pet shop animals to humans and caused disease, but have not been documented because of under-diagnosis and under-reporting, and a lack of follow-up of sporadic infections, e.g. cryptosporidium, giardia.
There are some diseases which were unexpected omissions in this review, e.g. pasteurellosis. A number of articles concerning pasteurella infections were initially accepted into the review on the basis of their abstracts, however they were not included in the final results because they did not specifically refer to pet shops. This might reflect a publication bias; because infections with Pasteurella spp. are commonly associated with animal exposures, case studies might not be written up in the literature. In addition, the association of pasteurellosis with cat and dog bites is very well established, so where articles on pasteurella infections do occur, links to pets and pet shops may not be deemed to be of sufficient interest to warrant inclusion in the final publication. Similarly, this may explain why the literature review included only one article on cat scratch disease. It is therefore important to note that unusual and unexpected zoonotic infections may be over-represented in peer-reviewed publications, and in this review.
A further limitation of this review was its restriction to English-language papers. Although a small number of foreign-language manuscripts were included where a translated abstract was available and provided sufficient information to fulfill the inclusion criteria, 137 out of 142 foreign-language papers were nonetheless excluded. The countries associated with incidents in this review (predominantly the Americas and Europe), reflect this bias. This may imply that pathogens that are more common in non-Western countries, or in more exotic animals not common in Europe and the Americas, were under-represented.
Incidents of rabies tracebacks and zoonoses from pet food were excluded from this review. They are nonetheless important public health considerations and can require a large amount of resource to deal with appropriately. For example, in the US in 1994, significant numbers of people were exposed to a rabid kitten in a pet shop and, although no human cases resulted, the final cost of the investigation and prophylaxis was estimated to be over $1 million with 665 people receiving prophylaxis , . Such incidents are not necessarily unusual, and Rotz et al. summarise 22 large-scale incidents of exposure to rabid or presumed rabid animals (defined as administration of PEP to 25 or more people after an exposure) that occurred in the US between 1990 and 1996 . The increase in Salmonella Typhimurium, designated definitive type 191a (DT191a), was an example of an outbreak from pet food detected in the UK in December 2008. The increase was found to be associated with raw frozen mice used as reptile feed and sold through wholesalers and distributors . Revised infection control guidance for reptile owners and handlers has been published on the Health Protection Agency (HPA) website . It is therefore important to note that there will be further significant events associated with pet shops beyond those summarized in this manuscript, which must be kept in mind when considering the importance of such facilities in the zoonotic transmission of disease.
While many zoonotic infections associated with pet shops are likely to result in single cases or familial incidents, e.g. rat bite fever, such premises also have the potential to amplify the risk of spread. A sick animal in a pet shop can potentially transmit the illness to other animals within the shop, and therefore to a large number of new pet owners, who may be geographically dispersed. Pet shops (and other locations that sell animals) can additionally act as a type of leisure activity, with families visiting to see and handle the animals, and potentially becoming exposed to zoonotic diseases even though they do not own a pet of their own. As such, pet shops can be the focus of very large outbreaks of disease, such as the 2003 incident in the USA where prairie dogs infected with monkeypox were widely disseminated through pet shops and pet swap meets, and resulted in over 50 cases of human disease. Such disease outbreaks can have a significant public health burden in the direct morbidity and mortality to cases, in financial and logistical impacts on laboratories and healthcare providers, and in the time and expertise required to investigate exposures and follow up potentially infected animals and human cases and contacts. The precise public health impacts will vary according to the zoonosis and the size of incident.
Given their potential to spread zoonotic infections, it is important that pet shops act to minimise the risk as far as possible. The current legislative framework is biased towards animal welfare in the UK, with few recommendations seeking explicitly to protect human health. However, those exposures that fall within occupational health and safety are an exception: employee safety is covered by health and safety at work legislation, and the Control Of Substances Hazardous to Health (COSHH) regulations additionally cover the health of other people who may be exposed to hazards in the workplace, including customers.– Local Authorities have powers to impose conditions on the licensing of pet shops, and most adopt model standards published by the Local Government Association which includes taking all reasonable precautions to prevent the outbreak and spread of disease . Whilst proposing specific recommendations to improve control measures associated with companion animals in pet shops is beyond the scope of this paper, legislative authorities might consider more stringent oversight of pet breeders and distributors before animals enter the market. Alternatively, practical hygiene measures similar to those implemented on farms open to the public could be made mandatory in pet shops, and information leaflets on zoonotic risks and prevention measures for prospective pet owners could be provided to help to reduce the risk of infection.
