To estimate diabetes-related direct health care costs in pediatric patients with early-onset type 1 diabetes of long duration in Germany.
Research Design and Methods
Data of a population-based cohort of 1,473 subjects with type 1 diabetes onset at 0–4 years of age within the years 1993–1999 were included (mean age 13.9 (SD 2.2) years, mean diabetes duration 10.9 (SD 1.9) years, as of 31.12.2007). Diabetes-related health care services utilized in 2007 were derived from a nationwide prospective documentation system (DPV). Health care utilization was valued in monetary terms based on inpatient and outpatient medical fees and retail prices (perspective of statutory health insurance). Multiple regression models were applied to assess associations between direct diabetes-related health care costs per patient-year and demographic and clinical predictors.
Mean direct diabetes-related health care costs per patient-year were €3,745 (inter-quartile range: 1,943–4,881). Costs for glucose self-monitoring were the main cost category (28.5%), followed by costs for continuous subcutaneous insulin infusion (25.0%), diabetes-related hospitalizations (22.1%) and insulin (18.4%). Female gender, pubertal age and poor glycemic control were associated with higher and migration background with lower total costs.
Main cost categories in patients with on average 11 years of diabetes duration were costs for glucose self-monitoring, insulin pump therapy, hospitalization and insulin. Optimization of glycemic control in particular in pubertal age through intensified care with improved diabetes education and tailored insulin regimen, can contribute to the reduction of direct diabetes-related costs in this patient group.
Citation:Bächle C, Icks A, Straßburger K, Flechtner-Mors M, Hungele A, et al. (2013) Direct Diabetes-Related Costs in Young Patients with Early-Onset, Long-Lasting Type 1 Diabetes. PLoS ONE 8(8): e70567. doi:10.1371/journal.pone.0070567
Editor: Maarten Postma, Groningen Research Institute of Pharmacy, United States of America
Received: January 11, 2013; Accepted: June 26, 2013; Published: August 13, 2013
Copyright: © 2013 Bächle et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding:This study was supported by the Competence Network Diabetes Mellitus by the German Federal Ministry of Education and Research (www.kompetenznetz-diabetes-mellitus.net/index.php/en; FKZ 01GI0802, 01GI1109A, 01GI0859, 01GI1106). The German Diabetes Center is institutionally funded by the German Ministry of Health and the Ministry of Innovation, Sciences and Research of the Federal State of North Rhine-Westphalia. The DPV initiative is supported by the European Foundation for the Study of Diabetes (EFSD), the Dr. Bürger-Büsing Foundation, and by a research grant of Novo Nordisk Germany. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The DPV initiative is supported by a research grant from Novo Nordisk Germany. The grant supports the establishment and the further development of the DPV database. The authors' analysis was not financially supported by Novo Nordisk and is independent of any commercial funders. This fact does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Pediatric type 1 diabetes is an illness with severe and long-lasting impact for the individual and its family, and in addition for the society , . In particular, children with early-onset pediatric type 1 diabetes show a more severe disease onset with increased risk of diabetic ketoacidosis , . They also bear greater life-time risks to develop diabetes-related chronic complications as a consequence of their almost life-long diabetes duration . According to the German CoDiM Study, direct diabetes-related costs increase considerably with the onset of diabetes-related complications , .
By now, there is limited information on the costs of pediatric type 1 diabetes. Only a few studies discuss direct diabetes-related costs of pediatric diabetes – with a wide range of estimated costs (about €2,800–6,200 per person-year).
So far, the studies analyzing diabetes-related costs mainly focused on mean costs of diabetes in patients with relatively short duration and irrespective of the age at onset. There are no specific studies on direct medical cost in early-onset pediatric type 1 diabetes of long duration. However, in times of limited economic resources it is essential to keep the health care resources in mind. This issue will gain importance in pediatric diabetes care since pediatric type 1 diabetes is increasing in Europe as well as worldwide –. A rapid incidence increase was particularly observed in children younger than five years of age and the number of new cases in this age group has been predicted to double between 2003 and 2020 .
The aim of this study was to estimate direct diabetes-related health care costs of pediatric type 1 diabetes and to assess their predictors in a population-based cohort of young patients with early-onset diabetes and at least eight years of diabetes duration.
