Annotation Cluster 1 Enrichment Score: 0.5898998072836374 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0042995~cell projection 6 8.450704225352112 0.11904648716828621 SH3RF1, SPRY1, MAGEE1, SH3PXD2A, GRM8, NEFM 49 697 12782 2.245542119286739 0.9999999385047023 0.9997520175455927 77.19258261841429 GOTERM_CC_FAT GO:0043005~neuron projection 3 4.225352112676056 0.36914341108285287 MAGEE1, GRM8, NEFM 49 342 12782 2.288220551378446 1.0 0.9994705020475105 99.53557466277081 GOTERM_CC_FAT GO:0045202~synapse 3 4.225352112676056 0.3867130895294034 MAGEE1, GRM8, NEFM 49 355 12782 2.2044265593561367 1.0 0.9991884278713351 99.6659077449372 Annotation Cluster 2 Enrichment Score: 0.5835858875316858 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0046872~metal ion binding 20 28.169014084507044 0.21649237316659986 SH3RF1, ZNF275, ZNF641, ZNF273, GCLC, PDLIM2, MMP16, CABP5, NR4A3, ANKRD5, ZDHHC21, CCBE1, RHEB, LIAS, SYTL3, CYP4F2, ZNF490, ING1, KCNG4, ADAMTS5 51 4140 12983 1.2298001326134318 1.0 0.9999991583237132 94.93250957780897 GOTERM_MF_FAT GO:0043169~cation binding 20 28.169014084507044 0.23036066935966154 SH3RF1, ZNF275, ZNF641, ZNF273, GCLC, PDLIM2, MMP16, CABP5, NR4A3, ANKRD5, ZDHHC21, CCBE1, RHEB, LIAS, SYTL3, CYP4F2, ZNF490, ING1, KCNG4, ADAMTS5 51 4179 12983 1.2183231751662138 1.0 0.9999871070621796 95.92634242868638 SP_PIR_KEYWORDS zinc 11 15.492957746478872 0.24170521992849056 ZNF641, SH3RF1, ZNF275, ZDHHC21, ZNF273, PDLIM2, MMP16, NR4A3, ZNF490, ING1, ADAMTS5 69 2189 19235 1.4008448037287886 1.0 0.9986934874256156 96.2398446697474 SP_PIR_KEYWORDS metal-binding 14 19.718309859154928 0.24472279285107706 ZNF275, ZNF641, SH3RF1, ZNF273, PDLIM2, MMP16, NR4A3, ZDHHC21, RHEB, LIAS, ZNF490, CYP4F2, ING1, ADAMTS5 69 2972 19235 1.3131741666179024 1.0 0.9968920496222594 96.41348482933907 GOTERM_MF_FAT GO:0043167~ion binding 20 28.169014084507044 0.2532925644836799 SH3RF1, ZNF275, ZNF641, ZNF273, GCLC, PDLIM2, MMP16, CABP5, NR4A3, ANKRD5, ZDHHC21, CCBE1, RHEB, LIAS, SYTL3, CYP4F2, ZNF490, ING1, KCNG4, ADAMTS5 51 4241 12983 1.2005122728176392 1.0 0.9999567111177325 97.1854976874946 GOTERM_MF_FAT GO:0046914~transition metal ion binding 14 19.718309859154928 0.2635110478752919 ZNF275, ZNF641, SH3RF1, ZNF273, PDLIM2, MMP16, NR4A3, ZDHHC21, LIAS, ZNF490, CYP4F2, SYTL3, ING1, ADAMTS5 51 2785 12983 1.2796986658218046 1.0 0.9998443680426856 97.62178700624146 GOTERM_MF_FAT GO:0008270~zinc ion binding 12 16.901408450704224 0.2682934278629495 ZNF641, SH3RF1, ZNF275, ZDHHC21, ZNF273, PDLIM2, MMP16, SYTL3, NR4A3, ZNF490, ING1, ADAMTS5 51 2311 12983 1.3218621936009367 1.0 0.9995359495469895 97.80383053752158 SP_PIR_KEYWORDS zinc-finger 8 11.267605633802818 0.40594781996111967 ZNF641, SH3RF1, ZNF275, ZDHHC21, ZNF273, NR4A3, ZNF490, ING1 69 1718 19235 1.2981053128848847 1.0 0.9907865698883691 99.7919470401516 Annotation Cluster 3 Enrichment Score: 0.5013086283884102 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:KRAB 5 7.042253521126761 0.030551309801565465 ZNF641, ZNF275, ZNF273, ZNF738, ZNF490 69 332 19113 4.171686746987953 0.9997700128256773 0.9997700128256773 33.49926284410126 INTERPRO IPR001909:Krueppel-associated box 5 7.042253521126761 0.04524684165903902 ZNF641, ZNF275, ZNF273, ZNF738, ZNF490 64 355 16659 3.6661531690140845 0.9998263653514887 0.9998263653514887 43.67106342282834 SMART SM00349:KRAB 5 7.042253521126761 0.059727869387552396 ZNF641, ZNF275, ZNF273, ZNF738, ZNF490 39 355 9079 3.278801011195377 0.9334486586223234 0.9334486586223234 43.796020357342904 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 10 14.084507042253522 0.1269113313999788 MYOD1, ZNF641, ZNF275, ZNF273, ZNF738, SIX2, NR4A3, ZNF490, NR0B1, TLX2 46 1773 13528 1.6586968782952007 1.0 0.9999995451390553 86.11719839605115 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 10 14.084507042253522 0.1403502284325342 MYOD1, ZNF641, ZNF275, ZNF273, ZNF738, SIX2, NR4A3, ZNF490, NR0B1, TLX2 46 1813 13528 1.622101249430442 1.0 0.9999987092786145 88.92189163969026 SP_PIR_KEYWORDS dna-binding 10 14.084507042253522 0.21160424755883817 HIST1H2AC, MYOD1, ZNF641, ZNF275, ZNF273, ZNF738, SIX2, NR4A3, ZNF490, TLX2 69 1868 19235 1.4923346677838811 