mRNA QUANTIFICATION SUMMARY Fields: SCO# Gene ID from the Sanger Institute "Sanger Abbreviation, Annotation, Category and Subcategory" Gene function information from the Sanger Institute "TIGR Abbreviation, Category" Gene function information from The Institute of Genome Research "7h, 11h, 14h, 16h, 22h, 26h, 34h, 38h mRNA ratios" mRNA quantification ratios with respect to gDNA signal intensity PC-1 and 2 Values along principal components 1 and 2 for mRNA data SET Set code (A-G) defined based on Figure presented along with Table S1 ANNOTATION mRNA QUANTIFICATION DATA PCA SCO# Sanger Abbreviation Sanger Annotation Sanger Category Sanger Subcategory TIGR Abbreviation TIGR Category 7h - mRNA ratio 11h - mRNA ratio 14h - mRNA ratio 16h - mRNA ratio 22h - mRNA ratio 26h - mRNA ratio 34h - mRNA ratio 38h - mRNA ratio PC-1 mRNA PC-2 mRNA SET SCO0167 other conserved hypothetical protein SCJ1.16c hypothetical protein Conserved in organism other than Escherichia coli universal stress protein family family -0.97 -1.24 -0.45 -0.99 1.09 -0.56 -0.76 2.13 SCO0199 other putative alcohol dehydrogenase "Energy metabolism, carbons" Anaerobic respiration alcohol dehydrogenase (EC 1.1.1.1) SCJ12.11c -1.41 -1.03 -0.32 -0.03 0.35 0.57 -1.35 -1.08 SCO0200 other conserved hypothetical protein SCJ12.12c hypothetical protein Conserved in organism other than Escherichia coli universal stress protein family family -0.79 -0.15 2.47 -1.05 1.5 5.18 1.95 C SCO0204 other putative luxR family two-component response regul Two-component system Response regulator "DNA-binding response regulator, LuxR family" -1.61 -0.54 -0.63 1.67 1.42 -0.57 2.65 SCO0229 other putative oxidoreductase (putative secreted protei Periplasmic/exported/lipoproteins Gram +ve membrane probable oxidoreductase SCO0247 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.36 0.88 0.08 0.97 1.16 1.09 -0.14 1.95 2.53 0.19 G SCO0260 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "Uncharacterized ACR, YneC family COG1359 subfamily" -0.24 -0.16 0.58 -0.13 0.86 -0.06 -1.22 0.39 1.86 0.81 G SCO0379 katA catalase (EC 1.11.1.6) Cell process Detoxification catalase -0.77 -1.17 -0.77 -0.46 4.01 3.18 -0.08 2.13 6.46 -0.79 C SCO0392 other putative methyltransferase Secondary metabolism Secondary metabolism Bme21 -2.15 -2.07 -1.42 -1.26 -0.71 0.16 -1.01 -0.48 SCO0494 other putative iron-siderophore binding lipoprotein Secondary metabolism Secondary metabolism fecB2 "ABC transporter, periplasmic substrate-binding protein" -1.45 -0.94 -1.37 -0.89 -1.08 -1.69 2.1 0.58 G SCO0498 other putative peptide monooxygenase Secondary metabolism Secondary metabolism probable peptide monooxygenase -0.45 -1.02 -0.99 -0.44 -0.91 -0.82 0.74 -0.62 SCO0506 nadE1 NH(3)-dependent NAD(+)synthetase "Biosynthesis of cofactors, carriers" Pyridine nucleotide nadE NAD+ synthetase -0.14 -0.03 -0.4 -1.2 -0.78 -0.66 -0.97 -0.57 -0.28 -0.11 G SCO0525 other conserved hypothetical protein SCF11.05 hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.2 0.99 0.82 -0.04 0.59 0.34 -0.34 -0.14 1.3 0.8 G SCO0527 other cold shock protein Cell process "Adaptations, atypical conditions" cold shock protein scof. {streptomyces 2.5 3.82 3.67 3.15 2.5 2.54 0.86 2.09 1.15 2.2 G SCO0546 pyc pyruvate carboxylase Central intermediary metabolisms Gluconeogenesis pyc pyruvate carboxylase -0.06 0.78 -0.8 0.31 -0.33 0.68 -0.92 -0.61 0.86 0.64 D SCO0560 cpeB catalase/peroxidase Cell process Detoxification katG catalase/peroxidase HPI -1.19 0.85 -1.09 0.82 1.27 0.78 -0.47 0.28 5.15 1.15 C SCO0596 other putative DNA-binding protein Other regulation Other regulation "DNA-binding stress response protein, Dps family, putative" -0.66 -1.08 0.04 -0.33 1.01 -0.63 -0.89 0.15 SCO0607 other hypothetical lipoportein SCF55.31 Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein conserved hypothetical protein -1.19 0.57 1.03 -0.41 1.78 2.23 0.14 0.3 6.44 0.84 G SCO0608 other putative regulatory protein Other regulation Other regulation conserved hypothetical protein 0.15 1.98 2.46 2.26 2.25 3.86 2.97 3.1 8.01 -0.08 C SCO0641 terD "tellurium resistance protein ""tellurite resistance" Cell process Detoxification 3.98 SCO0681 other putative ferredoxin/ferredoxin-NADP reductase (pu "Energy metabolism, carbons" Electron transport EC1.18.1.2 ferredoxin--NADP reductase 1.25 1.76 1.35 0.39 -0.56 0 0.28 0.07 -1.2 0.38 G SCO0705 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.1 1.16 0.56 0.69 1.95 1.78 0.61 1.45 4.06 0.3 G SCO0741 other putative oxidoreductase Central intermediary metabolisms Sulfur metabolism adhE2 zinc-binding dehydrogenase -0.96 -0.06 -0.85 -0.73 -1.35 -1.2 -1.37 -1.95 0.61 0.82 G SCO0803 other putative RNA polymerase sigma factor. RNA polymerase core enzyme binding sigma factor sigI "RNA polymerase sigma-70 factor, ECF subfamily" -1.47 -1.11 -1.39 -1.58 -1.19 -0.9 -1.12 -1.09 1.94 -0.34 G SCO0805 other putative prolyl aminopeptidase. Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" proline iminopeptidase 0.27 0.45 -0.76 0.31 -1.12 -0.97 -1.79 -0.92 -1.63 0.93 G SCO0852 other putative aldolase Degradation of small molecules Carbon compounds eda 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase -0.82 -1.37 -1.11 -1.39 -0.9 -1.04 -1.79 -0.89 SCO0884 other probable oxidoreductase Cell process Detoxification lpdB "mercuric reductase/transcriptional regulator, fusion" -0.59 -0.41 -1.11 -0.95 -0.93 -0.7 -1.06 -0.69 SCO0888 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein SEQ ID N_ 14P 0.25 -0.62 -0.61 -0.71 -1.4 -0.97 -1.44 -0.82 -2.01 -0.23 F SCO0913 other "hypothetical protein ""hypothetical protein""" hypothetical protein Conserved in organism other than Escherichia coli -1.53 -1.32 -0.99 -1.07 -1.57 -1.94 -1.54 -1.9 SCO0918 other putative excinuclease ABC subunit A Macromolecule metabolism "DNA - replication, repair, restr./modific'n" uvrA "excinuclease ABC, A subunit" -1.49 -1.22 -0.6 -1.46 -1.19 -1.77 -1.2 -1.14 1.8 0.07 G SCO0921 other conserved hypothetical protein SCM10.10c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.35 2.32 0.63 0.72 0.93 0 0.7 -0.6 SCO0957 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) conserved hypothetical protein 0.54 -0.34 -0.89 -0.67 -0.86 -0.7 -0.71 -0.46 -1.93 -0.75 G SCO0975 zwf3 6-phosphogluconate 1-dehydrogenase "Energy metabolism, carbons" "Oxidative branch, pentose pwy" gnd "6-phosphogluconate dehydrogenase, decarboxylating" -0.95 -0.93 -1 -1.16 -0.7 -0.88 -1.12 -0.57 1.33 -0.23 G SCO0999 sodF2 superoxide dismutase Cell process Detoxification superoxide dismutase (EC 1.15.1.1) (Fe/Mn) [validated] 1.97 2.55 1.21 2.44 0.72 2.16 1.88 2.27 0.9 -0.3 G SCO1054 other putative aminotransferase Not classified (included putative assignments) Not classified (included putative assignments) NifS-related protein -1.45 -1.48 -1.33 -1.25 -1.32 -0.73 -1.47 -1.04 SCO1074 other putative peptidase Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" "peptidase, M20/M25/M40 family" SCO1081 other "putative electron transfer flavoprotein, alpha su" "Energy metabolism, carbons" Electron transport etfA "electron transfer flavoprotein, alpha subunit" 1.64 1.53 1.49 0.87 1.54 1.29 0.83 0.57 -0.17 0.18 G SCO1082 other "putative electron transfer flavoprotein, beta sub" "Energy metabolism, carbons" Electron transport etfB-2 "electron transfer flavoprotein, beta subunit" 2.15 2.14 1.11 1.34 1.46 1.07 0.92 0.63 -1.38 0.23 G SCO1088 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) oxrA putative oxidoreductase 0.98 0.61 -0.64 -0.48 -0.62 -0.71 -0.15 -0.1 -2.25 -0.71 G SCO1089 other hypothetical protein 2SCG4.05c hypothetical protein No homologues conserved hypothetical protein 1.93 0.17 -0.62 -0.97 0.46 0.65 -0.23 1.17 -3.4 -1.73 F SCO1116 other hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0 -0.42 -1.13 -0.76 -0.47 -0.29 -1.08 1.3 0.27 -0.83 A SCO1152 other putative helicase Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" helY antiviral protein -1.08 -0.81 -1.4 -1.53 -1.27 -1.67 -0.98 -1.31 0.6 -0.33 G SCO1169 xylA xylose isomerase Degradation of small molecules Carbon compounds xylA xylose isomerase SCO1170 xylB "xylulose kinase (fragment) ""xylulose kinase""" Degradation of small molecules Carbon compounds -1.49 -1.4 -1.72 -1.4 -1.63 -1.8 -1.52 -1.66 0.89 -0.14 G SCO1210 other putative transcriptional regulatory protein Defined family regulators TetR "transcriptional regulator, TetR family" -0.54 -1.26 -1.26 -0.31 -1.55 -1.24 -2.09 -0.95 SCO1212 other putative ligase Not classified (included putative assignments) Not classified (included putative assignments) mur ligase family protein 0.12 -0.04 -0.25 -0.15 -0.52 -0.91 -0.81 -0.73 SCO1213 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli cobQ-2 cobyric acid synthase SCO1222 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -1.45 0.43 0 -0.69 -0.12 -0.35 -0.46 -1.13 3.88 1.02 D SCO1223 rocD ornithine aminotransferase amino acid biosynthesis Arginine rocD acetylornithine aminotransferase -0.73 0.51 -0.36 -0.16 -0.37 -0.77 -0.12 -0.71 2.15 0.47 D SCO1230 other putative secreted tripeptidylaminopeptidase Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein tripeptidylaminopeptidase 0.39 0.24 0.41 2.52 2.28 1.1 1.75 1.53 4.07 -0.23 C SCO1243 bioF 8-amino-7-oxononanoate synthase "Biosynthesis of cofactors, carriers" Biotin bioF "aminotransferase, class II" -0.26 -0.08 -1 -0.06 -0.58 -1.13 0.02 -0.81 SCO1244 bioB biotin synthase "Biosynthesis of cofactors, carriers" Biotin bioB biotin synthetase 0.42 0.55 2.44 0.6 0.25 1.08 -0.86 SCO1254 purB "putative adenylosuccino lyase (fragment) ""adenylos" Nucleotide biosynthesis Purine ribonucleotide biosynthesis 0.56 -0.6 -0.51 -0.71 -0.43 -0.7 -0.28 -1.1 -1.86 -0.78 G SCO1296 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.99 0.39 0.01 -0.15 -0.69 -0.8 -1.07 -1.15 2.17 1.29 G SCO1314 other putative sugar acetyltransferase Macromolecule metabolism Polysaccharides - (cytoplasmic) hexapeptide transferase family protein -0.81 -0.36 -1.52 -0.47 -0.76 -1.33 -0.76 -1.12 SCO1340 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli AA1-122 AmphORF1 -1.02 1.36 -0.72 -0.12 -0.63 0.22 -0.84 -0.21 3.21 1.08 C SCO1343 ung uracil-DNA glycosylase (EC 3.2.2.-) Macromolecule metabolism "DNA - replication, repair, restr./modific'n" ung uracil-DNA glycosylase -0.28 0.22 -0.87 0.57 -1.16 -1.32 -0.67 -0.97 0.11 0.5 G SCO1346 fabG3 putative 3-oxoacyl-[acyl-carrier protein] reducta Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth fabG 3-oxoacyl-acyl carrier protein reductase -1.25 -0.63 -0.91 -0.51 -1.05 -0.74 -1.31 -1.44 SCO1361 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -1.18 -1.25 -1.09 -1.57 -1.33 -1.28 -0.77 -0.54 1.43 -0.79 D SCO1366 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli Transcriptional regulator PadR-like family domain protein -1.25 -1.07 -1 -0.92 -0.83 -1.36 -1.23 -0.7 1.79 0.05 A SCO1378 other putative glycine dehydrogenase Degradation of small molecules Amino acids gcvP glycine dehydrogenase 1.12 -0.44 -1.01 -0.48 -1.58 -1.01 -1.6 -0.48 -4.27 -0.62 G SCO1382 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "Uncharacterized ACR, COG1259 superfamily" 0.72 0.69 -0.7 -0.77 -0.24 -0.21 0.57 -0.87 -1.33 -0.87 B SCO1384 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "ABC transporter, ATP-binding protein, putative" 0.48 -0.35 -0.46 0.76 -0.86 -0.12 -0.85 -0.22 -0.88 -0.08 G SCO1390 other putative PTS system sugar phosphotransferase comp Cell process Other Transport/binding proteins crr PTS system component 0.64 0.15 0.21 -0.06 0.55 -0.47 -0.73 0.3 -0.57 0.14 G SCO1391 other phosphoenolpyruvate-protein phosphotransferase Degradation of small molecules Carbon compounds ptsI phosphoenolpyruvate-protein phosphotransferase -0.19 -0.43 -0.46 -1.18 -0.76 -1.21 -0.82 -1.22 -0.7 -0.16 G SCO1393 acsA acetoacetyl-CoA synthetase Secondary metabolism Secondary metabolism acetoacetyl-CoA synthase -1.2 -0.85 -0.91 -0.39 -1.46 -0.77 -1.45 -1.33 SCO1395 other mutT-like protein Macromolecule metabolism "DNA - replication, repair, restr./modific'n" NUDIX domain protein -0.57 -0.65 -0.21 -0.79 -0.05 -0.52 0.01 -1.29 SCO1401 cvnB4 conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli evcK 1.46 0.84 0.59 0.93 0.62 1.29 2.58 0.65 0.34 -1.64 G SCO1404 other hypothetical protein hypothetical protein No homologues conserved hypothetical protein -1.08 -0.89 -0.76 -0.56 -1.25 -1.14 -1.24 -0.89 1.42 0.22 D SCO1405 other putative heat shock protein (hsp90-family) Cell process Chaperones "heat shock protein, putative" -0.63 -0.3 -0.79 -1.24 -0.8 -1.15 -1.12 -1.25 SCO1407 other "hypothetical protein SC6D7.32. ""hypothetical prote" hypothetical protein No homologues -0.85 -1.05 -0.77 -1.02 -1.04 -1.07 -1.07 -1.18 SCO1414 other putative ankyrin-like protein. Not classified (included putative assignments) Not classified (included putative assignments) ankB ankB protein -0.6 -1.13 -0.91 -0.53 -1.2 -1.11 -1.43 -0.99 0.01 -0.02 A SCO1421 other hypothetical protein SC6D7.18c. hypothetical protein No homologues SEQ ID NO 4M 1.9 1.95 0.32 1.46 0.75 1.34 1.22 1.77 -0.51 -0.62 G SCO1423 other putative glycosyl transferase. Macromolecule metabolism Polysaccharides - (cytoplasmic) Ppm1 apolipoprotein n-acyltransferase Lnt/dolichol-phosphate-mannosyl transferase Dpm1 0.83 -0.63 0.52 0.09 0.7 0.49 0.24 -1.14 SCO1425 other putative AsnC-family transcriptional regulatory Defined family regulators AsnC lrp leucine-responsive regulatory protein 0.08 -0.41 -1.42 -1.01 -0.77 -1.02 0.21 -1.41 -1.18 -1.14 B SCO1438 hisG ATP phosphoribosyltransferase (EC 2.4.2.17) (frag amino acid biosynthesis Histidine 0.47 0.1 -0.84 -0.22 -0.9 -1.03 -1.13 -1.07 -2.13 0.13 G SCO1439 hisE phosphoribosyl-ATP pyrophosphatase amino acid biosynthesis Histidine phosphoribosyl-ATP pyrophosphohydrolase 1.24 0.41 0.31 0.47 -0.42 0.28 -0.63 -0.07 -2.03 -0.02 G SCO1440 ribH "6,7-dimethyl-8-ribityllumazine synthase" "Biosynthesis of cofactors, carriers" Riboflavin ribH "riboflavin synthase, beta subunit" -0.37 -0.64 -0.47 -0.75 -0.71 -0.93 -0.84 -0.53 0.3 -0.21 G SCO1441 ribAB "3,4-dihydroxy-2-butanone 4-phosphate synthase" "Biosynthesis of cofactors, carriers" Riboflavin ribA "GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase" -1.15 -0.96 -0.45 -1.46 -0.72 -1.19 -1.41 -0.97 1.45 0.22 A SCO1450 other putative uracyl permease Cell process Transport/binding proteins uraA uracil permease SCO1454 other putative amino oxidase Cell process Differentiation/sporulation EC1.13.12.3 "amine oxidase, flavin-containing superfamily" 0.13 -1.42 -1.41 -0.66 -1.4 -1.64 -0.96 -1.01 SCO1461 guaB2 putative inosine monophosphate dehydrogenase Nucleotide biosynthesis Purine ribonucleotide biosynthesis IMP dehydrogenase family protein -0.78 0.11 -0.75 0.38 -0.62 -0.22 -0.55 -0.73 SCO1463 other putative transcriptional regulator Defined family regulators DeoR "transcriptional regulator, putative" -0.58 0.86 0.12 -0.37 0.19 -0.2 -0.65 -0.53 SCO1464 rpe ribulose-phosphate 3-epimerase Degradation of small molecules Carbon compounds rpe ribulose-phosphate 3-epimerase -0.81 -0.96 -1.24 -1.22 -1.5 -0.6 -0.83 0.69 -0.73 G SCO1472 other conserved hypothetical Sun-family protein SCL6.29 hypothetical protein Conserved in organism other than Escherichia coli "Sun protein, putative" -0.55 -1.83 -0.6 -0.71 -1.29 -1.53 -1.49 -0.99 SCO1473 fmt methionyl-tRNA formyltransferase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n fmt methionyl-tRNA formyltransferase -0.25 -0.46 -1.45 -0.24 -0.88 -0.93 -0.99 -0.92 -0.39 -0.16 G SCO1476 metK S-adenosylmethionine synthetase Central intermediary metabolisms S-adenosyl methionine metK S-adenosylmethionine synthetase 1.52 2.38 1.45 2.27 0.96 1.66 0.74 1.68 1.15 0.79 G SCO1477 other "putative flavoprotein homologue (partial) ""putativ" Not classified (included putative assignments) Not classified (included putative assignments) -0.95 -1.46 -0.73 -1.57 -0.79 0.13 -1.38 -1.36 1.1 -0.32 G SCO1478 other putative DNA-directed RNA polymerase omega chain Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" rpoZ "DNA-directed RNA polymerase, omega subunit" 0.64 -0.66 0.29 -1.26 -0.18 0.53 -0.69 -0.61 -1.35 -0.73 G SCO1479 other putative guanylate kinase Central intermediary metabolisms Nucleotide interconversions gmk guanylate kinase 0.71 0.41 -0.19 0.43 0.37 2.3 -0.07 0.62 -0.32 A SCO1480 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli mihF mIHF 1.72 2.83 2.64 3.37 3.46 3.38 2.85 1.87 4.27 0.79 G SCO1481 pyrF orotidine 5'-phosphate decarboxylase Nucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis pyrF orotidine 5`-phosphate decarboxylase 1.2 0.77 0.65 -0.37 SCO1483 pyrA carbamoylphosphate synthetase large chain Nucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis carB "carbamoyl-phosphate synthase, large subunit" -0.14 -0.41 -0.15 -1.4 -1.16 -1.09 -1.41 -1.44 -1.26 0.16 F SCO1484 pyrAA "carbamoyl-phosphate synthase, pyrimidine-specific" Nucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis carA "carbamoyl-phosphate synthase, small subunit" 0.2 1.47 0.64 1.79 1.17 0.17 -0.36 -0.38 2.02 1.89 A SCO1486 pyrC dihydroorotase Nucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis pyrC dihydroorotase 0.85 -0.1 -1.06 -0.45 -0.61 -0.67 0.38 -0.42 -2.04 -1.37 F SCO1487 pyrB aspartate carbamoyltransferase Nucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis pyrB aspartate carbamoyltransferase -0.62 -1.09 -0.89 -1.91 -1.41 -1.4 -1.41 -1.57 SCO1488 pyrimidine operon regulatory protein SCO1489 bldD putative DNA-binding protein Other regulation Other regulation putative DNA binding protein 1.42 1.65 1.21 -0.1 0.41 1.01 -0.52 -0.7 SCO1490 other putative NusB-family protein Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" nusB N utilization substance protein B 2.52 0.96 1.06 0.64 -0.39 -0.31 -0.62 -0.28 -5.26 0.08 E SCO1491 efp elongation factor P Macromolecule metabolism Proteins - translation and modification efp translation elongation factor P 2.27 0.83 1.81 0.16 0.74 1.03 -0.05 0.29 SCO1494 aroB 3-dehydroquinate synthase amino acid biosynthesis Chorismate aroB 3-dehydroquinate synthase 0.11 0.07 -0.44 -0.77 -0.04 -0.41 0.41 -0.93 0.1 -0.63 G SCO1495 aroK shikimate kinase I amino acid biosynthesis Chorismate aroK shikimate kinase -0.17 0.35 -0.83 0.25 -0.1 -0.25 -0.91 -0.6 0.72 0.58 G SCO1496 aroF chorismate synthase amino acid biosynthesis Chorismate aroC chorismate synthase -0.15 0.02 -0.46 0.04 -0.63 -0.85 -1.08 -0.12 0.29 0.37 G SCO1501 alaS alanine tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n alaS alanyl-tRNA synthetase 0.06 -0.29 -0.68 -1.09 -1.05 -0.86 -1.25 -1.13 -1.47 -0.11 G SCO1505 rspD 30S ribosomal protein S4 Ribosome "Ribosomal proteins - synthesis, modification" rpsD ribosomal protein S4 4.2 2.88 3.92 2.75 1.77 1.84 0.17 1.15 -4.81 1.42 E SCO1507 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane u0002b -0.46 -0.65 -0.75 -1.42 -0.63 -0.39 -0.77 -0.64 SCO1508 hisS histidyl tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n hisS histidyl-tRNA synthetase -0.29 -0.56 -0.26 -1.5 -1.33 -1.17 -1.55 -1.6 -1.23 0.17 G SCO1510 other putative peptidyl-prolyl cis-trans isomerase Macromolecule metabolism Proteins - translation and modification ppiB "peptidyl-prolyl cis-trans isomerase, cyclophilin-type" 1.87 2.03 0.71 2.48 0.23 -0.22 0.43 0.09 SCO1511 other "hypothetical protein (fragment) ""hypothetical prot" hypothetical protein Conserved in organism other than Escherichia coli 0.9 0.9 -0.18 -0.01 -0.49 -0.35 -0.78 -0.05 -1.73 0.17 G SCO1514 apt adenine phosphoribosiltransferase Central intermediary metabolisms Nucleotide interconversions apt adenine phosphoribosyltransferase -0.1 -0.74 -0.15 -0.8 -0.51 -0.58 0.42 -0.56 0.46 -1.04 G SCO1515 secF protein-export membrane protein Cell process Transport/binding proteins protein-export membrane protein secf. {streptomyces 1.36 -0.04 0.38 -0.15 -0.28 -0.05 -0.94 -0.86 -3.19 -0.06 B SCO1516 secD protein-export membrane protein Cell process Transport/binding proteins secD protein-export membrane protein SecD 1.1 -0.43 -0.36 -0.07 -0.55 -0.68 -0.61 -1.13 SCO1517 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein "similar to unknown proteins, putative" 2.25 0.51 1.26 1.29 0.32 0.95 -0.1 0.12 -3.13 -0.1 B SCO1522 other conserved hypothetical protein SCL2.12c hypothetical protein Conserved in organism other than Escherichia coli "amidotransferase, putative" 1.45 1.25 -0.4 0.13 -0.78 -1.17 -1.2 -0.11 SCO1523 other conserved hypothetical protein SCL2.13c hypothetical protein Conserved in organism other than Escherichia coli pyridoxine biosynthesis protein 2.74 3.17 0.93 1.34 -0.17 -0.27 2.37 -1.13 -4.12 -0.24 G SCO1527 other putative membrane transferase Periplasmic/exported/lipoproteins Gram +ve membrane pgsA CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -1.02 -0.39 -0.29 -0.62 0.92 -0.2 -1.25 0.38 3.34 0.64 C SCO1531 thrS threonine-tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n thrS threonyl-tRNA synthetase 0.41 -0.13 0.04 -1.14 -0.38 -0.51 -0.51 -1.33 -1.45 -0.26 G SCO1540 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein 0.44 0.23 -0.47 -0.37 -0.23 -0.04 -0.35 0.28 SCO1548 other hypothetical protein SCL11.04c hypothetical protein No homologues conserved hypothetical protein 0.7 0.82 1.48 0.96 0.73 1.57 2.06 -0.43 G SCO1553 other putative uroporphyrin-III methyltransferase "Biosynthesis of cofactors, carriers" "Heme, porphyrin" cysG uroporphyrinogen III methyltransferase -0.52 -1.26 -0.32 -0.73 -0.57 -0.63 -1.15 -1.24 SCO1554 other putative nicotinate-nucleotide-dimethylbenzimidaz "Biosynthesis of cofactors, carriers" Cobalamin Phosphoribosyltransferase family 0.78 0.18 -0.04 -0.11 0.06 -0.02 -0.47 -1.11 -1.53 0.05 G SCO1557 other putative lipoprotein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein outer membrane protein 0.38 -0.4 -0.5 -0.95 -0.73 -0.76 -1.39 -0.66 -1.89 -0.18 G SCO1565 other putative glycerophosphoryl diester phosphodiester Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein -1.36 4.68 2.58 2.1 2.69 2.46 0.59 1.38 10.2 4.09 C SCO1570 argH argininosuccinate lyase amino acid biosynthesis Arginine argH argininosuccinate lyase 0.96 0.22 0.62 0.31 0.49 0.11 2.39 0.48 0.58 -1.69 G SCO1582 other ATP/GTP binding protein Not classified (included putative assignments) Not classified (included putative assignments) tmrB tunicamycin resistance protein. {bacillus -1.25 -1.26 -1.92 -1.14 -1.47 -1.7 -1.37 -1.16 0.72 -0.34 G SCO1591 other putative 3-hydroxyacyl-CoA dehydrogenase Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth fadB2 3-hydroxyacyl-CoA dehydrogenase family protein 0.66 -0.05 -0.48 -1.07 -0.48 -0.67 -0.15 -0.61 SCO1594 pheT putative phenylalanyl-tRNA synthetase beta chain Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n pheT "phenylalanyl-tRNA synthetase, beta subunit" 0.74 0.06 0.56 -0.49 -0.57 -0.72 -0.95 -0.85 -2.05 0.22 G SCO1595 pheS putative phenylalanyl-tRNA synthetase alpha chain Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n pheS "phenylalanyl-tRNA synthetase, alpha subunit" 1.97 0.97 1.44 -0.26 0.31 0.76 -0.17 -0.3 -3.09 -0.09 G SCO1598 rplT 50S ribosomal protein L20 Ribosome "Ribosomal proteins - synthesis, modification" rplT ribosomal protein L20 4.79 3.2 3.63 2.74 2.94 2.77 1.07 3.41 -4.09 0.24 E SCO1599 rpmI 50S ribosomal protein L35 Ribosome "Ribosomal proteins - synthesis, modification" rpmI ribosomal protein L35 1.71 -0.36 1.8 -0.1 0.89 1.13 1.23 1.78 -0.6 -1.74 F SCO1600 infC putative translation initiation factor IF-3 Macromolecule metabolism Proteins - translation and modification infC translation initiation factor IF-3 4.76 2.8 3.52 2.43 2.14 3.7 3.35 2.44 -3.56 -1.5 G SCO1602 other hypothetical protein SCI35.24c hypothetical protein No homologues conserved hypothetical protein 0.23 -0.27 -1.15 -0.57 -0.91 -1.09 -0.41 -0.34 -1.19 -0.81 G SCO1621 opuAA glycine betaine transport ATP-binding protein Cell process Amino acids and amines proV glycine betaine/L-proline transport ATP binding subunit 1.9 0.5 -0.79 -0.08 -1.21 -1.24 -0.58 -1.09 -5.65 -0.66 G SCO1622 other putative 5'-3' exonuclease Macromolecule metabolism Degradation of DNA polA DNA-directed DNA polymerase I -0.5 -1.29 -0.95 -1.09 -0.51 -1.22 -0.43 -0.86 0.25 -0.85 G SCO1623 other conserved hypothetical protein SCI41.06 hypothetical protein Conserved