Research Design and Methods
The study cohort was selected from the nationwide diabetes register maintained at the German Diabetes Center (DDZ) since 1993 . Completeness of ascertainment of the register is estimated at about 95%. Basic inclusion criterion for this analysis was an onset of type 1 diabetes during the first five years of life between the years 1993 and 1999. Overall, 3,224 registered cases met the inclusion criteria. This cohort is followed-up within a project of the German Competence Network Diabetes Mellitus (www.kompetenznetz-diabetes-mellitus.net/index.php/en). Data on health care utilization in 2007 were taken from the DPV (Diabetes Software for Prospective Documentation) database and used as basis for estimating direct diabetes-related health care costs. DPV is a trusted, well-established software for prospective longitudinal documentation of routine diabetes care and outcomes –. It is presently used in more than 300 pediatric diabetes centers in Germany, which is the majority of German facilities with pediatric diabetes care. Twice yearly, data of all treatment centers are anonymized and transmitted to the Institute of Epidemiology and Medical Biometry at Ulm University for central plausibility checks. Inconsistent data are reported back to participating centers for validation and correction. Finally, corrected and validated data are jointly entered into a cumulative database for further analyses. To ensure that patients were treated continually, only subjects who had at least a once annual documentation in DPV for the years 2006 to 2008 were included. Thus, health care utilization is assumed to be largely covered for these patients. Altogether, data of 1,473 subjects (45.7% of eligible subjects in Germany) from 199 German diabetes care centers were available for analysis. The analyses were based on data for the year 2007.
Assessment of sociodemographic and clinical variables
Information about gender, age (as of 31 December 2007), and diabetes duration was available for all subjects. Migration background was assumed, if a subject's father or mother or both were born outside of Germany. For analysis of glycemic control, individual mean HbA1c in 2007 was standardized to the Diabetes Control and Complications Trial (DCCT) normal range by means of the “multiple of the mean method” –. In doing so, it was accounted for differences between center laboratories in HbA1c due to differing methods of measurement. HbA1c values were finally categorized according to recommendations of the International Society for Pediatric & Adolescent Diabetes (ISPAD) (<58, 58-<75, ≥75 mmol/mol, corresponding to <7.5, 7.5-<9.0; ≥9%) . All these factors have previously been reported to be associated with costs of care , , –.
Health care utilization
Health care service utilization included the number, the reason for and the length of hospital stays related to diabetes, the frequency of diabetes-related outpatient consultations (routine medical services and laboratory testing), the type of insulin and the insulin regimen, the mean daily insulin dose (international units, IU), and the number of daily blood glucose self-measurements (median of all documented values in 2007) for each subject. Additionally, the treatment with antihypertensive drugs (ACE inhibitors), lipid-lowering agents (statins), and biguanides (metformin) was included.
In Germany, the vast majority of the population (approximately 85% ) is insured via the statutory health insurance and almost all medical costs for diabetes care are covered by the health insurance. For this reason, the study took the perspective of the statutory health insurance. Since children and adolescents in Germany have free access to services in the health care sector, no patients' co-payments were included. Prices for insulin and other medication were taken from the official German Index of Medicines of 2007 by calculating mean retail prices for the biggest privately available package-size of the year 2007. For insulin pumps, syringes, lancets, blood glucose and ketone body strips as well as glucagon sets prices for 2007 were estimated by deflating 2010 prices using the Consumer Price Index (www.destatis.de). In Germany, between 2003 and 2005, diagnosis-related groups (DRGs) were implemented as a reimbursement system for inpatient care. Within the DRG system, hospitalizations are reimbursed by fixed rates mainly depending on diagnosis (www.g-drg.de). In table 1, average health care utilization of the study group is shown. Furthermore, there are corresponding unit costs for all included health care services. Fees for outpatient medical service were taken from the statutory health insurances' price scale (per capita quarterly rates plus additional fees for subjects undergoing laboratory testing). For subjects registered in a structured healthcare program for chronically ill patients (Disease Management Program [DMP]), average DMP fees were applied for outpatient care instead.
For all continuous variables, descriptive statistics with mean values, standard deviations (SD) and ranges were calculated. For categorical variables, proportions of subjects were used for description. In accordance with Thompson , total costs and costs in different subcategories were expressed as mean costs per patient-year in Euro (€) along with inter-quartile ranges.