0.9999999999999987 0.9989377294453466 94.03421609876396 GOTERM_BP_FAT GO:0045449~regulation of transcription 12 16.901408450704224 0.23579902974211078 MYOD1, ZNF641, ZNF275, GCLC, ZNF273, ZNF738, SIX2, NR4A3, ZNF490, NR0B1, TLX2, ING1 46 2601 13528 1.3568025675743443 1.0 0.999994194939955 98.00094330557016 UP_SEQ_FEATURE zinc finger region:C2H2-type 11 3 4.225352112676056 0.2799778019162337 ZNF275, ZNF273, ZNF490 69 293 19113 2.83617747440273 1.0 0.9999999999998551 98.668433913692 UP_SEQ_FEATURE zinc finger region:C2H2-type 5 4 5.633802816901409 0.2996759304539429 ZNF641, ZNF275, ZNF273, ZNF490 69 538 19113 2.059479553903346 1.0 0.9999999999638851 99.07536741343411 UP_SEQ_FEATURE zinc finger region:C2H2-type 10 3 4.225352112676056 0.3338470563656325 ZNF275, ZNF273, ZNF490 69 334 19113 2.4880239520958085 1.0 0.9999999997028379 99.52101229725706 UP_SEQ_FEATURE zinc finger region:C2H2-type 4 4 5.633802816901409 0.3358759060168566 ZNF641, ZNF275, ZNF273, ZNF490 69 575 19113 1.9269565217391305 1.0 0.9999999899719696 99.53984216856932 UP_SEQ_FEATURE zinc finger region:C2H2-type 2 4 5.633802816901409 0.3681424911233579 ZNF641, ZNF275, ZNF273, ZNF490 69 608 19113 1.8223684210526314 1.0 0.9999999796016132 99.76093760167984 UP_SEQ_FEATURE zinc finger region:C2H2-type 3 4 5.633802816901409 0.3817713169553498 ZNF641, ZNF275, ZNF273, ZNF490 69 622 19113 1.7813504823151125 1.0 0.9999999106110512 99.82052733413103 UP_SEQ_FEATURE zinc finger region:C2H2-type 9 3 4.225352112676056 0.3878591412673408 ZNF275, ZNF273, ZNF490 69 376 19113 2.210106382978723 1.0 0.9999995967809397 99.84242386536165 SP_PIR_KEYWORDS zinc-finger 8 11.267605633802818 0.40594781996111967 ZNF641, SH3RF1, ZNF275, ZDHHC21, ZNF273, NR4A3, ZNF490, ING1 69 1718 19235 1.2981053128848847 1.0 0.9907865698883691 99.7919470401516 GOTERM_MF_FAT GO:0003677~DNA binding 11 15.492957746478872 0.4087757833630188 HIST1H2AC, MYOD1, ZNF641, ZNF275, ZNF273, ZNF738, SIX2, NR4A3, ZNF490, NR0B1, TLX2 51 2331 12983 1.2013105542517308 1.0 0.9999876213691381 99.83784982965118 INTERPRO IPR013087:Zinc finger, C2H2-type/integrase, DNA-binding 4 5.633802816901409 0.41865960836119676 ZNF641, ZNF275, ZNF273, ZNF490 64 621 16659 1.6766304347826086 1.0 1.0 99.87980200423965 UP_SEQ_FEATURE zinc finger region:C2H2-type 7 3 4.225352112676056 0.47920729783572896 ZNF275, ZNF273, ZNF490 69 451 19113 1.8425720620842572 1.0 0.9999986957894395 99.9811778903191 UP_SEQ_FEATURE zinc finger region:C2H2-type 6 3 4.225352112676056 0.5212186338456262 ZNF275, ZNF273, ZNF490 69 488 19113 1.7028688524590165 1.0 0.9999959976421287 99.99377130045777 GOTERM_BP_FAT GO:0006350~transcription 8 11.267605633802818 0.5614374686466248 MYOD1, ZNF641, ZNF275, ZNF273, ZNF738, NR4A3, ZNF490, NR0B1 46 2101 13528 1.119798025784823 1.0 0.9999201263717 99.99938051184715 INTERPRO IPR007087:Zinc finger, C2H2-type 4 5.633802816901409 0.5745786584695973 ZNF641, ZNF275, ZNF273, ZNF490 64 784 16659 1.328045280612245 1.0 1.0 99.997494640129 UP_SEQ_FEATURE zinc finger region:C2H2-type 1 3 4.225352112676056 0.5784458062754652 ZNF641, ZNF275, ZNF490 69 542 19113 1.533210332103321 1.0 0.9999988989944238 99.99883179916179 SP_PIR_KEYWORDS transcription regulation 8 11.267605633802818 0.5839545724428294 MYOD1, ZNF641, ZNF275, ZNF273, ZNF738, NR4A3, ZNF490, NR0B1 69 2026 19235 1.1007625506101835 1.0 0.9987013628725491 99.9969517988921 INTERPRO IPR015880:Zinc finger, C2H2-like 4 5.633802816901409 0.5859182276207635 ZNF641, ZNF275, ZNF273, ZNF490 64 797 16659 1.306383312421581 1.0 1.0 99.99820763394594 SP_PIR_KEYWORDS Transcription 8 11.267605633802818 0.6080631962619139 MYOD1, ZNF641, ZNF275, ZNF273, ZNF738, NR4A3, ZNF490, NR0B1 69 2071 19235 1.076844484566022 1.0 0.9988219722102636 99.9984980793206 SMART SM00355:ZnF_C2H2 4 5.633802816901409 0.6604156425707828 ZNF641, ZNF275, ZNF273, ZNF490 39 797 9079 1.168355692822443 1.0 0.9999999999520434 99.99591055496622 GOTERM_MF_FAT GO:0030528~transcription regulator activity 6 8.450704225352112 0.707069148139247 MYOD1, SIX2, NR4A3, NR0B1, TLX2, ING1 51 1512 12983 1.010192966075319 1.0 0.999999911916962 99.99996967648066 SP_PIR_KEYWORDS nucleus 14 19.718309859154928 0.7763737409908573 