in organism other than Escherichia coli siderophore utilization protein -0.83 -1.24 -0.66 -0.44 -1.18 -0.47 -0.95 -0.68 SCO1626 other putative cytochrome P450 "Energy metabolism, carbons" Electron transport "biotin biosynthesis; cytochrome p450-like enzyme, putative" -1.34 -1.21 -0.95 -0.8 1.18 0.57 0.12 1.01 SCO1630 cvnA9 putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane "SEQ ID NO 21D, putative" -0.35 -1.01 -0.49 0.67 1.8 2.32 1.08 1.91 SCO1633 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein possible secreted protein 1.87 3.68 2.38 2.44 3.68 3.4 1.19 2.93 3.48 1.48 G SCO1636 other conserved hypothetical protein SCI41.19c hypothetical protein Conserved in organism other than Escherichia coli 1 possible DNA-binding protein -0.59 -0.98 -0.21 -1.89 -1.21 -0.2 -1.13 0.35 SCO1638 fkbP peptidyl-prolyl cis-trans isomerase Macromolecule metabolism Protein modification "peptidyl-prolyl cis-trans isomerase, FKBP-type" 2.52 2.73 1.5 2.23 1.1 1.01 -0.34 1.7 -2.05 1.23 B SCO1639 other putative secreted peptidyl-prolyl cis-trans isome Macromolecule metabolism Protein modification "fkbp-type peptidyl-prolyl cis-trans isomerase fkpa precursor, putative" 0.17 0.65 -0.47 0.87 -0.4 -0.51 0.12 -0.37 0.56 0.21 G SCO1640 other conserved hypothetical protein SCI41.23c hypothetical protein Conserved in organism other than Escherichia coli Putative proteasome component family -1.45 1.77 -0.11 0.96 0.61 0.83 0.03 -0.72 5.9 1.92 D SCO1643 pcrA 20S proteasome alpha-subunit Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" prcA "proteasome, alpha subunit" 0.25 1.96 0.29 2.05 1.72 2.02 0.41 1.69 4.25 1.04 G SCO1644 prcB 20S proteasome beta-subunit precursor Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" prcB "proteasome, beta subunit" 0.04 2.13 0.27 1.89 0.77 0.94 0.2 1.22 3.61 1.3 C SCO1646 other hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli hypothetical protein 0.4 2.48 0 2.86 1.03 0.8 1 1.72 SCO1647 other conserved hypothetical protein SCI41.30c hypothetical protein Conserved in organism other than Escherichia coli B2126_C1_172 -0.31 2.31 0.49 2.1 2.14 2.52 1.81 2.04 SCO1648 arc AAA ATPase Cell process Chaperones cdc48d cell division control protein Cdc48 -0.24 3.34 1.29 2.77 2.36 3.15 1.42 1.82 7.6 1.95 C SCO1651 other conserved hypothetical protein SCI41.34c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 1.28 0.85 0.27 -0.93 -0.81 -0.44 -0.57 -3.21 -0.29 E SCO1655 other putative lipoprotein oligopeptide binding protein Cell process Transport/binding proteins "oligopeptide ABC transporter, periplasmic oligopeptide-binding protein, putative" 2.72 1.48 1.16 1.44 1.26 1.06 0.82 -0.56 -3.58 0.01 E SCO1657 other putative methionine synthase RBS 1776722..1776726 amino acid biosynthesis Methionine metH 5-methyltetrahydrofolate-homocysteine methyltransferase -0.46 -0.93 -0.67 -1.03 0.05 0.09 -0.24 -0.57 1.32 -0.77 G SCO1660 glpK putative glycerol kinase Degradation of small molecules Carbon compounds glpK glycerol kinase 2.66 1.23 1.27 2.36 1.17 0.66 1.95 0.45 -2.39 -0.62 G SCO1661 other putative glycerol-3-phosphate dehydrogenase "Energy metabolism, carbons" Aerobic respiration glpD glycerol-3-phosphate dehydrogenase 0.23 -0.25 -0.96 -0.78 -0.19 -0.73 -0.38 -0.14 -0.64 -0.75 F SCO1663 other putative cysteinyl-tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n cysS cysteinyl-tRNA synthetase -0.2 -0.53 -0.9 -0.33 -1.09 -0.72 -1.43 -0.62 -0.47 0.06 G SCO1666 other putative phosphatase "Biosynthesis of cofactors, carriers" Cobalamin phosphoglycerate mutase family protein -0.65 -0.35 -0.26 -0.72 0.03 -0.27 -0.54 -0.19 2.02 -0.02 G SCO1676 other putative peptidase Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" "aminoacylase-1, putative" -0.96 -0.34 -1.12 -0.6 -0.74 -0.96 -1.02 -0.48 1.65 0.15 G SCO1700 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein 0.07 1.95 2.01 4.38 3.3 4.16 2.52 9.29 0.1 C SCO1705 other putative alcohol dehydrogenase (zinc-binding) "Energy metabolism, carbons" Fermentation adhC "alcohol dehydrogenase, class III" -1.11 -0.53 -1.45 0.28 -1.1 -1.18 -1 -0.96 1.77 0.41 G SCO1758 other putative GTP binding protein Not classified (included putative assignments) Not classified (included putative assignments) b2511 GTP-binding protein -0.15 -0.87 -1.08 -1.12 -0.86 -1.06 -1.4 -0.7 -1.05 -0.41 G SCO1760 other putative cytidylate kinase Nucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis cmk cytidylate kinase -0.09 -0.7 -0.64 -1.16 -1.06 -0.29 -1.14 -0.56 -0.63 -0.53 G SCO1768 other putative pseudouridine synthase Ribosome Ribosomes - maturation and modification probable pseudouridine synthase 0.77 0.64 0.13 -0.76 -1.15 -0.32 -0.49 SCO1772 other putative partitioning or sporulation protein Cell process Differentiation/sporulation probable partitioning or sporulation protein 0.88 0.46 0.34 -0.25 0.42 1.44 -0.08 -0.01 -0.22 -0.37 G SCO1773 other putative L-alanine dehydrogenase "Energy metabolism, carbons" TCA cycle ald alanine dehydrogenase -0.03 1.84 -0.27 -1.34 -1.18 -1.34 -0.82 -1.16 -0.84 0.81 G SCO1775 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli NUDIX domain protein 0 0.09 -0.42 -0.92 -0.57 -0.4 -0.79 -0.19 -0.09 -0.2 G SCO1776 pyrG putative CTP synthetase Central intermediary metabolisms Nucleotide interconversions pyrG CTP synthase 0.34 -0.91 -0.36 -1.65 -1 -1.15 -0.98 -1.63 -2.6 -0.66 G SCO1785 other putative iron-siderophore uptake system ATP-bindi Cell process Fe storage fepC "ferric vibriobactin ABC transporter, ATP-binding protein" 0.06 0.13 -0.08 0.88 -0.83 -0.86 0.23 0.18 SCO1793 other "hypothetical protein ""hypothetical protein (putati" Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein -0.36 -0.19 -0.53 0.02 -0.78 -0.5 -0.05 -0.45 1.17 -0.27 A SCO1794 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein TIGR00481 0.86 1.24 -0.15 1.12 -0.11 -0.29 -0.94 -0.07 -1.06 0.98 G SCO1796 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein SPFH domain / Band 7 family protein -0.14 0.61 0.15 0.74 0.49 0.26 -0.68 0.83 2.34 0.79 G SCO1798 other putative ABC transporter ATP-binding subunit Cell process Transport/binding proteins livG "ABC transporter, ATP-binding protein" 0.89 0.78 0.07 0.27 -0.28 0.09 -0.55 -0.15 SCO1806 other putative ABC transporter ATP-binding protein Cell process Transport/binding proteins "ABC transporter, ATP-binding protein" 0.27 -0.16 -0.63 -0.8 0.13 -0.14 -0.73 -0.2 -0.43 -0.39 G SCO1808 other putative phosphoserine phosphatase amino acid biosynthesis Serine probable phosphoserine phosphatase -0.32 -0.19 -0.97 -0.1 -0.13 -0.66 -0.85 -0.86 SCO1814 inhA putative enoyl-(acyl-carrier-protein) reductase Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth fabI enoyl-(acyl-carrier-protein) reductase 2.62 1.03 1.66 0.04 0.34 0.02 1.61 0 -3.98 -1.26 G SCO1815 fabG probable 3-oxacyl-(acyl-carrier-protein) reductas Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth fabG 3-oxoacyl-(acyl-carrier-protein) reductase 4.88 SCO1818 tyrS tyrosyl-tRNA synthetase (EC 6.1.1.1) Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n tyrS tyrosyl-tRNA synthetase SCO1820 putative integral membrane protein SCO1831 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) oxrA "oxidoreductase, short-chain dehydrogenase/reductase family" -0.8 -0.73 -1.56 -0.7 -1.63 -0.67 -1.63 -1.34 0.12 0.07 A SCO1839 other putative transcriptional regulator Other regulation Other regulation conserved hypothetical protein 0.92 -0.18 2.15 2.09 1.96 0.89 3.41 SCO1840 other putative ABC transporter ATP binding protein. Cell process Transport/binding proteins "ABC transporter, ATP-binding protein" -0.06 -0.98 -0.49 -0.77 -0.83 -0.8 -0.76 -0.34 SCO1844 other putative aldolase Degradation of small molecules Carbon compounds Class II Aldolase and Adducin N-terminal domain protein -1.05 -0.7 -1.68 -0.24 -1.5 -0.98 -1.51 -0.71 SCO1848 cobQ cobyric acid synthase "Biosynthesis of cofactors, carriers" Cobalamin cobQ cobyric acid synthase CobQ 0.88 -0.37 -1.49 -0.91 -1.42 -1.79 -1.64 -0.96 -4.43 -0.54 G SCO1849 cobN cobalamin biosynthesis protein. "Biosynthesis of cofactors, carriers" Cobalamin cobN cobalamin biosynthesis protein N 0.97 -0.14 -0.27 -0.22 -0.59 -1.38 0.08 -1.24 -2.86 -0.63 G SCO1850 other putative chelatase Cell process Other Transport/binding proteins chlI magnesium-chelatase subunit -0.5 -1.5 -1.47 -1.77 -1.49 -1.32 -1.54 -1.88 -1.59 -0.66 G SCO1851 cobO cob(I)alamin adenosyltransferase (EC 2.5.1.17) "Biosynthesis of cofactors, carriers" Cobalamin cobA cob(I)alamin adenosyltransferase 0.93 -0.32 -0.32 -0.11 -0.78 -1.21 -1.17 -0.74 -3.1 -0.1 G SCO1855 other putative precorrin-4 C11-methyltransferase "Biosynthesis of cofactors, carriers" Cobalamin cobM precorrin-4 C11-methyltransferase 0.36 -0.63 -0.81 0.11 -1.2 -1.41 -1.58 -1.16 SCO1857 other putative bifunctional protein (CbiGH) "Biosynthesis of cofactors, carriers" Cobalamin cbiH precorrin-3 methylase/precorrin-8X methylmutase 0.48 -0.61 0.23 -0.17 0.07 -0.09 0.44 -1.14 -0.46 -0.66 G SCO1858 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli nirR unknown conserved protein 0.17 -0.47 -1.07 -1.15 -1.69 -1.23 -1.42 -1.33 -2.52 -0.36 G SCO1860 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein putative ATP/GTP binding protein -0.95 -0.79 -0.84 -0.72 0.51 -0.2 -0.34 0.06 2.97 -0.38 G SCO1864 other putative acetyltransferase Cell process Osmotic adaptation ectA "L-2,4-diaminobutyric acid acetyltransferase" 0.97 0.28 -0.24 -0.03 -0.11 0.27 -0.28 0.05 -1.38 -0.51 G SCO1865 other putative aminotransferase Cell process Osmotic adaptation diaminobutyrate-2-oxoglutarate transaminase 2.52 1.16 0.97 2.11 0.07 0.3 -0.33 0.6 -3.78 0.35 G SCO1866 other putative condensing enzyme Cell process Osmotic adaptation ectC ectoine synthase 2.99 1.47 1.32 2.65 0.51 0.42 -0.07 -0.03 -4.56 0.7 E SCO1867 other putative hydroxylase Not classified (included putative assignments) Not classified (included putative assignments) L-proline 4-hydroxylase 2.66 1.57 1.01 2.71 -0.94 -0.26 -0.58 0.32 -4.73 0.79 G SCO1870 other hypothetical protein SCI39.17c hypothetical protein No homologues conserved hypothetical protein SCO1871 other putative aldehyde dehydrogenase Not classified (included putative assignments) Not classified (included putative assignments) fatty aldehyde dehydrogenase -0.97 -1.71 -1.19 -1.09 -1.54 -1.31 -0.91 -1.08 0.53 -0.79 G SCO1903 putative transport associated protein SCO1906 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein Tat (twin-arginine translocation) pathway signal sequence domain protein -0.33 3.21 1.31 1.11 1.74 1.86 0.08 -0.23 4.94 2.64 G SCO1907 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.11 0.04 -0.22 0.15 0.82 0.36 0.9 0.49 2 -0.77 G SCO1916 other putative transferase Not classified (included putative assignments) Not classified (included putative assignments) probable transferase 0.64 1.28 0.04 0.18 -0.21 -0.04 -0.42 -1.22 -0.96 0.75 G SCO1919 other "conserved hypothetical protein ""hypothetical prote" hypothetical protein Conserved in organism other than Escherichia coli 1.84 2.02 -0.53 1.05 -0.35 0.01 -0.19 0.82 -2.81 -0.01 G SCO1920 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli nifU NifU family protein 1.84 1.76 0.04 0.39 -0.01 0.59 -0.18 0.59 -2.62 -0.13 G SCO1921 other putative aminotransferase Central intermediary metabolisms Incorporation metal ions probable cysteine desulfurase 2.5 2.66 1.06 1.26 -0.03 0.78 -0.24 0.93 -3.33 0.6 E SCO1922 other putative ABC transporter ATP-binding subunit Cell process Transport/binding proteins "ABC transporter, ATP-binding protein" 1.96 2.51 1.23 0.62 1.44 1.79 1.85 1.83 0.22 -0.68 A SCO1924 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli Uncharacterized protein family (UPF0051) family 2.42 2.29 1.16 1.24 2.06 1.91 -0.06 0.57 -1.91 0.81 G SCO1925 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli Uncharacterized protein family (UPF0051) family 2.61 2.5 1.38 1.08 0.65 0.82 0.06 -0.47 -3.8 0.84 G SCO1935 tktA1 transketolase A Central intermediary metabolisms "Non-oxidative branch, pentose pwy" tkt transketolase 1.49 1.88 0.8 1.23 0.42 0.51 -0.54 0.3 -1.32 1.06 G SCO1936 tal2 putative transaldolase Central intermediary metabolisms "Non-oxidative branch, pentose pwy" tal transaldolase 0.51 1.73 0.52 0.36 0.98 0.48 -0.55 1.18 1.4 0.93 G SCO1937 zwf2 putative glucose-6-phosphate 1-dehydrogenase "Energy metabolism, carbons" "Oxidative branch, pentose pwy" zwf glucose-6-phosphate 1-dehydrogenase 0.92 1.43 0.07 0.25 0.36 0.22 -0.4 -0.1 SCO1939 other putative 6-phosphogluconolactonase "Energy metabolism, carbons" "Oxidative branch, pentose pwy" pgl 6-phosphogluconolactonase 1.04 1.37 -0.22 -0.08 -0.34 -0.4 -0.73 -0.28 -2.07 0.37 G SCO1942 pgi2 glucose-6-phosphate isomerase "Energy metabolism, carbons" Glycolysis Phosphoglucose isomerase -0.54 -0.12 -0.32 -1.35 -0.03 0.72 -0.78 0.43 2.14 -0.34 G SCO1945 tpiA triosephosphate isomerase "Energy metabolism, carbons" Glycolysis tpiA triosephosphate isomerase 1.57 2.29 0.38 1.22 -0.07 0.25 -0.36 -0.32 -2.08 1.06 G SCO1946 pgk phosphoglycerate kinase "Energy metabolism, carbons" Glycolysis pgk phosphoglycerate kinase 1.19 2.35 1.58 1.53 0.83 0.76 -0.63 0.08 0.04 1.99 G SCO1947 gap1 glyceraldehyde-3-phosphate dehydrogenase "Energy metabolism, carbons" Glycolysis gap "glyceraldehyde-3-phosphate dehydrogenase, type I" 3.81 4.82 2.85 3.71 2.81 2.07 0.6 2.99 -1.89 2.05 G SCO1950 other hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "Uncharacterized BCR, COG1481" 0.09 -0.01 -1.13 -1.01 -0.69 -1 -0.2 -1 -0.53 G SCO1952 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli Uncharacterised P-loop ATPase protein family (UPF0042) superfamily -0.47 0.25 -1.17 -0.36 -0.85 -1.17 -1.3 -1.01 0.1 0.59 G SCO1953 uvrC ABC excision nuclease subunit C Macromolecule metabolism Degradation of DNA uvrC "excinuclease ABC, C subunit" -0.11 -0.73 -1.62 -0.48 -0.93 -0.93 -0.75 -1.14 SCO1958 uvrA ABC excision nuclease subunit A Macromolecule metabolism "DNA - replication, repair, restr./modific'n" uvrA "excinuclease ABC, A subunit" -0.69 -0.4 -1.21 -0.56 -0.05 0.04 -0.65 -0.13 1.96 -0.29 A SCO1959 other hypothetical protein hypothetical protein No homologues conserved hypothetical protein -0.37 0.41 -0.9 -0.35 -0.05 -0.57 -0.23 -0.15 1.4 -0.03 G SCO1960 other putative hydrolase Not classified (included putative assignments) Not classified (included putative assignments) probable hydrolase 0.52 1.13 -0.64 0.52 -0.09 -0.07 0.11 -0.3 SCO1963 other putative integral membrane export protein Cell process Transport/binding proteins probable integral membrane export protein 1.3 0.61 0.41 0.3 0.61 -1.07 -0.45 SCO1964 other putative export associated protein Cell process Transport/binding proteins probable export associated protein -0.25 0.18 -0.18 1.11 1.25 1.52 0.14 -0.21 SCO1965 other putative export associated protein Cell process Transport/binding proteins probable export associated protein 0.67 1.59 0.44 1.27 1.75 2.26 0.43 2.44 3.31 0.18 G SCO1968 other putative secreted hydrolase Macromolecule metabolism Phospholipids glpQ glycerophosphoryl diester phosphodiesterase -1.74 5.24 2.36 4.02 4.93 2.93 1 3.12 SCO1998 rpsA 30S ribosomal protein S1 Ribosome "Ribosomal proteins - synthesis, modification" ribosomal protein S1 5.07 3.33 4.35 3.46 3.2 3.66 3.17 0.28 -4.25 0.19 E SCO2003 polA DNA polymerase I Macromolecule metabolism "DNA - replication, repair, restr./modific'n" DNA polymerase I 0.86 0.86 -0.79 -0.63 -0.59 0.14 -0.54 -0.5 -1.95 -0.37 G SCO2008 other putative branched chain amino acid binding protei Cell process Amino acids and amines probable periplasmic branched chain amino acid binding protein -0.56 2.12 0.76 4.33 3.21 3.67 5.31 3.07 11.4 -0.64 C SCO2010 other putative branched chain amino acid transport perm Cell process Amino acids and amines probable branched chain amino acid transport permease 0.03 0.16 0.48 2.4 1.74 1.8 0.5 0.41 4.01 0.73 G SCO2011 other putative branched chain amino acid transport ATP- Cell process Amino acids and amines livG "branched-chain amino acid ABC transporter, ATP-binding protein" -0.85 -0.13 -0.49 2.03 1.98 1.35 -0.15 0.52 5.46 1 G SCO2012 other putative branched chain amino acid transport ATP- Cell process Amino acids and amines livF "branched-chain amino acid ABC transporter, ATP-binding protein" 0.03 1.11 0.12 1.99 1.68 1.84 0.98 1.4 SCO2013 other putative two-component system response regulator Two-component system Response regulator probable response regulator 0.34 0.32 -0.22 -0.46 -0.19 -0.2 0.88 -0.79 0.03 -0.8 A SCO2014 pyk1 pyruvate kinase "Energy metabolism, carbons" Glycolysis pyk pyruvate kinase 2.46 2.87 1.72 2.46 1.82 0.92 0.48 0.39 -1.67 1.5 B SCO2019 other putative chorismate mutase amino acid biosynthesis Tyrosine probable mutase -0.93 -1.1 -1.19 -1.35 -0.85 -0.94 -1.22 0.11 1.29 -0.61 G SCO2025 gltD putative glutamate synthase small subunit amino acid biosynthesis Glutamate probable glutamate synthase small chain -0.69 -1.32 -1.16 -0.95 -1.27 -0.6 -1.46 -1.24 0.05 -0.3 G SCO2026 gltB putative glutamate synthase large subunit amino acid biosynthesis Glutamate glutamate synthase (NADPH) (EC 1.4.1.13) large chain SC3A3.04c precursor [similarity] 0.37 -0.37 -0.47 0.01 -0.44 -0.28 -0.23 -0.21 -0.48 -0.59 G SCO2034 other putative prolipoprotein diacyleglyceryl transfera Macromolecule metabolism Phospholipids probable prolipoprotein diacyleglyceryl transferase -0.41 -0.03 -0.6 -0.89 -0.52 -0.72 -1.39 -1.11 SCO2037 trpB tryptophan synthase beta subunit amino acid biosynthesis Tryptophan trpB "tryptophan synthase, beta subunit" -0.29 -0.52 -0.71 -0.33 -1.43 -1.13 -1.22 -1.29 -0.7 0.18 G SCO2039 trpC1 indoleglycerol phosphate synthase amino acid biosynthesis Tryptophan Indole-3-glycerol phosphate synthase -0.47 -0.94 -0.86 -1.24 -1.4 -0.71 -1.46 -1.37 -0.62 -0.21 G SCO2043 trpE3 putative anthranilate synthase component I amino acid biosynthesis Tryptophan probable anthranilate synthase component I -1.06 -0.87 -1.43 -1.64 -1.22 -1.1 -1.05 -0.94 0.89 -0.52 G SCO2045 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.83 1.26 1.26 0.29 -1.18 0.7 SCO2050 hisA phosphoribosylformimino-5-aminoimidazole carboxam amino acid biosynthesis Histidine hisA phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase -0.01 0.13 -0.88 -0.78 -0.44 -0.89 -0.95 -0.21 -0.39 -0.1 G SCO2051 hisH "hisH, amidotransferase" amino acid biosynthesis Histidine amidotransferase hish -0.5 -0.18 0.47 -0.48 -0.4 0.1 -0.5 SCO2052 hisB imidazoleglycerol-phosphate dehydratase amino acid biosynthesis Histidine EC4.2.1.19 imidazoleglycerol-phosphate dehydratase 1.14 0.94 -0.32 0.89 -0.32 -0.24 1.13 -0.2 -1.18 -0.72 G SCO2065 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.49 SCO2067 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein 1.8 1.74 2.04 1.77 2.45 2.12 0.26 -1.04 -0.28 1.61 G SCO2068 other "hypothetical protein ""putative secreted alkaline p" Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein -1.07 0.54 -0.02 0.02 1.06 1.66 0.05 0.31 5.38 0.54 G SCO2069 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.94 -0.59 -0.05 -1.27 -0.19 -0.53 -1.07 -1 1.81 0.37 A SCO2076 other putative isoleucyl-tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n ileS isoleucyl-tRNA synthetase 0.58 -0.17 -0.19 -0.99 -1.09 -0.5 -1.04 -1.21 -2.39 -0.25 G SCO2077 other hypothetical protein hypothetical protein No homologues conserved hypothetical protein 2.67 2.41 1.22 2.71 3.27 2.5 1.35 3.55 0.67 -0.08 A SCO2079 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 1.51 1.01 -0.07 1.18 1.4 2.12 2.4 2.03 1.33 -1.86 G SCO2082 ftsZ cell division protein Cell process Cell division ftsZ cell division protein FtsZ 1.72 1.4 0.91 1.12 1.86 1.98 0.44 0.72 -0.17 0.17 G SCO2084 murG putative UDP-N-acetylglucosamine-N-acetylmuramyl- Periplasmic/exported/lipoproteins "Gram +ve peptidoglycan, teichoic acid" murG UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 0.48 0.73 -0.11 -0.06 -0.44 -0.02 -0.52 -0.87 -0.76 0.33 G SCO2088 murF putative UDP-N-acetylmuramoylalanyl-D-glutamyl- 2 Periplasmic/exported/lipoproteins "Gram +ve peptidoglycan, teichoic acid" murF "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase" 1.25 -0.01 -0.16 -0.75 -0.96 -0.6 -1.16 -1.52 -4.18 -0.2 E SCO2089 murE putative UDP-N-acetylmuramoylalanyl-D-glutamate- Periplasmic/exported/lipoproteins "Gram +ve peptidoglycan, teichoic acid" murE "UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase" 0.91 0.05 -0.28 -1.03 0.23 -0.42 0.58 -0.67 -1.72 -1.18 G SCO2093 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 1.51 0.51 0.71 0.81 1.17 0.38 0.24 -0.65 SCO2094 other putative regulatory protein Other regulation Other regulation probable regulatory protein 1.08 0.9 0.25 -0.31 0.49 -0.08 0.58 0.29 -0.9 -0.61 B SCO2097 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane probable membrane protein 1.36 1.79 0.24 1.79 1.78 1.35 0.45 2.98 SCO2098 other putative methyltransferase Central intermediary metabolisms S-adenosyl methionine probable methyltransferase -0.9 -1.42 -0.96 -1.29 -1.13 -0.86 -1.48 -1.46 SCO2104 other putative thiamin phosphate pyrophosphorylase "Biosynthesis of cofactors, carriers" Thiamin thiE thiamine-phosphate pyrophosphorylase 0.13 -0.1 0.01 -0.71 -0.45 -0.52 -0.66 -0.39 -0.28 -0.12 G SCO2105 other putative transcriptional regulatory protein (frag Other regulation Other regulation 1.11 1.93 0.22 -0.68 0.32 0.52 -0.48 0.36 -1.15 0.27 G SCO2110 pkaF putative eukaryotic-type serine/threonine protein Protein kinases Serine/threonine serine/threonine protein kinase -0.38 -0.47 -0.67 -1.07 -0.96 -0.98 -0.83 -1.09 -0.16 -0.22 B SCO2115 aroH putative 2-dehydro-3-deoxyphosphoheptonate aldola amino acid biosynthesis Chorismate phospho-2-dehydro-3-deoxyheptonate aldolase 0.51 0.2 -0.05 -0.18 0.55 0.64 -0.39 -0.08 0.14 -0.11 G SCO2123 other putative esterase/lipase Not classified (included putative assignments) Not classified (included putative assignments) probable esterase/lipase -0.6 -0.38 -0.21 -0.11 -0.29 -0.47 -0.48 0.77 2.35 -0.14 A SCO2126 glk glucokinase Defined family regulators ROK glucokinase 0.98 1.02 0.3 0.67 0.74 0.54 0.11 -0.57 -0.46 0.39 G SCO2127 other hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.74 -0.41 0.01 -0.39 -0.56 -0.19 -0.65 0.48 SCO2129 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.01 -0.43 -0.92 -1.04 -1.03 -0.45 -0.86 -1.27 SCO2140 other putative transcriptional regulator Defined family regulators AsnC probable transcription regulator -1.02 -0.59 -0.52 -1.52 -0.55 -0.42 -1.28 -1.1 1.56 0.22 G SCO2147 trpD1 phosphoribosylanthranilate transferase amino acid biosynthesis Tryptophan trpD anthranilate phosphoribosyltransferase -0.51 -0.53 -1.12 -0.84 -1.09 -1.49 -0.9 -0.94 SCO2148 qcrB cytochrome B subunit "Energy metabolism, carbons" Electron transport ubiquinol-cytochrome c reductase cytochrome b subunit. {streptomyces 2.9 3.05 0.89 1.71 1.1 0.38 -0.12 0.93 -3.85 0.94 E SCO2149 qcrA Rieske iron-sulfur protein "Energy metabolism, carbons" Electron transport qcrA putative Rieske iron-sulphur reductase component SCO2150 qcrC cytochrome C heme-binding subunit "Energy metabolism, carbons" Electron transport probable diheme cytochrome qcrC precursor 0.36 -0.34 -1.14 -0.05 0.36 -0.97 0.72 -0.2 -0.56 G SCO2155 cox1 putative cytochrome c oxidase subunit I "Energy metabolism, carbons" Aerobic respiration ctaD cytochrome c oxidase polypeptide i 2.62 2.03 2.18 0.05 1.21 1.13 -0.62 -0.65 -4.04 1.02 E SCO2156 cox putative cytochrome c oxidase subunit II "Energy metabolism, carbons" Aerobic respiration "cytochrome c oxidase, subunit II, putative" 3.56 3.72 2.33 2.84 1.95 1.21 1.27 1.6 -2.96 0.97 G SCO2158 other putative kinase Other regulation Other regulation probable kinase 3.53 2.71 0.9 1.95 SCO2161 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "HesB-like domain, putative" 1.6 1.66 1.4 2.13 1.64 0.68 0.31 2 0.54 0.74 A SCO2162 other "putative quinolinate synthetase (fragment) ""putati" "Biosynthesis of cofactors, carriers" Pyridine nucleotide -0.9 0.43 -0.4 -0.57 0.19 -0.3 -1.13 -1.03 2.27 1.11 G SCO2164 other "putative integral membrane efflux protein ""putativ" Cell process Transport/binding proteins -0.68 -0.92 0.09 -0.48 -0.85 -0.84 -0.62 -1.38 1.04 0.14 G SCO2168 other hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.69 1.3 0.49 