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Open Access
Peer-reviewed
Research Article
Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence
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Abhirami A. Ananth ,
Contributed equally to this work with: Abhirami A. Ananth, Lee-Hwa Tai
Affiliations Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
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Lee-Hwa Tai ,
Contributed equally to this work with: Abhirami A. Ananth, Lee-Hwa Tai
Affiliation Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada
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Casey Lansdell,
Affiliations Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
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Almohanad A. Alkayyal,
Affiliations Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada, Department of Medical Laboratory Technology, University of Tabuk, Tabuk, Saudi Arabia
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Katherine E. Baxter,
Affiliations Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
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Leonard Angka,
Affiliations Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
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Jiqing Zhang,
Affiliations Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada, Department of Neurosurgery, The Second Hospital of Shandong University, Shandong, China
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Christiano Tanese de Souza,
Affiliation Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada
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Kyle B. Stephenson,
Affiliation Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada
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Kelley Parato,
Affiliation Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada
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Jonathan L. Bramson,
Affiliation McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada
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John C. Bell,
Affiliations Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
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Brian D. Lichty ,
¶‡ A. Ananth and L. Tai are primary authors on this work. B. Lichty and R. Auer are senior authors on this work. B. Lichty and R. Auer also contributed equally to this work.
Affiliation McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada
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Rebecca C. Auer
* E-mail: rauer@ottawahospital.on.ca
¶‡ A. Ananth and L. Tai are primary authors on this work. B. Lichty and R. Auer are senior authors on this work. B. Lichty and R. Auer also contributed equally to this work.
Affiliations Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada, Department of Surgery, University of Ottawa, Ottawa, ON, Canada
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Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence
- Abhirami A. Ananth,
- Lee-Hwa Tai,
- Casey Lansdell,
- Almohanad A. Alkayyal,
- Katherine E. Baxter,
- Leonard Angka,
- Jiqing Zhang,
- Christiano Tanese de Souza,
- Kyle B. Stephenson,
- Kelley Parato
- Published: May 19, 2016
- https://doi.org/10.1371/journal.pone.0155947