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Ørjan Samuelsen, Søren Overballe-Petersen, Jørgen Vildershøj Bjørnholt, Sylvain Brisse, Michel Doumith, Neil Woodford, Katie L. Hopkins, Bettina Aasnæs, Bjørg Haldorsen, Arnfinn Sundsfjord, on behalf of The Norwegian Study Group on CPE
Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014
www.plosone.org
www.plosone.org
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(Achaogen)Tj
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(UK)Tj
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1.9559 0.0283 Td
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(\(reference)Tj
4.2576 0 Td
(no.)Tj
1.4967 0 Td
(2017/146/REK)Tj
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(nord\))Tj
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q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 601.4551 cm
BT
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1 TL
-0.0033 Tc
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(Results)Tj
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0 -1.4976 Td
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Q
q
1 j
1 J
0 w
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BT
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1 TL
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(total)Tj
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(general)Tj
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(or)Tj
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(in)Tj
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(institutions)Tj
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(elderly)Tj
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(homes\).)Tj
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(one)Tj
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(no)Tj
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(obtained.)Tj
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(multiple)Tj
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(isolates)Tj
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(belonging)Tj
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(species)Tj
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(or)Tj
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(patient)Tj
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(four)Tj
/F13 1 Tf
1.9105 0 Td
[()10()4()]TJ
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Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
-0.0053 Tc
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(NDM-1)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-positive)Tj
3.668 0 Td
(strains)Tj
2.8573 0 Td
(of)Tj
1.0148 0 Td
(different)Tj
3.6566 0 Td
(species)Tj
2.9991 0 Td
(\()Tj
/F13 1 Tf
[()2()20()12()11()2(\n)-4()]TJ
3.4809 0 Td
[()18()12()20()22()11()4()12()-4()]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
3.9118 0 Td
[()2()20()12()-13()4()4()2( )6()1()4()]TJ
4.8359 0 Td
[()9()7(\n)4()16()-19()7()12()]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
3.2824 0 Td
[()13()14()7()20()]TJ
-35.2059 -1.3039 Td
[()4()6()-4()11()2()]TJ
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2.6022 0 Td
(sp.)Tj
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(and)Tj
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1.729 0 Td
[()]TJ
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(.)Tj
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1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
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(isolated)Tj
3.2882 0 Td
(within)Tj
2.8119 0 Td
(a)Tj
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(period.)Tj
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3.5773 0 Td
(had)Tj
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1.7121 0 Td
[()10()4()]TJ
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Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(KPC-2)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
-0.004 Tc
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(-pos-)Tj
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(itive)Tj
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1.9275 0 Td
[()]TJ
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(.)Tj
/F13 1 Tf
1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
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5.0627 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[(\r)16( )22()11()2()20()13()4()6()-4()11()2()]TJ
5.1987 0 Td
[()13()4()4()6()7()6()]TJ
/F8 1 Tf
3.0274 0 Td
(complex)Tj
3.6226 0 Td
(isolates)Tj
3.1181 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
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(same)Tj
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(faecal)Tj