1.25 0.53 1.08 0.4 -0.23 1.01 0.59 G SCO2169 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane probable integral membrane protein SCO2175 other putative nicotinate-nucleotide-dimethylbenzimidaz "Biosynthesis of cofactors, carriers" Cobalamin "nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, putative" -0.14 -0.39 -0.13 -0.12 -0.25 -0.31 -1.76 -0.3 0.25 0.7 G SCO2179 other putative aminopeptidase Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" probable aminopeptidase 1.25 0.75 -0.76 0.02 -0.77 0.16 -0.48 -1.34 -3.15 -0.21 E SCO2180 pdhL putative dihydrolipoamide dehydrogenase "Energy metabolism, carbons" Pyruvate dehydrogenase lpdA dihydrolipoamide dehydrogenase 1.97 3.51 2.42 2.01 2.44 2.94 1.16 2.25 2.03 1.16 A SCO2181 putative dihydrolipoamide succinyltransferase SCO2183 aceE1 putative pyruvate dehydrogenase E1 component "Energy metabolism, carbons" Pyruvate dehydrogenase probable pyruvate dehydrogenase E1 component -0.19 -0.8 0.16 -1.23 -0.57 -0.43 -0.98 0.27 0.4 -0.48 A SCO2193 lipB putative lipoate-protein ligase "Biosynthesis of cofactors, carriers" Lipoate -0.72 -1 -0.89 -1.77 -1.06 -0.27 -1.22 -1.02 0.43 -0.53 G SCO2194 lipA putative lipoic acid synthetase "Biosynthesis of cofactors, carriers" Lipoate lipA lipoic acid synthetase 0.58 1.72 1.02 0.32 0.43 -0.31 -0.18 0.72 SCO2196 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane probable integral membrane protein 0.6 1.27 0.54 0.1 0.99 0.89 -0.23 0.52 1.02 0.51 G SCO2198 glnA glutamine synthetase I amino acid biosynthesis Glutamine glnA "glutamine synthetase, type I" 1.47 1.43 0.7 2.57 -0.13 0.61 -0.5 -0.31 -1.35 1.33 G SCO2241 other probable glutamine synthetase (EC 6.3.1.2) amino acid biosynthesis Glutamine glnA "glutamine synthetase, type I" -0.73 -0.62 -0.25 -0.09 -0.64 -0.7 SCO2257 other "probable ABC transporter, ATP-binding component." Cell process Transport/binding proteins oleandomycin resistance ATP-binding protein (oleC) -0.29 1.07 -0.77 -0.19 -0.86 -0.64 0.39 -0.69 SCO2262 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) probable oxidoreductase [imported] -0.94 -0.47 -0.35 -0.46 -0.94 -1 -0.79 -0.94 1.65 0.33 G SCO2285 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) probable oxidoreductase [imported] -0.99 0.31 -0.86 0.18 -0.64 -1.13 -0.86 -0.9 SCO2286 other putative alkaline phosphatase Not classified (included putative assignments) Not classified (included putative assignments) probable alkaline phosphatase [imported] -1.14 3.49 3.28 0.65 3.11 2.18 -0.46 0.53 8.32 4.04 C SCO2300 other conserved hypothetical protein SCC30.08c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.18 0.41 -0.64 -0.51 -0.9 -0.76 -1.52 -1.22 -1.47 0.62 G SCO2314 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein 0.98 0.21 0.27 -0.29 -0.15 0.08 -1.07 -0.8 -2.16 0.24 B SCO2321 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein Prenyltransferase and squalene oxidase repeat domain protein 0.14 -0.53 -0.73 -1.28 -0.82 -0.91 -0.54 -1.54 -1.58 -0.63 G SCO2322 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein conserved hypothetical protein 0.03 -0.94 -1.25 -0.79 -1.67 -1.28 -1.76 -1.23 -2.29 -0.26 G SCO2346 other putative hydrolase Macromolecule metabolism Glycoprotein "hydrolase, CbbY/CbbZ/GpH/YieH family, putative" 1.36 0.19 -0.63 -0.11 -0.81 -0.85 -0.89 -0.24 -3.72 -0.49 B SCO2362 other hypothetical protein hypothetical protein No homologues conserved hypothetical protein -1.06 -0.28 -0.97 -1.44 -1.34 -1.03 -1.24 -0.96 SCO2363 other putative ATP/GTP-binding protein Not classified (included putative assignments) Not classified (included putative assignments) Z1166 gene product -0.55 0.25 -1.44 -0.11 -0.75 -1.38 -0.88 -1.17 SCO2367 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli terD-1 tellurium resistance protein TerD 0.89 1.13 0.11 1.38 -0.2 1.14 -0.06 0.1 SCO2368 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli terD-1 tellurium resistance protein TerD 3.15 4.02 2.42 3.96 2.86 3.15 3.61 3.4 1.62 -0.11 G SCO2369 other putative thiol-specific antioxidant protein Not classified (included putative assignments) Not classified (included putative assignments) ahpC "antioxidant, AhpC/Tsa family" 0.99 0.48 -0.06 -0.45 -0.11 0.07 -0.46 -0.15 -1.71 -0.33 G SCO2370 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 2 1.42 0.4 -0.22 0.25 0.95 -0.27 -0.4 -3.41 -0.16 B SCO2373 tcmA "tetracenomycin C efflux protein ""tetracenomycin C" Cell process Transport/binding proteins -0.69 0.08 0.29 -1.06 1.6 0.68 -0.7 0.63 3.63 0.4 G SCO2377 other putative aldo/keto reductase Secondary metabolism Secondary metabolism aldo/keto reductase -0.98 -0.34 -0.91 -1.39 -1.23 -0.98 -1.01 -1.57 0.83 0.1 G SCO2387 fabD malonyl CoA:acyl carrier protein malonyltransfera Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth malonyl CoA:acyl carrier protein malonyltransferase 2.97 1.77 0.05 1.41 -0.74 -0.4 -0.37 -0.21 -6.35 -0.01 E SCO2388 fabH 3-oxoacyl-[acyl-carrier-protein] synthase III Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth fabH 3-oxoacyl-(acyl-carrier-protein) synthase III 3.35 2.66 1.37 2.12 0.05 0.06 0.43 1.41 -4.91 0.2 G SCO2389 acpP acyl carrier protein Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth putative 3.64 3.34 2.77 2.92 1.81 2.01 0.97 2.27 -2.63 0.82 B SCO2390 fabF 3-oxoacyl-[acyl-carrier-protein] synthase II Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth putative 2.75 1.72 -0.01 1.12 -0.51 -0.52 -0.54 -0.68 -6.15 0.22 E SCO2440 putative transcriptional regulator SCO2449 other conserved hypothetical protein SCC24.20 hypothetical protein Conserved in organism other than Escherichia coli "ATPase, AAA family domain protein" -0.21 1.73 -0.11 -0.73 0.33 -0.12 -0.12 1.06 2.28 0.33 G SCO2462 other "putative sugar kinase (fragment) ""putative sugar k" Macromolecule metabolism Degradation of polysaccharides 0.6 0.4 -1.3 0.66 -1.15 -0.8 -0.49 -0.76 -1.82 -0.15 G SCO2497 other conserved hypothetical protein SCC82.03c hypothetical protein Conserved in organism other than Escherichia coli NifR3/Smm1famil NifR3/Smm1 family protein -0.79 -1.39 -0.43 -1.19 -1.34 -1.12 -1.16 -0.62 SCO2504 glyS glycyl-tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n glyS glycyl-tRNA synthetase 1.78 0.26 0.44 -0.4 -0.56 -0.14 -0.65 -1.1 -4.41 -0.35 E SCO2517 other putative two-component system response regulator Two-component system Response regulator nitrate/nitrite response regulator protein -1.24 -1.02 0.53 0.28 0.71 1.65 -0.28 1.96 6.18 -0.18 C SCO2519 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane "similar to transport protein, putative" -1.73 -1.9 2.82 4.14 3.54 3.85 3.92 4.12 14.23 -0.85 C SCO2520 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein -1.13 -1.24 -0.62 0.1 0.41 0.42 -0.51 -0.06 SCO2532 other PhoH-like protein Central intermediary metabolisms Phosphorus compounds phoH PhoH family protein 1.35 2.58 0.36 0.57 1.58 1.04 0.22 1.76 0.5 0.44 G SCO2538 other hypothetical protein SCC77.05. hypothetical protein No homologues conserved hypothetical protein 1.19 -0.32 0.38 1.59 -0.1 0.24 0.45 2.87 0.24 -1.25 G SCO2539 other Era-like GTP-binding protein. Not classified (included putative assignments) Not classified (included putative assignments) era GTP-binding protein Era 0.04 -0.28 -0.93 -0.98 -0.73 -0.4 -0.75 -1.38 SCO2548 other putative Hit-family protein. Central intermediary metabolisms Nucleotide interconversions hitA hitA protein 0.29 0.72 0.09 -0.18 -0.09 1.74 -0.45 -0.99 0.64 0.32 G SCO2549 other possible protease Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" tri tricorn protease homolog 1 -0.44 0.48 -0.22 -0.61 0.71 0.35 0.64 0.02 2.87 -0.33 G SCO2562 lepA GTP-binding protein. Macromolecule metabolism Proteins - translation and modification lepA GTP-binding protein LepA 0.68 0.8 -0.7 0.63 -0.84 -1.1 -1.37 -1.11 -2.33 0.92 G SCO2563 rspT 30s ribosomal protein S20. Ribosome "Ribosomal proteins - synthesis, modification" rpsT ribosomal protein S20 3.98 2.39 2.38 2.39 1.31 1.17 1.5 1.88 SCO2571 leuS leucyl-tRNA synthetase. Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n leuS leucyl-tRNA synthetase 0.31 -0.6 -0.37 -1.08 -1.21 -0.65 -0.96 -1.32 -2 -0.47 G SCO2577 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli IojAP-related protein 0.14 -0.4 -0.29 0.06 -0.21 0.68 -0.99 SCO2578 other putative membrane protein. Periplasmic/exported/lipoproteins Gram +ve membrane Cell envelope-related transcriptional attenuator domain family -0.31 -0.66 -0.5 -0.39 -1 -0.86 -1.19 -0.87 -0.13 0.11 G SCO2582 other conserved hypothetical protein SCC123.20. hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.48 -0.18 -0.68 -0.13 -0.61 -0.51 -1.02 -0.76 0.87 0.39 D SCO2585 proA gamma-glutamyl phosphate reductase. amino acid biosynthesis Proline proA gamma-glutamyl phosphate reductase -0.5 -0.51 -1.08 -1.28 -0.96 -0.74 -1.39 -0.98 -0.15 -0.11 G SCO2589 other putative glycosyl transferase Not classified (included putative assignments) Not classified (included putative assignments) tagF glycosyl transferase domain protein 0 -1.16 -1.24 -0.86 0.21 0.55 -0.92 0.38 -1.61 A SCO2590 other "putative glycosyltransferase ""putative glycosyl tr" Periplasmic/exported/lipoproteins "Gram +ve peptidoglycan, teichoic acid" -0.21 -0.89 -1.26 -1.17 -0.61 -0.65 -1.15 -0.59 SCO2592 other putative transferase hypothetical protein Conserved in organism other than Escherichia coli cpsY cpsY protein 0.98 -0.55 -0.75 0.43 -0.88 -0.77 -1.39 -0.9 -3.24 -0.07 G SCO2593 other hypothetical protein SCC88.04c hypothetical protein No homologues conserved hypothetical protein 0.85 -0.29 -0.95 0.88 -0.87 -0.46 -0.97 -1.42 -2.65 0.08 E SCO2594 other conserved hypothetical protein SCC88.05c hypothetical protein Conserved in organism other than Escherichia coli cpsY cpsY protein 0.83 -0.47 -0.03 -0.18 -0.61 -0.27 -0.56 -1 -2.17 -0.42 G SCO2596 rpmA 50S ribosomal protein L27 Ribosome "Ribosomal proteins - synthesis, modification" rpmA ribosomal protein L27 3.11 1.07 2.4 2.18 2.26 1.76 1.01 1.49 -2.34 -0.18 G SCO2597 rplU ribosomal protein L21 Ribosome "Ribosomal proteins - synthesis, modification" rplU ribosomal protein L21 2.37 2.54 2.22 -0.06 2.7 2.52 0.02 2.45 -0.47 0.37 G SCO2599 other conserved hypothetical protein SCC88.10c hypothetical protein Conserved in organism other than Escherichia coli rne "cytoplasmic axial filament protein, authentic frameshift" 0.39 -0.81 -1.13 -1.59 -0.71 -1.13 -1.21 -0.86 -2.56 -0.87 G SCO2600 other hypothetical protein SCC88.11c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein SCO2606 orfsyn hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.83 -0.01 -0.69 0.34 -0.35 -0.57 2.12 -0.8 -0.84 -1.8 F SCO2611 mreB rod shape-determining protein Periplasmic/exported/lipoproteins "Gram +ve peptidoglycan, teichoic acid" mreB cell shape-determining protein MreB 1.64 0.83 -0.52 1.27 0.54 0.78 4.26 1.44 0.49 -3.16 G SCO2612 ndk nucleoside diphosphate kinase Central intermediary metabolisms Nucleotide interconversions nucleoside diphosphate kinase 4.73 3.69 5.33 3.07 4.36 3.39 1.95 3.77 -1.8 0.83 F SCO2613 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein 0.27 -0.61 -0.78 -0.83 -0.28 -0.71 0.29 -0.57 -0.7 -1.23 G SCO2614 fpgS folylpolyglutamate synthase "Biosynthesis of cofactors, carriers" Folic acid folC folylpolyglutamate synthase 0.29 -0.2 -0.36 -0.98 -0.42 -0.83 0.48 -0.63 -0.64 -1.07 G SCO2615 valS valyl tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n valS valyl-tRNA synthetase 1.35 0.89 0.17 -0.77 -0.22 -0.54 0.01 0.12 -2.6 -0.66 G SCO2616 other "hypothetical protein SCC80.01 ""putative membrane p" Periplasmic/exported/lipoproteins Gram +ve membrane 0.2 0.68 -0.45 -0.46 -0.18 -0.88 -0.92 -0.47 -0.55 0.44 G SCO2617 clpX ATP dependent Clp Protease ATP binding subunit Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" clpX "ATP-dependent Clp protease, ATP-binding subunit ClpX" 1.34 1.9 0.15 1.15 -0.1 1.08 -0.06 0.52 -0.82 0.38 G SCO2618 clpP2 ATP dependent Clp protease proteolytic subunit 2 Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" clpP "ATP-dependent Clp protease, proteolytic subunit ClpP" 2.73 4.53 1.92 2.99 1.42 2.37 0.97 1.82 -0.47 1.58 G SCO2619 clpP1 ATP dependent Clp protease proteolytic subunit 1 Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" clpP "ATP-dependent Clp protease, proteolytic subunit ClpP" SCO2620 other putative cell division trigger factor Cell process Cell division tig trigger factor 3.36 3.26 3.68 3.05 3.13 3.77 2.86 3.34 1.02 -0.04 A SCO2627 other putative sugar-phosphate isomerase Central intermediary metabolisms "Non-oxidative branch, pentose pwy" rpi sugar-phosphate isomerase 1.39 2.12 0.54 -0.74 -0.48 0.08 -0.26 -0.98 -2.76 0.4 G SCO2633 sodF superoxide dismutase [Fe-Zn] (EC 1.15.1.1) Cell process Detoxification superoxide dismutase (EC 1.15.1.1) (Fe/Mn) [validated] SCO2634 other conserved hypothetical protein SC8E4A.04c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.25 0.76 -0.47 0.99 -0.01 -0.2 -0.41 0.48 SCO2635 other putative aminopeptidase Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" pepN aminopeptidase N -0.31 -0.12 -0.28 -0.47 -0.73 -0.7 -1.27 -0.51 0.33 0.42 G SCO2640 asd1 aspartate semialdehyde dehydrogenase amino acid biosynthesis Lysine asd aspartate-semialdehyde dehydrogenase 1.42 2.04 -0.42 1.75 -0.17 -0.56 -0.56 -0.25 -2.26 1.09 G SCO2643 pepN aminopeptidase N Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" aminopeptidase n 0.2 0.04 0.08 -1.12 -0.54 -0.57 -1.11 -0.78 -0.98 0.14 G SCO2667 hypothetical protein SC6D10.10 SCO2677 other putative ABC transpoter ATP-binding protein Cell process Transport/binding proteins "ABC transporter, ATP-binding protein" 1.58 1.46 -0.29 1.09 -0.35 -0.29 -0.88 -0.67 -3.26 0.76 E SCO2726 msdA methylmalonic acid semialdehyde dehydrogenase amino acid biosynthesis Valine methylmalonic acid semialdehyde dehydrogenase (msdA) -0.62 -0.13 -1.35 -0.61 0.66 0.32 -0.09 -0.53 SCO2736 citA citrate synthase. "Energy metabolism, carbons" TCA cycle Citrate synthase 2.81 3.19 2.05 2.54 2.09 2.11 -0.05 1.64 -1.44 1.58 G SCO2754 other hypothetical protein SCC57A.25. hypothetical protein No homologues conserved hypothetical protein -1.63 -1.48 -1.19 -1.93 -1.35 -1.6 -1.6 -1.7 1.36 -0.03 A SCO2770 speB "agmatinase (fragment) ""putative agmatinase (fragme" Central intermediary metabolisms Polyamine biosynthesis 0.96 0.06 -1.35 -1.36 -1.12 -0.46 -1.18 -0.91 -3.74 -0.84 G SCO2771 other hypothetical protein SCC105.02 hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.63 -0.03 -1.06 0.07 -0.67 -0.33 2.42 -0.3 -0.21 -2.34 G SCO2776 accD1 "acetyl/propionyl CoA carboxylase, beta subunit" Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth pccB-3 "propionyl-CoA carboxylase, beta subunit" 1.59 1.32 -0.03 0.86 -0.98 -0.89 -1.37 -1.12 SCO2779 acdH acyl-CoA dehydrogenase Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth fadE19 acyl-CoA dehydrogenase -0.34 -0.86 -0.8 -0.39 -1.04 -1.24 0.85 -1.02 SCO2780 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein ferrichrome ABC transporter 0.31 -0.89 -1.83 -0.15 -2.33 -1.72 -1.65 -1.54 -3.5 -0.4 B SCO2789 glmS2 glucosamine-fructose-6-phosphate aminotransferase Central intermediary metabolisms "Sugar-nucleotide biosynthesis, conversions" glmS "glucosamine--fructose-6-phosphate aminotransferase, isomerizing" -0.28 -0.96 -1.2 -2.08 -1.14 -1.08 -1.93 -1.01 -1.61 -0.46 G SCO2792 adpA araC-family transcriptional regulator Defined family regulators AraC "transcriptional regulator, AraC family" 0.11 1.59 0.14 1.83 0.83 1.04 -0.15 0.38 2.79 1.36 D SCO2793 ornA oligoribonuclease Macromolecule metabolism Degradation of RNA oligoribonuclease 0.81 0.42 0.08 -0.13 0.56 0.5 -0.65 -0.13 -0.74 0.1 G SCO2822 other putative decarboxylase Not classified (included putative assignments) Not classified (included putative assignments) 195AA unidentified product -1.23 0.08 -1.48 -0.67 -1.07 -1.41 -1.48 -0.91 1.59 0.71 G SCO2831 other "probable amino acid ABC transporter protein, ATP-" Cell process Amino acids and amines glnQ "amino acid ABC transporter, ATP-binding protein" -0.58 0.09 -1.58 -0.48 -0.83 -1.33 1.3 SCO2837 other putative secreted protein. Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein putative secreted protein. 0.03 -0.15 -0.66 0.22 0.28 0.19 0 -0.3 1.01 -0.31 G SCO2847 other putative oxidoreductase. Secondary metabolism Secondary metabolism "oxidoreductase, Gfo/Idh/MocA family" -1.12 -1.31 -0.77 -2.07 -1.21 -0.97 -1.4 -0.92 SCO2855 other hypothetical protein SCE20.29. hypothetical protein No homologues SEC-C motif domain protein -0.77 -0.53 -0.53 -0.82 -0.69 -0.62 -0.95 -0.53 1.41 0.03 D SCO2879 cvnA12 putative membrane protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein SEQ ID NO 21D -1.2 -0.93 -0.65 -0.43 -0.22 0.16 -0.56 -0.46 SCO2883 other putative cytochrome P450. "Energy metabolism, carbons" Electron transport "P450 heme-thiolate protein, putative" -1.62 -0.81 -0.59 -0.3 0.26 -0.19 -0.7 -1.21 SCO2884 other putative cytochrome P450. "Energy metabolism, carbons" Electron transport cytochrome P450-family protein -1.63 -1.03 -1.03 -0.9 -0.4 -0.09 -1.1 -1.03 3.42 0.23 D SCO2887 other putative membrane protein. Periplasmic/exported/lipoproteins Gram +ve membrane hypothetical protein 0.08 0.35 0.11 -0.33 0.16 -0.15 -0.35 0.34 SCO2899 other putative GroES-family molecular chaperone. Cell process Chaperones htpA heat shock protein groES 0.98 0.62 -0.44 0.74 -0.4 -0.09 -0.63 0.04 SCO2900 other putative membrane protein. Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein -0.07 -0.49 -0.77 -0.71 -1.08 -0.67 -1.62 -0.78 -1.01 0.07 B SCO2901 other "hypothetical protein ""hypothetical protein SCE6.38" hypothetical protein Conserved in organism other than Escherichia coli bcp-2 bacterioferritin comigratory protein 0.51 -0.24 -0.66 -0.77 -0.5 -0.4 -0.53 -1.03 -1.71 -0.56 G SCO2903 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein probable secreted protein -0.33 -0.76 -1.14 -0.8 0.55 0.62 -0.34 -0.29 1.48 -0.77 G SCO2904 rph putative ribonuclease PH Macromolecule metabolism Degradation of RNA probable ribonuclease PH 1.52 1.75 0.41 0.43 1.21 0.57 -0.56 0.04 -1.59 0.79 G SCO2911 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "Uncharacterized ACR, COG2104 superfamily" 0.16 1 1.04 1.52 0.8 0.29 1.35 2.32 3.88 -0.12 G SCO2913 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli Mov34/MPN/PAD-1 family family -1.56 -1.23 -0.88 -1.16 -1.27 -0.79 -1.18 -1.15 SCO2934 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein probable secreted protein -0.09 -1.33 -1.09 -0.59 -0.56 -1.21 -0.53 -0.85 -0.75 -0.88 F SCO2940 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) "xanthine dehydrogenase, putative" -0.02 -0.77 -1.31 -1.23 -0.9 -0.54 -0.65 -0.54 -0.86 -1.09 G SCO2941 other conserved hypothetical protein SCE56.05c hypothetical protein Conserved in organism other than Escherichia coli [2Fe-2S] binding domain protein -0.06 -0.28 -0.65 0.19 -0.6 -0.88 -0.72 -0.67 -0.08 0.11 G SCO2947 other hypothetical protein SCE59.06c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.16 -0.07 -0.03 -0.01 -0.7 -0.16 -0.91 -0.09 -0.05 0.11 G SCO2949 murA UDP-N-acetylglucosamine transferase Periplasmic/exported/lipoproteins "Gram +ve peptidoglycan, teichoic acid" murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase -0.06 -1.39 -1.2 -1.46 -1.66 -1.06 -1.71 -1.81 -2.5 -0.58 G SCO2950 hup DNA-binding protein Hu (hs1) Other regulation Other regulation hup DNA-binding protein HU 4.12 3.03 2.21 2.72 1.53 1.34 0.12 -0.1 -5.99 1.3 E SCO2951 other putative malate oxidoreductase Central intermediary metabolisms other Central intermediary metabolism EC1.1.1.38 malate oxidoreductase 1.99 1.56 0.73 -0.41 -0.65 -0.09 -0.89 -1.2 -4.77 0.44 G SCO2952 other putative helicase protein Macromolecule metabolism "DNA - replication, repair, restr./modific'n" "yvgS, putative" -1.09 -1.38 -1.17 -1.82 -1.4 -0.97 -1.48 -1.34 0.5 -0.43 A SCO2968 other putative cell division protein Cell process Cell division "ftsE protein, putative" 1.16 0.49 0 -0.63 -0.95 -0.82 -0.72 -1.25 SCO2969 ftsE cell division ATP-binding protein Cell process Cell division ftsE cell division ATP-binding protein -0.02 SCO2972 prfB chain release factor 2 Macromolecule metabolism Proteins - translation and modification prfB peptide chain release factor 2 0.39 0.26 -0.58 -1.25 -0.59 -0.09 -0.97 -1.25 -1.63 -0.13 G SCO2974 pkaA serine/threonine protein kinase Protein kinases Serine/threonine serine/threonine protein kinase pkaa 0.11 0.07 -0.82 -0.92 -0.25 -0.58 -0.61 -0.46 -0.48 -0.35 G SCO2975 other hypothetical protein SCE50.03 hypothetical protein No homologues "FtsK/SpoIIIE family subfamily, putative" -0.93 -0.58 -1.55 -0.58 -0.38 -0.96 -0.54 -1.08 SCO2978 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein "alpha-glucosides ABC transporter, substrate-binding protein" -1.18 -1.04 -1.06 -0.76 -0.87 -0.93 -0.66 -0.61 2.11 -0.35 D SCO2986 other conserved hypothetical protein SCE50.14c hypothetical protein Conserved in organism other than Escherichia coli ohr organic hydroperoxide resistance protein 0.19 0.06 -0.71 -0.92 -0.29 -0.89 -0.99 -0.49 -0.97 -0.1 G SCO2988 galE2 UDP-glucose 4-epimerase Degradation of small molecules Carbon compounds galE UDP-glucose 4-epimerase -0.5 -0.4 -0.66 -0.65 -1.28 -0.88 -1.35 -1.59 -0.23 0.41 G SCO2999 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli 0.87 2.37 0.31 -0.06 0.66 0.47 1.09 1.46 1.1 -0.28 G SCO3001 other conserved hypothetical protein SCE33.03c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -1.26 -1.24 -1.36 -1.36 -1.15 -0.72 -1.17 1.49 -0.37 G SCO3005 secA preprotein translocase Cell process Other Transport/binding proteins secA "preprotein translocase, SecA subunit" 1.91 1.78 0.38 1 0.44 0.82 0.23 -1.04 -2.73 0.44 G SCO3008 other putative two-component system response regulator Two-component system Response regulator DNA-binding response regulator -0.65 0.76 -0.31 0.25 -0.39 -0.89 -0.58 -0.57 1.97 0.98 G SCO3013 other putative two-component system response regulator Two-component system Response regulator mtrA DNA-binding response regulator MtrA 1.14 1.05 0.17 0.12 -0.19 -0.48 -0.8 -0.8 -2.44 0.59 B SCO3015 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein -0.89 -0.82 -1.28 -1.02 -1.28 -1.2 -1.28 -1.54 0.28 0 G SCO3023 sahH adenosylhomocysteinase amino acid biosynthesis Methionine ahcY adenosylhomocysteinase 2.46 3.58 3.14 2.74 2.68 3.35 3.35 2.77 2.73 0.04 G SCO3024 other putative transport protein Cell process Transport/binding proteins cation efflux family protein -0.76 -1.18 -1.17 -1.37 -0.98 -1.12 -1.25 -1.55 -0.05 -0.29 B SCO3026 other hypothetical protein SCE34.07c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.13 0.31 -0.62 -0.91 -0.96 -0.72 -0.92 -1.2 -0.55 0.19 G SCO3027 other hypothetical protein SCD84.08c hypothetical protein Conserved in organism other than Escherichia coli Protein of unknown function (DUF343) family -0.73 -0.74 -1.16 -0.88 -0.81 -0.99 -0.83 -1.1 0.65 -0.24 G SCO3028 manB phosphomannomutase Macromolecule metabolism Polysaccharides - (cytoplasmic) manB-1 phosphomannomutase -0.49 -0.53 -0.08 -0.59 -0.72 1.62 -1.3 SCO3036 other conserved hypothetical protein SCE34.18 hypothetical protein Conserved in organism other than Escherichia coli Uncharacterised protein family superfamily -0.32 0.72 -0.7 -0.7 -0.71 -0.94 -0.18 -0.63 0.64 0.02 G SCO3037 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) nitroreductase family protein -0.83 -0.97 -1.46 -0.94 -1.44 -1.58 -1.22 -1.04 SCO3041 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 1.07 0.12 -1.08 0.29 -0.53 -0.34 2.91 0.01 -0.85 -2.75 G SCO3045 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein fragment FrnA 0.82 -0.05 0.97 -0.48 0.48 0.74 -0.68 -0.55 SCO3051 fadE acyl-CoA dehydrogenase Degradation of small molecules Fatty acids acdA "acyl-CoA dehydrogenase, short-chain specific" -0.32 0.37 -0.1 1.01 -0.56 -0.1 -0.52 -0.38 SCO3052 other putative UDP-glucose 6-dehydrogenase Central intermediary metabolisms "Sugar-nucleotide biosynthesis, conversions" ugdA UDP-glucose 6-dehydrogenase -0.72 -0.93 -0.66 -1.04 -0.86 -0.82 -0.9 -0.66 0.89 -0.34 G SCO3058 other putative dipeptidase Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" renal trp-G type glutamine amidotransferase/dipeptidase 1.09 0.76 -0.72 -0.73 -0.78 -0.38 -0.74 -1.09 -3.23 -0.26 G SCO3059 purE phosphoribosylaminoimidazole carboxylase catalyti Nucleotide biosynthesis Purine ribonucleotide biosynthesis purE "phosphoribosylaminoimidazole carboxylase, catalytic subunit" 1.46 1.65 0.19 -0.29 0.1 0.3 1.46 -0.07 -1.49 -0.99 G SCO3060 purK phosphoribosylaminoimidazole carboxylase ATPase s Nucleotide biosynthesis Purine ribonucleotide biosynthesis 0.6 0.83 -0.6 -0.46 -0.82 -0.83 -0.54 -0.83 -1.84 -0.01 G SCO3063 other putative two-component system reponse regulator Two-component system Response regulator regX3 DNA-binding response regulator RegX3 0.4 0.09 -1 -0.47 -0.79 0.11 -0.46 -1.55 SCO3067 other putative anti anti sigma factor RNA polymerase core enzyme binding anti sigma factor antagonist anti-sigma b factor antagonist. {streptomyces 1.64 1.23 0.01 1.86 -0.45 -0.14 -0.05 -0.55 SCO3073 hutU urocanate hydratase Degradation of small molecules Amino acids hutU urocanate hydratase -1.02 -1.49 -0.86 -1.19 -1.15 -1.72 -1.45 -1.58 0.29 0 G SCO3077 other putative cystathionine beta-synthase amino acid biosynthesis Cysteine cystathionine beta-synthase 0.14 0.75 -0.4 -0.36 -0.23 -0.29 0.34 -0.6 0.4 -0.24 G SCO3079 other putative thiolase Degradation of small molecules Carbon compounds fadA3 thiolase -1.11 -0.83 -0.6 -0.87 -0.76 -0.64 -0.82 -0.86 2.07 -0.01 G SCO3089 other putative ABC transporter ATP-binding protein Cell process Transport/binding proteins vraD "ABC transporter, ATP-binding protein" -0.89 -1.62 -1.45 -1.43 -1.11 -0.88 -1.14 -1.23 SCO3091 other cyclopropane-fatty-acyl-phospholipid synthase Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth cfa-2 cyclopropane-fatty-acyl-phospholipid synthase -1.75 -1.49 -0.5 -1.01 -0.7 -1.05 -1.34 -0.72 SCO3092 other "putative oxidoreductase (fragment) ""putative dehyd" "Energy metabolism, carbons" Electron transport 2.2 1.77 1.99 0.88 0.96 0.78 -0.4 0.14 -2.6 0.99 G SCO3093 other putative hydrolase Central intermediary metabolisms Phosphorus compounds ppx putative hydrolase 0.05 -0.33 -0.81 -0.38 -1.24 -0.96 -1.32 -0.85 -1.26 0.04 G SCO3094 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.1 -0.22 -0.99 -0.15 -1.36 -0.82 -1.27 -1.34 -1.53 0.15 G SCO3096 eno enolase "Energy metabolism, carbons" Glycolysis eno enolase 1.96 3.52 2.35 2.86 1.63 0.64 -0.32 2.07 0.26 2.47 G SCO3097 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein putative secreted protein 1.86 0.39 1.72 2.18 4.15 4.55 3.39 2.38 3.97 -1.69 A SCO3100 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli mazG "transcriptional regulator, MazG family" -0.52 -0.28 -0.76 -0.8 -1.5 -0.95 -1.65 -1.85 -0.6 0.59 G SCO3102 pkaE eukaryotic-type protein kinase Protein kinases Serine/threonine eukaryotic-type protein kinase -1.01 -0.89 -0.33 -0.41 -0.63 0.62 -1.03 SCO3109 other putative transcriptional-repair coupling factor Macromolecule metabolism "DNA - replication, repair, restr./modific'n" mfd transcription-repair coupling factor -1.1 -0.75 -1.81 -0.7 -1.14 -1.58 -1.24 -1.41 SCO3115 hypothetical protein SCE41.24c SCO3122 other "putative nucleotidyltransferase, partial CDS ""puta" Macromolecule metabolism Glycoprotein 0.87 0.29 -1.13 -0.65 -1.27 -1.08 -1.02 -1.15 -3.52 -0.35 G SCO3123 prsA2 ribose-phosphate pyrophosphokinase Nucleotide biosynthesis Purine ribonucleotide biosynthesis prsA ribose-phosphate pyrophosphokinase 1.16 -0.54 -0.94 -1.15 -0.88 -1.29 -1.25 -0.76 -4.41 -0.89 E SCO3124 other ribosomal L25p family protein Ribosome "Ribosomal proteins - synthesis, modification" ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5 2.33 0.44 0.38 -0.18 0.51 -0.27 -0.96 -0.5 -5.24 -0.17 E SCO3127 ppc phosphoenolpyruvate carboxylase "Energy metabolism, carbons" Fermentation ppc phosphoenolpyruvate carboxylase 0.03 0.1 -0.39 0.24 -0.69 0.43 -0.78 -0.57 0.42 0.23 G SCO3137 galE1 UDP-glucose 4-epimerase Degradation of small molecules Carbon compounds galE UDP-glucose 4-epimerase -0.19 -0.62 0.04 -0.89 -1.01 -0.03 -0.77 0.15 -0.3 G SCO3146 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein conserved hypothetical protein -0.66 SCO3149 other putative dimethyladenosine transferase Cell process Detoxification ksgA dimethyladenosine transferase -0.33 -1.69 -1.03 -1.02 -0.88 -1.16 -1.07 -0.5 SCO3156 other putative penicillin-binding protein (putative sec Cell process Detoxification "penicillin-binding protein, putative" -0.39 -0.63 -0.55 -0.35 1.16 0.58 0.12 -0.24 SCO3182 gtaB UTP-glucose-1-phosphate uridylyltransferase Degradation of small molecules Carbon compounds galU UTP-glucose-1-phosphate uridylyltransferase 2.59 0.98 0 -0.8 -0.23 0.29 -0.8 -1.38 -6.5 -0.48 E SCO3184 other "putative secreted penicillin acylase (fragment) ""p" Cell process Detoxification 0.61 0.19 0.2 0.65 -0.3 -0.15 0.2 -1.38 -0.77 0.11 G SCO3196 other putative fructose-specific permease Cell process Transport/binding proteins fruA PTS system component 1.83 1.06 0.42 0.35 0.6 -0.14 1.26 0.05 -2.3 -0.9 G SCO3198 other putative deoR-family transcriptional regulator Defined family regulators DeoR glpR "transcriptional regulator, DeoR family" 2.52 SCO3229 hmas putative 4-hydroxyphenylpyruvic acid dioxygenase Secondary metabolism Secondary metabolism hppD 4-hydroxyphenylpyruvate dioxygenase -1.96 -1.85 0.24 -0.73 0.99 1.15 -1.04 -1.29 SCO3230 cdaPSI CDA peptide synthetase I Secondary metabolism NRPS -1.58 -1.45 -1.63 -0.46 -1.11 -0.27 -1.63 -1.14 SCO3231 cdaPS2 CDA peptide synthetase II Secondary metabolism NRPS CDA peptide synthetase II SCE63.02c [imported] -0.12 0.01 0.71 0.77 0.29 -0.08 0.71 -0.88 SCO3233 other putative hydrolase Secondary metabolism Secondary metabolism probable hydrolase -1.31 -1.2 0.22 -1.17 -0.04 0.37 -0.87 -1.01 3.31 0.19 G SCO3236 asnO putative oxygenase Secondary metabolism Secondary metabolism probable oxygenase -1.35 -1.81 0.38 -0.65 1.49 0.72 -0.98 -0.83 4.33 0.47 G SCO3243 other putative myo-inositol phosphate synthase Secondary metabolism Secondary metabolism ino1 myo-inositol-1-phosphate synthase -1.89 -1.83 -0.62 -1.71 -0.71 -0.52 -1.78 -1.89 SCO3246 fabH4 putative 3-oxoacyl-[acyl carrier protein] synthas Secondary metabolism PKS probable acyl carrier protein synthase -1.22 -0.87 -1.01 -1.08 0.04 -0.31 -1.14 -1.5 SCO3249 other putative acyl carrier protein Secondary metabolism PKS probable acyl carrier protein -1.99 -1.92 -0.59 -1.29 -0.58 -0.22 -1.08 0.33 SCO3261 other putative ATP-binding protein Not classified (included putative assignments) Not classified (included putative assignments) conserved hypothetical protein 1.06 -0.16 -0.55 -0.72 -0.99 -0.82 -1.02 -1.2 SCO3282 other putative precorrin-8X methylmutase "Biosynthesis of cofactors, carriers" Cobalamin cobH precorrin-3 methylase/precorrin-8X methylmutase -0.41 -0.4 -1.16 -0.24 -1.04 -1.06 -1.06 -0.74 SCO3301 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein probable secreted protein -0.5 -1.38 -0.79 -0.96 -0.58 0.14 1.43 0.78 SCO3303 putative lysyl-tRNA synthetase SCO3304 argS putative arginyl-tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n argS arginyl-tRNA synthetase 0.56 -0.13 -0.22 -0.52 -1.24 -0.54 -0.7 -0.88 -1.97 -0.37 G SCO3306 other putative aminotransferase Not classified (included putative assignments) Not classified (included putative assignments) "aminotransferase, class I" -0.27 -0.53 -0.9 -0.73 0.25 -0.66 0.56 -1.76 SCO3307 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.86 -0.99 -1.04 -0.66 -1.19 -1.08 -1.41 -0.98 0.65 0.06 G SCO3311 hemB delta-aminolevulinic acid dehydratase "Biosynthesis of cofactors, carriers" "Heme, porphyrin" delta-aminolevulinic acid dehydratase -0.26 -0.7 -0.95 -1.09 -1.21 -1.55 -1.5 -0.77 -1.13 -0.17 G SCO3317 other putative uroporphyrin-III C-methyltransferase/uro "Biosynthesis of cofactors, carriers" "Heme, porphyrin" hemD uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase 0.28 -0.25 -0.58 -0.99 -0.61 -0.4 -0.82 -0.26 SCO3318 hemC putative porphobilinogen deaminase "Biosynthesis of cofactors, carriers" "Heme, porphyrin" hemC porphobilinogen deaminase 0.21 -0.63 -1.63 -0.7 -1.38 -1.02 -1.54 -0.66 SCO3322 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane "HAD-superfamily subfamily IB hydrolase, TIGR01490, putative" -0.74 1.16 -0.85 -0.71 -0.95 -0.74 -1.16 -1.25 1.05 1.07 G SCO3345 other dihydroxy acid dehydratase amino acid biosynthesis Valine ilvD dihydroxy-acid dehydratase 0.45 0.33 0.44 0.5 1.92 1 0.55 0.79 2.21 -0.13 G SCO3350 other "alanine-rich hypothetical protein ""putative prolin" hypothetical protein No homologues -0.49 -0.38 -0.44 -0.85 -0.3 0 0.13 0.3 SCO3367 other putative tetR-family regulator Defined family regulators TetR "transcriptional regulator (TetR/AcrR family), putative" 0.04 1.13 1.45 0.21 1.04 2.68 2.47 SCO3373 other putative Clp-family ATP-binding protease Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" clpC "ATP-dependent Clp protease, ATP-binding subunit ClpC" 2.33 2.84 1.48 1.82 1.99 2.35 0.67 3.01 0.28 0.33 G SCO3375 other putative Lsr2-like protein Periplasmic/exported/lipoproteins Gram +ve surface anchored lsr2 lsr2 protein precursor. {mycobacterium 2.1 1.36 1.64 0.7 1.59 1.2 -0.46 1.98 -1.38 0.3 G SCO3381 nadC nicotinate-nucleotide pyrophophorylase "Biosynthesis of cofactors, carriers" Pyridine nucleotide nadC nicotinate-nucleotide pyrophosphorylase -0.65 -1.35 -0.85 -1.34 -1.25 -1.32 -1.3 -1.22 -0.33 -0.41 F SCO3382 nadB L-aspartate oxidase "Biosynthesis of cofactors, carriers" Pyridine nucleotide nadB L-aspartate oxidase SCO3383 other "putative pantoate-amino acid ligase ""putative pant" "Biosynthesis of cofactors, carriers" Pantothenate -0.87 -1.21 -1.22 -1.06 -1.37 -1.08 -0.92 -1.73 0.25 -0.4 A SCO3385 other putative L-allo-threonine aldolase Degradation of small molecules Amino acids probable lyase -1.34 -0.47 -1.11 -1.03 -0.85 -0.68 -1.07 -0.88 2.35 0.19 G SCO3395 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein conserved hypothetical protein -0.51 1.17 -1.13 -0.49 -1.09 -0.92 -1.23 -0.94 0.44 0.91 G SCO3398 folP putative dihydropteroate synthase "Biosynthesis of cofactors, carriers" Folic acid folP dihydropteroate synthase -0.44 -0.59 -1.25 -0.79 -1.74 -1.29 -2.07 -1.46 -1.28 0.37 G SCO3401 folK putative hydroxymethyldihydropteridine pyrophosph "Biosynthesis of cofactors, carriers" Folic acid folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase 0.19 -0.31 0 0.72 0.74 0.87 -0.56 SCO3404 ftsH2 cell division protein ftsH homolog Cell process Cell division cell division protein ftsH2 2.37 1.61 1.45 2.15 1.51 1.44 0.42 1.3 -1.41 0.39 G SCO3405 hprT putative hypoxanthine phosphoribosyltransferase Central intermediary metabolisms Salvage of nucleosides and nucleotides hpt hypoxanthine phosphoribosyltransferase 0.97 -0.7 0.71 -0.4 -1.65 -0.45 -1.72 0.2 -2.91 -0.24 F SCO3407 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -1.27 -0.9 -1.14 -0.84 -0.76 -0.99 -1.02 -1.03 2 0.06 G SCO3409 ppa putative inorganic pyrophosphatase Central intermediary metabolisms Phosphorus compounds ppa inorganic pyrophosphatase 2.67 1.85 1.55 0.67 0.8 1.16 -0.25 -0.65 -4.18 0.61 E SCO3420 other putative aldehyde dehydrogenase Degradation of small molecules Carbon compounds probable aldehyde dehydrogenase -1.05 -0.57 -0.28 -0.45 -0.44 -0.6 -0.58 -0.26 2.73 0.13 G SCO3542 other integral membrane protein with kinase activity Central intermediary metabolisms Nucleotide interconversions integral membrane protein with kinase activity 0.33 -0.31 -0.94 -0.92 -0.04 -0.36 0.1 -0.89 -0.85 -0.98 G SCO3543 other probable DNA topoisomerase I Macromolecule metabolism "DNA - replication, repair, restr./modific'n" dna topoisomerase i SCO3545 other putative transferase Macromolecule metabolism "DNA - replication, repair, restr./modific'n" putative transferase 0.65 0.44 -0.65 -0.27 -1.14 -0.82 -0.89 -0.82 SCO3546 other putative small secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein putative small secreted protein 0.48 -0.14 -0.78 -1.1 -0.89 -0.49 -0.55 -1.76 -0.85 B SCO3563 acsA acetyl-coenzyme A synthetase Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth acs acetyl-CoA synthase SCO3571 other putative transcriptional regulator Other regulation Other regulation probable transcription regulator 1.36 0.91 -0.04 1.15 0.77 0.75 0.01 0.4 -0.93 0.02 G SCO3576 other hypothetical protein hypothetical protein No homologues conserved hypothetical protein 2.02 1.34 0.3 -0.05 -0.23 1.3 0.15 -0.71 SCO3581 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli GatB/Yqey domain superfamily -0.01 1.02 -0.62 -0.83 -0.99 -0.98 -1.04 -0.49 -0.56 0.43 G SCO3582 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein Ser/Thr protein phosphatase family 0.27 0.1 -0.6 -0.73 -0.19 -0.22 0.3 -0.35 -0.11 -0.87 G SCO3607 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein probable membrane protein -1.21 0.4 -0.79 -0.42 -1.49 -1.19 -1.35 -1.21 SCO3610 other putative peptide hydrolase Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" probable peptide hydrolase -0.43 0.05 -1.19 -0.64 -1.15 -0.61 -1.41 -0.94 -0.05 0.29 G SCO3615 ask putative aspartokinase amino acid biosynthesis Threonine probable aspartokinase 2.21 2.56 0.77 2.24 0.51 -0.27 -0.19 -0.09 -3.02 1.42 E SCO3617 other hypothetical protein hypothetical protein No homologues conserved hypothetical protein -0.74 0.13 -0.78 -1.09 0.03 0.04 -0.65 -1.36 1.65 0.29 G SCO3619 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein TIGR00103 -0.28 0.65 -0.89 -0.04 -0.2 -0.72 -0.64 -0.44 0.87 0.47 G SCO3622 other putative aminotransferase Not classified (included putative assignments) Not classified (included putative assignments) probable aminotransferase -0.6 -0.43 -0.53 -0.53 -0.39 -0.96 -0.8 -0.8 1.02 0.19 A SCO3629 purA adenylosuccinate synthetase Nucleotide biosynthesis Purine ribonucleotide biosynthesis purA adenylosuccinate synthetase 2.08 2.07 1.31 1.3 0.78 -0.33 2.02 0.12 -1.78 -0.27 G SCO3647 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.32 -0.62 0.66 -0.94 -0.9 -0.51 -0.6 0.66 -0.12 G SCO3649 fba "putative fructose 1,6-bisphosphate aldolase" "Energy metabolism, carbons" Glycolysis fba "fructose-bisphosphate aldolase, class II" 2.8 2.15 1.85 1.97 1.7 1.71 -0.3 1.62 -2.34 0.89 G SCO3651 other hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.4 0.91 -0.26 0.71 -0.67 -0.84 0.05 -0.52 SCO3652 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein -0.74 -0.73 -1.19 -0.95 -1.06 -0.59 -1.36 -1.31 SCO3659 other hypothetical protein hypothetical protein No homologues conserved hypothetical protein 1.39 1.17 1.03 -0.35 0.77 0.67 -0.99 -0.75 -2.12 0.84 B SCO3661 "putative ATP-dependent protease ATP-binding subunit ""ATP-dependent protease ATP-binding subunit (fragment)""" SCO3669 dnaJ molecular chaperone Cell process Chaperones DnaJ 2.59 3.12 2.77 3.64 0.36 0.84 -0.18 -0.13 -2.38 2.59 B SCO3670 grpE heat chock protein Cell process Chaperones grpe protein 2.81 3.69 3.21 3.77 1.46 1.73 0.02 3.03 -0.35 2.18 F SCO3671 dnaK "heat shock protein 70 (fragment) ""heat shock prote" Cell process Chaperones 3.34 5.3 4.37 4.39 2.34 2.49 1.39 2.96 0.45 2.67 G SCO3673 other putative iron-sulphur-binding reductase Not classified (included putative assignments) Not classified (included putative assignments) "ferredoxin, 4Fe-4S" 0.95 0.1 -0.35 -0.5 -0.38 -0.42 0.17 -0.09 -1.82 -1.03 G SCO3678 other putative deoxynucleotide triphosphate deaminase Central intermediary metabolisms Nucleotide interconversions deoxycytidine triphosphate deaminase 1.67 0.87 0.03 0.97 -0.46 -0.62 0.16 -0.58 -3.24 -0.17 G SCO3727 other putative stress response protein Cell process Detoxification "tellurium resistance protein TerZ, putative" 0.54 0.1 -0.15 -0.22 0.4 -0.37 -0.51 -0.72 SCO3731 other cold-shock protein Cell process "Adaptations, atypical conditions" cspB "cold shock protein, CSD family" 3.62 2.83 2.35 2.5 2.04 2.1 3 2.36 -1.88 -0.94 G SCO3748 f40 cold shock protein Cell process "Adaptations, atypical conditions" cspB "cold shock protein, CSD family" 3.53 3.62 2.18 3.4 1.61 1.1 1.63 2.24 -2.51 0.64 G SCO3765 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane CBS domain protein -0.63 -0.37 -0.94 -2.05 -1.16 -0.34 -1.55 -1.26 -0.1 -0.14 G SCO3767 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli tellurium resistance protein TerB (terB) putative 3.44 4.78 2.65 4.54 4.5 4.6 5.79 5.12 4.32 -1.12 C SCO3768 other putative translocase protein Not classified (included putative assignments) Not classified (included putative assignments) twin arginin translocation complex component -0.91 -0.42 -0.3 -0.88 0.23 1.6 -0.56 0.88 SCO3790 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli HYPOTHETICAL TRANSMEMBRANE PROTEIN -0.43 5.41 2.43 2.69 2.75 2.1 1.19 3.13 8.99 3.42 C SCO3791 other hypothetical protein SCH63.38 hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.47 0.27 0.4 0.06 -0.21 -0.13 -0.2 0.43 SCO3792 other putative methionyl tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n metG methionyl-tRNA synthetase 0.82 0.03 -0.87 -0.52 -0.15 -1.19 0.45 -0.62 -2.01 -1.09 G SCO3795 aspS aspartyl-tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n aspS aspartyl-tRNA synthetase 1.53 0.84 0.66 0.1 -0.37 -0.47 -0.82 -0.47 -3.28 0.34 G SCO3800 other "putative acyl-CoA dehydrogenase ""putative dehydrog" Degradation of small molecules Fatty acids -0.79 -1.05 -0.88 -1.19 -0.78 -0.85 -1.07 -0.23 1.07 -0.48 G SCO3801 other putative aminopeptidase Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" probable m18-family aminopeptidase 2 -0.67 -0.29 -0.28 4.6 -0.75 -0.52 4.88 1.32 A SCO3808 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.44 -0.21 -1.1 0.4 -0.48 -0.41 -0.6 -0.49 1.23 0.11 G SCO3815 bkdC1 putative dihydrolipoamide acyltransferase compone "Energy metabolism, carbons" Pyruvate dehydrogenase probable dihydrolipoamide acyltransferase component 0.99 1.21 -0.46 1.56 -0.53 -0.77 -0.41 -0.8 -1.8 0.8 B SCO3816 bkdB1 putative branched-chain alpha keto acid dehydroge "Energy metabolism, carbons" Pyruvate dehydrogenase pdhB "2-oxo acid dehydrogenase, E1 component, beta subunit" 0.16 1.01 -0.95 1.15 -0.8 -1.25 -0.93 -0.74 -0.53 1.05 G SCO3817 bkdA1 putative branched-chain alpha keto acid dehydroge "Energy metabolism, carbons" Pyruvate dehydrogenase pdhA "pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase alpha subunit" 1.13 1.44 0.61 2.09 -1.17 -0.49 -0.71 -1.08 -2.01 1.49 B SCO3822 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 1.04 1.94 1.05 0.3 0.77 0.33 -0.58 -0.54 -0.71 1.37 G SCO3823 other putative quinone oxidoreductase "Energy metabolism, carbons" Electron transport probable quinone oxidoreductase -0.57 1.43 0.03 -0.1 -0.6 SCO3828 other putative molybdopterin-guanine dinucleotide biosy "Biosynthesis of cofactors, carriers" Molybdopterin conserved hypothetical protein -0.56 -1.58 -0.81 0.08 -0.94 -1.06 -0.67 -0.93 0.53 -0.42 G SCO3829 bkdC2 putative dihydrolipoamide acyltransferase compone "Energy metabolism, carbons" Pyruvate dehydrogenase probable dihydrolipoamide acyltransferase component E2 -0.25 -0.89 -0.5 0.95 -0.34 -0.77 1.91 -0.55 1.95 -1.35 G SCO3830 bkdB2 putative branched-chain alpha keto acid dehydroge "Energy metabolism, carbons" Pyruvate dehydrogenase pdhB "2-oxo acid dehydrogenase, E1 component, beta subunit" -0.26 -0.54 -0.57 1.62 -0.93 -1.12 -0.49 -0.92 SCO3835 other putative dehydrogenase Not classified (included putative assignments) Not classified (included putative assignments) probable dehydrogenase -1.67 -1.35 -1.24 -0.46 0.2 0.84 0.26 -0.69 SCO3840 other hypothetical protein hypothetical protein No homologues conserved hypothetical protein -0.12 -0.32 -0.77 -0.19 -1.15 -1.23 -1.68 -0.36 -0.79 0.35 G SCO3845 other putative protein phosphatase Not classified (included putative assignments) Not classified (included putative assignments) probable protein phosphatase 1.69 1.44 -0.46 0.97 0.42 -0.16 -0.03 -0.26 -2.71 0.12 B SCO3846 other putative FtsW/RodA/SpoVE family cell cycle protei Cell process Cell division probable cell division protein SCH69.16 0.74 -0.16 -0.5 -0.45 -0.43 -0.03 -0.84 -0.41 SCO3848 other putative serine/threonine protein kinase Protein kinases Serine/threonine probable serine/threonine protein kinase SCO3857 other putative regulatory protein Other regulation Other regulation probable regulatory protein -0.78 -0.18 -1.07 -0.62 -1.02 -0.64 -0.94 -0.95 1.08 0.13 A SCO3859 other putative DNA-binding protein Other regulation Other regulation gra-orf8 0.1 0.45 -0.43 0.31 -0.64 -0.97 -0.09 -0.82 -0.08 0.18 G SCO3873 gyrA DNA gyrase subunit A Macromolecule metabolism "DNA - replication, repair, restr./modific'n" gyrA "DNA gyrase, A subunit" 1.3 1.18 0.26 1.15 0.95 0.77 -0.61 0.29 -0.88 0.73 G SCO3874 gyrB DNA gyrase subunit B Macromolecule metabolism "DNA - replication, repair, restr./modific'n" gyrB "DNA gyrase, B subunit" 1.65 1.69 -0.01 1.46 1.32 0.6 -0.11 1.73 -0.72 0.26 G SCO3877 other putative 6-phosphogluconate dehydrogenase "Energy metabolism, carbons" "Oxidative branch, pentose pwy" 6-phosphogluconate dehydrogenase family protein 1.97 1.81 -0.68 0.04 -0.45 -0.33 -0.88 -0.2 -4.53 0.08 E SCO3878 dnaN "DNA polymerase III, beta chain" Cell process Chromosome replication "DNA polymerase iii, beta chain" 0.6 0.42 -0.33 -0.25 -0.12 0.15 -0.42 -0.99 -1.05 -0.01 G SCO3884 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli R3H domain protein 1.65 0.93 -0.1 0.82 0.08 -0.04 1.02 0.18 -2.08 -0.88 G SCO3885 other conserved hypothetical GidB-family protein hypothetical protein Conserved in organism other than Escherichia coli glucose inhibited division protein b. {streptomyces -0.28 -0.9 -1.07 -0.45 -1.26 -1.13 -0.74 -1.14 -0.59 -0.47 F SCO3887 other putative partitioning or sporulation protein Cell process Differentiation/sporulation probable partitioning or sporulation protein 0.53 0.36 0.05 0.36 0.14 -0.14 -0.64 0.6 0.01 0.16 G SCO3889 trxA thioredoxin "Biosynthesis of cofactors, carriers" "Thioredoxin, glutaredoxin, glutathione" trx thioredoxin 0.76 0.52 0.22 0.24 -0.04 0.07 -0.64 1.04 -0.34 -0.03 G SCO3890 trxB thioredoxin reductase (NADPH) Central intermediary metabolisms 2'-Deoxyribonucleotide metabolism NADPH thioredoxin reductase 1.22 0.36 -0.29 -0.62 -0.4 -0.08 -1.2 1.1 -2.44 -0.57 G SCO3893 other hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.69 -0.1 -0.4 -0.37 -0.06 0.16 -0.54 -0.79 -1.4 -0.35 G SCO3895 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein 0.87 -0.21 -0.86 0.07 -1.02 -0.64 0.03 -0.78 SCO3896 other putative RNA nucleotidyltransferase Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" probable RNA nucleotidyltransferase -0.24 -0.94 -1.03 -0.64 -1.67 -1.23 -1.05 -0.95 -1.03 -0.51 G SCO3899 other hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli Myo-inositol-1-phosphate synthase superfamily SCO3903 other hypothetical protein hypothetical protein No homologues conserved hypothetical protein -0.16 0.21 -0.34 0.15 -0.82 -0.75 -0.92 -1.49 SCO3904 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli FemAB family superfamily 0.27 -0.13 -0.92 -0.36 0 0.05 -0.03 -0.91 -0.33 -0.59 G SCO3906 rpsF putative 30S ribosomal protein S6 Ribosome "Ribosomal proteins - synthesis, modification" rpsF ribosomal protein S6 4.1 2.19 3.88 1.16 2.83 2.71 0.42 2.05 -3.94 0.27 E SCO3907 putative single-strand DNA-binding protein SCO3908 rpsR putative 30S ribosomal protein S18 Ribosome "Ribosomal proteins - synthesis, modification" rpsR ribosomal protein S18 SCO3909 rplI 50S ribosomal protein L9 Ribosome "Ribosomal proteins - synthesis, modification" rplI ribosomal protein L9 2.89 1.57 0.84 1.71 -0.31 -0.47 -1.22 -0.33 -6.13 0.95 E SCO3920 cysA putative cystathionine/methionine gamma-synthase/ amino acid biosynthesis Methionine putative cystathionine gamma-lyase -0.12 -0.54 -0.1 -0.58 -0.71 -1.21 -1.06 -0.64 -0.4 0.1 G SCO3941 other putative serine/threonineprotein kinase Protein kinases Serine/threonine "phosphatase, putative" -0.15 -0.67 -0.63 -1.07 -1.3 -0.33 -1.22 -1.63 SCO3944 other putative histidinol-phophate aminotransferase amino acid biosynthesis Histidine hisC histidinol-phosphate aminotransferase -1 -0.5 -1.06 -1.05 -1.42 -1.17 -1.83 -1.69 0.34 0.62 G SCO3950 other conserved hypothetical protein SCD78.17c hypothetical protein Conserved in organism other than Escherichia coli "haloacid dehalogenase-like hydrolase, putative" -0.2 -0.58 -1.08 -0.62 0.01 -0.74 