ZNF275, ZNF641, MYOD1, HIST1H2AC, ZNF273, PDLIM2, SIX2, NR4A3, NR0B1, KIAA1009, ZNF738, ZNF490, TLX2, ING1 69 4283 19235 0.9112196178352571 1.0 0.9996605402715661 99.9999980631015 Annotation Cluster 4 Enrichment Score: 0.49858024606432944 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043405~regulation of MAP kinase activity 3 4.225352112676056 0.07987311616913363 SPRY1, LRRN3, MAP2K6 46 141 13528 6.257169287696577 1.0 0.9999996713821865 70.21262538694579 GOTERM_BP_FAT GO:0045859~regulation of protein kinase activity 3 4.225352112676056 0.31912016708654545 SPRY1, LRRN3, MAP2K6 46 345 13528 2.5572778827977314 1.0 0.9999975622195767 99.62726812147626 GOTERM_BP_FAT GO:0043549~regulation of kinase activity 3 4.225352112676056 0.3338577687995399 SPRY1, LRRN3, MAP2K6 46 357 13528 2.4713189623675555 1.0 0.99999467140527 99.72889773037203 GOTERM_BP_FAT GO:0051338~regulation of transferase activity 3 4.225352112676056 0.35216267100868315 SPRY1, LRRN3, MAP2K6 46 372 13528 2.3716690042075736 1.0 0.9999754819477925 99.81924943674169 GOTERM_BP_FAT GO:0042325~regulation of phosphorylation 3 4.225352112676056 0.462264441696127 SPRY1, LRRN3, MAP2K6 46 466 13528 1.893263668594887 1.0 0.9999454685834303 99.98797368991927 GOTERM_BP_FAT GO:0019220~regulation of phosphate metabolic process 3 4.225352112676056 0.4832746916556974 SPRY1, LRRN3, MAP2K6 46 485 13528 1.8190945764231288 1.0 0.9999128311163294 99.993265442662 GOTERM_BP_FAT GO:0051174~regulation of phosphorus metabolic process 3 4.225352112676056 0.4832746916556974 SPRY1, LRRN3, MAP2K6 46 485 13528 1.8190945764231288 1.0 0.9999128311163294 99.993265442662 Annotation Cluster 5 Enrichment Score: 0.46477752894658864 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS extracellular matrix 4 5.633802816901409 0.05374666667988551 WNT10B, MMP16, WNT6, ADAMTS5 69 241 19235 4.626856696133261 0.999649192538091 0.999649192538091 48.05865576370003 GOTERM_CC_FAT GO:0005578~proteinaceous extracellular matrix 4 5.633802816901409 0.11831752259982665 WNT10B, MMP16, WNT6, ADAMTS5 49 320 12782 3.2607142857142852 0.9999999314670432 0.9999999314670432 76.97152987642848 GOTERM_CC_FAT GO:0031012~extracellular matrix 4 5.633802816901409 0.13930369876178333 WNT10B, MMP16, WNT6, ADAMTS5 49 345 12782 3.024430641821946 0.9999999970802766 0.998570731245909 82.61156157799408 SP_PIR_KEYWORDS Secreted 9 12.676056338028168 0.24503309355597802 WNT10B, FGF7, CCBE1, SRCRB4D, MMP16, WNT6, MUC6, CHGB, ADAMTS5 69 1689 19235 1.485442891342961 1.0 0.9936510417707898 96.4309175793079 SP_PIR_KEYWORDS glycoprotein 18 25.352112676056336 0.3511006086707634 HGSNAT, WNT10B, FGF7, LRRN3, ERLIN2, MMP16, MUC6, GRM8, PVRL3, LTB4R2, CCBE1, HS6ST3, WNT6, CHGB, SLC43A1, ADAMTS5, PQLC2, NEFM 69 4318 19235 1.1620718126346739 1.0 0.9916918727480524 99.40716527915211 GOTERM_CC_FAT GO:0005576~extracellular region 9 12.676056338028168 0.48931331104934517 WNT10B, FGF7, CCBE1, SRCRB4D, MMP16, WNT6, MUC6, CHGB, ADAMTS5 49 2010 12782 1.1680170575692965 1.0 0.9988542345286807 99.96049244188093 GOTERM_CC_FAT GO:0044421~extracellular region part 5 7.042253521126761 0.4910896836143041 WNT10B, FGF7, MMP16, WNT6, ADAMTS5 49 960 12782 1.3586309523809523 1.0 0.9982011277904463 99.96206559986865 UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 16 22.535211267605636 0.5111979622103281 HGSNAT, WNT10B, FGF7, LRRN3, ERLIN2, MMP16, MUC6, GRM8, PVRL3, LTB4R2, CCBE1, HS6ST3, WNT6, SLC43A1, ADAMTS5, PQLC2 69 4129 19113 1.0733833858077018 1.0 0.9999974625695911 99.99182147350346 SP_PIR_KEYWORDS signal 12 16.901408450704224 0.6132360741769263 WNT10B, FGF7, GRM8, PVRL3, LRRN3, CCBE1, SRCRB4D, MMP16, WNT6, MUC6, CHGB, ADAMTS5 69 3250 19235 1.0292976588628762 1.0 0.9985172838756661 99.9987169917834 UP_SEQ_FEATURE signal peptide 12 16.901408450704224 0.6222417516177792 WNT10B, FGF7, GRM8, PVRL3, LRRN3, CCBE1, SRCRB4D, MMP16, WNT6, MUC6, CHGB, ADAMTS5 69 3250 19113 1.0227692307692307 1.0 0.9999995447925727 99.99972384881511 SP_PIR_KEYWORDS disulfide bond 9 12.676056338028168 0.8310606399259551 PVRL3, LRRN3, LTB4R2, CCBE1, SRCRB4D, MMP16, MUC6, CHGB, ADAMTS5 69 2924 19235 0.8580413965383928 1.0 0.9996651974157545 99.99999993033974 UP_SEQ_FEATURE disulfide