PRISMA 2009 Checklist.
The authors would like to thank the reviewers of this manuscript for their valuable contributions.
Conceived and designed the experiments: DM CC K. Hewitt. Analyzed the data: K. Halsby AW CC. Wrote the paper: K. Halsby CC. Prepared Table 1: K. Halsby AW. Read and commented on draft manuscript: K. Halsby CC K. Hewitt AW DM. Initiated and supervised the development of the paper: DM. Suggested and developed the public health proposals put forward at the end of the discussion section: DM.
- 1. Pet Food Manufacturers association (2012) Pet population 2008 to 2012. Available: http://www.pfma.org.uk/pet-population-2008-2012. Accessed 28 January 2014.
- 2. [Anonymous] (2007) The Dangerous Wild Animals Act 1976 (Modification) (No. 2) Order 2007. Available: www.legislation.gov.uk/uksi/2007/2465/introduction/made. Accessed 28 January 2014.
- 3. Geffray L (1999) Infections associated with pets. Rev Med Interne 20: 888–901. doi: 10.1016/s0248-8663(00)80094-6
- 4. Plaut M, Zimmerman EM, Goldstein RA (1996) Health hazards to humans associated with domestic pets. Annu Rev Public Health 17: 221–245. doi: 10.1146/annurev.pu.17.050196.001253
- 5. Day MJ, Breitschwerdt E, Cleaveland S, Karkare U, Khanna C, et al.. (2012) Surveillance of zoonotic infectious disease transmitted by small companion animals. Emerg Infect Dis [Internet] Available: http://dx.doi.org/10.3201/eid1812.120664. Accessed 28 January 2014.
- 6. Pet Food Manufacturers association (2014) Pet statistics FAQ’s. Available: http://www.pfma.org.uk/faqs/pet-statistics. Accessed 28 January 2014.
- 7. Stehr-Green JK, Murray G, Schantz PM, Wahlquist SP (1987) Intestinal parasites in pet store puppies in Atlanta. Am J Public Health 77: 345–346. doi: 10.2105/ajph.77.3.345
- 8. Oxberry SL, Hampson DJ (2003) Colonisation of pet shop puppies with Brachyspira pilosicoli. Vet Microbiol 93: 167–174. doi: 10.1016/s0378-1135(03)00017-8
- 9. Bugg RJ, Robertson ID, Elliot AD, Thompson RC (1999) Gastrointestinal parasites of urban dogs in Perth, Western Australia. Vet J 157: 295–301. doi: 10.1053/tvjl.1998.0327
- 10. Itoh N, Itagaki T, Kawabata T, Konaka T, Muraoka N, et al. (2011) Prevalence of intestinal parasites and genotyping of Giardia intestinalis in pet shop puppies in east Japan. Vet Parasitol 176: 74–78. doi: 10.1016/j.vetpar.2010.10.048
- 11. Shiraki Y, Hiruma M, Matsuba Y, Kano R, Makimura K, et al. (2006) A case of tinea corporis caused by Arthroderma benhamiae (teleomorph of Tinea mentagrophytes) in a pet shop employee. J Am Acad Dermatol 55: 153–154. doi: 10.1016/j.jaad.2005.05.048
- 12. Mochizuki T (2002) Molecular epidemiology of Japanese isolates of Arthroderma benhamiae by polymorphisms of non-transcribed spacer region of the ribosomal DNA. [Article in Japanese]. Nihon Ishinkin Gakkai Zasshi 43: 1–4. doi: 10.3314/jjmm.43.1
- 13. Mochizuki T, Takeda K, Nakagawa M, Kawasaki M, Tanabe H, et al. (2005) The first isolation in Japan of Trichophyton mentagrophytes var. erinacei causing tinea manuum. Int J Dermatol 44: 765–768. doi: 10.1111/j.1365-4632.2004.02180.x
- 14. Katoh T, Maruyama R, Nishioka K, Sano T (1991) Tinea corporis due to Microsporum canis from an asymptomatic dog. J Dermatol 18: 356–359.