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(screening)Tj
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(sample.)Tj
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(A)Tj
0.9015 0 Td
(third)Tj
2.211 0 Td
(had)Tj
/F13 1 Tf
1.7121 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(NDM-1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 316.5732 475.4834 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-positive)Tj
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3.668 0 Td
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7()10()12()]TJ
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(and)Tj
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1.7348 0 Td
[(\r)]TJ
/F8 1 Tf
(.)Tj
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0.9921 0 Td
[()13()4()4()6()7()6()]TJ
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3.0274 0 Td
(complex)Tj
3.6227 0 Td
(isolates)Tj
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(identified)Tj
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(in)Tj
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(specimens)Tj
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(\(wound)Tj
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(secretion)Tj
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(and)Tj
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(urine,)Tj
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(respectively\))Tj
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(yielded)Tj
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(two)Tj
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1.712 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 335.2818 447.8173 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(NDM-1)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-positive)Tj
/F13 1 Tf
3.668 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
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5.0569 0 Td
(strains)Tj
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(with)Tj
1.9956 0 Td
(unrelated)Tj
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(STs)Tj
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(21)Tj
1.1679 0 Td
(months)Tj
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(apart.)Tj
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Q
q
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1 J
0 w
11.9999 0 0 11.9999 200.0125 400.8755 cm
BT
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1 TL
-0.0033 Tc
0 0 Td
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4.7764 0 Td
(number)Tj
3.5716 0 Td
(of)Tj
1.0441 0 Td
(CPE)Tj
2.2631 0 Td
(identified)Tj
4.1622 0 Td
(during)Tj
2.9575 0 Td
(the)Tj
1.5921 0 Td
(study)Tj
2.589 0 Td
(period)Tj
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(a)Tj
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(high)Tj
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(proportion)Tj
4.663 0 Td
(of)Tj
1.0441 0 Td
(clinical)Tj
3.1701 0 Td
(isolates)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 369.8645 cm
BT
/F8 1 Tf
1 TL
-0.01 Tc
0 0 Td
(CPE)Tj
1.9899 0 Td
(isolates)Tj
3.067 0 Td
(were)Tj
2.0977 0 Td
(identified)Tj
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(in)Tj
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(14)Tj
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(22)Tj
1.1566 0 Td
(clinical)Tj
3.0273 0 Td
(microbiology)Tj
5.4879 0 Td
(laboratories)Tj
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(representing)Tj
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(all)Tj
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(health)Tj
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(regions)Tj
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(in)Tj
1.0262 0 Td
(Norway.)Tj
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(The)Tj
1.7688 0 Td
(number)Tj
3.3789 0 Td
(of)Tj
1.0035 0 Td
(CPE)Tj
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(cases)Tj
2.194 0 Td
(per)Tj
1.5137 0 Td
(year,)Tj
2.0977 0 Td
(diversity)Tj
3.5886 0 Td
(of)Tj
1.0034 0 Td
(carbapenemase)Tj
6.2646 0 Td
(variants)Tj
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(and)Tj
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(species)Tj
2.9536 0 Td
(increased)Tj
3.9458 0 Td
(during)Tj
2.8914 0 Td
(the)Tj
1.4513 0 Td
(study)Tj
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(period)Tj
2.8006 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7439 0 Td
(1)Tj
0 g
(\),)Tj
1.2473 0 Td
(but)Tj
1.5307 0 Td
(with)Tj
1.9729 0 Td
(a)Tj
0.6519 0 Td
(trend)Tj
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(towards)Tj
3.3619 0 Td
(dominance)Tj
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(of)Tj
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(NDM)Tj