1.37 -1.04 0.88 -1.48 G SCO3958 other ABC transporter ATP-binding protein Cell process Transport/binding proteins "ABC transporter, ATP-binding protein" -0.59 -0.86 -0.72 -0.39 -1.04 -0.55 -0.81 -0.09 SCO3960 other conserved hypothetical protein SCD78.27c hypothetical protein Conserved in organism other than Escherichia coli "haloacid dehalogenase-like hydrolase, putative" 0.22 -0.54 -0.52 -0.69 -0.65 -0.57 -0.7 0.14 SCO3961 serS seryl-tRNA synthase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n serS seryl-tRNA synthetase 1.42 0.89 1.03 0.78 0.5 0.48 0.2 0.51 -0.99 0.02 G SCO3962 pheA prephenate dehydratase amino acid biosynthesis Amino Acid Biosynthesis prephenate dehydratase -0.49 0 -1.18 -0.9 -0.97 -0.98 -1.61 -0.81 -0.1 0.37 G SCO3963 other conserved hypothetical protein SCD78.30c hypothetical protein Conserved in organism other than Escherichia coli Tat-translocated enzyme -0.57 -0.77 -0.21 -1.14 -0.96 -0.56 -0.95 -1.5 0.32 -0.01 G SCO3966 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein SCO1/2 family protein -0.9 -1.43 -1.54 -1.3 -1.41 -1.61 0.09 -1.01 0.63 -1.45 A SCO3967 other conserved hypothetical membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane "ycnI, putative" 0.39 1.1 1.22 1.13 -0.08 0.65 -0.54 -1.01 0.75 1.51 G SCO3970 other Xaa-Pro aminopeptidase Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" xaa-pro aminopeptidase i SCO3974 other hypothetical protein hypothetical protein No homologues SEC-C motif domain protein 1.79 0.94 0.15 -0.26 -0.31 -0.34 -0.32 -0.37 -3.86 -0.38 E SCO3977 other putative protease (putative secreted protein) Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" htrA heat shock protein HtrA 0.65 0.12 -0.16 1.18 0.56 0.88 -0.29 -1.36 -0.21 0.51 B SCO3979 other putative TetR-family transcriptional regulator Defined family regulators TetR "transcriptional regulator, TetR family" -0.76 -0.46 -1.66 -0.27 -1.28 -1.14 -0.71 -1.09 SCO4006 other putative fatty acid CoA ligase Degradation of small molecules Fatty acids fadD14 medium-chain-fatty-acid--CoA ligase -1.4 -1.28 -1.05 -1.11 -1.19 -0.98 -0.71 -0.65 2.33 -0.52 G SCO4009 other putative bifunctional protein (histidine kinase a Two-component system Sensor kinase/response regulator fusion histidinekinase putative bifunctional protein 0.03 -0.71 -1.44 -1 -1.13 -1.32 -1.36 -0.96 -1.88 -0.48 G SCO4020 other putative two component system response regulator Two-component system Response regulator trcR DNA-binding response regulator SCO4033 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane putative membrane protein 0.11 -0.72 -0.7 -0.22 -0.77 -0.58 -1.48 -0.37 SCO4036 other Not Specified Not classified (included putative assignments) Not classified (included putative assignments) conserved hypothetical protein 1.03 0.83 0.07 0.58 0.09 -0.19 -0.13 1 SCO4041 other putative uracil phosphoribosyltransferase Central intermediary metabolisms "Sugar-nucleotide biosynthesis, conversions" upp uracil phosphoribosyltransferase 0.57 0.22 -0.83 -0.19 -0.76 -1.15 -0.85 -1.13 -2.23 0.04 G SCO4043 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -1.05 -1.55 -0.46 -1.53 -0.42 -0.26 -1.16 -0.91 1.72 -0.34 A SCO4058 other hypothetical protein 2SCD60.24 hypothetical protein No homologues conserved hypothetical protein -0.14 -0.02 -0.91 -0.24 -0.88 -0.99 1.36 -0.5 SCO4068 purD phosphoribosylamine-glycine ligase (EC 6.3.4.13) Nucleotide biosynthesis Purine ribonucleotide biosynthesis purD phosphoribosylamine--glycine ligase -0.62 0.17 2.28 1.86 2.17 2.44 1.68 0.36 7.01 0.78 A SCO4071 purC phosphoribosylaminoimidazole-succinocarboxamide s Nucleotide biosynthesis Purine ribonucleotide biosynthesis purC phosphoribosylaminoimidazole-succinocarboxamide synthase -0.13 -0.92 -0.91 -0.94 0.08 1.35 2.19 2.69 3.51 -3.39 A SCO4075 other "ABC transport protein, ATP-binding subunit" Cell process Transport/binding proteins open reading frame -0.11 0.96 -1.28 0.34 -0.13 0.29 -0.45 -0.47 1.06 0.37 G SCO4077 other hypothetical protein SCD25.13 hypothetical protein No homologues conserved hypothetical protein TIGR00302 0.75 -0.45 0.9 -1.03 0.86 0.58 0.09 0.2 -0.19 -0.84 F SCO4078 purQ phosphoribosyl formylglycinamidine synthase I (EC Nucleotide biosynthesis Purine ribonucleotide biosynthesis purQ phosphoribosylformylglycinamidine synthase I 2.72 2.02 1.72 0.56 1.09 -0.65 1.03 -0.03 -4.09 0 G SCO4079 purL phosphoribosyl formylglycinamidine synthase II (E Nucleotide biosynthesis Purine ribonucleotide biosynthesis purL phosphoribosylformylglycinamidine synthase II 1.31 0.44 0.73 -0.89 0.1 0.22 -0.06 -0.22 -2.17 -0.6 G SCO4086 purF amidophosphoribosyltransferase Nucleotide biosynthesis Purine ribonucleotide biosynthesis purF amidophosphoribosyltransferase 2.18 2.22 -0.26 -0.19 1.07 1.41 0.6 0.41 -2.63 -0.66 G SCO4087 purM phosphoribosylformylglycinamidine cyclo-ligase Nucleotide biosynthesis Purine ribonucleotide biosynthesis purM phosphoribosylformylglycinamidine cyclo-ligase 1.25 0.68 -0.39 0.21 0.72 0.26 0.18 0.13 -1.4 -0.51 G SCO4088 other hypothetical protein SCD25.24c hypothetical protein No homologues conserved hypothetical protein 2.95 2.46 1.01 2.74 0.69 0.91 0.46 2.39 -2.74 0.18 E SCO4089 vdh valine dehydrogenase (EC 1.4.1.-) amino acid biosynthesis Glutamate valine dehydrogenase (NADP+) (EC 1.4.1.8) 0.89 0.69 0.12 1.65 0.06 0.56 -1.11 0.02 -0.57 1.02 G SCO4091 other putative DNA-binding protein Other regulation Other regulation soxR redox-sensitive transcriptional activator soxr. {escherichia coli 3.13 3.42 2.21 4.01 3.37 2.85 2.77 3.99 1.46 0.05 A SCO4096 other ATP-dependent RNA helicase Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" deaD ATP-dependent RNA helicase DeaD -0.04 -1.09 -1.02 -1.07 -0.82 -1.18 -1.19 -0.6 SCO4125 other putative acetyltransferase Not classified (included putative assignments) Not classified (included putative assignments) putative acetyltransferase protein -1.03 -0.79 -0.87 -0.92 0.31 -0.09 -1.4 0.93 SCO4136 other conserved hypothetical protein SCD84.04c hypothetical protein Conserved in organism other than Escherichia coli "Uncharacterized BCR, COG1937 family" -0.4 -0.72 -1.07 -1.49 -0.85 -0.41 -0.82 -1.2 -0.18 -0.64 G SCO4137 other conserved hypothetical protein SCD84.04 hypothetical protein Conserved in organism other than Escherichia coli Protein of unknown function subfamily 1.02 -0.45 -1.13 0.16 -1.21 -1.2 -0.86 -1.14 -3.73 -0.56 G SCO4139 pstB phosphate ABC transport system ATP-binding protei Cell process Transport/binding proteins pstB-1 "phosphate ABC transporter, ATP-binding protein" -1.19 2.91 0.69 0.73 1.45 1.26 -0.3 1.63 7.03 2.28 G SCO4140 pstA phosphate ABC transport system permease protein Cell process Transport/binding proteins pstA-1 "phosphate ABC transporter, permease protein" -1.43 3.23 1.33 1.65 1.24 1.79 0.57 -0.36 SCO4141 pstC phosphate ABC transport system permease protein Cell process Transport/binding proteins pstC "phosphate ABC transporter, permease protein" -1.84 4.39 2.2 1.6 2.02 3.15 2.32 -0.11 SCO4142 pstS phosphate-binding protein precursor Not classified (included putative assignments) Not classified (included putative assignments) pstS-1 "phosphate ABC transporter, phosphate-binding protein" -1.25 6.2 4.26 4.28 5.54 5.63 5.71 5.74 18.22 2.27 C SCO4144 other conserved hypothetical protein SCD84.12c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -1.58 0.74 -0.95 -0.34 -0.66 0.64 -0.78 -0.53 SCO4145 ppk polyphosphate kinase Central intermediary metabolisms Phosphorus compounds ppk polyphosphate kinase -1.1 0.11 -1.19 -1.35 -0.37 0.89 -0.1 -1 2.98 -0.39 G SCO4151 other putative acetyltransferase Macromolecule metabolism Proteins - translation and modification "acetyltransferase, GNAT family family" -0.75 -0.64 -1.11 -1.06 -1.02 -0.83 -1.21 -0.97 0.54 -0.1 G SCO4164 cysA putative thiosulfate sulfurtransferase (fragment) Central intermediary metabolisms Sulfur metabolism -0.71 0.02 0.9 2.13 -1.16 0.62 3.22 6.66 -1.84 C SCO4165 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli sseC2 sseC2 -1.1 -1.2 -0.62 -0.86 -0.49 -0.56 -0.9 0.6 SCO4173 other hypothetical protein SCD66.10c hypothetical protein No homologues "conserved protein, putative" -1.74 -1.76 -0.84 -1.88 -0.98 -0.57 -1.42 -0.38 SCO4179 other hypothetical protein SCD66.16 hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 1.39 1.49 -0.06 -0.51 -0.27 -0.22 -0.57 -0.65 -3.03 0.15 G SCO4181 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli Glycine cleavage T-protein (aminomethyl transferase) superfamily -0.19 -0.43 -1.01 -1.09 -1.15 -0.99 -0.62 -0.92 -0.68 -0.62 G SCO4185 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli L-ASPARAGINASE II -1.21 -1.41 -1.42 -1.62 -1.47 -0.66 -1.27 1.02 -0.59 A SCO4186 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli Eis 0.41 -0.05 -0.87 -0.62 -0.3 -1.23 0.27 -0.58 -1.16 -0.9 G SCO4199 other hypothetical protein hypothetical protein No homologues conserved hypothetical protein 0.88 2.96 1.85 2.78 3.35 2.77 1.11 2.66 5.28 1.65 G SCO4205 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli u2168e; B2168_C3_245 -0.59 -0.38 -0.85 -0.97 -1.09 -1.07 -0.93 -0.92 SCO4209 pgm phosphoglycerate mutase "Energy metabolism, carbons" Glycolysis phosphoglycerate mutase 1.67 3.6 1.92 0.77 0.85 1.88 -0.36 -0.29 -0.65 2.05 G SCO4228 other putative phosphate transport system regulatory pr Other regulation Other regulation -0.74 3.87 0.23 1.34 1.32 0.74 -0.41 1.82 5.88 2.67 G SCO4229 other putative sensor kinase Two-component system Sensor kinase phoR sensory box histidine kinase -0.97 2.77 0.48 -0.63 0.62 1 0.17 -0.53 SCO4230 other putative response regulator Two-component system Response regulator regX3 DNA-binding response regulator RegX3 -0.91 2.75 -0.9 0.71 0.61 0.79 -0.52 1.17 4.95 1.65 G SCO4231 other putative lipoprotein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein "lipoprotein, putative" 1.94 1.42 1.14 1.03 -0.37 -0.13 -0.66 -0.97 -3.75 0.95 G SCO4232 other putative transcriptional factor regulator Other regulation Other regulation carD probable transcription factor Rv3583c 2.97 3.16 2.64 2.77 3.32 3.36 2.84 4.18 1.84 -0.49 A SCO4233 ispD 4-diphodphocytidyl-2C-methyl-D-erythriol synthase Secondary metabolism Secondary metabolism ispD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase -0.19 -0.7 -1.13 -1.02 -0.97 -0.6 -1.13 -0.74 SCO4236 other putative tRNA/rRNA methyltransferase Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" "RNA methyltransferase, TrmH family, group 3" -0.04 -0.52 -1.11 -0.2 -0.2 -0.55 -0.69 -0.69 -0.14 -0.28 F SCO4240 msiK ABC transporter ATP-binding protein Cell process Transport/binding proteins MsiK 0.43 -1.16 -0.72 -0.31 -0.75 1.1 -0.29 -0.56 -1.37 G SCO4242 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein -0.19 1.34 0.13 0.2 -0.05 -0.39 -0.54 -1.09 SCO4244 other hypothetical protein SCD8A.17c hypothetical protein No homologues conserved hypothetical protein -0.65 1.6 -0.05 0.11 -0.41 -0.64 -1.25 -1.3 SCO4251 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein conserved hypothetical protein 1.87 3.65 2.55 3.43 2.06 1.86 0.17 0.84 1.16 2.85 G SCO4252 other hypothetical protein SCD8A.25c hypothetical protein No homologues conserved hypothetical protein 2.51 5.06 3.75 4.55 3.77 2.29 2.2 1.73 2.73 2.96 D SCO4253 other conserved hypothetical protein SCD8A.26c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 2.68 3.84 3.79 4.17 3.2 2.87 1.07 1.86 1.5 2.61 D SCO4259 other putative AAA family ATPase Not classified (included putative assignments) Not classified (included putative assignments) "ATPase, AAA family domain protein" -1.1 -0.51 -1.68 -0.98 -1.34 -1.92 -1.68 -1.43 0.32 0.41 D SCO4266 other putative oxidoreductase Degradation of small molecules Fatty acids Zinc-binding dehydrogenase superfamily -1.22 -1.23 -1.86 -1.43 -1.72 0.2 -0.7 0.1 2.14 -1.4 A SCO4277 other putative tellurium resistance protein Cell process Detoxification Bacterial stress protein domain protein 3.87 5.2 3.51 4.78 4.55 4.02 1.41 3.75 0.86 2.35 G SCO4282 other putative dimeric protein Not classified (included putative assignments) Not classified (included putative assignments) hypothetical protein 0.6 -0.12 0.1 0.37 0.04 0.37 0.37 -0.36 -0.03 -0.53 G SCO4293 other putative threonine synthase amino acid biosynthesis Threonine thrC-1 threonine synthase -0.64 -1.44 -1.66 -1.04 0.15 -0.14 0.41 -0.23 SCO4294 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli 9.5 kDa culture filtrate antigen 0.38 0.56 -0.25 -0.36 1.19 0.72 -0.24 1.26 SCO4295 other cold shock protein Cell process "Adaptations, atypical conditions" cold-shock protein CspD-related protein 2.95 SCO4296 groEL2 chaperonin 2 Cell process Chaperones "open reading frame; GROEL1 encodes two gene products, related to a second GROEL-like gene (GROEL2) in S.albus" 3.3 4.2 3.32 4.15 2.2 2.17 -0.06 4.36 -0.31 2.21 G SCO4297 other putative oxidoreduxtase Not classified (included putative assignments) Not classified (included putative assignments) nemA FMN oxidoreductase -0.42 -1.22 -1.2 -1.33 -1.57 -0.7 -1.77 -0.81 -0.89 -0.51 F SCO4314 other hypothetical protein SCD95A.47 hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.82 -1 -0.84 -0.81 -0.73 -1.14 -0.78 -0.57 1.17 -0.33 G SCO4325 cspB cold shock protein B Cell process "Adaptations, atypical conditions" cspB cold-shock domain family protein -0.91 -1.28 -1.2 -2.18 -1.19 -1.06 -1.21 -1.2 SCO4326 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli unknown conserved protein in others 0.18 -0.58 -1.21 -0.75 -1.54 -1.47 -1.75 -1.41 SCO4328 other putative lipoprotein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein conserved hypothetical protein 2.23 1 0.6 0.33 0.02 -0.1 -1.11 -0.14 -4.65 0.29 E SCO4330 other conserved hypothetical protein SCD12A.13 hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.53 -0.99 -0.85 -0.88 -0.65 0.98 0.5 -0.79 SCO4331 other hypothetical protein SCD12A.14 hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.57 -0.9 -1.37 -1.07 -1.53 -0.53 -0.65 -2.68 -1.51 E SCO4352 other putative oxidoreductase Secondary metabolism PKS mocA "oxidoreductase, aldo/keto reductase family" SCO4366 other putative phosphoserine aminotransferase amino acid biosynthesis Serine "phosphoserine aminotransferase, putative" 0.57 0.52 0.99 0.31 1.82 1.87 1.61 0.42 2.7 -0.63 G SCO4371 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 4.04 SCO4397 other putative ABC transport system ATP-binding protein Cell process Transport/binding proteins trp3 "ABC transporter, ATP-binding protein" -0.83 -0.8 -1.2 -1.33 -1.29 -1.48 -1.66 -1.57 -0.25 0.15 B SCO4402 other hypothetical protein SCD10.35 hypothetical protein No homologues conserved hypothetical protein -0.39 -0.73 -1.22 -1.11 -0.26 -0.23 -0.28 0.43 1.15 -1.18 G SCO4411 other putative calcium binding protein Cell process Cations phosphorylaseki EF hand domain protein -0.85 -0.64 -0.91 0.34 0.65 -0.17 -0.53 2.9 0.22 D SCO4436 other putative lyase Not classified (included putative assignments) Not classified (included putative assignments) "similar to methylglyoxalase, putative" -0.8 -0.36 0.33 -0.03 0.66 -0.05 -1.22 0.53 SCO4439 other putative D-alanyl-D-alanine carboxypeptidase Periplasmic/exported/lipoproteins "Gram +ve peptidoglycan, teichoic acid" pbp2 0.85 0.1 -0.41 -1.08 -0.6 -0.15 -0.84 -0.73 -2.49 -0.52 G SCO4444 other putative glutathione peroxidase Cell process Detoxification btuE glutathione peroxidase -0.67 -1.01 -1.21 -0.92 -0.53 -0.77 -0.33 -1.49 0.68 -0.6 G SCO4469 hemL "glutamate-1-semialdehyde 2,1-aminomutase" "Biosynthesis of cofactors, carriers" "Heme, porphyrin" hemL "glutamate-1-semialdehyde-2,1-aminomutase" -0.19 -0.92 -0.8 -1.22 -1.12 -0.71 -0.93 -1.17 -0.86 -0.61 F SCO4470 other putative phosphoglycerate mutase "Energy metabolism, carbons" Glycolysis phosphoglycerate mutase family protein -0.57 -1.45 -0.85 -1.27 -1.28 -1.01 -1.43 -1.37 -0.53 -0.38 F SCO4471 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein putative secreted protein -0.18 0.09 -0.6 -0.54 -0.12 -0.27 -0.16 -0.56 0.82 -0.23 A SCO4472 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein ccmG "cytochrome c biogenesis protein, thiol:disulfide interchange protein" 0.56 0.02 -1.01 -1.08 -1.13 0.3 -0.58 0.84 SCO4475 other putative cytochrome biogenesis related protein "Biosynthesis of cofactors, carriers" "Heme, porphyrin" ccsB cytochrome c assembly family protein 0.48 -0.2 -0.7 -0.98 -0.49 -0.73 -0.85 -1.37 SCO4488 other putative serine/threonine protein kinase Protein kinases Serine/threonine ppkA serine/threonine protein kinase PpkA -0.62 -0.92 -0.83 -0.65 -0.1 -0.28 -0.05 -0.47 SCO4493 other putative asnC-family transcriptional regulator Defined family regulators AsnC lrp leucine-responsive regulatory protein -1.21 -0.7 -1.54 -0.46 -1.39 -1.81 -1.78 -1.23 SCO4494 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli 0.51 0.62 -0.95 -0.89 -1.12 -0.45 -0.11 -1.34 -1.89 -0.58 G SCO4497 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein 1.41 0.4 0.79 -0.06 0.34 1.07 -0.62 1.13 -1.32 -0.37 F SCO4505 other cold shock protein Cell process "Adaptations, atypical conditions" cold-shock domain family protein-related protein -0.45 -1.61 -1.28 -0.27 -1.11 0.01 -0.05 G SCO4506 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "Uncharacterized ACR, COG1427" -0.23 0.11 -0.91 -1.11 -1.17 -0.72 -0.89 -1.39 -0.65 -0.05 G SCO4509 other hypothetical protein SCD35.16 hypothetical protein No homologues conserved hypothetical protein 2.44 4.07 2.71 3.43 2.7 2.86 1.45 2.3 1.73 1.73 G SCO4514 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein 0.35 0.68 1.23 1.05 0.49 1.47 0.42 1.61 SCO4527 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein -0.01 -0.69 -0.45 -1.26 -1.05 -1.36 -1.42 -1.44 SCO4544 other hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli abaA protein A 0.19 2.41 1.09 3.45 3.11 2.65 3.92 1.62 SCO4545 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.2 2.31 0.52 3.23 2.49 2.88 2.93 3.26 8.44 0.1 C SCO4546 other putative lipoprotein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein "lipoprotein, putative" -0.09 0.51 -0.71 0.77 1.09 1.02 0.04 1.83 3.29 -0.2 A SCO4548 other "hypothetical protein ""putative integral membrane p" Periplasmic/exported/lipoproteins Gram +ve membrane 0.27 -0.65 -1.06 -0.79 -0.47 -0.53 0.9 -0.61 -0.52 -1.75 G SCO4550 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "conserved hypothetical protein TIGR00423, putative" -0.17 0.1 -1.43 -0.26 -1.26 -0.95 -0.7 -1.03 -0.58 -0.14 G SCO4556 other putative ubiquinone/menaquinone methyltransferase "Biosynthesis of cofactors, carriers" "Menaquinone, ubiquinone" putative ubiquinone/menaquinone methyltransferase -0.81 -0.89 -1.28 -1.58 -1.34 -1.09 -1.46 -1.43 SCO4559 other putative electron transfer oxidoreductase "Energy metabolism, carbons" Electron transport putative electron transfer oxidoreductase 0.43 0.89 -0.22 -0.46 -0.17 -0.39 -1.08 -0.46 -0.88 0.57 G SCO4573 nuoL "NuoL, NADH dehydrogenase subunit" "Energy metabolism, carbons" Electron transport nadh dehydrogenase i chain l -1.47 -1.51 -0.92 -1.42 -1.1 -0.85 -0.85 -0.94 SCO4577 other putative helicase Macromolecule metabolism "DNA - replication, repair, restr./modific'n" recQ ATP-dependent DNA helicase RecQ -0.65 -0.36 -0.21 -0.24 -0.25 0.54 -0.91 SCO4580 other putative fumarylacetoacetase Degradation of small molecules Amino acids fahA fumarylacetoacetase -0.73 0.67 -1.09 0.68 -0.19 -0.39 -0.4 -0.88 SCO4583 other putative polyprenyl diphosphate synthase "Biosynthesis of cofactors, carriers" "Menaquinone, ubiquinone" grcC1 polyprenyl synthetase -0.08 -0.37 -0.95 -0.18 -0.72 -0.36 1.16 -1.29 0.46 -1.23 A SCO4594 putative oxidoreductase SCO4595 putative oxidoreductase SCO4596 other putative two-component system response regulator Two-component system Response regulator yfiK DNA-binding response regulator -0.53 -0.6 -0.93 -0.38 -0.93 -0.45 -1.56 -0.06 0.72 0.09 G SCO4601 other putative dehydrogenase "Energy metabolism, carbons" Electron transport fragment putative dehydrogenase -0.79 -0.77 -1.5 -0.5 -1.44 -1.46 -1.4 -1.55 -0.1 0.17 G SCO4603 nuoI2 NADH dehydrogenase subunit NuoI2 "Energy metabolism, carbons" Electron transport nuoI "NADH dehydrogenase I, I subunit" 0.33 0.19 0.42 1.33 0.75 0.49 0.35 SCO4605 nuoK2 NADH dehydrogenase subunit NuoK2 "Energy metabolism, carbons" Electron transport nuoK "NADH dehydrogenase I, K subunit" -1.14 -1.27 -1.6 -1.55 -1.42 -1.06 -1.69 -1.54 SCO4614 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.64 -0.41 0.23 -0.73 -1 -1.09 -1.17 -0.83 -2.49 -0.1 G SCO4635 rpmG3 50S ribosomal protein L33 Ribosome "Ribosomal proteins - synthesis, modification" rpmG ribosomal protein L33 3.99 1.91 1.79 1.55 2.06 1.95 1 2.41 -4.45 -0.91 E SCO4636 other hypothetical protein SCD82.07 hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.61 0.75 0.26 -0.6 0.6 0.25 -0.38 -0.09 -0.21 0.11 G SCO4637 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli maoC MaoC family protein -0.05 -0.04 0 -0.88 -0.66 -0.36 -0.97 -1.46 SCO4645 aspC aspartate aminotransferase amino acid biosynthesis Aspartate aspartate aminotransferase 1.39 0.9 0.21 1.15 0.06 -0.48 -0.7 0.15 -2.18 0.54 G SCO4647 nusG transcription antitermination protein Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" probable transcription antitermination factor nusG 2.96 0.96 0.96 -0.12 0.46 1.39 -0.07 -0.11 -5.29 -0.81 E SCO4648 rplK 50S ribosomal protein L11 Ribosome "Ribosomal proteins - synthesis, modification" 50s ribosomal protein l11. [strain fri-5] {streptomyces 4.43 3 3.26 2.49 2.75 2.63 2.55 2.75 -3.17 -0.67 G SCO4649 rlpA 50S ribosomal protein L1 Ribosome "Ribosomal proteins - synthesis, modification" rplA ribosomal protein L1 4.2 2.34 3.07 2.88 2.18 2.99 0.95 2.22 -3.65 0.14 G SCO4652 rplJ 50S ribosomal protein L10 Ribosome "Ribosomal proteins - synthesis, modification" 50s ribosomal protein l10. {streptomyces 6.1 4.52 5.3 3.95 3.81 1.81 3.81 4.28 -4.74 -0.3 E SCO4653 rplL 50S ribosomal protein L7/L12 Ribosome "Ribosomal proteins - synthesis, modification" rplL ribosomal protein L7/L12 6.05 4.72 4.12 3.86 2.45 2.87 2.5 3.67 -5.9 -0.06 E SCO4654 rpoB DNA-directed RNA polymerase beta chain Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" rpoB "DNA-directed RNA polymerase, beta subunit" 2.81 0.97 1.71 0.46 0.59 0.9 -0.11 0.53 -4.37 -0.33 E SCO4655 rpoC DNA-directed RNA polymerase beta' chain (fragment Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" 2.65 0.84 1.64 -0.01 0.83 1.01 -0.17 0.71 -3.96 -0.49 E SCO4659 rspL 30S ribosomal protein S12 Ribosome "Ribosomal proteins - synthesis, modification" rpsL ribosomal protein S12 4.43 2.74 4.51 2 1.49 3.41 1.87 0.92 -4.28 -0.03 E SCO4660 rspG 30S ribosomal protein S7 Ribosome "Ribosomal proteins - synthesis, modification" rpsG ribosomal protein S7 5.74 3.44 4.57 3.16 2.89 3.86 3.42 3.3 -4.61 -1.13 E SCO4661 fusA elongation factor G Macromolecule metabolism Proteins - translation and modification fusA translation elongation factor G 5.33 4.22 4.87 4.05 3.61 3.59 2.03 3.82 -3.2 0.79 G SCO4662 tuf1 elongation factor TU-1 Macromolecule metabolism Proteins - translation and modification tuf translation elongation factor Tu 5.76 5.27 4.87 3.58 4.71 4.79 4.16 4.59 -2.01 -0.44 G SCO4677 other putative regulatory protein Other regulation Other regulation abaA protein A -1.43 -1.38 -0.82 -0.57 3.51 2.74 0.47 1.45 7.63 -0.86 D SCO4683 gdhA NADP-specific glutamate dehydrogenase amino acid biosynthesis Glutamate gdhA "glutamate dehydrogenase, NADP-specific" -0.32 -0.63 -0.18 0.21 -0.44 2.01 0.12 -0.53 2.41 -0.57 A SCO4701 rpsJ 30S ribosomal protein S10 Ribosome "Ribosomal proteins - synthesis, modification" rpsJ ribosomal protein S10 5.72 3.64 5.08 3.16 3.62 3.68 3.54 3.73 -3.9 -0.86 G SCO4702 rplC 50S ribosomal protein L3 Ribosome "Ribosomal proteins - synthesis, modification" rplC ribosomal protein L3 5.7 4.18 4.34 3.38 2.73 3.56 3.66 3 -4.57 -0.81 E SCO4703 rplD 50S ribosomal protein L4 Ribosome "Ribosomal proteins - synthesis, modification" rplD ribosomal protein L4/L1 family 1.18 0.46 0.68 -0.28 0.31 -0.14 0.15 -0.19 -1.6 -0.37 G SCO4704 rplW 50S ribosomal protein L23 Ribosome "Ribosomal proteins - synthesis, modification" rplW ribosomal protein L23 5.65 4.43 4.85 3.97 3.87 3.91 3.86 4.69 -2.59 -0.61 G SCO4705 rplB 50S ribosomal protein L2 Ribosome "Ribosomal