- 15. Palmer SR, Soulsby L, Simpson DIH (Editors) (1998) Zoonoses: Biology, clinical practice, and public health control. New York: Oxford University Press.
- 16. Shvartsblat S, Kochie M, Harber P, Howard J (2004) Fatal rat bite fever in a pet shop employee. Am J Ind Med 45: 357–360. doi: 10.1002/ajim.10359
- 17. Downing ND, Dewnany GD, Radford PJ (2001) A rare and serious consequence of a rat bite. Ann R Coll Surg Engl 83: 279–280.
- 18. Elliott SP (2007) Rat bite fever and Streptobacillus moniliformis. Clin Microbiol Rev 20: 13–22. doi: 10.1128/cmr.00016-06
- 19. Ipsos MORI (2004) Exotic pets. Available: http://www.ipsos-mori.com/researchpublications/researcharchive/912/Exotic-Pets.aspx. Accessed 28 January 2014.
- 20. Chomel BB (1992) Zoonoses of house pets other than dogs, cats and birds. Pediatr Infect Dis J 11: 479–487. doi: 10.1097/00006454-199206000-00011
- 21. CDC (1995) Mass treatment of humans exposed to rabies - New Hampshire, 1994. MMWR Morb Mortal Wkly Rep 44: 484–486.
- 22. Noah DL, Smith MG, Gotthardt JC, Krebs JW, Green D, et al. (1996) Mass human exposure to rabies in New Hampshire: exposures, treatment, and cost. Am J Public Health 86: 1149–1151. doi: 10.2105/ajph.86.8_pt_1.1149
- 23. Rotz LD, Hensley JA, Rupprecht CE, Childs JE (1998) Large-scale human exposures to rabid or presumed rabid animals in the United States: 22 cases (1990–1996). J Am Vet Med Assoc 212: 1198–1200.
- 24. HPA (2009) Reptile-associated salmonella infections (S. Typhimurium DT 191a) - an update. HPR 3: Online report. Available: http://www.hpa.org.uk/hpr/archives/2009/news3109.htm#dt191a. Accessed 28 January 2014.
- 25. HPA (2009) Reducing the risks of salmonella infection from reptiles. Available: http://www.hpa.org.uk/Topics/InfectiousDiseases/InfectionsAZ/Salmonella/GeneralInformation/salmReptiles. Accessed 28 January 2014.
- 26. [Anonymous] (2002) The Control of Substances Hazardous to Health Regulations 2002. Available: http://www.legislation.gov.uk/uksi/2002/2677/made. Accessed 28 January 2014.
- 27. [Anonymous] (2003) The Control of Substances Hazardous to Health (Amendment) Regulations 2003. Available: http://www.legislation.gov.uk/uksi/2003/978/made. Accessed 28 January 2014.
- 28. [Anonymous] (2004) The Control of Substances Hazardous to Health (Amendment) Regulations 2004. Available: http://www.legislation.gov.uk/uksi/2004/3386/made. Accessed 28 January 2014.
- 29. Local Government Association (2006) Pet Animals Act 1951: model standards for pet shop licence conditions. Available: http://www.local.gov.uk/web/guest/publications/-/journal_content/56/10171/3378153/PUBLICATION-TEMPLATE. Accessed 28 January 2014.
- 30. Breitschwerdt EB, Kordick DL (1995) Bartonellosis. J Am Vet Med Assoc 206: 1928–1931.