bond 8 11.267605633802818 0.891442970439146 PVRL3, LRRN3, CCBE1, SRCRB4D, MMP16, MUC6, CHGB, ADAMTS5 69 2819 19113 0.7860943597020221 1.0 0.9999999999952196 99.99999999997907 Annotation Cluster 6 Enrichment Score: 0.4582174480151871 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 6 8.450704225352112 0.1538637379075108 MYOD1, GCLC, SIX2, NR4A3, ING1, PSMD8 46 857 13528 2.0589518542945564 1.0 0.9999973498567087 91.20263483406714 GOTERM_BP_FAT GO:0045596~negative regulation of cell differentiation 3 4.225352112676056 0.1612818725179509 SIX2, NR0B1, TLX2 46 216 13528 4.084541062801932 1.0 0.9999927024346148 92.26047259478518 GOTERM_MF_FAT GO:0043565~sequence-specific DNA binding 5 7.042253521126761 0.20472404303003042 MYOD1, SIX2, NR4A3, NR0B1, TLX2 51 607 12983 2.0969409180476144 1.0 0.9999999972168581 93.91951491917298 GOTERM_BP_FAT GO:0048598~embryonic morphogenesis 3 4.225352112676056 0.2721182163640769 SIX2, NR4A3, TLX2 46 307 13528 2.8738139073785582 1.0 0.9999980436734149 99.0156078321703 GOTERM_BP_FAT GO:0045941~positive regulation of transcription 4 5.633802816901409 0.28899556385902386 MYOD1, SIX2, NR4A3, ING1 46 564 13528 2.085723095898859 1.0 0.9999979692124128 99.30025727871829 GOTERM_BP_FAT GO:0010628~positive regulation of gene expression 4 5.633802816901409 0.3046031018056089 MYOD1, SIX2, NR4A3, ING1 46 581 13528 2.0246950535059494 1.0 0.9999978051006786 99.49336458294336 GOTERM_BP_FAT GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4 5.633802816901409 0.3442561885698733 MYOD1, SIX2, NR4A3, ING1 46 624 13528 1.8851727982162765 1.0 0.9999935332777595 99.78436192248986 GOTERM_BP_FAT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 3 4.225352112676056 0.3509469621670759 MYOD1, SIX2, NR4A3 46 371 13528 2.3780616430329307 1.0 0.9999844833783712 99.81425144085424 GOTERM_BP_FAT GO:0051173~positive regulation of nitrogen compound metabolic process 4 5.633802816901409 0.3626957555132412 MYOD1, SIX2, NR4A3, ING1 46 644 13528 1.8266270591412368 1.0 0.9999734895739367 99.85760152296167 GOTERM_BP_FAT GO:0010557~positive regulation of macromolecule biosynthetic process 4 5.633802816901409 0.37189655490585105 MYOD1, SIX2, NR4A3, ING1 46 654 13528 1.798696981784337 1.0 0.9999703153328467 99.88475523218727 GOTERM_BP_FAT GO:0031328~positive regulation of cellular biosynthetic process 4 5.633802816901409 0.4002799043014942 MYOD1, SIX2, NR4A3, ING1 46 685 13528 1.7172960964773087 1.0 0.9999623798706748 99.9411906502351 GOTERM_BP_FAT GO:0009891~positive regulation of biosynthetic process 4 5.633802816901409 0.4093760956634519 MYOD1, SIX2, NR4A3, ING1 46 695 13528 1.6925868001251172 1.0 0.9999596443262531 99.95291545664512 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 4 5.633802816901409 0.43822377914680427 MYOD1, SIX2, NR4A3, NR0B1 46 727 13528 1.6180850427606004 1.0 0.9999384066452329 99.97727632286947 GOTERM_MF_FAT GO:0016563~transcription activator activity 3 4.225352112676056 0.4716279698514886 MYOD1, NR4A3, ING1 51 410 12983 1.8626972740315637 1.0 0.9999949292510273 99.95895704534004 GOTERM_BP_FAT GO:0045893~positive regulation of transcription, DNA-dependent 3 4.225352112676056 0.47448646202687733 MYOD1, SIX2, NR4A3 46 477 13528 1.849603500136724 1.0 0.9999493037881964 99.99139271659007 GOTERM_BP_FAT GO:0051254~positive regulation of RNA metabolic process 3 4.225352112676056 0.4788912986713677 MYOD1, SIX2, NR4A3 46 481 13528 1.834222182048269 1.0 0.9999411629244255 99.99238478436325 GOTERM_MF_FAT GO:0003700~transcription factor activity 5 7.042253521126761 0.5236243631192147 MYOD1, SIX2, NR4A3, NR0B1, TLX2 51 975 12983 1.3054801407742584 1.0 0.999997111102525 99.98843139262156 GOTERM_MF_FAT GO:0030528~transcription regulator activity 6 8.450704225352112 0.707069148139247 MYOD1, SIX2, NR4A3, NR0B1, TLX2, ING1 51 1512 12983 1.010192966075319 1.0 0.999999911916962 99.99996967648066 Annotation Cluster 7 Enrichment Score: 0.4483757394265526 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 13 18.30985915492958 0.2576667180182709 ZNF275, HIST1H2AC, SH3PXD2A, PDLIM2, MYOZ2, NR0B1, KIAA1009, PFN4, LIAS, KRT85, PPP2R2B, NEFM, PSMD8 49 2596 12782 1.3062953995157387 1.0 0.9995929085084019 