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Open Access
Peer-reviewed
Research Article
Lessons Learned from Whole Exome Sequencing in Multiplex Families Affected by a Complex Genetic Disorder, Intracranial Aneurysm
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Janice L. Farlow,
Affiliation Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Hai Lin,
Affiliation Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Laura Sauerbeck,
Affiliation Department of Neurology and Rehabilitation Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America
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Dongbing Lai,
Affiliation Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Daniel L. Koller,
Affiliation Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Elizabeth Pugh,
Affiliation Center for Inherited Disease Research, Johns Hopkins University; Baltimore, Maryland, United States of America
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Kurt Hetrick,
Affiliation Center for Inherited Disease Research, Johns Hopkins University; Baltimore, Maryland, United States of America
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Hua Ling,
Affiliation Center for Inherited Disease Research, Johns Hopkins University; Baltimore, Maryland, United States of America
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Rachel Kleinloog,
Affiliation Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands
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Pieter van der Vlies,
Affiliation Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
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Patrick Deelen,
Affiliations Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands, Genomics Coordination Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
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Morris A. Swertz,
Affiliations Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands, Genomics Coordination Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
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Bon H. Verweij,
Affiliation Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands
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Luca Regli,
Affiliations Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands, Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland
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Gabriel J. E. Rinkel,
Affiliation Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands
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Ynte M. Ruigrok,
Affiliation Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands
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Kimberly Doheny,
Affiliation Center for Inherited Disease Research, Johns Hopkins University; Baltimore, Maryland, United States of America
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Yunlong Liu,
Affiliation Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Joseph Broderick,
Affiliation Department of Neurology and Rehabilitation Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America
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Tatiana Foroud ,
* E-mail: tforoud@iu.edu
Affiliation Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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FIA Study Investigators
¶Membership of the FIA Study Investigators is provided in the Acknowledgements.
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Lessons Learned from Whole Exome Sequencing in Multiplex Families Affected by a Complex Genetic Disorder, Intracranial Aneurysm
- Janice L. Farlow,
- Hai Lin,
- Laura Sauerbeck,
- Dongbing Lai,
- Daniel L. Koller,
- Elizabeth Pugh,
- Kurt Hetrick,
- Hua Ling,
- Rachel Kleinloog,
- Pieter van der Vlies
- Published: March 24, 2015
- https://doi.org/10.1371/journal.pone.0121104