- 31. Harris JR, Blaney DD, Lindsley MD, Zaki SR, Paddock CD, et al. (2011) Blastomycosis in man after kinkajou bite. Emerg Infect Dis 17: 268–270. doi: 10.3201/eid1702.101046
- 32. Elsendoorn A, Agius G, Le Moal G, Aajaji F, Favier AL, et al. (2011) Severe ear chondritis due to cowpox virus transmitted by a pet rat. J Infect 63: 391–393. doi: 10.1016/j.jinf.2011.06.004
- 33. Campe H, Zimmermann P, Glos K, Bayer M, Bergemann H, et al. (2009) Cowpox virus transmission from pet rats to humans, Germany. Emerg Infect Dis 15: 777–780. doi: 10.3201/eid1505.090159
- 34. Ninove L, Domart Y, Vervel C, Voinot C, Salez N, et al. (2009) Cowpox virus transmission from pet rats to humans, France. Emerg Infect Dis 15: 781–784. doi: 10.3201/eid1505.090235
- 35. Becker C, Kurth A, Hessler F, Kramp H, Gokel M, et al. (2009) Cowpox virus infection in pet rat owners. Dtsch Arztebl Int 106: 329–334.
- 36. Xiao L, Hlavsa MC, Yoder J, Ewers C, Dearen T, et al. (2009) Subtype analysis of Cryptosporidium specimens from sporadic cases in Colorado, Idaho, New Mexico, and Iowa in 2007: widespread occurrence of one Cryptosporidium hominis subtype and case history of an infection with the Cryptosporidium horse genotype. J Clin Microbiol 47: 3017–3020. doi: 10.1128/jcm.00226-09
- 37. Nagel P, Serritella A, Layden TJ (1982) Edwardsiella tarda gastroenteritis associated with a pet turtle. Gastroenterology 82: 1436–1437.
- 38. Ceianu C, Tatulescu D, Muntean M, Molnar GB, Emmerich P, et al. (2008) Lymphocytic choriomeningitis in a pet store worker in Romania. Clin Vaccine Immunol 15: 1749. doi: 10.1128/cvi.00275-08
- 39. Amman BR, Pavlin BI, Albarino CG, Comer JA, Erickson BR, et al. (2007) Pet rodents and fatal lymphocytic choriomeningitis in transplant patients. Emerg Infect Dis 13: 719–725. doi: 10.3201/eid1305.061269
- 40. Gregg MB (1975) Recent outbreaks of lymphocytic choriomeningitis in the United States of America. Bull World Health Organ 52: 549–553.
- 41. Hirsch MS, Moellering RC Jr, Pope HG, Poskanzer DC (1974) Lymphocytic-choriomeningitis virus infection traced to a pet hamster. N Engl J Med 291: 610–612. doi: 10.1056/nejm197409192911206
- 42. Gaudie CM, Featherstone CA, Phillips WS, McNaught R, Rhodes PM, et al. (2008) Human Leptospira interrogans serogroup Icterohaemorrhagiae infection (Weil’s disease) acquired from pet rats. Vet Rec 163: 599–601. doi: 10.1136/vr.163.20.599
- 43. Finsterer J, Stollberger C, Sehnal E, Stanek G (2005) Mild leptospirosis with three-year persistence of IgG- and IgM-antibodies, initially manifesting as carpal tunnel syndrome. J Infect 51: E67–E70. doi: 10.1016/j.jinf.2004.08.019
- 44. Friedmann CT, Spiegel EL, Aaron E, McIntyre R (1973) Leptospirosis ballum contracted from pet mice. Calif Med 118: 51–52.
- 45. Reed KD, Melski JW, Graham MB, Regnery RL, Sotir MJ, et al. (2004) The detection of monkeypox in humans in the Western Hemisphere. N Engl J Med 350: 342–350. doi: 10.1056/nejmoa032299
- 46. Kile JC, Fleischauer AT, Beard B, Kuehnert MJ, Kanwal RS, et al. (2005) Transmission of monkeypox among persons exposed to infected prairie dogs in Indiana in 2003. Arch Pediatr Adolesc Med 159: 1022–1025.