96.90254198015195 GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 13 18.30985915492958 0.2576667180182709 ZNF275, HIST1H2AC, SH3PXD2A, PDLIM2, MYOZ2, NR0B1, KIAA1009, PFN4, LIAS, KRT85, PPP2R2B, NEFM, PSMD8 49 2596 12782 1.3062953995157387 1.0 0.9995929085084019 96.90254198015195 GOTERM_CC_FAT GO:0005856~cytoskeleton 8 11.267605633802818 0.25780820626280626 SH3PXD2A, PFN4, PDLIM2, MYOZ2, KRT85, PPP2R2B, NEFM, KIAA1009 49 1381 12782 1.5111203061963379 1.0 0.9985108587261846 96.90941955720639 SP_PIR_KEYWORDS cytoskeleton 4 5.633802816901409 0.39143848786152236 PFN4, PDLIM2, PPP2R2B, KIAA1009 69 636 19235 1.7532585908303713 1.0 0.9915018766459931 99.72302733155313 SP_PIR_KEYWORDS cytoplasm 10 14.084507042253522 0.8551541134224351 SH3RF1, SPRY1, SH3PXD2A, PFN4, PDLIM2, MYOZ2, CABP5, NR0B1, PPP2R2B, KIAA1009 69 3332 19235 0.8366390034274579 1.0 0.9996470377759649 99.99999998876363 Annotation Cluster 8 Enrichment Score: 0.43071124229185903 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0003006~reproductive developmental process 3 4.225352112676056 0.21655212400688473 FGF7, NR0B1, PPP2R2B 46 262 13528 3.367407899103883 1.0 0.9999934516676806 97.12930202324755 GOTERM_BP_FAT GO:0032504~multicellular organism reproduction 3 4.225352112676056 0.48545827982155604 FGF7, NR0B1, PPP2R2B 46 487 13528 1.8116239621462367 1.0 0.9998955077471364 99.9936678379701 GOTERM_BP_FAT GO:0048609~reproductive process in a multicellular organism 3 4.225352112676056 0.48545827982155604 FGF7, NR0B1, PPP2R2B 46 487 13528 1.8116239621462367 1.0 0.9998955077471364 99.9936678379701 Annotation Cluster 9 Enrichment Score: 0.34142448826806876 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005739~mitochondrion 7 9.859154929577464 0.22074678577509377 PEX11B, CXORF23, PDK4, GCAT, LIAS, PPP2R2B, C14ORF153 49 1087 12782 1.6798528058877644 0.9999999999999936 0.9997165514591734 94.54464021436952 SP_PIR_KEYWORDS mitochondrion 5 7.042253521126761 0.3392478882980496 CXORF23, PDK4, GCAT, LIAS, PPP2R2B 69 832 19235 1.6752891583054628 1.0 0.9930743152784175 99.26523910963768 SP_PIR_KEYWORDS transferase 7 9.859154929577464 0.3708113022517905 HGSNAT, ZDHHC21, PDK4, HS6ST3, GCAT, LIAS, MAP2K6 69 1394 19235 1.3998398935396006 1.0 0.9914823859162176 99.58876689786906 GOTERM_CC_FAT GO:0031090~organelle membrane 6 8.450704225352112 0.3946912916971762 PEX11B, PDK4, GCAT, ERLIN2, CYP4F2, PPP2R2B 49 1096 12782 1.4280500521376434 1.0 0.9986071713944652 99.71321871913989 GOTERM_CC_FAT GO:0031966~mitochondrial membrane 3 4.225352112676056 0.43813273652149193 PDK4, GCAT, PPP2R2B 49 394 12782 1.9862218999274837 1.0 0.9989568054240419 99.87966702557671 GOTERM_CC_FAT GO:0005740~mitochondrial envelope 3 4.225352112676056 0.4699083481905041 PDK4, GCAT, PPP2R2B 49 419 12782 1.8677122400272756 1.0 0.9990208902725843 99.93896867245441 UP_SEQ_FEATURE transit peptide:Mitochondrion 3 4.225352112676056 0.4976435288626038 PDK4, GCAT, LIAS 69 467 19113 1.779443254817987 1.0 0.9999982868204688 99.98828177546852 SP_PIR_KEYWORDS transit peptide 3 4.225352112676056 0.5044284715025867 PDK4, GCAT, LIAS 69 476 19235 1.7569419071976615 1.0 0.9973856037419446 99.97574567092846 GOTERM_CC_FAT GO:0044429~mitochondrial part 3 4.225352112676056 0.661308978726754 PDK4, GCAT, PPP2R2B 49 595 12782 1.3152460984393757 1.0 0.999761920225154 99.99967125154285 GOTERM_CC_FAT GO:0031967~organelle envelope 3 4.225352112676056 0.6836487610390546 PDK4, GCAT, PPP2R2B 49 620 12782 1.2622119815668202 1.0 0.9994677563547489 99.99985164956865 GOTERM_CC_FAT GO:0031975~envelope 3 4.225352112676056 0.685384553430147 PDK4, GCAT, PPP2R2B 49 622 12782 1.2581534221405604 1.0 0.9992636164696787 99.99986086897896 Annotation Cluster 10 Enrichment Score: 0.3408708275557047 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009725~response to hormone stimulus 3 4.225352112676056 0.346077228583888 GCLC, NR4A3, NR0B1 46 367 13528 2.4039805710223905 1.0 0.9999890940927432 99.7929122357308 GOTERM_BP_FAT GO:0009719~response to endogenous stimulus 3 4.225352112676056 0.3918351938011778 GCLC, NR4A3, NR0B1 46 405 13528 2.1784219001610308 1.0 0.9999660451386021 99.92792313880912 GOTERM_BP_FAT GO:0010033~response to