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Open Access
Peer-reviewed
Research Article
Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma
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Brian Cunniff ,
Contributed equally to this work with: Brian Cunniff, Kheng Newick, Kimberly J. Nelson
* E-mail: Nicholas.Heintz@uvm.edu
Affiliation University of Vermont, College of Medicine, Department of Pathology, 149 Beaumont Ave, Burlington, VT, 05405, United States of America
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Kheng Newick ,
Contributed equally to this work with: Brian Cunniff, Kheng Newick, Kimberly J. Nelson
Affiliation University of Pennsylvania School of Medicine, Division of Pulmonary, Thoracic Oncology Research Laboratory, Philadelphia, PA, 19147, United States of America
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Kimberly J. Nelson ,
Contributed equally to this work with: Brian Cunniff, Kheng Newick, Kimberly J. Nelson
Affiliation Wake Forest School of Medicine, Department of Biochemistry, Medical Center Boulevard, Winston-Salem, NC, 27157, United States of America
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Alexandra N. Wozniak,
Affiliation University of Vermont, College of Medicine, Department of Pathology, 149 Beaumont Ave, Burlington, VT, 05405, United States of America
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Stacie Beuschel,
Affiliation University of Vermont, College of Medicine, Department of Pathology, 149 Beaumont Ave, Burlington, VT, 05405, United States of America
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Bruce Leavitt,
Affiliation University of Vermont, College of Medicine, Department of Surgery, 149 Beaumont Ave, Burlington, VT, 05405, United States of America
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Anant Bhave,
Affiliation University of Vermont, College of Medicine, Department of Radiology, 149 Beaumont Ave, Burlington, VT, 05405, United States of America
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Kelly Butnor,
Affiliation University of Vermont, College of Medicine, Department of Pathology, 149 Beaumont Ave, Burlington, VT, 05405, United States of America
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Andreas Koenig,
Affiliation University of Vermont, Department of Immunology medicine, 149 Beaumont Ave, Burlington, VT, 05405, United States of America
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Edward T. Chouchani,
Affiliations Medical Research Council, Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, United Kingdom, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom
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Andrew M. James,
Affiliation Medical Research Council, Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, United Kingdom
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Alexina C. Haynes,
Affiliation Wake Forest School of Medicine, Department of Biochemistry, Medical Center Boulevard, Winston-Salem, NC, 27157, United States of America
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W. Todd Lowther,
Affiliation Wake Forest School of Medicine, Department of Biochemistry, Medical Center Boulevard, Winston-Salem, NC, 27157, United States of America
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Michael P. Murphy,
Affiliation Medical Research Council, Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, United Kingdom
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Arti Shukla,
Affiliation University of Vermont, College of Medicine, Department of Pathology, 149 Beaumont Ave, Burlington, VT, 05405, United States of America
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Nicholas H. Heintz
Affiliation University of Vermont, College of Medicine, Department of Pathology, 149 Beaumont Ave, Burlington, VT, 05405, United States of America
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Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma
- Brian Cunniff,
- Kheng Newick,
- Kimberly J. Nelson,
- Alexandra N. Wozniak,
- Stacie Beuschel,
- Bruce Leavitt,
- Anant Bhave,
- Kelly Butnor,
- Andreas Koenig,
- Edward T. Chouchani
- Published: May 26, 2015
- https://doi.org/10.1371/journal.pone.0127310