- 47. Weese JS, Dick H, Willey BM, McGeer A, Kreiswirth BN, et al. (2006) Suspected transmission of methicillin-resistant Staphylococcus aureus between domestic pets and humans in veterinary clinics and in the household. Vet Microbiol 115: 148–155. doi: 10.1016/j.vetmic.2006.01.004
- 48. Budoia J, Tagliari C, Villa R, Gatto S, Bedin V (2012) Dermatologic manifestation of psittacosis. J Am Acad Dermatol 66: 108.
- 49. Saito T, Ohnishi J, Mori Y, Iinuma Y, Ichiyama S, et al. (2005) Infection by Chlamydophila avium in an elderly couple working in a pet shop. J Clin Microbiol 43: 3011–3013. doi: 10.1128/jcm.43.6.3011-3013.2005
- 50. Vanrompay D, Harkinezhad T, van de Walle M, Beeckman D, van Droogenbroeck C, et al. (2007) Chlamydophila psittaci transmission from pet birds to humans. Emerg Infect Dis 13: 1108–1110. doi: 10.3201/eid1307.070074
- 51. Maegawa N, Emoto T, Mori H, Yamaguchi D, Fujinaga T, et al. (2001) Two cases of Chlamydia psittaci infection occurring in employees of the same pet shop [Article in Japanese]. Nihon Kokyuki Gakkai Zasshi 39: 753–757.
- 52. Dovc A, Dovc P, Kese D, Vlahovic K, Pavlak M, et al. (2005) Long-term study of Chlamydophilosis in Slovenia. Vet Res Commun 29: 23–36. doi: 10.1007/s11259-005-0834-2
- 53. [Anonymous] (2000) Compendium of measures to control Chlamydia psittaci infection among humans (psittacosis) and pet birds (avian chlamydiosis), 2000. MMWR Recomm Rep 49: 1–17.
- 54. Messmer TO, Skelton SK, Moroney JF, Daugharty H, Fields BS (1997) Application of a nested, multiplex PCR to psittacosis outbreaks. J Clin Microbiol 35: 2043–2046.
- 55. Hughes C, Maharg P, Rosario P, Herrell M, Bratt D, et al. (1997) Possible nosocomial transmission of psittacosis. Infect Control Hosp Epidemiol 18: 165–168. doi: 10.1086/647581
- 56. Gregory DW, Schaffner W (1997) Psittacosis. Semin Respir Infect 12: 7–11.
- 57. Moroney JF, Guevara R, Iverson C, Chen FM, Skelton SK, et al. (1998) Detection of chlamydiosis in a shipment of pet birds, leading to recognition of an outbreak of clinically mild psittacosis in humans. Clin Infect Dis 26: 1425–1429. doi: 10.1086/516368
- 58. Viciana P, Bozada JM, Martin-Sanz V, Martinez-Marcos F, Martin A, et al. (1993) Psittacosis of avian origin as etiology of community-acquired pneumonia with severe onset. [Article in Spanish]. Rev Clin Esp 192: 28–30.
- 59. Morrison WM, Hutchison RB, Thomason J, Harrington JH, Herd GW (1991) An outbreak of psittacosis. J Infect 22: 71–75. doi: 10.1016/0163-4453(91)91038-y
- 60. Jernelius H, Pettersson B, Schvarcz J, Vahlne A (1975) An outbreak of ornithosis. Scand J Infect Dis 7: 91–95.
- 61. Broholm KA, Bottiger M, Jernelius H, Johansson M, Grandien M, et al. (1977) Ornithosis as a nosocomial infection. Scand J Infect Dis 9: 263–267.
- 62. Kanazawa Y, Suga S, Niwayama S (1976) A case of psittacosis treated with rifampicin (author’s transl). [Article in Japanese]. Jpn J Antibiot 29: 601–606.
- 63. [Anonymous] (1973) An outbreak of psittacosis. Br Med J 4: 58.
- 64. [Anonymous] (1975) Psittacosis in a pet shop. Br Med J 1: 283.
