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Phosphodiesterase Type 5 Inhibitors Increase Herceptin Transport and Treatment Efficacy in Mouse Metastatic Brain Tumor Models

  • Jinwei Hu ,

    Contributed equally to this work with: Jinwei Hu, Julia Y. Ljubimova

    Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  • Julia Y. Ljubimova ,

    Contributed equally to this work with: Jinwei Hu, Julia Y. Ljubimova

    ljubimovaj@cshs.org

    Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  • Satoshi Inoue,

    Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  • Bindu Konda,

    Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  • Rameshwar Patil,

    Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  • Hui Ding,

    Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  • Andres Espinoza,

    Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  • Kolja A. Wawrowsky,

    Affiliation Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  • Chirag Patil,

    Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  • Alexander V. Ljubimov,

    Affiliations Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America

  • Keith L. Black

    Affiliation Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Phosphodiesterase Type 5 Inhibitors Increase Herceptin Transport and Treatment Efficacy in Mouse Metastatic Brain Tumor Models

  • Jinwei Hu, 
  • Julia Y. Ljubimova, 
  • Satoshi Inoue, 
  • Bindu Konda, 
  • Rameshwar Patil, 
  • Hui Ding, 
  • Andres Espinoza, 
  • Kolja A. Wawrowsky, 
  • Chirag Patil, 
  • Alexander V. Ljubimov
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