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A Single Base-Pair Change in 2009 H1N1 Hemagglutinin Increases Human Receptor Affinity and Leads to Efficient Airborne Viral Transmission in Ferrets

  • Akila Jayaraman,

    Affiliation Harvard-MIT Division of Health Sciences and Technology, Singapore-MIT Alliance for Research and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

  • Claudia Pappas,

    Affiliation Influenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States of America

  • Rahul Raman,

    Affiliation Harvard-MIT Division of Health Sciences and Technology, Singapore-MIT Alliance for Research and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

  • Jessica A. Belser,

    Affiliation Influenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States of America

  • Karthik Viswanathan,

    Affiliation Harvard-MIT Division of Health Sciences and Technology, Singapore-MIT Alliance for Research and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

  • Zachary Shriver,

    Affiliation Harvard-MIT Division of Health Sciences and Technology, Singapore-MIT Alliance for Research and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

  • Terrence M. Tumpey,

    Affiliation Influenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States of America

  • Ram Sasisekharan

    rams@mit.edu

    Affiliation Harvard-MIT Division of Health Sciences and Technology, Singapore-MIT Alliance for Research and Technology, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

A Single Base-Pair Change in 2009 H1N1 Hemagglutinin Increases Human Receptor Affinity and Leads to Efficient Airborne Viral Transmission in Ferrets

  • Akila Jayaraman, 
  • Claudia Pappas, 
  • Rahul Raman, 
  • Jessica A. Belser, 
  • Karthik Viswanathan, 
  • Zachary Shriver, 
  • Terrence M. Tumpey, 
  • Ram Sasisekharan
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