2.5568 0 Td
(and)Tj
1.7008 0 Td
(OXA-48-like)Tj
5.3121 0 Td
(carbapenemase)Tj
6.2531 0 Td
(variants)Tj
3.3336 0 Td
(and)Tj
1.7007 0 Td
(increasing)Tj
4.2577 0 Td
(number)Tj
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(of)Tj
0.9921 0 Td
(carbapenemase-pro-)Tj
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(ducing)Tj
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2.9423 0 Td
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[()7()10()12()]TJ
/F8 1 Tf
(.)Tj
1.7574 0 Td
(Fifty-six)Tj
3.447 0 Td
(percent)Tj
3.1804 0 Td
(of)Tj
1.0035 0 Td
(the)Tj
1.4513 0 Td
(patients)Tj
3.3222 0 Td
(were)Tj
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(male.)Tj
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1.7631 0 Td
(patient)Tj
2.9651 0 Td
(age)Tj
1.525 0 Td
(ranged)Tj
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(from)Tj
2.1826 0 Td
(396)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 289.7524 m
576 289.7524 l
576 289.2523 l
36 289.2523 l
f*
74.3873 289.2523 m
74.3873 267.2524 l
73.8873 267.2524 l
73.8873 289.2523 l
f*
73.8873 267.2524 m
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36 267.7524 l
73.8873 267.7524 l
f*
118.9009 289.2523 m
118.9009 267.2524 l
118.4009 267.2524 l
118.4009 289.2523 l
f*
118.4009 267.2524 m
74.3873 267.2524 l
74.3873 267.7524 l
118.4009 267.7524 l
f*
159.0817 289.2523 m
159.0817 267.2524 l
158.5817 267.2524 l
158.5817 289.2523 l
f*
158.5817 267.2524 m
118.9009 267.2524 l
118.9009 267.7524 l
158.5817 267.7524 l
f*
349.5569 289.2523 m
349.5569 267.2524 l
349.0569 267.2524 l
349.0569 289.2523 l
f*
349.0569 267.2524 m
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159.0817 267.7524 l
349.0569 267.7524 l
f*
484.0744 289.2523 m
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483.5744 267.2524 l
483.5744 289.2523 l
f*
483.5744 267.2524 m
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349.5569 267.7524 l
483.5744 267.7524 l
f*
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484.0744 267.2524 l
484.0744 267.7524 l
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f*
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74.3873 254.7524 l
73.8873 254.7524 l
73.8873 267.2524 l
f*
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36 255.2525 l
73.8873 255.2525 l
f*
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118.4009 254.7524 l
118.4009 267.2524 l
f*
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74.3873 255.2525 l
118.4009 255.2525 l
f*
159.0817 267.2524 m
159.0817 254.7524 l
158.5817 254.7524 l
158.5817 267.2524 l
f*
158.5817 254.7524 m
118.9009 254.7524 l
118.9009 255.2525 l
158.5817 255.2525 l
f*
349.5569 267.2524 m
349.5569 254.7524 l
349.0569 254.7524 l
349.0569 267.2524 l
f*
349.0569 254.7524 m
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349.0569 255.2525 l
f*
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483.5744 254.7524 l
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f*
483.5744 254.7524 m
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349.5569 255.2525 l
483.5744 255.2525 l
f*
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f*
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73.8873 242.2525 l
73.8873 254.7524 l
f*
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73.8873 242.7525 l
f*
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118.9009 242.2525 l
118.4009 242.2525 l
118.4009 254.7524 l
f*
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118.4009 242.7525 l
f*
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159.0817 242.2525 l
158.5817 242.2525 l
158.5817 254.7524 l
f*
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f*
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349.0569 254.7524 l
f*
349.0569 242.2525 m
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f*
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f*
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349.5569 242.7525 l
483.5744 242.7525 l
f*
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484.0744 242.2525 l
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f*
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73.8873 229.7526 l
73.8873 242.2525 l
f*
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f*
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118.9009 229.7526 l
118.4009 229.7526 l
118.4009 242.2525 l
f*
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f*
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158.5817 229.7526 l
158.5817 242.2525 l
f*
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118.9009 229.7526 l
118.9009 230.2526 l
158.5817 230.2526 l
f*
349.5569 242.2525 m
349.5569 229.7526 l
349.0569 229.7526 l
349.0569 242.2525 l
f*
349.0569 229.7526 m