proteins - synthesis, modification" rplB ribosomal protein L2 4.47 3.52 4.33 3.11 3.46 3.74 2.75 3.32 -1.51 -0.05 G SCO4706 rpsS 30S ribosomal protein S19 Ribosome "Ribosomal proteins - synthesis, modification" rpsS ribosomal protein S19 5.14 4.34 5.46 3.6 4.46 4.87 1.48 3.4 -2.19 1.47 G SCO4707 rplV 50S ribosomal protein L22 Ribosome "Ribosomal proteins - synthesis, modification" rplV ribosomal protein L22 5.82 3.51 5.89 3.32 4.87 5.08 1.71 4.46 -3.25 0.42 G SCO4708 other 30S ribosomal protein S3 Ribosome "Ribosomal proteins - synthesis, modification" rpsC ribosomal protein S3 4.72 3.73 4.49 3.02 2.08 3.67 2.08 2.59 -3.31 0.25 E SCO4709 rplP 50S ribosomal protein L16 Ribosome "Ribosomal proteins - synthesis, modification" rplP ribosomal protein L16 5.86 4.09 5.26 3.76 3.54 4.42 4.41 2.91 -3.58 -0.81 E SCO4710 rpmC 50S ribosomal protein L29 Ribosome "Ribosomal proteins - synthesis, modification" rpmC ribosomal protein L29 5.35 4.04 5.33 4 4.52 3.26 4.19 4.99 -1.48 -0.55 G SCO4711 rpsQ 30S ribosomal protein S17 Ribosome "Ribosomal proteins - synthesis, modification" rpsQ ribosomal protein S17 4.34 2.98 3.65 1.87 3.6 1.58 1.31 2.74 -3.71 0.31 G SCO4712 rplN 50S ribosomal protein L14 Ribosome "Ribosomal proteins - synthesis, modification" rplN ribosomal protein L14 5.42 3.94 3.95 3.63 2.75 2.74 3.46 3.34 -4.22 -0.71 G SCO4713 rplX 50S ribosomal protein L24 Ribosome "Ribosomal proteins - synthesis, modification" rplX ribosomal protein L24 5.75 3.83 4.84 2.9 3.97 4.32 1.99 4.75 -3.92 -0.26 G SCO4714 rplE 50S ribosomal protein L5 Ribosome "Ribosomal proteins - synthesis, modification" rpL5 ribosomal protein L5 4.68 3.67 5.12 2.59 3.27 3.08 2.78 4.67 -1.72 -0.35 G SCO4716 rpsH 30S ribosomal protein S8 Ribosome "Ribosomal proteins - synthesis, modification" rpsH ribosomal protein S8 5.98 4.5 5.47 3.95 4.09 3.82 4.58 2.88 -3.65 -0.44 E SCO4718 rplR 50S ribosomal protein L18 Ribosome "Ribosomal proteins - synthesis, modification" rplR ribosomal protein L18 4.73 3.99 5.47 3.26 4.21 3.91 1.65 3.2 -1.85 1.35 G SCO4719 rpsE 30S ribosomal protein S5 Ribosome "Ribosomal proteins - synthesis, modification" ribosomal protein S5 5.77 4.16 3.88 3.73 3.7 3.64 3.05 3.99 -4.18 -0.56 E SCO4720 rpmD 50S ribosomal protein L30 Ribosome "Ribosomal proteins - synthesis, modification" rpmD ribosomal protein L30 5.3 3.93 4.19 3.88 3.57 3.14 3.13 2.95 SCO4721 rplO 50S ribosomal protein L15 Ribosome "Ribosomal proteins - synthesis, modification" rplO ribosomal protein L15 4.11 2.85 3.5 2.26 2.66 2.06 0.51 2.39 -3.73 0.77 E SCO4723 adk "adenylate kinase (fragment) ""adenylate kinase""" Nucleotide biosynthesis Purine ribonucleotide biosynthesis 2.86 1.53 1.48 1.52 1.77 1.77 0.33 1.86 -2.45 -0.18 E SCO4724 map methionine aminopeptidase Macromolecule metabolism Proteins - translation and modification map "methionine aminopeptidase, type I" 0.68 0.03 -0.13 -0.15 -0.47 -0.19 -0.7 -0.65 -1.51 -0.1 G SCO4725 infA translational initiation factor IF1 Macromolecule metabolism Proteins - translation and modification infA translation initiation factor IF-1 5.98 4.57 5 4.04 3.44 4.49 5.58 4.12 -2.74 -1.66 E SCO4726 rpmJ 50S ribosomal protein L36 Ribosome "Ribosomal proteins - synthesis, modification" rpmJ ribosomal protein L36 3.05 2.18 2.71 0.67 1.56 1.86 1.29 1.64 SCO4727 rpsM 30S ribosomal protein S13 Ribosome "Ribosomal proteins - synthesis, modification" rpsM ribosomal protein S13/S18 6.16 4.61 5.76 3.36 5.34 5.62 3.98 5.55 -2.02 -0.82 G SCO4728 rpsK 30S ribosomal protein S11 Ribosome "Ribosomal proteins - synthesis, modification" rpsK ribosomal protein S11 5.28 4.07 4.11 3.8 2.65 4.67 4.78 3.05 -2.46 -1.4 G SCO4729 rpoA DNA-directed RNA polymerase alpha chain Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" DNA-directed RNA polymerase alpha chain 3.28 2.35 3.39 1.08 2.41 1.74 0.8 3.61 -1.71 -0.09 G SCO4730 50S ribosomal protein L17 SCO4734 rplM 50S ribosomal protein L13 Ribosome "Ribosomal proteins - synthesis, modification" rplM ribosomal protein L13 5.71 3.32 4.74 3.34 3.34 3.91 3.9 0.86 -5.08 -0.62 E SCO4735 rpsI 30S ribosomal protein S9 Ribosome "Ribosomal proteins - synthesis, modification" 30s ribosomal protein s9. {streptomyces 4.12 2.71 3.92 2.46 1.87 2.77 1.1 1.04 -3.92 0.66 E SCO4736 other putative phospho-sugar mutase Degradation of small molecules Carbon compounds glmM phosphoglucosamine mutase 0.58 -0.31 -0.78 -0.29 -1.57 -1.06 -1.6 -0.85 -2.91 -0.06 G SCO4739 other putative lipoprotein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein putative lipoprotein -0.57 -0.81 -0.44 -0.9 -0.91 -0.77 -1.18 -1.62 0.13 0.19 G SCO4752 gcp putative O-sialoglycoprotein endopeptidase Macromolecule metabolism Glycoprotein gcp O-sialoglycoprotein endopeptidase -1.03 -1.3 -1.44 -1.52 -1.67 -1.27 -0.9 -1.73 0.23 -0.68 G SCO4761 groES 10 kD chaperonin cpn10 Cell process Chaperones groES "chaperonin, 10 kDa" 5.19 6.09 4.73 5.87 4.36 2.58 1.94 5.92 -1.14 2.21 G SCO4762 groEL1 60 kD chaperonin cpn60 Cell process Chaperones 60 kD chaperonin cpn60 3.45 5.3 4.35 5.13 2.58 1.7 0.92 4.84 0.78 2.83 G SCO4770 guaB inosine 5' monophosphate dehydrogenase Nucleotide biosynthesis Purine ribonucleotide biosynthesis guaB inosine-5-monophosphate dehydrogenase 1.68 0.6 0.11 -0.08 -0.75 0.3 -0.73 -1.06 -3.98 -0.17 E SCO4771 other putative inosine-5'-monophosphate dehydrogenase Nucleotide biosynthesis Purine ribonucleotide biosynthesis guaB inosine-5-monophosphate dehydrogenase 1.45 0.45 -0.67 -0.2 -0.2 -0.57 0.23 -0.04 -2.98 -1.08 G SCO4775 pkaH serine/threonine protein kinase Protein kinases Serine/threonine ppkA serine/threonine protein kinase PpkA 0.86 0.29 -0.53 -0.21 -0.59 -0.92 -0.84 -0.51 -2.44 -0.12 G SCO4785 guaA GMP synthase Nucleotide biosynthesis Purine ribonucleotide biosynthesis guaA GMP synthase 1.74 0.38 -0.9 0.3 -0.95 -0.91 -1.05 -0.55 -4.88 -0.36 E SCO4797 other putative ATP-dependent DNA helicase II Macromolecule metabolism "DNA - replication, repair, restr./modific'n" pcrA ATP-dependent DNA helicase PcrA -0.24 -0.45 -1.65 -0.46 -0.67 -0.48 -0.85 -0.71 -0.11 -0.44 G SCO4800 icmB "isobutiryl CoA mutase, small subunit" Degradation of small molecules Fatty acids mcmA2 "methylmalonyl-CoA mutase, alpha subunit, chain B" 0.02 -0.04 -0.27 1.37 0.05 0.91 -0.31 0.7 2.11 0.13 G SCO4808 sucC succinyl-CoA synthetase beta chain "Energy metabolism, carbons" TCA cycle sucC "succinyl-CoA synthetase, beta subunit" 2.84 3.84 2.94 2.51 3.11 3.29 0.82 2.04 0.37 1.66 G SCO4809 sucD succinyl CoA synthetase alpha chain "Energy metabolism, carbons" TCA cycle sucD "succinyl-CoA synthetase, alpha subunit" 3.32 3.4 3.62 3.31 1.66 2.49 -0.56 2.69 -1.74 2.17 G SCO4812 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein -0.77 -0.88 -0.44 -1.29 -0.74 -0.64 -0.96 -0.94 1 -0.19 G SCO4814 purH bifunctional purine biosynthesis protein Nucleotide biosynthesis Purine ribonucleotide biosynthesis purH phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1.79 0.26 1.7 1.22 1.37 0.55 -0.66 0.96 -1.51 0.51 G SCO4824 folD bifunctional protein (methylenetetrahydrofolate d "Biosynthesis of cofactors, carriers" Folic acid folD methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase 1.8 1.76 0.82 1.04 0.09 -0.13 -0.59 -0.31 -2.91 0.97 G SCO4825 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein -1.36 -1.36 -0.86 -1.6 -1.2 -0.2 -1.44 -0.83 2.03 -0.29 A SCO4827 mdh malate dehydrogenase "Energy metabolism, carbons" TCA cycle mdh malate dehydrogenase 2.69 2.06 2.07 0.81 1.04 1.68 -0.34 0.14 -3.35 0.79 G SCO4829 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) betA GMC oxidoreductase SCO4830 other putative glycine betaine ABC transport system ATP Cell process Amino acids and amines proV glycine betaine/L-proline transport ATP binding subunit -0.56 -1.35 -1.76 -0.66 -1.39 -1.48 -1.83 -1.08 -0.9 -0.22 G SCO4839 trpS2 tryptophanyl-tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n trpS tryptophanyl-tRNA synthetase 0.32 1.1 -0.22 -1 -0.32 -0.27 -0.78 -1.03 -0.88 0.44 G SCO4855 dhsB putative succinate dehydrogenase iron-sulfur subu "Energy metabolism, carbons" TCA cycle sdhB "succinate dehydrogenase, iron-sulfur protein" 3.09 1.59 2.42 2.04 2.78 1.94 -0.2 0.32 SCO4856 dhsA putative succinate dehydrogenase flavoprotein sub "Energy metabolism, carbons" TCA cycle sdhA "succinate dehydrogenase, flavoprotein subunit" 2.6 1.15 1.91 1.44 0.95 1.47 -0.37 0.39 -3.17 0.52 B SCO4857 other putative succinate dehydrogenase membrane subunit "Energy metabolism, carbons" TCA cycle sdhD "succinate dehydrogenase, hydrophobic membrane anchor protein" 2.18 1.08 1.16 0.31 0.51 0.79 -0.25 -0.43 SCO4873 other hypothetical protein SCK20.14c hypothetical protein No homologues conserved hypothetical protein -1.65 -0.46 -0.59 -1.29 -0.03 0.35 -0.45 -0.11 SCO4875 other "putative sugar transferase (fragment) ""putative tr" Macromolecule metabolism Polysaccharides - (cytoplasmic) 0.28 1.51 -0.33 -0.96 -0.64 0.97 1.01 1.4 -1.16 D SCO4877 other hypothetical protein 2SCK8.03c hypothetical protein No homologues conserved hypothetical protein -0.77 2.76 -0.29 -0.63 -0.08 -0.56 -0.19 0.08 3.1 1.35 D SCO4879 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -1.92 3.57 -0.66 -1.38 -0.31 0.47 -0.5 -0.18 5.97 1.98 C SCO4880 other putative transferase Not classified (included putative assignments) Not classified (included putative assignments) putative transferase -1.05 5.51 0.28 1.08 1.23 0.77 0.89 1.97 7.56 2.71 G SCO4881 other putative polysaccharide biosynthesis related prot Macromolecule metabolism Polysaccharides - (cytoplasmic) "neuB protein, putative" -0.78 5.86 2.3 1.63 2.52 1.64 1.55 3.92 9.81 2.94 C SCO4884 other putative lipoprotein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein tmbC membrane lipoprotein 0.63 0.15 0.81 1.77 0.31 1.41 -1.13 1.03 1.14 0.87 D SCO4885 other putative lipoprotein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein tmbC membrane lipoprotein 3.08 1.22 1.55 2.99 0.03 0.68 -0.48 0 -4.9 0.84 B SCO4886 other putative sugar ABC transporter ATP-binding protei Cell process Transport/binding proteins rbsA "sugar ABC transporter, ATP-binding protein" 0.98 -0.93 -0.59 0.51 -0.93 -0.55 -1.47 -1.65 -3.53 0.03 E SCO4890 deoA thymidine phosphorylase Central intermediary metabolisms Nucleotide interconversions pdp pyrimidine-nucleoside phosphorylase 0.41 -0.07 -1.01 1.17 -1.14 -0.63 -0.46 -0.94 -1.16 0.01 G SCO4901 other putative adenosine deaminase Central intermediary metabolisms Nucleotide interconversions add adenosine deaminase -1.55 -0.94 -0.94 -1.53 -1.31 -1.1 -1.86 -0.76 SCO4906 afsQ2 sensor kinase protein Two-component system Sensor kinase sensor protein afsq2 -0.1 -0.51 -1.11 -1.11 -1.35 -1.17 -1.52 -1.58 SCO4907 afsQ1 transcriptional regulatory protein Two-component system Response regulator transcriptional regulatory protein afsq1 1.12 0.84 0.42 -0.43 0.28 0.03 -0.68 0.28 -1.6 0.07 G SCO4912 other putative aldehyde dehydrogenase Not classified (included putative assignments) Not classified (included putative assignments) dhaS evbY 0.39 1.92 -0.1 0.05 -0.59 -0.91 -0.82 -1.11 -0.94 1.3 B SCO4913 other putative aldehyde dehydrogenase Degradation of small molecules Carbon compounds dhaS evbX 0.29 2.2 0.17 0.58 0.15 -0.73 -1 -0.98 0.01 2 G SCO4914 other putative deoxyribose-phosphate aldolase Central intermediary metabolisms Nucleotide interconversions deoC deoxyribose-phosphate aldolase 0.93 2.3 -0.38 0.14 -0.44 -0.74 -0.6 -0.81 -1.93 0.98 G SCO4915 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane putative integral membrane protein -0.39 -0.93 -0.27 -0.79 -1.1 0.48 -0.84 SCO4916 other putative phosphomannomutase Degradation of small molecules Carbon compounds manB-2 phosphomannomutase 0.14 0.73 0.15 -0.19 -0.51 -0.65 -0.46 -0.63 -0.01 0.47 G SCO4917 other putative purine nucleoside phosphorylase Central intermediary metabolisms Nucleotide interconversions deoD purine nucleoside phosphorylase 1.47 2.14 0.42 1.04 -0.24 -0.65 -0.81 -0.18 -2.51 1.26 G SCO4919 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) lpdA-2 "alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase" 0.51 0.32 -0.29 -0.39 -0.29 -0.76 -0.59 -0.2 -1.08 -0.1 B SCO4921 accA2 putative acyl-CoA carboxylase complex A subunit "Biosynthesis of cofactors, carriers" biotin carboxyl carrier protein (BCCP) bccA-3 "acetyl/propionyl-CoA carboxylase, alpha subunit" 1.92 1.38 3.85 3.68 2.1 1.94 1.31 0.39 1.42 1.65 G SCO4925 other hypothetical protein SCK13.17c hypothetical protein No homologues conserved hypothetical protein SCO4926 pccB propionyl-CoA carboxylase complex B subunit Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth pccB-4 "propionyl-CoA carboxylase, beta subunit" 0.16 1.7 -0.82 0.31 -0.25 -0.64 -0.9 -1.02 -0.24 1.23 B SCO4930 other putative enoyl-CoA hydratase Degradation of small molecules Fatty acids crt 3-hydroxybutyryl-CoA dehydratase 0.48 0.36 -1.37 -1.47 -1.8 -0.88 -1.2 SCO4932 hutH histidine ammonia-lyase Degradation of small molecules Amino acids hutH histidine ammonia-lyase -1.03 -1.15 -1.51 -1.87 -0.49 -1.28 -1.38 -1.71 0.38 -0.21 A SCO4934 other putative lipoprotein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein "lppS, putative" 2.33 1.35 2.17 1.87 3.35 3.16 1.92 2.42 1.42 -0.55 A SCO4945 other putative dehydrogenase Not classified (included putative assignments) Not classified (included putative assignments) yahK hypothetical zinc-type alcohol dehydrogenase-like protein yahk. {escherichia 3.02 5.6 SCO4957 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein 0.24 0.15 -0.85 -0.57 -0.38 -1.28 0.54 -0.5 -0.56 -0.9 G SCO4958 metB cystathionine gamma-synthase amino acid biosynthesis Methionine metC cystathionine beta-lyase 0.78 1.56 -0.21 0.42 -0.66 -0.62 -0.59 -0.52 -1.44 0.71 G SCO4965 other putative transcription elongation factor Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" greA transcription elongation factor GreA 2.16 1.02 -0.06 0.51 -0.1 -0.12 -0.21 1.2 -3.69 -0.73 E SCO4967 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli lmbE lmbE protein 0.41 SCO4968 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane putative membrane protein -0.9 -0.75 -0.82 -0.76 -1.18 -0.17 -1.08 -0.61 SCO4975 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "Protein of unknown function, DUF255 family" -0.81 -0.95 -1.36 -0.03 -1.15 -1.71 -1.63 -0.13 0.67 0.18 G SCO4979 other putative phosphoenolpyruvate carboxykinase Central intermediary metabolisms Gluconeogenesis Phosphoenolpyruvate carboxykinase -0.28 0.96 -0.92 0.47 0.64 -0.31 1.5 -0.73 SCO4990 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli putative regulator of purine biosynthesis. {bacillus 0.53 -0.64 -0.84 -0.84 -0.74 -1.07 0.32 -0.85 SCO5022 other putative lipoprotein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein "lipoprotein, putative" 0.17 -0.08 0.02 -0.66 0.28 0.33 -0.72 -0.39 0.27 -0.01 G SCO5024 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) "N5,N10-methylene-tetrahydromethanopterin reductase, putative" -0.81 0.07 -0.91 -0.01 -1.15 -1.27 -0.82 -1.06 SCO5028 other putative ATP-binding protein Not classified (included putative assignments) Not classified (included putative assignments) PhoH-related protein -1.53 3.13 -0.97 0.63 -0.98 -0.73 -0.91 -0.44 SCO5031 ahpD alkyl hydroperoxide reductase system hypothetical Cell process Detoxification ahpD alkyl hydroperoxide reductase D 1.78 1.48 0.28 -0.78 -0.23 -0.93 -1.55 -0.68 -4.77 0.65 E SCO5032 ahpC alkyl hydroperoxide reductase Cell process Detoxification ahpC alkyl hydroperoxide reductase C 2.18 1.72 1.11 -0.7 -0.86 -0.89 -1.07 -1.6 -5.91 0.7 E SCO5042 fumC fumarate hydratase C "Energy metabolism, carbons" TCA cycle fum fumarate hydratase -1.31 -1.31 -1.19 -1.12 -0.88 -1.51 -1.54 -1.16 1.34 0.13 G SCO5044 fumB fumarate hydratase class I "Energy metabolism, carbons" TCA cycle fumB "fumarate hydratase class I, anaerobic" -0.31 0.71 -0.55 0.56 -0.26 -0.93 -0.46 -1.04 0.97 0.91 A SCO5047 other conserved hypothetical protein GlpX hypothetical protein Conserved in organism other than Escherichia coli glpX glpX protein -0.78 -1.36 -0.46 -0.32 -0.98 -0.3 -2.01 -0.02 1.25 0.25 G SCO5058 lytB "LytB protein ""hypothetical protein (fragment)""" Other regulation Other regulation 0.5 1.26 -1.01 0.52 -0.55 -0.62 -0.64 -0.62 SCO5059 ppgK polyphosphate glucokinase Macromolecule metabolism Degradation of polysaccharides ppgK ROK family protein -0.71 -0.3 -1.23 -1.09 -0.65 -0.78 -0.95 -1.01 0.73 -0.07 A SCO5061 other putative ATP/GTP binding protein Not classified (included putative assignments) Not classified (included putative assignments) ychF GTP-binding protein YchF 1.17 0.12 0.18 -0.6 -1.21 -0.76 -0.56 -1.5 -3.68 -0.33 G SCO5071 actVI-ORFA hydroxylacyl-CoA dehydrogenase Secondary metabolism PKS hydroxylacyl-CoA dehydrogenase -1.09 -0.95 -1.38 -0.37 -0.75 2.76 5.7 3.52 8.23 -5.56 C SCO5072 actVIORF1 hydroxylacyl-CoA dehydrogenase Secondary metabolism PKS hydroxylacyl-CoA dehydrogenase -2.07 -1.86 -2.01 -1.6 -1.61 -0.91 -1.67 -1.33 2.61 -0.34 G SCO5073 actVIORF2 putative oxidoreductase Secondary metabolism PKS putative oxidoreductase -1.18 -2.11 -0.42 -0.58 0.62 3.91 6.19 5.14 10.44 -6.39 C SCO5074 actVIORF3 putative dehydratase Secondary metabolism PKS conserved hypothetical protein -2.15 -1.8 -1.13 -0.66 -0.19 4.62 6.03 5.54 12.84 -6.29 C SCO5075 actVIORF4 putative oxidoreductase Secondary metabolism PKS -1.28 -1.38 -1.51 -0.91 -0.74 2.95 5.09 3.78 8.34 -5.65 C SCO5077 actVA2 hypothetical protein Secondary metabolism PKS actVA 2 protein -0.99 -1.26 -1 -0.82 -0.4 2.4 4.58 2.83 7.06 -4.84 G SCO5078 actVA3 hypothetical protein Secondary metabolism PKS actVA 3 protein -1.33 -1.3 -1.14 -0.31 -0.79 2.46 5.82 3.2 8.64 -5.49 C SCO5079 actVA4 conserved hypothetical protein Secondary metabolism PKS actVA 4 protein -1.82 -1.62 -0.53 -0.75 -0.26 2.98 5.87 4.45 10.89 -5.66 C SCO5080 actVA5 putative hydrolase Secondary metabolism PKS putative hydrolase -1.26 -1.19 -0.86 -0.31 2 4.77 4.02 8.36 -4.9 C SCO5083 actII-2 putative actinorhodin transporter Secondary metabolism PKS probable actinorhodin transporter. {streptomyces -1.07 -0.75 -1.75 -0.6 -1.47 0.41 0.65 2.51 4.02 -2.28 G SCO5084 actII-3 putative membrane protein Secondary metabolism PKS putative membrane protein actii-3. {streptomyces -0.5 -1.18 -1.65 -1.06 -1.01 1.02 0.98 2.46 SCO5086 actIII ketoacyl reductase Secondary metabolism PKS putative ketoacyl reductase -0.99 -1.55 -1.06 -1.01 -0.25 2 4.75 4.16 7.46 -5.45 C SCO5087 actIORF1 actinorhodin polyketide beta-ketoacyl synthase al Secondary metabolism PKS actinorhodin polyketide putative beta-ketoacyl synthase 1 -1.46 -0.88 -1.3 -1.41 -0.76 3.62 6.06 3.19 9.26 -5.94 C SCO5088 actIORF2 actinorhodin polyketide beta-ketoacyl synthase be Secondary metabolism PKS actinorhodin polyketide putative beta-ketoacyl synthase 2 -1.6 -1.86 -1.16 -0.74 -0.82 2.61 5.8 4.44 9.65 -6.14 C SCO5089 actIORF3 actinorhodin polyketide synthase acyl carrier pro Secondary metabolism PKS actinorhodin polyketide synthase acyl carrier protein -1.15 0.42 -0.16 0.41 3.98 5.91 5.27 SCO5090 actinorhodin polyketide synthase bifunctional cyclase/dehydratase SCO5101 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -1.37 -0.84 -0.53 -0.45 0.78 2.18 -0.57 1.38 5.85 -0.38 D SCO5111 other putative GTP-binding protein Not classified (included putative assignments) Not classified (included putative assignments) typA GTP-binding protein TypA 1.61 0.11 0.05 -0.45 -0.52 -0.66 -0.87 -0.92 -4.38 -0.35 G SCO5113 bldKB "BldKB, putative ABC transport system lipoprotein" Cell process Transport/binding proteins BldKB 4.44 3.18 2.63 4.42 5.05 3.53 2.25 1.82 -1.9 0.78 B SCO5114 bldKC "BldKC, putative ABC transport system integral mem" Cell process Transport/binding proteins BldKC 2.6 1.24 1.16 2.05 1.76 1.09 -0.26 -0.86 SCO5115 bldKD "BldKD, putative ABC transporter intracellular ATP" Cell process Transport/binding proteins putative ABC transporter intracellular ATPase subunit BldkD 0.83 -0.65 0.26 -0.54 0.71 0.26 -0.88 -0.75 -1.5 -0.18 G SCO5116 bldKE putative peptide transport system ATP-binding pro Cell process Transport/binding proteins SCO5128 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane conserved hypothetical protein 0.26 1.03 -0.91 0.75 -0.09 -0.36 -0.49 -0.58 0.05 0.63 G SCO5135 fdxA1 ferredoxin "Energy metabolism, carbons" Electron transport ferredoxin. {streptomyces 1.87 1.33 2.53 1.52 1.98 2.26 1.02 1.68 0.92 0.17 G SCO5139 dapE succinyl-diaminopimelate desuccinylase amino acid biosynthesis Lysine dapE succinyl-diaminopimelate desuccinylase -0.83 -1.1 -1.16 -1.43 -1.48 -1.04 -1.53 -1.38 -0.08 -0.23 F SCO5140 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli pid:e118088 -0.98 2.5 0.52 0.3 0.6 -0.05 -0.67 -0.26 4.3 2.41 G SCO5144 other putative acyl CoA isomerase Degradation of small molecules Fatty acids paaG enoyl-CoA hydratase/isomerase family protein -0.16 0 -0.67 0.32 0.18 0.06 -0.91 1.01 0.3 G SCO5145 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli hypothetical protein 0.32 0.6 0.59 -0.62 0.71 0.61 -0.72 0.63 0.96 0.28 G SCO5152 other putative ATP-binding protein Not classified (included putative assignments) Not classified (included putative assignments) mrp mrp protein 0.4 0.08 -0.55 0.16 -0.26 -0.49 0.27 0.35 0.03 -0.74 G SCO5166 other putative helicase Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" deaD-2 ATP-dependent RNA helicase DeaD -0.16 -1.22 -0.6 -1.42 -0.75 0.01 -1.06 -1.19 -0.62 -0.69 G SCO5167 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.46 -0.46 -1.38 -0.6 -0.91 -0.43 -0.77 -0.62 0.47 -0.43 G SCO5169 other putative ATP-binding protein Not classified (included putative assignments) Not classified (included putative assignments) putative ATP-binding protein 2.23 1.93 -0.72 1.9 -0.14 0.49 -0.25 -0.2 -3.79 0.31 B SCO5170 other putative tetR-family transcriptional regulator Defined family regulators TetR "transcriptional regulator, TetR family" -0.75 -0.43 -1.16 0.21 -0.84 0.26 -0.85 0.93 2.55 -0.3 A SCO5171 other hypothetical protein SCP8.34c hypothetical protein No homologues conserved hypothetical protein 0.18 0.51 -0.24 0.67 0.05 -0.1 -0.64 1.67 SCO5178 other putative sulfurylase "Biosynthesis of cofactors, carriers" Thiamin moeZ HesA/MoeB/ThiF family protein 0.02 1 1.79 1.91 0.98 0.81 0.79 0.12 3.7 1.24 C SCO5185 other putative peptidase Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" ArgE/DapE/Acy1 family protein -0.28 0.56 -0.82 -1.17 -0.5 -0.57 -1.08 -0.6 0.18 0.25 G SCO5186 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli MutT/nudix family protein -0.71 0.1 -0.84 -1.01 -1.15 -0.93 -1.19 -1.09 0.56 0.36 G SCO5195 conserved hypothetical protein SCO5199 conserved hypothetical protein SCO5203 other hypothetical protein 2SC3B6.27c hypothetical protein No homologues conserved hypothetical protein -0.02 -0.42 -0.78 -0.85 -0.63 -0.57 -1.31 -0.78 SCO5204 other "hypothetical protein (fragment) ""putative integral" Periplasmic/exported/lipoproteins Gram +ve membrane 1.08 1.54 0.43 1.11 0.42 0.32 -0.58 -0.81 -1.07 1.25 B SCO5212 aroA2 3-phosphoshikimate 1-carboxyvinyltransferase amino acid biosynthesis Chorismate aroA 3-phosphoshikimate 1-carboxyvinyltransferase 0.01 -0.21 -0.96 -1.06 -0.99 -0.77 -1.25 -1.57 -1.52 -0.01 G SCO5221 other putative polypeptide deformylase Macromolecule metabolism Protein modification def polypeptide deformylase 1.07 0.49 0.06 -0.96 -0.94 -0.69 -0.63 -0.75 SCO5225 nrdM ribonucleotide-diphosphate reductase small chain Central intermediary metabolisms Nucleotide interconversions "Ribonucleotide reductase, small chain" 1.86 -0.45 -0.67 -1.16 -1.59 -1.11 -0.81 -1.19 -6.32 -1.41 G SCO5226 nrdL ribonucleotide-diphosphate reductase large chain Central intermediary metabolisms Nucleotide interconversions ribonucleotide-diphosphate reductase large chain 2.37 0.11 0.35 -0.29 -1.06 -0.99 -0.3 -0.5 -6.11 -1.08 G SCO5243 sig1 RNA polymerase sigma factor RNA polymerase core enzyme binding sigma factor sigF stress response/stationary phase sigma factor SigF 0.41 0.45 -1.04 1.02 -0.07 0.2 -0.33 -0.01 0.18 0.04 D SCO5244 prs1 anti-sigma factor RNA polymerase core enzyme binding anti sigma factor rsbW anti-sigma b factor -0.95 -0.72 -1.65 -1.53 -1.14 -0.55 -0.62 SCO5249 other putative nucleotide-binding protein Not classified (included putative assignments) Not classified (included