Mean total costs, mean costs for self-monitoring of blood and urine glucose (SMBUG), or for insulin were dependent variables. Gender, age (8–11, 12–15, 16–19 years, as of 31 December 2007), diabetes duration (8–10, 11–14 years, as of 31 December 2007), migration background, and glycemic control (HbA1c <58, 58-<75, ≥75 mmol/mol, corresponding to <7.5, 7.5-<9.0, ≥9%) constituted independent variables. The associations between independent and dependent variables were analyzed using multiple log-linear regression models (Ordinary Least Squares estimation for log-transformed costs) , . Cost ratios were estimated by retransformation of expected cost differences on the log-scale. Estimates of expected costs were derived from regression coefficients using the non-parametric Smearing transformation . Because most subjects had no inpatient treatment or no continuous subcutaneous insulin infusion (CSII) therapy in 2007, two-part models were applied to analyze determinants of costs for hospitalization or CSII in the total cohort , –. First, the relative risk (RR) for hospitalization or CSII therapy was estimated by multiple log-binomial regression . Second, a multiple log-linear regression procedure was used to assess expected cost ratios among subjects with inpatient care or CSII therapy. The convenience of applying log-binomial regression in the first part of the model is that results from both parts of the model can easily be combined to estimate expected cost ratios and expected costs for the whole study population (unlike for the common logistic approach). Total cost ratios were then estimated by multiplying the relative risk of hospitalization or CSII therapy and the expected cost ratios of hospitalized subjects or subjects with CSII therapy, respectively . Accordingly, total expected costs were estimated by multiplying the probability of hospitalization or CSII therapy and the expected costs of hospitalized subjects or subjects with CSII therapy, respectively . All tests were performed at a two-sided significance level of 0.05. For statistical evaluation, SAS for Windows Version 9.2 (SAS Institute, Cary, NC, USA) was used.
The study was approved by the ethical review board of Heinrich Heine University Düsseldorf.
Table 2 describes the characteristics of the patients. Mean age was 13.9 (SD 2.2) years, mean diabetes duration was 10.9 (SD 1.9) years. A total of 21.7% of the study patients were 8–11 years old, 58.2% were 12–15 years old, and 20.0% were 16–19 years old. Altogether 53.8% of the patients had a diabetes duration of 8–10 years and 46.2% of 11–14 years.
Utilization of diabetes care
More than one third of the subjects (36.2%) were on CSII therapy, nearly three-quarters of those (73.0%) used insulin pump therapy throughout 2007, the others started CSII therapy in 2007. Mean insulin dose per kilogram body weight was 0.9 (SD 0.3) IU. Antihypertensive drugs were taken by 1.7%, lipid-lowering agents by 0.3%, and biguanides by 0.2% of the subjects, respectively.
Regarding outpatient consultations, half of the subjects had at least one contact per quarter-year (49.6%). The mean number of diabetes-related outpatient consultations was 4.2 per year. More than a third of the subjects (36.9%) were registered in a DMP.
During 2007, most of the subjects (71.4%) had no inpatient treatment because of diabetes. A quarter of the study patients had one stay (24.6%), 4.1% had more than one diabetes-related hospitalization. The average hospital stay lasted 8.8 days. In 2007, a total of 17.9% of the patients had a cumulative length of inpatient treatment of up to one week, 6.3% of >1–2 weeks, 1.2% of >2–3 weeks, and 3.3% of more than 3 weeks. Further details on the reasons for diabetes-related hospital admissions and days in hospital are reported in table 2. Related to the whole study population, there was a mean of 0.35 diabetes-related hospital stays and 2.85 hospital days per person-year in 2007.
Factors associated with inpatient care or CSII therapy
Table 3 summarizes the results of the first part of the applied two-part model and gives an overview of factors that were associated with hospitalization and CSII therapy. The risk for hospitalization was significantly lower in 16 to 19-year-olds compared with 8–11 year old patients (RR 0.67, 95% confidence interval (95%-CI) 0.48–0.94). Impaired and poor glycemic control were associated with significantly higher hospitalization (RR 1.60, 95%-CI 1.30–1.96 and 2.31, 95%-CI 1.87–2.86, respectively). Gender, diabetes duration, and migration background were not significantly associated with hospitalization (table 3). The use of CSII therapy was significantly lower among male patients (RR 0.76, 95%-CI 0.67–0.87) and patients with migration background (RR 0.72, 95%-CI 0.57–0.92). Age, diabetes duration, and glycemic control were not associated with CSII (table 3).
In 2007, average direct diabetes-related health care costs per study subject amounted to €3,745 (table 4). The spread of individual total costs among study patients was considerable, ranging from €948 up to €34,498 (inter-quartile range: €1,943–4,881). The largest share of costs in the study cohort was attributable to SMBUG, followed by CSII and diabetes-related hospitalizations. Almost one fifth of the costs were spent for insulin. A total of 3.6% was spent for diabetes-related outpatient care. The percentage of diabetes-related costs for injection needles/syringes, glucagon sets, and other medication amounted to each at most 2% of total costs.
Factors associated with diabetes-related costs
Associations between total costs or different cost categories and influencing factors are given in table 5 in terms of expected cost ratios and in table 6 in terms of expected costs and cost differences.