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159.0817 230.2526 l
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f*
484.0744 242.2525 m
484.0744 229.7526 l
483.5744 229.7526 l
483.5744 242.2525 l
f*
483.5744 229.7526 m
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483.5744 230.2526 l
f*
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484.0744 229.7526 l
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f*
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73.8873 217.2526 l
73.8873 229.7526 l
f*
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f*
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f*
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f*
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f*
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f*
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349.0569 217.2526 l
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f*
349.0569 217.2526 m
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159.0817 217.7527 l
349.0569 217.7527 l
f*
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484.0744 217.2526 l
483.5744 217.2526 l
483.5744 229.7526 l
f*
483.5744 217.2526 m
349.5569 217.2526 l
349.5569 217.7527 l
483.5744 217.7527 l
f*
576 217.2526 m
484.0744 217.2526 l
484.0744 217.7527 l
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f*
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74.3873 204.7527 l
73.8873 204.7527 l
73.8873 217.2526 l
f*
73.8873 204.7527 m
36 204.7527 l
36 205.2527 l
73.8873 205.2527 l
f*
118.9009 217.2526 m
118.9009 204.7527 l
118.4009 204.7527 l
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(\(mean)Tj
2.7553 0 Td
(63)Tj
1.1622 0 Td
(and)Tj
1.7121 0 Td
(median)Tj
3.2031 0 Td
(66)Tj
1.1566 0 Td
(years\).)Tj
2.7892 0 Td
(The)Tj
1.7632 0 Td
(majority)Tj
3.5829 0 Td
(of)Tj
1.0035 0 Td
(CPE)Tj
1.9956 0 Td
(were)Tj
2.0976 0 Td
(isolated)Tj
3.2372 0 Td
(from)Tj
2.1826 0 Td
(urine)Tj
2.3244 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0772 0 Td
(=)Tj
0.7937 0 Td
(22,)Tj
-35.07 -1.3039 Td
(37%\),)Tj
2.4604 0 Td
(blood)Tj
2.4888 0 Td
(culture)Tj
2.9934 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0771 0 Td
(=)Tj
0.7937 0 Td
(9,)Tj
0.9071 0 Td
(15%\))Tj
2.245 0 Td
(and)Tj
1.7122 0 Td
(faecal)Tj
2.4377 0 Td
(screening)Tj
3.9969 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0771 0 Td
(=)Tj
0.7937 0 Td
(9,)Tj
0.9071 0 Td
(15%\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 668.2393 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Association)Tj
5.2724 0 Td
(with)Tj
1.9749 0 Td
(travel)Tj
2.6362 0 Td
(or)Tj
1.0961 0 Td
(hospitalization)Tj
6.4677 0 Td
(abroad)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 651.2881 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Thirty-three)Tj
5.142 0 Td
(patients)Tj
3.3675 0 Td
(\(62%\))Tj
2.6135 0 Td
(had)Tj
1.7065 0 Td
(a)Tj
0.6519 0 Td
(known)Tj
3.0047 0 Td
(history)Tj
3.0104 0 Td
(of)Tj
1.0148 0 Td
(travel)Tj
2.4491 0 Td
(and/or)Tj
2.9367 0 Td
(hospitalization)Tj
6.1115 0 Td
(abroad)Tj
-32.0086 -1.3039 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7779 0 Td
(2)Tj
0 g
(\).)Tj
1.2642 0 Td
(Sixteen)Tj
3.1238 0 Td
(patients)Tj
3.3675 0 Td
(\(30%\))Tj
2.6079 0 Td
(reported)Tj
3.6567 0 Td
(no)Tj
1.2755 0 Td
(travel)Tj
2.4492 0 Td
(or)Tj
1.0998 0 Td
(hospitalization)Tj
6.1114 0 Td
(abroad)Tj
3.0048 0 Td
(and)Tj
1.7291 0 Td
(for)Tj
1.3833 0 Td
(four)Tj
-33.8511 -1.2982 Td
(patients)Tj
3.3675 0 Td
(\(8%\),)Tj
2.3584 0 Td
(no)Tj
1.2756 0 Td
(information)Tj
5.074 0 Td
(was)Tj
1.7007 0 Td
(obtained.)Tj
3.9572 0 Td
(With)Tj
2.279 0 Td
(respect)Tj
3.0387 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(non-direct)Tj
4.4844 0 Td
(import)Tj
3.0047 0 Td
(cases,)Tj
-33.0347 -1.2983 Td
(eight)Tj
2.1996 0 Td
(cases)Tj
2.2224 0 Td
(were)Tj
2.1259 0 Td
(associated)Tj
4.252 0 Td
(with)Tj
2.0012 0 Td
(secondary)Tj
4.269 0 Td
(spread)Tj
2.8573 0 Td
(from)Tj
2.2053 0 Td
(imported)Tj
3.9515 0 Td
(cases.)Tj
2.4491 0 Td
(This)Tj
1.9843 0 Td
(included)Tj
3.7133 0 Td
(six)Tj
1.3153 0 Td
(cases)Tj
-35.5462 -1.3039 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(a)Tj
0.652 0 Td
(previously)Tj
4.354 0 Td
(described,)Tj
4.2746 0 Td
(small)Tj
2.3301 0 Td
(but)Tj
1.5534 0 Td
(long-term)Tj
4.2462 0 Td
(outbreak)Tj
3.7871 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 496.6299 597.6 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(KPC-2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 516.9826 599.244 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-positive)Tj
/F13 1 Tf
3.668 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
-35.3648 -1.2982 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
(/)Tj
/F13 1 Tf
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
6.1625 0 Td