putative assignments) sporulation protein -1.76 -1.23 -1.08 -0.09 -1.06 -1.16 -1.1 -1.42 SCO5254 sodN superoxide dismutase Cell process Detoxification superoxide dismutase [ni] precursor 2.77 4.82 2.75 2.83 2.63 2.27 0.96 2.62 0.47 2 G SCO5257 metZ methyltransferase Not classified (included putative assignments) Not classified (included putative assignments) methyltransferase -0.86 -0.72 -1.19 -1.04 -0.88 -0.84 -0.6 -0.89 1.15 -0.46 G SCO5258 atrC ATP-binding protein Not classified (included putative assignments) Not classified (included putative assignments) glnQ "glutamine ABC transporter, ATP-binding protein" -0.46 -1.04 -0.45 -0.7 -0.57 -0.85 -1.59 -0.78 SCO5260 atrA secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein glnH "glutamine ABC transporter, periplasmic glutamine-binding protein" -0.88 -0.3 1.77 -0.29 0.15 1.92 -0.12 SCO5261 other putative malate oxidoreductase Central intermediary metabolisms other Central intermediary metabolism EC1.1.1.38 malate oxidoreductase 1.03 0.01 0.49 1.39 0.42 -0.35 -0.07 -0.3 -0.98 0.26 G SCO5262 other putative dehydrogenase Not classified (included putative assignments) Not classified (included putative assignments) yogA "alcohol dehydrogenase, zinc-containing" -0.68 1.02 -1.17 0.75 -0.42 -0.96 -0.63 -0.6 SCO5265 other hypothetical protein hypothetical protein No homologues "hypothetical glycine-rich protein, putative" -1.99 -1.88 -0.91 -1.41 -1.57 -0.91 -1.53 -1.85 SCO5281 other putative 2-oxoglutarate dehydrogenase "Energy metabolism, carbons" TCA cycle sucA 2-oxoglutarate dehydrogenase E1 component SCO5283 other putative two-component system response regulator Two-component system Response regulator mtrA DNA-binding response regulator MtrA -0.19 -0.75 -0.85 -1.31 -1.01 -0.57 -0.92 -1.24 -0.8 -0.56 F SCO5285 lon ATP-dependent protease Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" lon ATP-dependent protease La -0.2 0.7 0.13 2.67 -0.16 -0.47 -0.36 0.99 2.8 1.28 G SCO5289 cvnA5 "hypothetical protein (fragment) ""possible sensor k" Periplasmic/exported/lipoproteins Gram +ve membrane 0.31 -0.71 -0.66 -0.82 -0.91 -1.22 -1.5 -1.34 -2.4 -0.06 G SCO5290 cvnB5 hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli Roadblock/LC7 family family 0.27 0 -0.71 -0.35 -1.11 -1.23 -1.28 -1.02 SCO5292 cvnD5 putative ATP/GTP-binding protein Not classified (included putative assignments) Not classified (included putative assignments) evcJ 0.62 -0.43 0.21 -0.58 0.02 0.57 -1.37 -0.54 SCO5293 other putative oxygenase subunit Not classified (included putative assignments) Not classified (included putative assignments) putative oxygenase subunit 0.43 -0.81 0.34 -1.59 -0.66 -0.46 -1.63 -1.44 -2.35 -0.04 E SCO5354 thrA homoserine dehydrogenase amino acid biosynthesis Amino Acid Biosynthesis hom homoserine dehydrogenase -0.38 -0.55 -0.69 0.08 -0.72 -0.95 -0.66 -0.67 0.58 0 G SCO5355 thrC threonine synthase amino acid biosynthesis Threonine thrC threonine synthase -0.12 -0.28 -0.81 -0.05 -0.91 -0.11 -1.03 -0.42 0.12 -0.03 G SCO5356 thrB homoserine kinase amino acid biosynthesis Threonine thrB homoserine kinase 0.96 -0.41 -0.83 -0.17 -0.59 -0.23 -0.8 -0.42 -2.57 -0.72 G SCO5357 rho "transcription terminator factor (fragment) ""transc" Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" 2.89 SCO5359 rpmE3 50S ribosomal protein L31 Ribosome "Ribosomal proteins - synthesis, modification" 4.69 3.2 3.27 3.26 2.97 3.12 3.14 3.14 -2.8 -0.85 G SCO5365 other putative transferase Periplasmic/exported/lipoproteins "Gram +ve peptidoglycan, teichoic acid" rfe undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase -0.2 -1.04 -0.69 -0.84 -1.01 -0.8 -1.18 -1.21 -0.82 -0.29 G SCO5366 atpI ATP synthase protein I "Energy metabolism, carbons" ATP-proton motive force atp synthase protein i. {streptomyces 2.16 1.33 1.69 0.36 1.78 2.73 1.62 0.91 -0.43 -0.95 G SCO5367 atpB ATP synthase A chain "Energy metabolism, carbons" ATP-proton motive force atpB "ATP synthase F0, A subunit" 2.66 0.98 0.72 -0.29 0.07 0.8 -0.03 -0.84 -5.36 -0.67 E SCO5368 atpE ATP synthase C chain "Energy metabolism, carbons" ATP-proton motive force atp synthase c chain 4.35 2.91 3.58 2.71 2.44 3.82 3.44 1.8 -2.43 -0.96 G SCO5369 atpf ATP synthase B chain "Energy metabolism, carbons" ATP-proton motive force atpF "ATP synthase F0, B subunit" SCO5370 atpH ATP synthase delta chain "Energy metabolism, carbons" ATP-proton motive force H(+)-transporting ATP synthase 4.21 3.63 4.32 3.37 3.67 4.05 2.1 3.94 -0.52 0.47 G SCO5371 atpA ATP synthase alpha chain "Energy metabolism, carbons" ATP-proton motive force atpA "ATP synthase F1, alpha subunit" 4.08 3.13 3.15 2.51 2.14 2.95 1.75 2.03 -3.05 0.04 E SCO5372 atpG ATP synthase gamma chain "Energy metabolism, carbons" ATP-proton motive force atpG "ATP synthase F1, gamma subunit" 3.49 2.61 2.95 2.51 2.4 2.97 1.77 2.35 -1.43 -0.04 G SCO5373 atpD ATP synthase beta chain "Energy metabolism, carbons" ATP-proton motive force atpD "ATP synthase F1, beta subunit" 3.66 2.93 2.95 2.38 2.19 1.83 0.58 2.2 -3.03 0.81 G SCO5374 atpC ATP synthase epsilon chain "Energy metabolism, carbons" ATP-proton motive force atpC "ATP synthase F1, epsilon subunit" 1.96 0.8 0.87 0.18 1.11 0.94 -0.61 1.04 -2.33 -0.11 E SCO5381 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli u471a SCO5385 other putative 3-hydroxybutyryl-coA dehydrogenase Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth hbd-2 3-hydroxyacyl-CoA dehydrogenase 0.14 1.15 -0.31 0.76 0.42 1.3 -0.34 -0.81 1.46 0.87 G SCO5388 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli Protein of unknown function superfamily 0.15 -0.51 -1.27 -0.51 -1.28 -1.13 -1.07 -1.25 -1.91 -0.34 G SCO5389 other hypothetical protein 2SC6G5.33 hypothetical protein No homologues conserved hypothetical protein SCO5393 other putative ABC transporter ATP-binding subunit Cell process Transport/binding proteins "ABC transporter, ATP-binding protein" 0.48 -1.02 -0.75 -1.54 -0.55 -0.09 -1.32 -0.81 SCO5396 other putative cellulose-binding protein Cell process Transport/binding proteins AbpS-related protein 1.12 1.86 1.32 1.42 2.72 2.15 0.14 1.87 2.5 1.01 C SCO5397 other large Ala/Glu-rich protein hypothetical protein No homologues "cell wall surface anchor family protein, putative" 0.42 -0.08 -0.13 -0.64 -0.41 -0.55 -0.42 -0.53 -1 -0.37 G SCO5398 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli 4-hydroxyphenylpyruvate dioxygenase C terminal domain containing protein -1.97 -0.91 -0.7 -1.31 -0.59 -0.25 -1.68 -0.37 4.17 0.55 G SCO5399 other probable acetoacetyl-coA thiolase Degradation of small molecules Fatty acids atoB acetyl-CoA acetyltransferase -0.81 -0.53 -0.1 1.53 -0.5 0.63 -0.56 -0.06 3.47 0.65 G SCO5405 other putative transcriptional regulator Defined family regulators MarR "transcriptional regulator, MarR family, putative" 1.46 3.58 4.25 SCO5409 other putative membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane ydzA ydzA -0.06 -0.36 -0.23 -1.32 -0.51 -0.04 -0.73 -0.46 SCO5415 icmA isobutyryl-CoA mutase A Secondary metabolism Secondary metabolism mcmA1 "methylmalonyl-CoA mutase, subunit alpha, N-terminus" -0.11 -0.41 -0.01 1.79 -0.18 -0.19 0.2 -0.57 SCO5419 trxA4 putative thioredoxin "Biosynthesis of cofactors, carriers" "Thioredoxin, glutaredoxin, glutathione" thioredoxin 0.81 0.78 0.15 0.75 -0.21 0.01 -0.72 -1.34 -1.41 0.88 G SCO5423 pyk2 pyruvate kinase "Energy metabolism, carbons" Glycolysis pyk pyruvate kinase 1.99 2.32 1.58 1.24 1.39 0.29 2.03 0.6 -0.7 -0.09 G SCO5424 ackA acetate kinase Degradation of small molecules Carbon compounds ackA acetate kinase -0.9 -0.43 -1.38 -1.42 -1.13 -0.92 -1.13 -1.51 0.49 -0.08 A SCO5426 pfkA2 6-phosphofructokinase "Energy metabolism, carbons" Glycolysis Phosphofructokinase -0.56 -0.83 -0.87 -1.03 -0.7 -0.97 -1.2 0.61 0.85 -0.52 G SCO5436 other putative sodium:dicarboxylate symporter Cell process Cations dctA C4-dicarboxylate transport protein 1.97 -0.33 -0.69 -0.33 -0.36 0.18 1.45 -0.4 SCO5444 glgP "putative glycogen phosphorylase ""putative glycogen" Macromolecule metabolism Polysaccharides - (cytoplasmic) SCO5459 other putative enoyl-coA hydratase Not classified (included putative assignments) Not classified (included putative assignments) 3-hydroxybutyry enoyl-CoA hydratase/isomerase family protein -0.83 -0.6 -0.46 -0.46 -1.09 -0.57 -1.19 -1.19 1.16 0.41 G SCO5464 other Not Specified hypothetical protein Conserved in organism other than Escherichia coli 148AA squidulin 2.5 2.64 1.61 1.85 0.78 1.12 0.06 0.67 -2.47 1.04 B SCO5470 glyA2 serine hydroxymethyltransferase amino acid biosynthesis Glycine glyA Serine hydroxymethyltransferase 2.48 1.29 0.05 -0.91 -0.57 -0.37 -0.69 -0.31 -6.08 -0.64 G SCO5472 gcvT aminomethyltransferase Degradation of small molecules Amino acids probable aminomethyltransferase -0.21 -1.19 -1.63 -0.99 -1.61 -1.44 -1.67 -1.24 -1.92 -0.5 F SCO5475 other hypothetical protein SC2A11.09 hypothetical protein No homologues conserved hypothetical protein -0.83 -1.1 0.91 -1.07 -0.88 -0.67 -0.69 SCO5477 other putative oligopeptide-binding lipoprotein Cell process Transport/binding proteins "oligopeptide-binding protein oppa precursor. {bacillus, putative" 4.03 4.53 3.79 5.12 4.86 4.78 4.51 4.38 2.63 0.11 G SCO5479 other oligopeptide ABC transporter ATP-binding protein Cell process Transport/binding proteins oppD "oligopeptide ABC transporter, ATP-binding protein" 1.86 1.54 1.81 2.58 2.79 2.13 0.34 0.18 0.45 1.42 D SCO5480 other oligopeptide ABC transporter ATP-binding protein Cell process Transport/binding proteins appF "peptide ABC transporter, ATP-binding protein" 0.08 -0.28 -0.01 0.15 0.02 0.27 -0.98 -0.08 0.63 0.27 D SCO5488 trmU tRNA (5-methylaminomethyl-2- thiouridylate)-methy Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" trmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase -0.6 -0.83 -1.33 -0.37 -1.4 SCO5491 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "conserved hypothetical protein TIGR00730, putative" 0.16 -0.33 -0.82 -0.9 -0.47 -0.51 1.29 -0.84 SCO5494 ligA putative DNA ligase Macromolecule metabolism "DNA - replication, repair, restr./modific'n" ligA "DNA ligase, NAD-dependent" 0.12 -0.9 -0.92 -0.86 -0.48 -0.42 -0.66 -0.51 -0.78 -0.87 G SCO5498 gatC probable Glu-tRNAGln amidotransferase subunit C Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n gatC "glutamyl-tRNA(Gln) amidotransferase, C subunit" 2.13 1.34 2.15 0.27 1.36 0.88 -0.57 -0.35 -2.75 0.93 B SCO5499 gatA probable Glu-tRNA Gln amidotransferase subunit Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n gatA "glutamyl-tRNA(Gln) amidotransferase, A subunit" 2.59 2.07 2.32 1.59 1.73 1.65 1.38 0.82 -1.42 0.16 G SCO5501 gatB probable Glu-tRNAGln amidotransferase subunit B Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n gatB "glutamyl-tRNA(Gln) amidotransferase, B subunit" 2.73 2.33 2.34 2.12 1.44 1 0.22 0.45 -2.61 1.24 G SCO5514 acetolactate synthase small subunit SCO5515 serA probable D-3-phosphoglycerate dehydrogenase amino acid biosynthesis Serine serA D-3-phosphoglycerate dehydrogenase 1.63 0.57 1.07 2.4 2.33 2.01 0.79 1.12 0.92 0.13 G SCO5519 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli Proline dehydrogenase superfamily 1.48 -0.32 -1.44 0.74 -1.15 -1.04 -1.22 -1.26 -4.9 -0.35 G SCO5520 other "delta-1-pyrroline-5-carboxylate dehydrogenase ""pro" amino acid biosynthesis Glutamate 1.82 -0.11 -1.08 0.44 -0.88 -0.75 -0.93 -1.39 -5.42 -0.51 G SCO5522 leuB 3-isopropylmalate dehydrogenase amino acid biosynthesis Leucine leuB 3-isopropylmalate dehydrogenase -0.7 -0.68 -0.91 1.18 2.66 2.53 2.4 SCO5523 ilvE branched-chain amino acid aminotransferase amino acid biosynthesis Valine ilvE branched-chain amino acid aminotransferase 0.69 -0.03 0.09 -0.32 0.22 -0.12 -0.27 -0.22 -0.84 -0.35 G SCO5535 other putative carboxyl transferase Not classified (included putative assignments) Not classified (included putative assignments) mmdA "methylmalonyl-CoA decarboxylase, alpha subunit" 0.74 -0.62 -0.28 -1.4 -0.43 0.23 -0.89 -1.05 -2.35 -0.79 G SCO5537 putative ATP/GTP binding protein SCO5539 cvnB2 conserved hypothetical protein SC1C2.20c hypothetical protein Conserved in organism other than Escherichia coli Roadblock/LC7 family superfamily 0.58 -1.04 -0.14 -0.63 -0.23 -0.47 -1.09 0.17 -1.49 -0.67 G SCO5540 cvnA2 putative membrane protein SC1C2.21c Periplasmic/exported/lipoproteins Gram +ve membrane "Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein" 1.76 0.87 -0.03 0.25 0.76 1.28 2.02 0.87 -0.96 -1.92 G SCO5541 cvnD1 putative ATP-GTP binding protein Not classified (included putative assignments) Not classified (included putative assignments) probable ATP/GTP binding protein 1.01 -0.26 -0.5 -0.62 -0.49 -0.33 -1.01 -1.07 -3.1 -0.4 B SCO5542 cvnC1 hypothetical protein SC1C2.23c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 1.5 0.86 0.45 -0.06 0.65 0.61 -0.53 0.22 SCO5543 cvnB1 conserved hypothetical protein SC1C2.24c hypothetical protein Conserved in organism other than Escherichia coli Roadblock/LC7 family superfamily SCO5544 cvnA1 putative membrane protein SC1C2.25c Periplasmic/exported/lipoproteins Gram +ve membrane "Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein" 2.02 0.31 0.27 -0.54 0.82 1.04 1.79 0.07 -2.45 -2.15 G SCO5545 other hypothetical protein SC1C2.26 hypothetical protein No homologues conserved hypothetical protein -0.64 -0.31 -1.09 -0.8 -0.01 -0.18 -0.59 -0.12 SCO5547 gltX glutamyl-tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n gltX glutamyl-tRNA synthetase 1.43 0.75 0.36 0.1 0.12 0.11 0.83 -0.85 -2.12 -0.61 G SCO5552 other putative regulator Other regulation Other regulation probable transcription regulator SCO5556 other histone-like DNA binding protein Macromolecule metabolism "Basic proteins - synthesis, modification" hupB dna-binding protein hu 2. {streptomyces 0.96 -0.45 -0.58 -0.85 -1.12 -0.94 -0.96 0.01 -3.14 -0.96 F SCO5559 gpsA glycerol-3-phosphate dehydrogenase Macromolecule metabolism Phospholipids gpsA "glycerol-3-phosphate dehydrogenase, NAD-dependent" 0.05 0.99 -1.04 0.12 -0.92 -1.34 -0.73 -1.09 -0.78 0.62 G SCO5560 other D-alanine-D-alanine ligase Periplasmic/exported/lipoproteins "Gram +ve peptidoglycan, teichoic acid" D-alanine--D-alanine ligase 1.52 0.37 -0.34 1.34 0.34 0.17 1.16 -0.49 -1.79 -0.86 G SCO5562 other putative thiamine monphosphate kinase "Biosynthesis of cofactors, carriers" Thiamin thiL thiamine-monophosphate kinase -0.05 -0.94 -0.67 -1.35 -1.02 -0.71 -1.07 -1.04 -1.19 -0.62 G SCO5564 other putative 50S ribosomal protein L28 Ribosome "Ribosomal proteins - synthesis, modification" rpmB ribosomal protein L28 1.46 0.18 -0.34 1.85 0.26 -0.72 -0.83 -0.04 SCO5570 other hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "Uncharacterized ACR, COG1399" 3.6 2.39 2.61 2.1 1.04 4.12 2.48 -1.68 -1.35 G SCO5571 other 50S ribosomal protein L32 Ribosome "Ribosomal proteins - synthesis, modification" 1.95 0.95 1.61 0.37 1.47 1.14 -0.32 0.46 -1.87 0.32 G SCO5572 other ribonuclease III Macromolecule metabolism Degradation of RNA ribonuclease iii 2.09 0.77 0.28 -0.29 -0.35 -0.1 -0.12 -0.47 -4.51 -0.69 E SCO5580 other putative prokaryotic docking protein Macromolecule metabolism Proteins - translation and modification probable prokaryotic docking protein 1.48 1.25 1.19 1.36 1.84 1.25 -0.13 0.53 -0.08 0.87 G SCO5586 ffh signal recognition particle protein Macromolecule metabolism Proteins - translation and modification signal recognition particle protein 1.32 0.56 0.16 0.49 -0.57 0.08 -0.23 -0.7 -2.49 -0.11 G SCO5590 other hypothetical protein SC2E1.07 hypothetical protein No homologues conserved hypothetical protein 1.65 2.31 1.64 0.94 2.27 1.02 2.25 2.49 1.68 -0.53 A SCO5591 rpsP 30S ribosomal protein S16 Ribosome "Ribosomal proteins - synthesis, modification" 30s ribosomal protein s16. {streptomyces 4.98 3.29 3.1 2.5 2.38 2.96 4.57 2.32 -3.87 -2.06 E SCO5592 other conserved hypothetical protein SC2E1.09 hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 4.84 3.38 3.14 2.92 1.56 3.1 3.57 3.24 -3.65 -1.6 G SCO5595 rplS 50S ribosomal protein L19 Ribosome "Ribosomal proteins - synthesis, modification" rplS ribosomal protein L19 1.11 -0.14 0.71 -1.12 -0.54 -0.19 -1.5 -0.69 -3.14 0.01 G SCO5598 sip3 putative signal peptidase I Macromolecule metabolism Proteins - translation and modification signal peptidase I -0.22 -0.7 -0.95 -1.28 -0.86 0.14 -1.19 -1.8 -0.72 -0.27 B SCO5624 rpsB 30S ribosomal protein S2 Ribosome "Ribosomal proteins - synthesis, modification" ribosomal protein S2 5.5 3.67 3.82 3.4 2.89 3.62 2.8 2.97 -4.61 -0.58 E SCO5625 tsf elongation factor Ts Macromolecule metabolism Proteins - translation and modification tsf translation elongation factor Ts 3.23 2 3.59 2.15 3.21 3.03 0.25 1.19 -1.63 1.24 G SCO5626 pyrH uridylate kinase Central intermediary metabolisms Nucleotide interconversions uridylate kinase 1.5 0.07 0.52 -0.95 -0.05 0.55 -0.59 -0.15 -2.94 -0.74 G SCO5627 frr ribosome recycling factor Macromolecule metabolism Proteins - translation and modification frr ribosome recycling factor 2.53 1.59 1.06 0.58 0.95 2.06 0.17 1.61 -2.43 -0.54 G SCO5645 other conserved hypothetical protein SC6A9.22c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein TIGR00048 -0.69 -0.76 -1.05 -1.26 -0.96 -0.77 -1.34 -1.05 0.26 -0.14 A SCO5652 other conserved hypothetical protein SC6A9.15 hypothetical protein Conserved in organism other than Escherichia coli glyoxalase family protein superfamily -0.68 -0.72 -0.88 -0.51 -0.23 -0.59 0.52 -0.65 SCO5657 other aldehyde dehydrogenase Cell process Osmotic adaptation aldehyde dehydrogenase -1.24 0.02 -0.8 -0.66 -0.88 -0.21 -1.03 -0.98 2.59 0.58 C SCO5662 other putative adenosine deaminase Central intermediary metabolisms Nucleotide interconversions add adenosine deaminase -0.63 -0.78 -1.23 -0.85 -1.09 -0.37 -0.29 -0.75 0.92 -0.86 G SCO5676 gabT putative 4-aminobutyrate aminotransferase Central intermediary metabolisms "Pool, multipurpose conversions of intermed. met'm" gabT 4-aminobutyrate aminotransferase 1.44 0.44 -1.36 -1.44 -1.47 -1.22 -1.56 -1.53 -5.84 -0.53 E SCO5679 other putative aldehyde dehydrogenase Not classified (included putative assignments) Not classified (included putative assignments) gapN "glyceraldehyde-3-phosphate dehydrogenase, NADP-dependent" 1.58 0.67 -1.12 -1.28 -0.77 -0.69 -0.75 -0.94 -4.9 -0.88 G SCO5694 dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase "Biosynthesis of cofactors, carriers" "Menaquinone, ubiquinone" dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase -0.18 -0.38 -0.73 -1.09 -0.8 -0.8 -1.19 -0.41 -0.4 -0.23 F SCO5696 gcpE hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli ispG 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase 1.32 1.55 0.33 0.05 0.92 0.69 -0.33 -0.68 -1.55 0.58 G SCO5699 proS prolyl tRNA synthetase Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n proS prolyl-tRNA synthetase SCO5703 other hypothetical protein SC5H4.27 hypothetical protein Conserved in organism other than Escherichia coli "Uncharacterized BCR, YhbC family COG0779 family" 1.98 0.84 -0.33 -0.49 -0.79 0.96 -0.16 SCO5704 other putative transcriptional termination/antiterminat Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" nusA N utilization substance protein A 1.94 0.7 0.08 -0.6 0.18 -0.04 0.39 -0.07 -3.66 -1.15 G SCO5706 other "probable translational initiation factor ""putative" Macromolecule metabolism Proteins - translation and modification 2.85 1.45 1.62 1.93 0.46 1.05 -0.06 0.09 -4.05 0.47 G SCO5708 other putative ribosome-binding factor Macromolecule metabolism Proteins - translation and modification rbfA ribosome-binding factor A 2.11 2.27 0.74 0.32 1.19 1.01 1.02 0.74 -1.76 -0.34 G SCO5717 other conserved hypothetical protein SC3C3.03c hypothetical protein Conserved in organism other than Escherichia coli hypothetical protein 0 0.16 0.4 -0.06 0.34 0.22 0.3 -0.12 1.63 -0.11 G SCO5723 bldB "putative regulator, BldB" Other regulation Other regulation hypothetical protein 0.6 0.99 -0.24 0.12 -0.21 0.62 0.31 0.12 0.18 -0.35 D SCO5724 other hypothetical protein SC3C3.10 hypothetical protein No homologues hypothetical protein 2.12 3.44 2.38 2.93 1.97 1.65 2.37 2.15 1.67 0.71 G SCO5736 rpsO 30S ribosomal protein S15 Ribosome "Ribosomal proteins - synthesis, modification" rpsO ribosomal protein S15 2.96 1.17 2.81 -0.14 2.38 2.02 -0.26 1.06 -3.2 0.08 G SCO5737 gpsI guanosine pentaphosphate synthetase/polyribonucle Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" 2.74 2.25 1.73 1.4 0.53 0.53 -0.43 -0.49 -4.36 1.19 E SCO5739 dapB putative dihydrodipicolinate reductase amino acid biosynthesis Lysine dapB dihydrodipicolinate reductase 0.36 -0.28 -0.59 -0.24 -1.09 -0.75 -1.41 -1.19 -1.97 0.2 G SCO5743 other conserved hypothetical protein SC9A10.07 hypothetical protein Conserved in organism other than Escherichia coli Thymidylate synthase complementing protein superfamily 1.24 0.28 -0.42 -0.66 -0.2 -0.23 0.06 -0.66 -2.75 -0.92 G SCO5744 dapA putative dihydrodipicolinate synthase amino acid biosynthesis Lysine dapA dihydrodipicolinate synthase 1.24 0.42 0.79 -0.18 0.25 -1.24 0.91 -1.7 0.26 B SCO5745 other conserved hypothetical protein SC9A10.09 hypothetical protein Conserved in organism other than Escherichia coli Uncharacterized protein family UPF0036 family 2.1 1.15 0.32 1.05 0.01 0 -0.51 -0.21 -3.86 0.25 E SCO5746 other hypothetical protein SC7C7.01 hypothetical protein Conserved in organism other than Escherichia coli DegT/DnrJ/EryC1/StrS aminotransferase family superfamily 3.1 1.13 1.88 2.88 2.38 1.17 3.27 SCO5748 other putative sensory histidine kinase Two-component system Sensor kinase probable sensory histidine kinase -0.75 -0.97 -1.05 -1.24 -1.1 -0.38 -1.01 -1.06 0.66 -0.47 D SCO5769 recA recombinase A Cell process Chromosome replication recA recA protein 1.53 1.39 0.5 0.92 1.18 2.15 0.84 2.51 0.88 -0.82 A SCO5774 gluD glutamate permease Cell process Transport/binding proteins glutamate transport protein gluD 1.32 1.24 0.55 -1.03 -0.35 -1.17 -1 -0.83 -3.61 0.44 B SCO5776 gluB glutamate binding protein Cell process Transport/binding proteins "amino acid ABC transporter, amino acid-binding protein, putative" 2.96 3.26 3.12 1.57 1.3 0.91 2.05 1.95 -1.6 0.13 B SCO5777 gluA glutamate uptake system ATP-binding protein Cell process Transport/binding proteins gltL "amino acid ABC transporter, ATP-binding protein" 2.21 1.81 2.14 -0.01 0.4 0.03 0.01 -3.31 0.45 B SCO5783 other conserved hypothetical protein SC4H2.04c hypothetical protein Conserved in organism other than Escherichia coli TrkA potassium uptake protein family -0.76 -0.75 -0.04 -0.91 -0.79 -0.66 -1.03 -1.61 0.91 0.35 G SCO5798 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein probable secreted protein 0.64 0.27 0.54 0.89 1.3 0.87 -0.63 1.77 1.47 0.28 G SCO5805 nrdJ ribonucleotide reductase Macromolecule metabolism "DNA - replication, repair, restr./modific'n" ribonucleotide reductase 2.59 0.44 0.48 0.02 -0.73 -0.05 -0.73 -1.42 -6.51 -0.38 E SCO5817 other putative DNA hydrolase with mutT domain Macromolecule metabolism Degradation of DNA probable DNA hydrolase -1.45 -1.03 -1.39 -1.47 -1.68 -1.23 -1.24 -1.4 SCO5820 hrdB major vegetative sigma factor RNA polymerase core enzyme binding sigma factor AA1-442 principal sigma subunit 0.32 0.73 0.79 1.7 1.97 0.45 0.22 SCO5822 gyrB2 putative DNA gyrase subunit B Macromolecule metabolism "DNA - replication, repair, restr./modific'n" gyrB "DNA gyrase, B subunit" -0.19 -0.63 0.1 -1.21 -1.23 -0.14 -0.73 -1.15 -0.22 -0.37 SCO5832 other putative citrate synthase "Energy metabolism, carbons" TCA cycle Citrate synthase -1.5 -1.19 -0.82 -1.4 -1.43 -1.95 -1.51 -1.35 SCO5836 other DNA gyrase-like protein Macromolecule metabolism "DNA - replication, repair, restr./modific'n" gyrA DNA gyrase subunit A -0.08 -0.76 -1.12 -0.96 -1.23 -1.12 -0.77 -0.43 -0.96 -0.87 B SCO5837 other zinc protease Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" zinc proteinase 0.46 0.89 -0.04 0.4 -0.02 0.84 -0.62 -1.32 -0.17 0.8 G SCO5838 other putative protease Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" probable proteinase SC9B10.05 0.41 0.65 -0.27 0.56 -0.32 -0.39 0.66 -0.43 0.18 -0.26 G SCO5841 ptsH phosphocarrier protein hpr Cell process Transport/binding proteins phosphocarrier protein hpr 0.63 0.23 -0.34 -0.19 0.86 -0.62 -0.6 -0.52 -0.96 