- 65. Alestig K, Bakos K, Barr J, Heller L (1963) An Ornithosis epidemic in Orebro. Acta Med Scand 174: 441–449. doi: 10.1111/j.0954-6820.1963.tb07943.x
- 66. Bilek J, Baranova Z, Kozak M, Fialkovicova M, Weissova T, et al. (2005) Trichophyton mentagrophytes var. quinckeanum as a cause of zoophilic dermatomycosis in a human family. Bratisl Lek Listy 106: 383–385. doi: 10.2754/avb200372020313
- 67. Rosen T (2000) Hazardous hedgehogs. South Med J 93: 936–938. doi: 10.1097/00007611-200093090-00023
- 68. CDC (2011) Notes from the field: Update on human Salmonella Typhimurium infections associated with aquatic frogs – United States, 2009–2011. MMWR Morb Mortal Wkly Rep 60: 628.
- 69. Harris JR, Bergmire-Sweat D, Schlegel JH, Winpisinger KA, Klos RF, et al. (2009) Multistate outbreak of Salmonella infections associated with small turtle exposure, 2007–2008. Pediatrics 124: 1388–1394. doi: 10.1542/peds.2009-0272
- 70. Swanson SJ, Snider C, Braden CR, Boxrud D, Wunschmann A, et al. (2007) Multidrug-resistant Salmonella enterica serotype Typhimurium associated with pet rodents. N Engl J Med 356: 21–28. doi: 10.1056/nejmoa060465
- 71. Gaulin C, Vincent C, Ismail J (2005) Sporadic infections of Salmonella Paratyphi B, Var. Java associated with fish tanks. Can J Public Health 96: 471–474.
- 72. Wright JG, Tengelsen LA, Smith KE, Bender JB, Frank RK, et al. (2005) Multidrug-resistant Salmonella Typhimurium in four animal facilities. Emerg Infect Dis 11: 1235–1241. doi: 10.3201/eid1108.050111
- 73. Lynch M, Daly M, O’Brien B, Morrison F, Cryan B, et al. (1999) Salmonella tel-el-kebir and terrapins. J Infect 38: 182–184. doi: 10.1016/s0163-4453(99)90248-7
- 74. Anand CM, Fonseca K, Longmore K, Rennie R, Chui L, et al. (1997) Epidemiological investigation of Salmonella tilene by pulsed-field gel electrophoresis and polymerase chain reaction. Can J Infect Dis 8: 318–322.
- 75. Craig C, Styliadis S, Woodward D, Werker D (1997) African pygmy hedgehog-associated Salmonella tilene in Canada. Can Commun Dis Rep 23: 129–131.
- 76. Mermin J, Hoar B, Angulo FJ (1997) Iguanas and Salmonella marina infection in children: a reflection of the increasing incidence of reptile-associated salmonellosis in the United States. Pediatrics 99: 399–402. doi: 10.1542/peds.99.3.399
- 77. CDC (1995) African pygmy hedgehog-associated Salmonellosis - Washington, 1994. MMWR Morb Mortal Wkly Rep 44: 462–463.
- 78. Nagano N, Oana S, Nagano Y, Arakawa Y (2006) A severe Salmonella enterica Serotype Paratyphi B infection in a child related to a pet turtle, Trachemys scripta elegans. Jpn J Infect Dis 59: 132–134.
- 79. Tauxe RV, Rigau-Perez JG, Wells JG, Blake PA (1985) Turtle-associated salmonellosis in Puerto Rico. Hazards of the global turtle trade. JAMA 254: 237–239. doi: 10.1001/jama.254.2.237
- 80. Lamm SH, Taylor A Jr, Gangarosa EJ, Anderson HW, Young W, et al. (1972) Turtle-associated salmonellosis. I. An estimation of the magnitude of the problem in the United States, 1970–1971. Am J Epidemiol 95: 511–517.
- 81. Jack DC (1997) The legal implications of the veterinarian’s role as a private practitioner and health professional, with particular reference to the human-animal bond: Part 2, The veterinarian’s role in society. Can Vet J 38: 653–659.
- 82. Avashia SB, Petersen JM, Lindley CM, Schriefer ME, Gage KL, et al. (2004) First reported prairie dog-to-human tularemia transmission, Texas, 2002. Emerg Infect Dis 10: 483–486. doi: 10.3201/eid1003.030695