[()13()4()4()6()7()6()]TJ
/F8 1 Tf
3.0274 0 Td
(complex)Tj
3.6227 0 Td
(in)Tj
1.0374 0 Td
(20072010)Tj
4.5411 0 Td
([)Tj
0.83 0.64 0.02 0 k
(50)Tj
0 g
(].)Tj
2.075 0 Td
(In)Tj
1.1111 0 Td
(addition,)Tj
3.8211 0 Td
(two)Tj
1.7121 0 Td
(other)Tj
2.3471 0 Td
(intra-hospital)Tj
5.6465 0 Td
(trans-)Tj
-35.104 -1.2983 Td
(missions)Tj
3.7134 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 259.2566 571.5779 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(KPC-2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 279.6094 573.2787 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-positive)Tj
/F13 1 Tf
3.668 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
5.0569 0 Td
([)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(])Tj
1.8539 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 425.537 571.5779 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(VIM-27)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 449.6881 573.2787 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-positive)Tj
/F13 1 Tf
3.668 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
5.0569 0 Td
(were)Tj
-34.7808 -1.3039 Td
(observed)Tj
3.7928 0 Td
(involving)Tj
3.9798 0 Td
(one)Tj
1.7008 0 Td
(additional)Tj
4.2746 0 Td
(patient)Tj
3.0104 0 Td
(in)Tj
1.0374 0 Td
(each)Tj
2.024 0 Td
(case.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 534.1606 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Bacterial)Tj
4.0582 0 Td
(species)Tj
3.5717 0 Td
(and)Tj
1.8662 0 Td
(carbapenemas)Tj
6.5339 0 Td
(e)Tj
0.7701 0 Td
(diversity)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 517.1527 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Overall)Tj
/F13 1 Tf
3.1407 0 Td
[()4()4()20()7()10()4()15()4()4()]TJ
/F8 1 Tf
3.9118 0 Td
(spp.)Tj
1.8425 0 Td
(\()Tj
/F13 1 Tf
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.4287 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
5.2837 0 Td
[( )]TJ
/F8 1 Tf
0.7484 0 Td
(=)Tj
0.7993 0 Td
(36;)Tj
/F13 1 Tf
1.3947 0 Td
[()4()4()20()7()10()4()15()4()4()]TJ
3.9174 0 Td
[()3()16()-9()12()4()7()10()4()]TJ
3.5886 0 Td
[( )]TJ
/F8 1 Tf
0.7484 0 Td
(=)Tj
0.7994 0 Td
(1;)Tj
/F13 1 Tf
0.924 0 Td
[()4()4()20()7()10()4()15()4()4()]TJ
3.9118 0 Td
[()14(\n)4()10()10()11( )6()2(\n)]TJ
-32.4394 -1.3039 Td
[()6()11( )18()4()6()]TJ
3.135 0 Td
[( )]TJ
/F8 1 Tf
0.7484 0 Td
(=)Tj
0.7994 0 Td
(1\))Tj
1.0374 0 Td
(were)Tj
2.1203 0 Td
(dominant,)Tj
4.3994 0 Td
(followed)Tj
3.6453 0 Td
(by)Tj
/F13 1 Tf
1.1849 0 Td
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7()10()12()]TJ
/F8 1 Tf
1.559 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(14\),)Tj
/F13 1 Tf
1.7348 0 Td
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()13()4()4()6()7()6()]TJ
/F8 1 Tf
3.0274 0 Td
(complex)Tj
3.6226 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(4\))Tj
1.0318 0 Td
(and)Tj
1.7348 0 Td
(sin-)Tj
-35.5462 -1.2982 Td
(gle)Tj
1.3549 0 Td
(isolates)Tj
3.1181 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()9()7(\n)4()16()-19()7()12()]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
3.2825 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()18()12()20()22()11()4()12()-4()]TJ
/F8 1 Tf
3.685 0 Td
(and)Tj
/F13 1 Tf
1.7348 0 Td
[()13()14()7()20()13()4()6()-4()11()2()]TJ
/F8 1 Tf
4.6148 0 Td
(sp.)Tj
1.3266 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.778 0 Td
(1)Tj
0 g
0.6973 0 Td
(and)Tj
0.83 0.64 0.02 0 k
1.7291 0 Td
(S1)Tj
1.1735 0 Td
(Table)Tj
0 g
(\).)Tj
3.0047 0 Td
(The)Tj
1.7858 0 Td
(most)Tj
-33.2841 -1.2983 Td
(dominant)Tj
4.1669 0 Td
(carbapenemase)Tj
6.3438 0 Td
(gene)Tj
2.0807 0 Td
(family)Tj
2.7269 0 Td
(was)Tj
/F13 1 Tf
1.7008 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 382.1669 476.4472 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(KPC)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 396.3968 478.148 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4422 0 Td
(found)Tj
2.6191 0 Td
(in)Tj
/F13 1 Tf
1.0375 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
5.057 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(18\))Tj
1.5136 0 Td
(and)Tj
/F13 1 Tf
1.7292 0 Td
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()13()4()]TJ
-36.0054 -1.3039 Td
[()6()7()6()]TJ
/F8 1 Tf
1.9559 0 Td
(complex)Tj
3.6227 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(2\),)Tj
1.2585 0 Td
(followed)Tj
3.651 0 Td
(by)Tj
/F13 1 Tf
1.1792 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 347.5275 463.4645 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(NDM)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 367.4834 465.1086 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(identified)Tj
4.0591 0 Td
(in)Tj
/F13 1 Tf
1.0318 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