0.17 B SCO5855 other putative DNA-binding protein Not classified (included putative assignments) Not classified (included putative assignments) conserved hypothetical protein 0.46 0.06 -0.69 -0.26 -0.32 0.19 0.05 0.41 SCO5859 hemH ferrochelatase "Biosynthesis of cofactors, carriers" "Heme, porphyrin" hemH ferrochelatase -1 -0.64 -0.77 -1.01 -0.11 -1.49 -0.09 SCO5862 cutR two-component regulator CutR Two-component system Response regulator transcriptional regulatory protein cutr 0.28 -0.43 0.24 -0.08 -0.47 -0.5 -0.6 -0.71 -0.55 0 G SCO5864 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 2.29 0.64 1.02 0.61 0.31 0.95 -0.25 1 -3.2 -0.52 G SCO5869 other hypothetical protein SC2E9.10 hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 1.97 1.66 0.39 1.15 1.03 0.53 0.09 -0.28 -2.47 0.46 B SCO5874 other putative membrane protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 1.47 1.27 1.26 -0.11 1.43 1.27 -0.15 2.14 0.01 -0.15 D SCO5875 other putative potassium uptake protein Cell process Cations probable potassium uptake protein -0.52 -0.89 -1.46 -1.74 -1.52 -1.24 -1.44 -1.65 -1.23 -0.47 G SCO5878 redX polyketide synthase RedX Secondary metabolism PKS polyketide synthase redX -1.62 -0.84 0.59 0.59 0.15 0.61 -0.34 -0.03 SCO5879 redW acyl-coa dehydrogenase RedW Secondary metabolism PKS ivd isovaleryl-CoA dehydrogenase -1.35 -1.61 -0.03 0.09 0.07 1.18 -0.13 -0.12 4.81 -0.34 G SCO5880 redY RedY protein Secondary metabolism PKS redY protein -1.3 -0.97 -0.48 0.39 0.64 1.1 -0.37 -0.3 4.79 0.26 G SCO5881 redZ response regulator Secondary metabolism PKS -1.75 -0.15 -0.46 -1.5 0.24 0.98 -0.6 -1.28 SCO5882 redV RedV protein Secondary metabolism PKS redV protein 0.08 -0.1 -0.95 0.66 0 -0.37 0.27 -0.25 SCO5884 other hypothetical protein SC3F7.04c Secondary metabolism PKS conserved hypothetical protein -0.73 -0.81 0.69 -0.47 -0.39 1.24 0.12 -0.75 3.07 -0.29 D SCO5886 redR 3-oxoacyl-[acyl-carrier-protein] synthase II Secondary metabolism PKS fabF 3-oxoacyl-(acyl-carrier-protein) synthase II -1.79 -1.6 2.12 2.2 1.66 3.03 1.74 1.21 SCO5887 redQ acyl carrier protein Secondary metabolism PKS acyl carrier protein 1.12 2.24 3.1 2.44 4.42 3.17 3.07 4.18 6.93 0.08 G SCO5888 redP 3-oxoacyl-[acyl-carrier-protein] synthase Secondary metabolism PKS fabH 3-oxoacyl-(acyl-carrier-protein) synthase III -1.14 -1.28 2.18 1.12 2.5 3.84 1.06 -0.04 SCO5890 redN putative 8-amino-7-oxononanoate synthase Secondary metabolism PKS transferase -0.78 -0.42 3.29 2 2.91 4.52 2.98 2.55 10.41 -0.44 C SCO5892 redL polyketide synthase Secondary metabolism PKS polyketide synthase -0.52 -0.44 -0.35 -0.64 1.91 0.56 -0.24 -0.52 2.82 0.11 G SCO5893 redK oxidoreductase Secondary metabolism PKS oxidoreductase -1.35 -0.52 2.98 1.48 2.01 3.2 1.7 0.06 9 0.83 C SCO5895 redI putative methyltransferase Secondary metabolism PKS probable methyltransferase -1.68 -0.77 3.11 2.03 3.16 4.01 2.19 0.01 11.04 0.99 C SCO5896 redH phosphoenolpyruvate-utilizing enzyme Secondary metabolism PKS -1.95 -1.2 3.59 1.7 2.97 3.9 1.31 -0.65 10.89 1.62 C SCO5897 redG putative oxidase Secondary metabolism PKS probable oxidase -2.14 -1.85 2.52 0.45 1.93 4.12 1.37 1.71 11.21 -0.35 C SCO5901 other putative RNA methyltransferase stem_loop 6469662.. Macromolecule metabolism Amino acyl tRNA syn; tRNA modific'n TRAM domain protein 0.22 -0.39 -1.21 -0.91 -0.61 -1.17 0.42 -0.67 -1 -1.35 G SCO5960 cbiN puative cobalt transport protein Cell process Cations cobalt transport protein cbin. {streptomyces 0.37 0.01 -0.17 0.96 0.25 -0.28 -1.1 -0.18 -0.08 0.73 G SCO5971 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli mer-2 Luciferase-like monooxygenase family -1.58 -1.02 -0.4 -1.4 -1.07 -0.92 -1.26 -0.4 2.88 0.09 A SCO5982 other putative regulator Other regulation Other regulation "repressor in the phenylacetic acid catabolic pathway, putative" -0.98 -0.86 -0.98 -1.62 -1.68 -1.17 -1.33 0.32 -0.21 A SCO5998 murA2 "putative bifunctional protein (fragment) ""putative" Periplasmic/exported/lipoproteins "Gram +ve peptidoglycan, teichoic acid" -0.25 -0.5 -0.7 -0.64 -0.1 -0.48 -0.82 -0.51 0.47 -0.16 A SCO5999 sacA aconitase "Energy metabolism, carbons" TCA cycle acnA aconitate hydratase 1 1.36 1.13 1.2 -0.39 -0.07 -0.05 -0.84 -0.57 -2.53 0.63 G SCO6005 other putative lipoprotein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein Bacterial extracellular solute-binding protein domain protein -0.68 -1.14 -0.97 0.32 -0.55 1.01 0.07 -0.77 2.43 -0.72 G SCO6008 other probable transcriptional repressor protein Defined family regulators ROK ROK family domain protein -0.59 0.3 -0.48 -0.25 -0.56 -0.39 -0.35 -0.94 1.56 0.34 D SCO6009 other solute-binding protein Cell process Transport/binding proteins xylF d-xylose-binding periplasmic protein precursor. {escherichia 1.94 2.47 1.2 2.37 0.19 0.57 0.21 -0.46 -1.91 1.4 B SCO6010 other probable ABC-transport system ATP binding protein Cell process Transport/binding proteins hypothetical abc transporter atp-binding protein ytfr. {escherichia coli 0.96 0.93 0.69 1.19 -1.02 0.1 -0.61 -1.01 -1.57 0.89 B SCO6011 other probable ABC-type transmembrane transport protein Cell process Transport/binding proteins xylH "sugar ABC transporter, permease protein" 0.85 0.21 -0.83 0.93 -1.11 -0.27 -0.41 -0.78 -1.99 -0.19 B SCO6013 other probable 1-deoxyxylulose-5-phosphate synthase Central intermediary metabolisms Oligosaccharides -1.68 -1.52 -1.43 -1.83 -0.67 -0.38 -1.75 0.13 2.99 -0.42 A SCO6026 other fatty acid oxidation complex alpha-subunit Degradation of small molecules Fatty acids "enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase, putative" 0.25 -0.12 0.02 0.16 0.01 -0.2 0.48 -0.95 0.31 -0.34 G SCO6027 other acetyl-coa acetyltransferase (thiolase) Degradation of small molecules Fatty acids pcaF beta-ketoadipyl-CoA thiolase -0.29 -0.57 -0.6 -1.12 -0.43 -0.3 -0.59 0.32 0.82 -0.76 G SCO6028 other putative ribonuclease Macromolecule metabolism Degradation of RNA 3-5 exonuclease domain protein -0.37 -0.48 -0.79 -0.89 -0.89 -1.04 -0.91 -0.59 SCO6031 uroporphyrinogen decarboxylase SCO6042 other conserved hypothetical protein SC1B5.02 hypothetical protein Conserved in organism other than Escherichia coli hypothetical protein 1.74 1.79 1.08 0.19 0.51 0.77 -0.38 0.01 -2.16 0.57 G SCO6057 other putative ATP/GTP-binding integral membrane protei Periplasmic/exported/lipoproteins Gram +ve membrane AFG1-like ATPase superfamily -0.85 -0.71 -1.52 -0.86 -1.44 -1.44 -1.15 -1.41 SCO6060 murC putative UDP-N-acetylmuramoyl-L-alanine ligase Periplasmic/exported/lipoproteins "Gram +ve peptidoglycan, teichoic acid" murC UDP-N-acetylmuramate--alanine ligase 0.01 -0.52 -1.48 -0.39 -1.48 -1.56 -1.73 -1.3 -2.14 0.11 G SCO6065 other putative secreted substrate-binding protein Cell process Transport/binding proteins hypothetical protein -0.58 -0.79 -1.1 -1.1 -1.09 -0.55 -0.68 0.53 -0.7 G SCO6069 cvnA6 putative large secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein "Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein" -1.17 -0.82 -0.31 -1.34 -1.19 -0.95 -1.15 -0.58 SCO6084 other putative DNA polymerase Macromolecule metabolism "DNA - replication, repair, restr./modific'n" dnaQ "PROBABLE DNA POLYMERASE III, EPSILON CHAIN PROTEIN" -0.86 -0.74 -1.04 -1.25 -0.83 -0.75 -0.99 -0.9 1.01 -0.27 G SCO6124 other hypothetical protein SC9B2.11 hypothetical protein No homologues conserved hypothetical protein 0.46 1.35 0.03 -1.32 -0.84 0.08 -0.9 -1.07 -1.35 0.39 B SCO6147 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) "oxidoreductase, FAD-binding" 3.13 SCO6148 other hypothetical protein SC1A9.12 hypothetical protein No homologues conserved hypothetical protein 0.5 2.74 0.43 1.31 0.13 -0.48 0.38 0.25 1.17 1.36 A SCO6198 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein probable secreted protein -0.6 2 2.51 3.9 4.75 4.9 3.08 3.41 SCO6219 other "putative ATP/GTP binding protein ""putative serine/" Protein kinases Serine/threonine -1.09 -0.65 -1.06 -0.2 -1.43 -1.12 -1.52 -1.09 SCO6222 other putative aminotransferase Not classified (included putative assignments) Not classified (included putative assignments) b2290 "aminotransferase, class I" -1.12 -1.22 -1.04 -1.47 -0.98 -1.08 -0.65 -0.85 1.48 -0.68 A SCO6224 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein probable secreted protein -0.12 -0.73 -0.99 -1.28 -1.2 -1.08 -1.09 -1.73 -1.58 -0.38 B SCO6225 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein probable secreted protein 0.64 -0.53 -0.97 -1.11 -1.22 -0.61 -0.81 -1.16 SCO6264 other reductase Not classified (included putative assignments) Not classified (included putative assignments) fabG 3-oxoacyl-acyl carrier protein reductase -1.09 0.58 -0.21 0.05 0.98 1.22 0.01 1.44 SCO6265 scbR gamma-butyrolactone binding protein Defined family regulators TetR gamma-butyrolactone binding protein -0.88 -0.84 1.38 0.55 -0.81 0.26 -0.28 -0.28 3.43 0.51 C SCO6269 other putative oxidoreductase beta-subunit Not classified (included putative assignments) Not classified (included putative assignments) "ferredoxin oxidoreductase, beta subunit" -1.14 0.76 2.99 3.13 1.39 0.8 0 0.55 SCO6272 other putative secreted FAD-binding protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein "similar to reticuline oxidase, putative" -0.8 -1.14 3.53 4.62 0.47 0.24 -0.4 0.73 6.13 2.69 G SCO6273 other putative type I polyketide synthase Secondary metabolism PKS fragment polyketide synthase -1.37 -1.42 2.65 4.47 1.51 0.92 -0.79 -1.4 6.85 3.41 C SCO6274 other putative type I polyketide synthase Secondary metabolism PKS polyketide synthase SCO6275 other putative type I polyketide synthase Secondary metabolism PKS -2.04 -1.35 2.89 1.6 0.43 0.05 -0.97 -1.22 6.85 2.66 C SCO6276 other putative secreted protein Secondary metabolism Secondary metabolism putative secreted protein -1.1 -1.08 5.38 5.39 5.34 4.39 4.88 4.28 15.45 0.32 C SCO6277 other putative epoxide hydrolase Secondary metabolism Secondary metabolism ephA epoxide hydrolase -1.57 -2 5.5 5.31 5.25 4.88 4.32 1.78 15.33 1.01 C SCO6278 other putative integral membrane transport protein Secondary metabolism Secondary metabolism possible transmembrane-transport protein -1.52 -1.16 5.13 4.48 4.74 4.85 2.33 2.28 14.08 1.93 G SCO6279 other putative diaminobutyrate-pyruvate aminotransferas Secondary metabolism Secondary metabolism "ornithine aminotransferase, putative" 0.01 0.97 5.82 5.57 5.96 5.68 3.37 5.19 13.74 1.72 C SCO6282 other putative 3-oxoacyl-[acyl-carrier protein] reducta Secondary metabolism PKS fabG 3-oxoacyl-acyl carrier protein reductase -0.75 -1.5 6.28 6.24 6.28 6.28 6.27 17.73 -0.77 C SCO6283 other conserved hypothetical protein Secondary metabolism Secondary metabolism conserved hypothetical protein -0.38 0.27 5.11 5.02 5.28 4.99 4.21 4.96 13.9 0.58 C SCO6284 putative decarboxylase SCO6286 other putative regulatory protein Secondary metabolism Secondary metabolism BarB -0.91 -1.22 -0.51 2.2 0.9 1.43 1.14 0.94 SCO6292 other putative dihydropicolinate synthase amino acid biosynthesis Lysine "probable dihydrodipicolinate synthetase, putative" -1.27 -0.41 0.06 -0.36 -0.65 -0.92 -0.74 -1.15 2.78 0.77 G SCO6310 other putative cytochrome P450 "Energy metabolism, carbons" Electron transport "AmphN, putative" 0.82 0.59 1.4 -0.77 1.02 -0.42 0.11 -0.03 -0.37 0.09 G SCO6339 other 3-oxoadipate enol-lactone hydrolase/4-carboxymuco amino acid biosynthesis Amino Acid Biosynthesis pcaL 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase -0.68 -1.37 -1.08 -0.55 -0.98 -0.56 -1.56 -1.2 SCO6341 other putative exonuclease Macromolecule metabolism Degradation of DNA xth exodeoxyribonuclease III -0.02 -1.05 -1.03 -0.6 0.03 -0.57 0.1 -0.73 -0.01 -1.1 G SCO6445 other putative inositol monophosphatase Macromolecule metabolism Phospholipids Inositol monophosphatase family superfamily -0.82 1.34 -0.6 -0.86 -1.33 -1.01 -1.2 -1.27 1.01 1.19 D SCO6451 other putative substrate binding protein Cell process Transport/binding proteins "Bacterial extracellular solute-binding proteins, family 5 superfamily" 1.59 1.29 0.75 -0.1 0.18 0.65 -0.58 -0.59 -2.61 0.38 B SCO6454 other putative ABC transporter ATP-binding protein Cell process Transport/binding proteins oppD "peptide ABC transporter, ATP-binding protein" 0.2 -0.44 -0.46 -0.49 -0.39 -0.52 -0.67 0.16 SCO6466 other putative transferase "Energy metabolism, carbons" Aerobic respiration glycerate kinase subfamily -0.14 -1.27 -0.49 -0.41 -0.78 -0.87 -0.2 -0.16 0.15 -1.01 D SCO6468 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli "phosphatidylserine decarboxylase-related protein, putative" 2.14 1.92 1.34 1.6 1.69 0.95 0.1 1.35 -1.24 0.68 G SCO6471 other putative citratelyase Central intermediary metabolisms "Pool, multipurpose conversions of intermed. met'm" probable lyase -0.12 0.52 -0.08 1.46 0.91 0.1 -0.89 1.93 1.3 A SCO6482 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 1.13 2.05 0.86 1.6 0.58 0.49 0.53 1.08 0.66 0.66 G SCO6487 other putative aminoacylase Macromolecule metabolism "Degradation of proteins, peptides, glycoproteins" probable aminoacylase SCO6517 other uvrA-like protein Cell process Detoxification drrC daunorubicin resistance protein -1.01 -0.42 -0.9 -0.89 -0.62 -0.54 -0.78 -0.59 2.03 -0.04 A SCO6531 other putative ATP/GTP binding protein Not classified (included putative assignments) Not classified (included putative assignments) probable ATP/GTP binding protein 1.51 3.41 2.79 2.95 2.46 2.07 0.92 2.73 3.37 1.93 G SCO6551 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) probable oxidoreductase 0.9 0.84 0.26 0.49 0.63 0.13 0.25 -0.49 -0.5 0.17 G SCO6564 fabH2 3-oxoacyl-[acyl-carrier-protein] synthase II Fatty acid and phosphatidic acid biosynthesis Fatty acid and phosphatidic acid biosynth fabH 3-oxoacyl-(acyl-carrier-protein) synthase III -0.39 -1.02 -0.67 -0.79 -1.15 -1.62 -1.45 -1.69 -1.05 0.17 F SCO6593 other hypothetical protein hypothetical protein No homologues Short repeats of unknown function (DUF312) family 0.23 0.09 0.22 0.7 1.66 2.27 -0.06 0.88 SCO6606 other conserved hypothetical protein SC1F2.03c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.7 1.28 -0.2 1.67 0.87 0.3 0.03 -0.82 3.91 1.69 C SCO6621 other hypothetical protein SC1F2.18 Protein kinases Serine/threonine PQQ enzyme repeat domain protein -1.32 -1.09 -0.76 -0.56 -0.07 -0.65 -0.62 -0.3 3.23 -0.09 G SCO6627 other "hypothetical protein SC4G2.01 ""hypothetical protei" hypothetical protein No homologues -0.98 -0.63 -0.53 -1.47 -0.7 -0.71 -1.42 -0.57 1.44 0.13 G SCO6638 other hypothetical protein SC4G2.12c hypothetical protein Conserved in organism other than Escherichia coli Protein of unknown function DUF262 family -0.4 -0.06 -0.71 -0.04 -0.39 -0.09 -0.51 -0.63 1.27 0.1 D SCO6643 other hypothetical protein SC4G2.17 hypothetical protein Conserved in organism other than Escherichia coli "acetyltransferase, GNAT family family" 2.57 0.82 1.05 -0.33 0.06 1.49 0.08 0.16 -4.29 -1.01 G SCO6644 other putative solute-binding lipoprotein Cell process Transport/binding proteins "ABC transporter, periplasmic substrate-binding protein, putative" 0.28 1.96 1.64 0.9 0.53 0.21 SCO6658 6-phosphogluconate dehydrogenase SCO6659 glucose-6-phosphate isomerase SCO6660 other hypothetical protein SC5A7.10c hypothetical protein Conserved in organism other than Escherichia coli opcA opcA protein -0.05 -0.06 -0.11 -0.54 -0.52 -0.59 -0.74 -0.79 -0.06 0.15 G SCO6661 zwf glucose-6-phosphate 1-dehydrogenase "Energy metabolism, carbons" "Oxidative branch, pentose pwy" zwf glucose-6-phosphate 1-dehydrogenase -0.36 -0.61 -0.47 -1.26 0.07 -0.55 -1.17 -0.32 0.54 -0.11 G SCO6662 tal1 transaldolase Central intermediary metabolisms "Non-oxidative branch, pentose pwy" tal transaldolase -0.01 -0.12 -0.54 -0.08 -0.47 -0.82 -0.56 -0.22 0.09 -0.1 A SCO6663 tktB transketolase B Central intermediary metabolisms "Non-oxidative branch, pentose pwy" tkt transketolase 0.45 -0.13 0.7 -0.37 -0.14 0.45 -1.12 0.62 -0.01 0.06 G SCO6691 other "putative phospholipase C ""putative phospholipase C" Degradation of small molecules Fatty acids -0.8 3.76 3.05 2.94 4.4 2.83 0.66 2.97 SCO6717 other putative acyl-[acyl-carrier protein] desaturase Fatty acid and phosphatidic acid biosynthesis Fatty acid biosynthesis desA1 fatty acid desaturase 1.62 0.23 -0.05 0.94 0.38 0.22 -0.5 -0.67 -2.9 0.02 G SCO6732 other putative fatty acid oxidative multifunctional enz Degradation of small molecules Fatty acids probable -1.06 -1.08 -0.19 -0.81 -0.53 0.71 -1.16 -0.9 SCO6743 other putative transcriptional accessory protein Macromolecule metabolism "RNA synthesis, modification, DNA transcript'n" S1 RNA binding domain protein 0.09 0.01 -0.38 0.48 -0.07 -0.18 -1.27 -0.14 0.28 0.63 G SCO6750 other putative IPP isomerase Secondary metabolism Secondary metabolism NUDIX domain protein -0.9 -0.57 -0.41 -1.32 -0.6 -0.69 -1.13 -0.94 1.36 0.16 G SCO6753 other putative nucleotide sugar-1-phosphate transferase Secondary metabolism Secondary metabolism Nucleotidyl transferase superfamily 1.7 -0.28 0.27 -0.04 -0.71 -0.54 -1.24 -0.76 -4.59 -0.22 G SCO6800 kbl 2-amino-3-ketobutyrate coenzyme A ligase Degradation of small molecules Amino acids "aminotransferase, classes I and II family" -0.72 -1.42 -1.46 -1.71 -1.66 -2.23 -0.71 -0.97 -0.34 F SCO6832 mutA methylmalonyll-CoA mutase Degradation of small molecules Fatty acids mcmA1 "methylmalonyl-CoA mutase, subunit alpha, N-terminus" -1.65 -1.48 -1.87 -1.26 -1.14 -0.73 -1.94 -1.28 SCO6953 other conserved hypothetical protein SC6F7.06c hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.03 0.29 -0.09 1.31 -0.51 -0.1 3.45 0.15 SCO6960 other hypothetical protein SC6F7.13c. hypothetical protein No homologues conserved hypothetical protein -0.27 -0.76 -0.24 -0.37 -0.25 -0.4 -0.57 0.11 1.05 -0.37 G SCO6979 other probable solute-binding lipoprotein. Cell process Transport/binding proteins D-RIBOSE-BINDING PERIPLASMIC PROTEIN PRECURSOR -0.12 -0.38 1.57 1.57 0.78 0.44 SCO6981 other "probable ABC transport protein, ATP-binding compo" Cell process Transport/binding proteins SUGAR TRANSPORT ATP-BINDING PROTEIN -0.92 -0.64 -0.15 -0.87 0.19 0.67 -1.14 -1.1 SCO6988 other putative oxidoreductase. Not classified (included putative assignments) Not classified (included putative assignments) "oxidoreductase, Gfo/Idh/MocA family, putative" -0.71 -0.63 -1.41 -0.74 -0.59 0.45 -0.64 SCO6990 other putative membrane transport protein. Cell process Transport/binding proteins yocS bile acid transporter family protein -1.34 -1.36 -1.19 -1.56 -1.57 -0.55 -0.84 SCO7000 idh isocitrate dehydrogenase Central intermediary metabolisms Glyoxylate bypass "isocitrate dehydrogenase, NADP-dependent" 2.06 1.28 1.28 0.72 -0.16 0.1 -0.72 -0.74 -3.89 0.75 E SCO7013 other putative sugar-binding lipoprotein. Cell process Transport/binding proteins sugar binding lipoprotein precursor -1.27 -1.17 -0.34 0.01 0.27 1.61 3.47 3.8 8.14 -3.48 G SCO7036 argG argininosuccinate synthase amino acid biosynthesis Arginine argG argininosuccinate synthase -0.47 -0.44 1.99 1.04 -0.14 -0.16 -0.76 -0.33 2.67 1.4 G SCO7057 other putative esterase Not classified (included putative assignments) Not classified (included putative assignments) axeA acetyl xylan esterase -0.42 0.28 -0.2 -0.29 -0.54 -0.63 -0.16 -0.72 1.28 0.18 D SCO7072 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli EC2.7.1.2 dihydroxyacetone kinase family protein -1.08 -0.83 -1.07 -0.94 -0.93 -1.57 -1.07 -1.3 1.04 0.11 G SCO7073 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli EC2.7.1.2 dihydroxyacetone kinase family protein -1.24 -0.82 -0.76 -0.56 -1.44 -0.92 -2.01 -1.33 1.33 0.85 G SCO7102 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.54 -0.8 -1.6 -1.02 -1.14 -1.58 -1.39 -1.25 -0.75 -0.2 F SCO7153 putative sugar transporter SCO7154 ilvC2 ketol-acid reductoisomerase amino acid biosynthesis Valine ilvC ketol-acid reductoisomerase 0.28 0.1 -0.8 0 0.7 0.41 1.03 -0.69 0.87 -0.88 G SCO7271 other putative ion channel subunit Cell process Cations probable ion channel subunit -0.76 -0.65 -1.19 -0.94 -1.11 -1.12 -1.41 -0.97 0.33 0.05 A SCO7286 other putative oxidoreducatse Not classified (included putative assignments) Not classified (included putative assignments) "oxidoreductase, aldo/keto reductase family superfamily" 0.33 0.38 -1.07 -0.28 -0.3 -0.71 0.79 -0.75 -0.42 -0.92 G SCO7296 other hypothetical protein SC5F8.06c. hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -0.37 -0.24 -0.19 -0.11 -0.46 -0.29 -0.43 0.61 SCO7301 other conserved hypothetical protein SC5F8.11c. hypothetical protein Conserved in organism other than Escherichia coli metallo-beta-lactamase superfamily protein -0.49 -0.52 -0.54 -0.36 -0.45 -0.76 -0.85 -0.38 SCO7324 other putative regulatory protein RNA polymerase core enzyme binding anti sigma factor rsbR sigma-B regulator RsbR 0.12 -0.32 -0.38 -0.1 0.53 -0.05 0.35 -0.13 0.96 -0.64 G SCO7325 other anti-sigma factor antagonist. RNA polymerase core enzyme binding anti sigma factor antagonist "anti-sigma F factor antagonist, putative" -0.49 -0.4 -0.35 0.06 -0.74 -0.83 -0.69 -0.91 0.92 0.31 D SCO7404 other conserved hypothetical protein SC10G8.32c. hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein -1.43 -1.38 -0.33 -1.74 -0.5 -0.11 -1.71 0.6 3.15 -0.2 C SCO7417 other putative cytochrome P450-family protein. "Energy metabolism, carbons" Electron transport "P450 heme-thiolate protein, putative" -0.26 -0.21 -0.69 -0.8 -1.19 -1.23 0.91 -1.15 0.2 -1.12 D SCO7443 pgm phosphoglucomutase. Degradation of small molecules Carbon compounds pgm "phosphoglucomutase, alpha-D-glucose phosphate-specific" -0.86 -0.25 -0.45 -0.72 -0.2 -0.54 -0.19 -1.28 2.02 0.12 G SCO7460 other putative lipoprotein. Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein conserved hypothetical protein -1.35 -1.21 -0.32 0.1 -0.03 0.34 -0.29 -0.5 SCO7463 cvnA13 putative sensor histidine kinase Two-component system Sensor kinase "SEQ ID NO 21D, putative" 0.85 0.93 -0.13 0.08 -0.64 -0.59 -0.81 -0.84 -2.08 0.47 B SCO7468 other "putative flavin-binding monooxygenase ""putative mo" Not classified (included putative assignments) Not classified (included putative assignments) -0.76 -0.88 -1.24 -1.04 -0.79 -0.09 SCO7481 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli tellurium resistance protein TerB (terB) putative 0.5 1.6 0.46 0.52 1.15 0.69 -0.15 1.25 1.8 0.67 G SCO7510 cypH peptidyl-prolyl cis-trans isomerase Macromolecule metabolism Proteins - translation and modification AA1-162 peptidyl-prolyl cis-trans isomerase 3.09 2.59 2.22 2.51 1.08 1.32 0.14 -0.17 -3.71 1.4 E SCO7516 htpG heat shock protein Cell process Chaperones htpG heat shock protein 0.27 1.03 0.53 -0.52 0.62 0.27 -0.03 0.36 1.19 0.2 G SCO7536 other putative integral membrane protein. Periplasmic/exported/lipoproteins Gram +ve membrane "MmpL efflux pump, putative" -0.01 -0.54 2.11 2.38 2.65 3.43 4.66 2.61 8.36 -2.1 C SCO7588 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) probable dyhydroflavanol-4-reductase -0.95 -1.17 -1.01 -1.88 -1.33 -1.48 -1.63 -1.56 -0.16 -0.15 G SCO7613 other putative integral membrane protein Periplasmic/exported/lipoproteins Gram +ve membrane putative integral membrane protein -0.5 -0.75 -0.2 -0.07 0.49 0.05 -0.36 -0.39 SCO7617 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli conserved hypothetical protein 0.26 1.85 0.73 0.82 1.76 0.67 0.11 -0.54 2.22 1.55 G SCO7631 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein putative secreted protein -0.77 3.2 2.11 1.59 2.07 0.88 -0.55 -0.2 5.92 3.83 G SCO7632 other conserved hypothetical protein hypothetical protein Conserved in organism other than Escherichia coli lmbE lmbE protein 0.4 -0.03 -0.46 -0.08 -0.25 -0.34 1.62 -0.61 SCO7638 eno2 enolase "Energy metabolism, carbons" Glycolysis eno enolase -0.65 -1.1 -0.92 -0.77 -1.35 -1.09 -0.95 -0.82 0.3 -0.45 A SCO7654 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) aldo/keto reductase -2.04 -1.61 -1.29 -1.73 -1.74 -0.8 -1.71 -0.76 2.98 -0.2 G SCO7655 other putative oxidoreductase Not classified (included putative assignments) Not classified (included putative assignments) "oxidoreductase, aldo/keto reductase 2 family" -0.18 -0.31 -0.85 -0.85 -0.92 -0.46 -1.02 SCO7657 other putative secreted protein Periplasmic/exported/lipoproteins Gram +ve exported/lipoprotein putative secreted protein -0.05 0.55 1.86 3.43 3.1 4.21 3.28 2.86