organic substance 3 4.225352112676056 0.7000209736036351 GCLC, NR4A3, NR0B1 46 721 13528 1.2236627871917023 1.0 0.9999923264173939 99.99999753188531 Annotation Cluster 11 Enrichment Score: 0.33204391714124026 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043065~positive regulation of apoptosis 3 4.225352112676056 0.42120881963646906 SH3RF1, C14ORF153, MAP2K6 46 430 13528 2.0517694641051567 1.0 0.9999607018697901 99.96492413594214 GOTERM_BP_FAT GO:0043068~positive regulation of programmed cell death 3 4.225352112676056 0.4246886102311265 SH3RF1, C14ORF153, MAP2K6 46 433 13528 2.0375539712822572 1.0 0.9999505393332998 99.96787032158126 GOTERM_BP_FAT GO:0010942~positive regulation of cell death 3 4.225352112676056 0.42700282194971795 SH3RF1, C14ORF153, MAP2K6 46 435 13528 2.0281859070464767 1.0 0.9999364997621237 99.96970024731111 GOTERM_BP_FAT GO:0042981~regulation of apoptosis 4 5.633802816901409 0.5054539646489993 SH3RF1, GCLC, C14ORF153, MAP2K6 46 804 13528 1.463119186675319 1.0 0.9999028605686618 99.99644276114896 GOTERM_BP_FAT GO:0043067~regulation of programmed cell death 4 5.633802816901409 0.5122234348895344 SH3RF1, GCLC, C14ORF153, MAP2K6 46 812 13528 1.448704219318912 1.0 0.9998985484717401 99.9970890974737 GOTERM_BP_FAT GO:0010941~regulation of cell death 4 5.633802816901409 0.5147503261549006 SH3RF1, GCLC, C14ORF153, MAP2K6 46 815 13528 1.4433715657508668 1.0 0.9998553856159151 99.99730095252787 Annotation Cluster 12 Enrichment Score: 0.27687744485897336 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY hsa05200:Pathways in cancer 3 4.225352112676056 0.3966969283308839 WNT10B, FGF7, WNT6 22 328 5085 2.1140521064301554 0.9999998427460253 0.9999998427460253 98.69799195437245 GOTERM_CC_FAT GO:0044421~extracellular region part 5 7.042253521126761 0.4910896836143041 WNT10B, FGF7, MMP16, WNT6, ADAMTS5 49 960 12782 1.3586309523809523 1.0 0.9982011277904463 99.96206559986865 GOTERM_BP_FAT GO:0007166~cell surface receptor linked signal transduction 6 8.450704225352112 0.7581375662694042 WNT10B, FGF7, GPR119, GRM8, LTB4R2, WNT6 46 1856 13528 0.9507121439280359 1.0 0.9999980854545695 99.99999989241857 Annotation Cluster 13 Enrichment Score: 0.2765005112280977 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006468~protein amino acid phosphorylation 4 5.633802816901409 0.383828785441633 MYOD1, LRRN3, PDK4, MAP2K6 46 667 13528 1.7636399191708492 1.0 0.9999701891574848 99.9128165393494 GOTERM_BP_FAT GO:0016310~phosphorylation 4 5.633802816901409 0.5020525382945827 MYOD1, LRRN3, PDK4, MAP2K6 46 800 13528 1.4704347826086956 1.0 0.9999154490711718 99.99606973804053 GOTERM_BP_FAT GO:0006793~phosphorus metabolic process 4 5.633802816901409 0.6376107390137117 MYOD1, LRRN3, PDK4, MAP2K6 46 973 13528 1.2089905715179408 1.0 0.9999725109307853 99.99996140020477 GOTERM_BP_FAT GO:0006796~phosphate metabolic process 4 5.633802816901409 0.6376107390137117 MYOD1, LRRN3, PDK4, MAP2K6 46 973 13528 1.2089905715179408 1.0 0.9999725109307853 99.99996140020477 Annotation Cluster 14 Enrichment Score: 0.2697895511678959 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005856~cytoskeleton 8 11.267605633802818 0.25780820626280626 SH3PXD2A, PFN4, PDLIM2, MYOZ2, KRT85, PPP2R2B, NEFM, KIAA1009 49 1381 12782 1.5111203061963379 1.0 0.9985108587261846 96.90941955720639 GOTERM_CC_FAT GO:0044430~cytoskeletal part 4 5.633802816901409 0.7042210658875034 SH3PXD2A, KRT85, NEFM, KIAA1009 49 952 12782 1.0960384153661464 1.0 0.9992922980683445 99.99993227487786 SP_PIR_KEYWORDS coiled coil 6 8.450704225352112 0.8543298819626121 SH3PXD2A, GPATCH4, KRT85, NEFM, KIAA1009, LZIC 69 2019 19235 0.8284342227103387 1.0 0.9997138275102277 99.99999998798162 Annotation Cluster 15 Enrichment Score: 0.26649650998076835 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3 4.225352112676056 0.5122864266294662 GCLC, GRM8, NR0B1 46 512 13528 1.723165760869565 1.0 0.9998745604346966 99.99709456176544 GOTERM_BP_FAT GO:0051172~negative regulation of nitrogen compound metabolic process 3 4.225352112676056 0.5196399693721778 GCLC, GRM8, NR0B1 46 519 13528 1.6999246041719025 1.0 0.9998440609263618 99.99767073017131 GOTERM_BP_FAT GO:0031327~negative regulation