Total costs and costs for CSII therapy in male patients were 6.2% (€240) and 26% (€274) lower than in female patients, respectively. Reduced CSII costs among the male subgroup were mainly attributable to the reduced rate of CSII therapy in this group (table 3). There were no significant gender differences with respect to the other single cost categories. Total costs, costs for hospitalizations, and CSII costs were highest in the age group of the 12 to 15-year-olds. In contrast, costs for insulin increased steadily and costs for SMBUG dropped steadily with increasing age. Patients with a diabetes duration of 11–14 years had 15% (€96) higher costs for insulin, but 4.1% (€42) lower costs for SMBUG compared with patients with 8–10 years of diabetes duration. Poor glycemic control was significantly associated with increased total costs, higher costs for hospitalization (up to three times higher costs) and higher costs for insulin, but with decreased costs for SMBUG. Glycemic control was not significantly associated with costs for CSII therapy. Patients with migration background had significantly lower total costs and lower costs for SMBUG and CSII therapy, but higher costs for hospitalization (not statistically significant).
Main findings and implications
Using a population-based cohort and data of a standardized prospective computer-based documentation system (DPV), we estimated direct diabetes-related health care costs of a special group of patients with early disease onset and at least 8 years of diabetes duration, who were expected to have increased total direct diabetes-related costs compared with patients with shorter diabetes duration. Average costs of subjects with early-onset and long diabetes duration amounted to €3,745 per patient-year. Costs varied widely between different patient groups. As in previous cost analyses , , total diabetes-related costs were lower in male than in female patients. Worse glycemic conditions in pubertal age , ,  and higher comorbidity ,  or more intensive health care seeking behavior in female subjects  may explain these findings. There was a strong association between diabetes-related costs and HbA1c as an indicator for glycemic control. Worse glycemic control was associated with increased total costs, costs for hospitalization, and costs for insulin. We hypothesize that subjects with worse glycemic control measure their blood glucose level less frequently, but have more hospitalizations and higher demands for insulin. The decrease with age observed in the costs for SMBUG corresponds to less frequent glycemic control with older age as previously shown . Migration background was associated with lower total direct medical costs. This was obviously due to less utilization of SMBUG and in particular CSII therapy (tables 3 and 5) in patients with migration background.
Comparison of costs in the study population to average costs in pediatric patients in Germany
Despite almost two-fold longer diabetes duration, direct diabetes-related health care costs were only 6.3% higher than estimated average costs in previously analyzed patients in Germany (€3,524), who were slightly younger (mean age 12.1 (SD 4.2) years) and had about half the diabetes duration (mean duration 4.7 (SD 3.6) years) . This can be attributed to the fact that the study patients with at least 8 years of diabetes duration have largely remained free of severe chronic diabetic complications, as is indicated by the low rate of inpatient care because of complications and the lack of medication for comorbidities. The German Costs of Diabetes Mellitus (CoDiM) study revealed that the treatment of diabetic complications was far more costly than the underlying disease . Therefore, the analysis of patients with diabetes duration longer than ten years on average is likely to reveal different results. In former analyses, mean diabetes duration of DPV patients with severe diabetes-related retinopathy was 26.5 years  and the proportion of patients affected by renal complications increased with age . Other cohort studies corroborate these findings. For example, in case of renal complications, data from the Swedish Childhood Diabetes Registry (SCDR) , the Epidemiology of Diabetes Interventions and Complications (EDIC) study , , and the Allegheny County population-based registry  show that severe complications can be expected much later than after one decade of disease duration.
Absolute and relative costs for insulin and CSII were higher in study patients with long diabetes duration compared with a previously analyzed pediatric cohort of DPV patients <20 years of age with on average half the diabetes duration . The reason for an increase in insulin requirement may be due to insulin resistance with increasing age and diabetes duration. Furthermore, the honeymoon period, a period after the initial treatment of diabetes, in which the insulin production temporarily regenerates, reduces average insulin requirement in the previously analyzed group of pediatric patients with type 1 diabetes <20 years of age. The increase in CSII costs is attributable to increased use of CSII therapy in patients with longer diabetes duration and thus more complicated glycemic control. In contrast, patients of this study cohort had lower absolute and relative costs regarding SMBUG, hospitalization, and outpatient care compared with the previously analyzed cohort with shorter diabetes duration. Further investigation should consider whether the present findings will apply to patients with even longer diabetes duration.
Comparison of the study results with previous reports
In general, it's difficult to compare findings of studies because there is large heterogeneity regarding methodological approaches, but also with respect to patients included (type 1, 2 or both, age classes, diabetes duration), and reimbursements under different national health care systems. Most studies analyzed patients irrespective of diabetes duration. Therefore, comparability with the present results is limited. In particular, results of studies including patients with type 2 diabetes are not comparable due to differences in therapeutic regimes (e. g. number of prescribed test strips, prescription of insulin and/or oral antidiabetic medication) and resulting costs , , , .
