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Correction: Helicobacter pylori bab Paralog Distribution and Association with cagA, vacA, and homA/B Genotypes in American and South Korean Clinical Isolates

  • Aeryun Kim,
  • Stephanie L. Servetas,
  • Jieun Kang,
  • Jinmoon Kim,
  • Sungil Jang,
  • Ho Jin Cha,
  • Wan Jin Lee,
  • June Kim,
  • Judith Romero-Gallo,
  • Richard M. Peek Jr.,
  • D. Scott Merrell,
  • Jeong-Heon Cha

Correction: Helicobacter pylori bab Paralog Distribution and Association with cagA, vacA, and homA/B Genotypes in American and South Korean Clinical Isolates

  • Aeryun Kim, 
  • Stephanie L. Servetas, 
  • Jieun Kang, 
  • Jinmoon Kim, 
  • Sungil Jang, 
  • Ho Jin Cha, 
  • Wan Jin Lee, 
  • June Kim, 
  • Judith Romero-Gallo, 
  • Richard M. Peek Jr.
PLOS
x

Upon review of the published manuscript, four typographical errors in the underlying dataset were identified.

Two errors occurred in the labeling of the disease status of the AH clinical isolates in S1 Table; J262 was isolated from a patient with CA and J300 was isolated from a patient with BE. Due to the mislabeled disease states, a sentence within the “Sample Population” sub-header in the “Results” section should be amended to read as follows: Of these clinical isolates, 8.8% were from patients with cancer/pre-malignant lesions (of those, 2.5% were gastric carcinoma and 6.3% were Barrett's Esophagus), 43.7% were from patients with peptic ulcer disease (of those 31.2% were duodenal ulcers and 12.5% were gastric ulcers), 32.5% were from patients with gastritis, and 15.0% were from patients with esophagitis.

Next, the cagA EPIYA type of B130A should be reported as AB instead of ABCC in S1 Table, this lead to a miscoding for strain B130A listed in S3 Table.

Finally, the bab genotype for B130A is babA/babB/babAB but locus C was miscoded in S3 Table; therefore, S3 Table has been updated to reflect babAB at locus C.

The authors have re-run all statistical analyses. P-values that need to be adjusted are indicated in red in the corrected Tables 3 and 4. Despite slight variations to P-values listed in the corrected Tables 3 and 4, all significant associations remain significant and non-significant associations are also unchanged. In addition, the phylogenetic analysis was also re-run to accommodate updates to S3 Table. To account for updates to the analysis programs (figtree and Phylip), the authors ran the correct and uncorrect datasets side-by-side following the same parameters listed in the materials and methods. The results showed very similar distributions for both data sets and the significant findings did not change. Therefore, no changes to figure 4 are needed.

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Table 3. Significant two-way comparisons of bab genotype and other factors in both populationsa.

https://doi.org/10.1371/journal.pone.0176468.t001

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Table 4. Three-way comparisons of bab genotype and other factors in both populations.

https://doi.org/10.1371/journal.pone.0176468.t002

Please see the correct Tables 3 and 4 below. The corrected S1 and S3 Tables are attached as supporting information files.

Supporting information

S1 Table.

A. cagA EPIYA polymorphism, vacA s/i/m polymorphism and homA/B genotype of 80 AH. B. cagA EPIYA polymorphism, vacA s/i/m polymorphism and homA/B genotype of 80 KH.

https://doi.org/10.1371/journal.pone.0176468.s001

(XLSX)

S3 Table. Discrete character code for phylogenetic analysis.

https://doi.org/10.1371/journal.pone.0176468.s002

(XLSX)

Reference

  1. 1. Kim A, Servetas SL, Kang J, Kim J, Jang S, Cha HJ, et al. (2015) Helicobacter pylori bab Paralog Distribution and Association with cagA, vacA, and homA/B Genotypes in American and South Korean Clinical Isolates. PLoS ONE 10(8): e0137078. pmid:26317221