of cellular biosynthetic process 3 4.225352112676056 0.5622519889186082 GCLC, GRM8, NR0B1 46 561 13528 1.5726575215066265 1.0 0.999904781565987 99.9993970417681 GOTERM_BP_FAT GO:0009890~negative regulation of biosynthetic process 3 4.225352112676056 0.5739414123221392 GCLC, GRM8, NR0B1 46 573 13528 1.5397222854541317 1.0 0.9998969400517831 99.99959330426445 Annotation Cluster 16 Enrichment Score: 0.1272702715356555 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 16 22.535211267605636 0.5111979622103281 HGSNAT, WNT10B, FGF7, LRRN3, ERLIN2, MMP16, MUC6, GRM8, PVRL3, LTB4R2, CCBE1, HS6ST3, WNT6, SLC43A1, ADAMTS5, PQLC2 69 4129 19113 1.0733833858077018 1.0 0.9999974625695911 99.99182147350346 GOTERM_CC_FAT GO:0044459~plasma membrane part 9 12.676056338028168 0.601168278084812 MAGEE1, GRM8, PVRL3, LTB4R2, RHEB, MMP16, KCNG4, SLC43A1, CLDN23 49 2203 12782 1.065689643991959 1.0 0.9994611528182135 99.99778864579486 GOTERM_CC_FAT GO:0005887~integral to plasma membrane 5 7.042253521126761 0.6637967932974166 GRM8, LTB4R2, MMP16, KCNG4, SLC43A1 49 1188 12782 1.097883597883598 1.0 0.9996413147860023 99.9996983342863 SP_PIR_KEYWORDS cell membrane 8 11.267605633802818 0.6702197031308113 GPR119, GRM8, PVRL3, LTB4R2, RHEB, MMP16, KCNG4, CLDN23 69 2194 19235 1.0164744428150556 1.0 0.9990369081318762 99.99980615556771 UP_SEQ_FEATURE topological domain:Cytoplasmic 12 16.901408450704224 0.6742736118613359 HGSNAT, GPR119, GRM8, PVRL3, LRRN3, LTB4R2, HS6ST3, ERLIN2, MMP16, KCNG4, PQLC2, CLDN23 69 3374 19113 0.985180794309425 1.0 0.9999998804955892 99.99996065234508 GOTERM_CC_FAT GO:0031226~intrinsic to plasma membrane 5 7.042253521126761 0.6815525912988842 GRM8, LTB4R2, MMP16, KCNG4, SLC43A1 49 1215 12782 1.0734861845972958 1.0 0.9996253930298731 99.99983977298741 SP_PIR_KEYWORDS membrane 21 29.577464788732392 0.7485105762895932 HGSNAT, GPR119, LRRN3, ERLIN2, MMP16, CLDN23, PEX11B, SPRY1, ZDHHC21, GRM8, PVRL3, LTB4R2, HS6ST3, RHEB, SYTL3, CYP4F2, TMEM86A, PPP2R2B, SLC43A1, KCNG4, PQLC2 69 6256 19235 0.9357625375291895 1.0 0.9996476343054375 99.99999220543421 UP_SEQ_FEATURE transmembrane region 16 22.535211267605636 0.7936206767859548 HGSNAT, GPR119, LRRN3, ERLIN2, MMP16, CLDN23, PEX11B, ZDHHC21, GRM8, PVRL3, LTB4R2, HS6ST3, TMEM86A, SLC43A1, KCNG4, PQLC2 69 4911 19113 0.9024638566483404 1.0 0.9999999984562917 99.9999999024718 SP_PIR_KEYWORDS transmembrane 16 22.535211267605636 0.8019666487626886 HGSNAT, GPR119, LRRN3, ERLIN2, MMP16, CLDN23, PEX11B, ZDHHC21, GRM8, PVRL3, LTB4R2, HS6ST3, TMEM86A, SLC43A1, KCNG4, PQLC2 69 4973 19235 0.8969012376980623 1.0 0.9995789399698523 99.99999954161912 UP_SEQ_FEATURE topological domain:Extracellular 8 11.267605633802818 0.8680105833625198 GPR119, GRM8, PVRL3, LRRN3, LTB4R2, MMP16, PQLC2, CLDN23 69 2719 19113 0.8150055167340934 1.0 0.9999999999839078 99.99999999972665 GOTERM_CC_FAT GO:0005886~plasma membrane 11 15.492957746478872 0.9354323989577158 SPRY1, MAGEE1, GPR119, GRM8, PVRL3, LTB4R2, RHEB, MMP16, KCNG4, SLC43A1, CLDN23 49 3777 12782 0.7597110329437574 1.0 0.9999865569604336 99.99999999999866 GOTERM_CC_FAT GO:0016021~integral to membrane 16 22.535211267605636 0.9452419936949586 HGSNAT, GPR119, LRRN3, ERLIN2, MMP16, CLDN23, PEX11B, ZDHHC21, GRM8, PVRL3, LTB4R2, HS6ST3, TMEM86A, SLC43A1, KCNG4, PQLC2 49 5297 12782 0.7879392648129668 1.0 0.9999901820827007 99.9999999999998 GOTERM_CC_FAT GO:0031224~intrinsic to membrane 16 22.535211267605636 0.9644190115843477 HGSNAT, GPR119, LRRN3, ERLIN2, MMP16, CLDN23, PEX11B, ZDHHC21, GRM8, PVRL3, LTB4R2, HS6ST3, TMEM86A, SLC43A1, KCNG4, PQLC2 49 5485 12782 0.760932413074619 1.0 0.9999973822497573 100.0 Annotation Cluster 17 Enrichment Score: 0.10753505034264729 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS receptor 6 8.450704225352112 0.6681344804288021 GPR119, GRM8, PVRL3, LTB4R2, NR4A3, NR0B1 69 1583 19235 1.0566068829135653 1.0 0.9992680533794416 99.99979111281986 SP_PIR_KEYWORDS cell membrane 8 11.267605633802818 0.6702197031308113 GPR119, GRM8, PVRL3, LTB4R2, RHEB, MMP16, KCNG4, CLDN23 69 2194 19235 1.0164744428150556 1.0 0.9990369081318762 99.99980615556771 SP_PIR_KEYWORDS g-protein coupled receptor 3 4.225352112676056 