In a recent examination in the U.S., Ying et al. estimated direct costs of diabetes care in type 1 diabetic subjects less than 20 years of age (mean age 12.8 (SD 3.7) years) . Mean total diabetes-related direct costs per person-year were US$4,730 (i.e. €3,493) and thus were slightly lower than our estimates. Mean diabetes duration of the subjects of Ying et al. was 5.6 (SD 3.1) years in contrast to 10.9 years in the present cohort. However, as patients with diabetes duration less than 6 months were excluded by Ying et al., a comparison seems feasible. Main cost categories in the study of Ying et al. were supplies (38% of total annual costs), medication (33%), and hospitalization (15%). Other cost categories were outpatient visits (9%), emergency room (4%), and education visits (1%). In our study, main contributors to total costs were the same, but the share of single cost items was different, probably due to differences in health care systems and diabetes therapy between the U.S. and Germany. Furthermore, the cost categories used by Ying et al. are different from ours, so that a direct comparison is difficult. CSII therapy, for example, is not separately listed by Ying et al.
Other studies reported lower direct medical costs in subjects with type 1 diabetes in Australia (AU$3640 (i.e. €2,283), mean age 32.0 (range 5–88) years, mean diabetes duration 8.3 years)  and Spain (€2,104, mean age 29.2 (SD 12.2), mean diabetes duration 10.5 (SD 7.9) years) .The subjects of the Spanish study had lower costs for hospitalization (€164 vs. €827) . In Germany, a large proportion of diabetes education is commenced in the hospital setting and this is likely to be one reason for high hospitalization costs. Unfortunately, Ballesta et al.  did not report whether costs for structured patient education were covered by their analysis. Furthermore, Spanish subjects measured blood glucose less frequently than German ones (2.7 vs. 5.1 times per day) and costs for CSII were not included.
Study limitations and strength
Despite the advantage of including a large population-based cohort of type 1 diabetic patients and the benefits of continuous standardized documentation from a comprehensive computer database, some limitations have to be considered.
The study cohort was selected from a population-based, almost complete incidence register. We could include nearly 50% of all patients who were diagnosed between the years 1993–1999. The proportion of males in study patients was comparable to that among patients not included (53.0% vs. 52.0%). On average, study patients were slightly younger and had a slightly shorter diabetes duration than not included patients (mean age 15.04 (SD 2.50) years, mean diabetes duration 11.80 (SD 2.07) years). Further, we cannot exclude that our study group differs from not included patients with respect to other potentially influencing factors, e.g. education, household income or socio-economic status, as respective information was not available. Thus, a selection bias cannot be excluded, even though DPV is used in a broad spectrum of pediatric facilities including small-sized centers and tertiary university centers. Our inclusion criteria (at least one annual documentation during 2006–2008) may have caused further selection bias by excluding relatively non-adherent patients who would generate more or less diabetes-related costs. Although diabetes care is highly standardized in Germany and available for all patients and covered by the statutory health insurance, the results may not apply to all respective patients with type 1 diabetes in Germany. Nevertheless, we consider our results to hold true for most patients with early-onset type 1 diabetes and more than 8 years of diabetes duration according to the inclusion criteria of the study.
Total cost of health care may not be transferable to other countries due to the varying basic conditions of health care systems. However, the estimated cost ratios can be assumed to be less dependent on such basic conditions and thus to be better comparable to other countries (table 5).
The DPV patient documentation is used by many clinics for administrative purposes (basis for reimbursement of costs from statutory health insurance funds), and regular checks on plausibility and validity of data are implemented. Therefore, the data of health care utilization are supposed to be rather valid. However, some extent of underreporting cannot completely be excluded. Further, we cannot completely exclude that patients have received diabetes care outside the DPV coverage. Thus, health care utilization may be underestimated in this study.
Regarding outpatient care, we employed the general items of the medical fee schedule. For subjects in DMP, only fees for basic diabetes care were considered, as compensation for further health care services varies enormously among the different DMPs. In addition, special diabetes-related per capita fees were not considered in our estimations. Thus, our cost estimates are expected to be rather conservative.
As prices for insulin and other medication were derived from the official German Index of Medicines by calculating mean retail prices for the biggest privately available package-size, respective cost estimates are assumed to be conservative and lower bound of real costs.
We used 2010 mean prices for insulin pumps, syringes, lancets, blood glucose and ketone body strips as well as for glucagon sets to estimate 2007 prices. Since we deflated medical prices of the year 2010 to 2007, we consider our cost estimates to be valid.
