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A Systems Biology Strategy Reveals Biological Pathways and Plasma Biomarker Candidates for Potentially Toxic Statin-Induced Changes in Muscle

  • Reijo Laaksonen ,

    To whom correspondence should be addressed. E-mail: reijo.laaksonen@helsinki.fi (RL); matej.oresic@vtt.fi (MO)

    Affiliation Research Unit, University Hospital of Tampere, Tampere, Finland

  • Mikko Katajamaa,

    Affiliation Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

  • Hannu Päivä,

    Affiliation Department of Internal Medicine, University Hospital of Tampere, Tampere, Finland

  • Marko Sysi-Aho,

    Affiliation VTT Technical Research Centre of Finland, Espoo, Finland

  • Lilli Saarinen,

    Affiliation Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

  • Päivi Junni,

    Affiliation Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

  • Dieter Lütjohann,

    Affiliation Department of Clinical Pharmacology, University of Bonn, Bonn, Germany

  • Joél Smet,

    Affiliation Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium

  • Rudy Van Coster,

    Affiliation Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium

  • Tuulikki Seppänen-Laakso,

    Affiliation VTT Technical Research Centre of Finland, Espoo, Finland

  • Terho Lehtimäki,

    Affiliations Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere, Finland, Centre for Laboratory Medicine, University Hospital of Tampere, Tampere, Finland, Medical School, University of Tampere, Tampere, Finland

  • Juhani Soini,

    Affiliation Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

  • Matej Orešič

    To whom correspondence should be addressed. E-mail: reijo.laaksonen@helsinki.fi (RL); matej.oresic@vtt.fi (MO)

    Affiliation VTT Technical Research Centre of Finland, Espoo, Finland

A Systems Biology Strategy Reveals Biological Pathways and Plasma Biomarker Candidates for Potentially Toxic Statin-Induced Changes in Muscle

  • Reijo Laaksonen, 
  • Mikko Katajamaa, 
  • Hannu Päivä, 
  • Marko Sysi-Aho, 
  • Lilli Saarinen, 
  • Päivi Junni, 
  • Dieter Lütjohann, 
  • Joél Smet, 
  • Rudy Van Coster, 
  • Tuulikki Seppänen-Laakso
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