0.7900351931572782 GPR119, GRM8, LTB4R2 69 816 19235 1.0248827791986361 1.0 0.9995693675108239 99.99999908272747 SP_PIR_KEYWORDS transducer 3 4.225352112676056 0.8211516236617247 GPR119, GRM8, LTB4R2 69 874 19235 0.9568699631877424 1.0 0.999662967123974 99.9999998630689 UP_SEQ_FEATURE topological domain:Extracellular 8 11.267605633802818 0.8680105833625198 GPR119, GRM8, PVRL3, LRRN3, LTB4R2, MMP16, PQLC2, CLDN23 69 2719 19113 0.8150055167340934 1.0 0.9999999999839078 99.99999999972665 GOTERM_BP_FAT GO:0007186~G-protein coupled receptor protein signaling pathway 3 4.225352112676056 0.8976639979982749 GPR119, GRM8, LTB4R2 46 1123 13528 0.7856285570482792 1.0 0.9999999986718258 99.9999999999996 Annotation Cluster 18 Enrichment Score: 0.06751467917546695 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005624~membrane fraction 3 4.225352112676056 0.8165940054477009 LTB4R2, CYP4F2, NR0B1 49 809 12782 0.9673318029313085 1.0 0.9999046182035587 99.9999997427308 GOTERM_CC_FAT GO:0005626~insoluble fraction 3 4.225352112676056 0.8325035520605898 LTB4R2, CYP4F2, NR0B1 49 839 12782 0.9327430614677338 1.0 0.9999141403029502 99.99999991070294 GOTERM_CC_FAT GO:0000267~cell fraction 3 4.225352112676056 0.9227067120235 LTB4R2, CYP4F2, NR0B1 49 1083 12782 0.7225959635931936 1.0 0.999990505588508 99.99999999998917 Annotation Cluster 19 Enrichment Score: 0.052933133647489 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005730~nucleolus 3 4.225352112676056 0.745881548094544 ZNF275, LIAS, PSMD8 49 698 12782 1.1211625051166598 1.0 0.9995914049090727 99.99998846803987 GOTERM_CC_FAT GO:0070013~intracellular organelle lumen 5 7.042253521126761 0.9167434749616235 MYOD1, ZNF275, PDK4, LIAS, PSMD8 49 1779 12782 0.7331566690757247 1.0 0.9999942186477089 99.99999999997426 GOTERM_CC_FAT GO:0031981~nuclear lumen 4 5.633802816901409 0.9212474073403515 MYOD1, ZNF275, LIAS, PSMD8 49 1450 12782 0.7196059113300493 1.0 0.9999931435973997 99.99999999998654 GOTERM_CC_FAT GO:0043233~organelle lumen 5 7.042253521126761 0.9255052646476283 MYOD1, ZNF275, PDK4, LIAS, PSMD8 49 1820 12782 0.716640502354788 1.0 0.9999881163904769 99.99999999999297 GOTERM_CC_FAT GO:0031974~membrane-enclosed lumen 5 7.042253521126761 0.9325271148855495 MYOD1, ZNF275, PDK4, LIAS, PSMD8 49 1856 12782 0.7027401477832513 1.0 0.9999887247297278 99.99999999999778 Annotation Cluster 20 Enrichment Score: 0.009279659295033752 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS nucleotide-binding 4 5.633802816901409 0.9444982649537663 GCLC, PDK4, RHEB, MAP2K6 69 1686 19235 0.6613715680712432 1.0 0.9999905108734304 99.99999999999987 SP_PIR_KEYWORDS atp-binding 3 4.225352112676056 0.9533571695386152 GCLC, PDK4, MAP2K6 69 1326 19235 0.6306970948914683 1.0 0.9999934074302266 99.99999999999999 GOTERM_MF_FAT GO:0032555~purine ribonucleotide binding 4 5.633802816901409 0.9794130338429677 GCLC, PDK4, RHEB, MAP2K6 51 1836 12983 0.5546157460805673 1.0 1.0 100.0 GOTERM_MF_FAT GO:0032553~ribonucleotide binding 4 5.633802816901409 0.9794130338429677 GCLC, PDK4, RHEB, MAP2K6 51 1836 12983 0.5546157460805673 1.0 1.0 100.0 GOTERM_MF_FAT GO:0005524~ATP binding 3 4.225352112676056 0.9824569571730936 GCLC, PDK4, MAP2K6 51 1477 12983 0.5170655940101159 1.0 1.0 100.0 GOTERM_MF_FAT GO:0032559~adenyl ribonucleotide binding 3 4.225352112676056 0.9837083232063037 GCLC, PDK4, MAP2K6 51 1497 12983 0.5101575700420449 1.0 1.0 100.0 GOTERM_MF_FAT GO:0017076~purine nucleotide binding 4 5.633802816901409 0.984436478825241 GCLC, PDK4, RHEB, MAP2K6 51 1918 12983 0.530904332535934 1.0 1.0 100.0 GOTERM_MF_FAT GO:0030554~adenyl nucleotide binding 3 4.225352112676056 0.9879159891245168 GCLC, PDK4, MAP2K6 51 1577 12983 0.4842776679473311 1.0 1.0 100.0 GOTERM_MF_FAT GO:0001883~purine nucleoside binding 3 4.225352112676056 0.9889613216162886 GCLC, PDK4, MAP2K6 51 1601 12983 0.47701804019546606 1.0 1.0 100.0 GOTERM_MF_FAT GO:0001882~nucleoside binding 3 4.225352112676056 0.9894110856103873 GCLC, PDK4, MAP2K6 51 1612 12983 0.47376295431323895 1.0 0.9999999999999999 100.0 GOTERM_MF_FAT GO:0000166~nucleotide binding 4 5.633802816901409 0.9951568072871175 GCLC, PDK4, RHEB, MAP2K6 51 2245 12983 0.45357439189484255 1.0 1.0 100.0