In conclusion, type 1 diabetes in young patients with early disease onset and about 11 years of diabetes duration is an economic challenge, even before the development of severe and costly complications related to diabetes. Main cost categories were costs for glucose self-monitoring, pump therapy, hospitalization, and insulin. Glycemic control and pubertal age were main determinants for total costs, while diabetes duration had little effect on total costs at this disease stage. Optimization of glycemic control and intensified care, in particular in pubertal age, can contribute to the reduction of direct diabetes-related costs. Further analyses should estimate costs of patients with longer diabetes duration.
DPV centers contributing data for this analysis.
The authors wish to express their gratitude to all participating centers of the DPV initiative. Diabetes centers contributing data to the present analysis are listed in appendix S1.
The abstract of the study was presented as a poster at the 47th annual meeting of the EASD in Lisbon 2011.
Conceived and designed the experiments: CB AI JR. Analyzed the data: KS RWH JR. Contributed reagents/materials/analysis tools: MFM AH RWH. Wrote the paper: CB. Assisted in the analyses: CB. Contributed to the discussion: AI PB JR. Reviewed the manuscript: AI KS MFM PB MF UH KP AS ASP RWH JR.
- 1. Tao B, Pietropaolo M, Atkinson M, Schatz D, Taylor D (2010) Estimating the cost of type 1 diabetes in the U.S.: a propensity score matching method. PLoS One 5(7): e11501 doi:10.1371/journal.pone.0011501.
- 2. Köster I, von Ferber L, Ihle P, Schubert I, Hauner H (2006) The cost burden of diabetes mellitus: the evidence from Germany–the CoDiM study. Diabetologia 49(7): 1498–1504 doi:10.1007/s00125-006-0277-5.
- 3. Karges B, Neu A, Hofer SE, Rosenbauer J, Kiess W, et al. (2011) (Frequency and influencing factors of ketoacidosis at diabetes onset in children and adolescents – a long-term study between 1995 and 2009). Klin Padiatr 223(2): 70–73 doi:10.1055/s-0030-1269884.
- 4. Neu A, Hofer SE, Karges B, Oeverink R, Rosenbauer J, et al. (2009) Ketoacidosis at diabetes onset is still frequent in children and adolescents: a multicenter analysis of 14,664 patients from 106 institutions. Diabetes Care 32(9): 1647–1648 doi:10.2337/dc09-0553.
- 5. Dabelea D (2009) The accelerating epidemic of childhood diabetes. Lancet 373(9680): 1999–2000 doi:10.1016/S0140-6736(09)60874-6.
- 6. von Ferber L, Köster I, Hauner H (2007) Medical costs of diabetic complications total costs and excess costs by age and type of treatment results of the German CoDiM Study. Exp Clin Endocrinol Diabetes 115(2): 97–104 doi:10.1055/s-2007-949152.
- 7. Köster I, Hauner H, von Ferber L (2006) Heterogeneity of costs of diabetic patients: the Cost of Diabetes Mellitus Study. Dtsch Med Wochenschr 131(15): 804–810 doi:10.1055/s-2006-939850.
- 8. Bächle CC, Holl RW, Strassburger K, Molz E, Chernyak N, et al. (2012) Costs of paediatric diabetes care in Germany: current situation and comparison to the year 2000. Diabet Med 29: 1327–1334 doi:10.1111/j.1464-5491.2012.03645.x.
- 9. Ying AK, Lairson DR, Giardino AP, Bondy ML, Zaheer I, et al. (2011) Predictors of direct costs of diabetes care in pediatric patients with type 1 diabetes. Pediatr Diabetes 12: 177–182 doi:10.1111/j.1399-5448.2010.00680.x.
- 10. Wiréhn A, Andersson A, Ostgren CJ, Carstensen J (2008) Age-specific direct healthcare costs attributable to diabetes in a Swedish population: a register-based analysis. Diabet Med 25(6): 732–737 doi:10.1111/j.1464-5491.2008.02444.x.
- 11. Zhang P, Imai K (2007) The relationship between age and healthcare expenditure among persons with diabetes mellitus. Expert Opin Pharmacother 8(1): 49–57 doi:10.1517/146565126.96.36.199.
- 12. Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G (2009) Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. Lancet 373(9680): 2027–2033 doi:10.1016/S0140-6736(09)60568-7.
- 13. Tao BT, Taylor DG (2010) Economics of type 1 diabetes. Endocrinol Metab Clin North Am 39(3): 499–512 doi:10.1016/j.ecl.2010.05.004.
- 14. Rosenbauer J, Stahl A (2010) Häufigkeit des Diabetes mellitus im Kindes- und Jugendalter in Deutschland. Der Diabetologe 10(6): 177–189. doi: 10.1007/s11428-009-0497-7
- 15. Soltesz G, Patterson C, Dahlquist G (2009) Diabetes in the Young: a Global Perspective. IDF Diabetes Atlas. Brussels: International Diabetes Federation.
- 16. Rosenbauer J, Herzig P, von Kries R, Neu A, Giani G (1999) Temporal, seasonal, and geographical incidence patterns of type I diabetes mellitus in children under 5 years of age in Germany. Diabetologia 42(9): 1055–1059 doi:10.1007/s001250051270.
- 17. Hammes HP, Kerner W, Hofer S, Kordonouri O, Raile K, et al. (2011) Diabetic retinopathy in type 1 diabetes-a contemporary analysis of 8,784 patients. Diabetologia 54(8): 1977–1984 doi:10.1007/s00125-011-2198-1.
- 18. Rosenbauer J, Dost A, Karges B, Hungele A, Stahl A, et al. (2012) Improved Metabolic Control in Children and Adolescents With Type 1 Diabetes: A trend analysis using prospective multicenter data from Germany and Austria. Diabetes Care 35(1): 80–86 doi:10.2337/dc11-0993.
- 19. Grulich-Henn J, Wagner V, Thon A, Schober E, Marg W, et al. (2010) Entities and frequency of neonatal diabetes: data from the diabetes documentation and quality management system (DPV). Diabet Med 27(6): 709–712 doi:10.1111/j.1464-5491.2010.02965.x.
- 20. Dost A, Klinkert C, Kapellen T, Lemmer A, Naeke A, et al. (2008) Arterial hypertension determined by ambulatory blood pressure profiles: contribution to microalbuminuria risk in a multicenter investigation in 2,105 children and adolescents with type 1 diabetes. Diabetes Care 31(4): 720–725 doi:10.2337/dc07-0824.
- 21. The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 329(14): 977–986 doi:10.1056/NEJM199309303291401.
- 22. Kilpatrick ES, Rumley AG, Dominiczak MH, Small M (1994) Glycated haemoglobin values: problems in assessing blood glucose control in diabetes mellitus. BMJ 309(6960): 983–986 doi:10.1136/bmj.309.6960.983.
- 23. Marshall SM, Barth JH (2000) Standardization of HbA1c measurements: a consensus statement. Ann Clin Biochem 37(Pt 1): 45–46. doi: 10.1258/0004563001901506
- 24. Gerstl E, Rabl W, Rosenbauer J, Gröbe H, Hofer SE, et al. (2008) Metabolic control as reflected by HbA1c in children, adolescents and young adults with type-1 diabetes mellitus: combined longitudinal analysis including 27,035 patients from 207 centers in Germany and Austria during the last decade. Eur J Pediatr 167(4): 447–453 doi:10.1007/s00431-007-0586-9.
- 25. Rewers M, Pihoker C, Donaghue K, Hanas R, Swift P, et al. (2009) Assessment and monitoring of glycemic control in children and adolescents with diabetes. Pediatr Diabetes 10 Suppl 12: 71–81 doi:10.1111/j.1399-5448.2009.00582.x.
- 26. Ballesta M, Carral F, Olveira G, Girón JA, Aguilar M (2005) Costes económicos asociados a la diabetes tipo 1. Rev Clin Esp (Revista Clínica Española) 205(11): 523–527. doi: 10.1016/s0014-2565(05)72631-x
- 27. Govan L, Wu O, Briggs A, Colhoun HM, McKnight JA, et al. (2011) Inpatient costs for people with type 1 and type 2 diabetes in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group. Diabetologia 54(8): 2000–2008 doi:10.1007/s00125-011-2176-7.
- 28. Icks A, Rosenbauer J, Haastert B, Rathmann W, Grabert M, et al. (2004) Direct costs of pediatric diabetes care in Germany and their predictors. Exp Clin Endocrinol Diabetes 112(6): 302–309 doi:10.1055/s-2004-820909.
- 29. Busch K (2007) GKV-Versicherte nach Alter und Wohnort. GKV-Statistik KM6 zum 1. Juli 2007. Berlin. Available: http://www.bmg.bund.de/fileadmin/redaktion/pdf_statistiken/krankenversicherung/2007-km6-pdf.pdf. Accessed 2013 Apr 15.
- 30. Thompson SG (2000) How should cost data in pragmatic randomised trials be analysed. BMJ 320(7243): 1197–1200. doi: 10.1136/bmj.320.7243.1197
- 31. Mihaylova B, Briggs A, O'Hagan A, Thompson SG (2011) Review of statistical methods for analysing healthcare resources and costs. Health Econ 20(8): 897–916 doi:10.1002/hec.1653.
- 32. Duan N, Manning WG, Morris CN, Newhouse JP (1983) A comparison of alternative models for the demand for medical care. J Bus Econ Stat (Journal of Business & Economic Statistics) 1(2): 115–126. doi: 10.1080/07350015.1983.10509330
- 33. McNutt L, Wu C, Xue X, Hafner JP (2003) Estimating the relative risk in cohort studies and clinical trials of common outcomes. Am J Epidemiol 157(10): 940–943. doi: 10.1093/aje/kwg074
- 34. Chodick G, Heymann AD, Wood F, Kokia E (2005) The direct medical cost of diabetes in Israel. Eur J Health Econ 6(2): 166–171 doi:10.1007/s10198-004-0269-7.
- 35. Petitti D, Klingensmith GJ, Bell RA, Andrews JS, Dabelea D, et al. (2009) Glycemic control in youth with diabetes: The SEARCH for Diabetes in the Youth Study. J Pediatr 155: 668–672 doi:10.1016/j.jpeds.2009.05.025.
- 36. DeBeaufort C, Swift P, Skinner TC, Aanstoot HJ, Aman J, et al. (2007) Continuing stability of center differences in pediatric diabetes care: Do advances in diabetes treatment improve outcome? The Hvidoere study group on childhood diabetes 30(2245–2250). doi:10.2337/dc07-0475.
- 37. Krishnan S, Fields D, Kenneth C (2012) Sex differences in cardiovascular disease risk in adolescents with type 1 diabetes. Gender Medicine 9(4): 251–258 Available: http://dx.doi.org/10.1016/j.genm.2012.05.003.
- 38. Schwab KO, Doerfer J, Hecker W, Grulich-Henn J, Wiemann D, et al. (2006) Spectrum and prevalence of atherogenic risk factors in 27,358 children, adolescents, and young adults with type 1 diabetes: cross-sectional data from the German diabetes documentation and quality management system (DPV). Diabetes Care 29(2): 218–225. doi: 10.2337/diacare.29.02.06.dc05-0724
- 39. Kamtsiuris P, Bergmann E, Rattay P, Schlaud M (2007) Inanspruchnahme medizinischer Leistungen. Ergebnisse des Kinder- und Jugendgesundheitssurveys (KiGGS). Bundesgesundheitsbl 50(836–850). doi: 10.1007/s00103-007-0247-1
- 40. Ziegler R, Heidtmann B, Hilgard D, Hofer S, Rosenbauer J, et al. (2011) Frequency of SMBG correlates with HbA1c and acute complications in children and adolescents with type 1 diabetes. Pediatr Diabetes 12(1): 11–17 doi:10.1111/j.1399-5448.2010.00650.x.
- 41. Raile K, Galler A, Hofer S, Herbst A, Dunstheimer D, et al. (2007) Diabetic nephropathy in 27,805 children, adolescents, and adults with type 1 diabetes: effect of diabetes duration, A1C, hypertension, dyslipidemia, diabetes onset, and sex. Diabetes Care 30(10): 2523–2528 doi:10.2337/dc07-0282.
- 42. Molitch ME, Steffes M, Sun W, Rutledge B, Cleary P, et al. (2010) Development and progression of renal insufficiency with and without albuminuria in adults with type 1 diabetes in the diabetes control and complications trial and the epidemiology of diabetes interventions and complications study. Diabetes Care 33(7): 1536–1543 doi:10.2337/dc09-1098.
- 43. Boer IH de, Rue TC, Cleary PA, Lachin JM, Molitch ME, et al. (2011) Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort. Arch Intern Med 171(5): 412–420 doi:10.1001/archinternmed.2011.16.
- 44. Nishimura R, Dorman JS, Bosnyak Z, Tajima N, Becker DJ, et al. (2003) Incidence of ESRD and survival after renal replacement therapy in patients with type 1 diabetes: a report from the Allegheny County Registry. Am J Kidney Dis 42(1): 117–124 doi:10.1016/S0272-6386(03)00414-1.
- 45. Johnson JA, Pohar SL, Majumdar SR (2006) Health care use and costs in the decade after identification of type 1 and type 2 diabetes: a population-based study. Diabetes Care 29(11): 2403–2408 doi:10.2337/dc06-0735.
- 46. Jonsson PM, Marké LA, Nyström L, Wall S, Ostman J (2000) Excess costs of medical care 1 and 8 years after diagnosis of diabetes: estimates from young and middle-aged incidence cohorts in Sweden. Diabetes Research and Clinical Practice 50(1): 35–47. doi: 10.1016/s0168-8227(00)00161-3
- 47. Colagiuri S, Brnabic A, Gomez M, Fitzgerald B, Buckley A, et al.. (2009) DiabCo$t Australia Type 1: Assessing the burden of Type 1 Diabetes in Australia. Diabetes Australia, Canberra. November, 2009.