5.0627 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0828 0 Td
(=)Tj
0.805 0 Td
(8\),)Tj
/F13 1 Tf
1.2586 0 Td
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7()10()12()]TJ
/F8 1 Tf
1.5591 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7993 0 Td
(6\),)Tj
/F13 1 Tf
-35.5744 -1.2982 Td
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()13()4()4()6()7()6()]TJ
/F8 1 Tf
3.0274 0 Td
(complex)Tj
3.6226 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(1\),)Tj
/F13 1 Tf
1.2642 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9922 0 Td
[()9()7(\n)4()16()-19()7()12()]TJ
/F8 1 Tf
3.0557 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7993 0 Td
(1\),)Tj
/F13 1 Tf
1.2585 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()18()12()20()22()11()4()12()-4()]TJ
/F8 1 Tf
3.685 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(1\))Tj
1.0375 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()13()14()7()20()13()4()6()-4()11()2()]TJ
/F8 1 Tf
4.6148 0 Td
(sp.)Tj
1.3266 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7993 0 Td
(1\).)Tj
/F13 1 Tf
-35.1549 -1.2983 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 211.9748 437.4425 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(VIM)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 228.5858 439.1433 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(was)Tj
1.7007 0 Td
(identified)Tj
4.0592 0 Td
(in)Tj
/F13 1 Tf
1.0375 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0828 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
5.0627 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7993 0 Td
(4\),)Tj
/F13 1 Tf
1.2586 0 Td
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[()7()10()12()]TJ
/F8 1 Tf
1.559 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(2\))Tj
1.0318 0 Td
(and)Tj
/F13 1 Tf
1.7348 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0828 0 Td
[()14(\n)4()10()10()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
7.1489 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(1\))Tj
-36.2775 -1.2982 Td
(while)Tj
/F13 1 Tf
2.3698 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 235.6724 424.4598 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(OXA-48-like)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 276.548 426.1606 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(was)Tj
1.6951 0 Td
(identified)Tj
4.0591 0 Td
(in)Tj
/F13 1 Tf
1.0375 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
5.057 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(5\),)Tj
/F13 1 Tf
1.2642 0 Td
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7()10()12()]TJ
/F8 1 Tf
1.5591 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7993 0 Td
(5\))Tj
1.0375 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0885 0 Td
[()3()16()-9()12()4()7()10()4()]TJ
/F8 1 Tf
-32.0368 -1.3039 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7993 0 Td
(1\).)Tj
1.2586 0 Td
(In)Tj
1.1112 0 Td
(addition,)Tj
3.8209 0 Td
(we)Tj
1.3266 0 Td
(identified)Tj
4.0592 0 Td
(one)Tj
/F13 1 Tf
1.7008 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
5.057 0 Td
(isolate)Tj
2.7552 0 Td
(harbouring)Tj
4.7509 0 Td
(both)Tj
/F13 1 Tf
2.0579 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 520.7244 411.4771 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(NDM)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 540.6236 413.1212 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
/F13 1 Tf
-34.0608 -1.2982 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 211.9748 398.4944 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(OXA-48-like)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 252.8503 400.1385 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7291 0 Td
(single)Tj
2.5285 0 Td
(isolates)Tj
3.1181 0 Td
(with)Tj
/F13 1 Tf
2.0012 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 358.5826 398.4944 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(IMI)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 372.5291 400.1385 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\()Tj
/F13 1 Tf
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.3379 0 Td
[()13()4()4()6()7()6()]TJ
/F8 1 Tf
3.0274 0 Td
(complex\))Tj
3.9628 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 485.0645 398.4944 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(IMP)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 500.6551 400.1385 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\()Tj
/F13 1 Tf
[(\r)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.3379 0 Td
[()7()10()12()]TJ
/F8 1 Tf
(\).)Tj
2.126 0 Td
(With)Tj
-33.5279 -1.2982 Td
(respect)Tj
3.0387 0 Td
(to)Tj
1.0261 0 Td
(KPC,)Tj
2.3414 0 Td
(KPC-2)Tj
2.9424 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0828 0 Td
(=)Tj
0.8051 0 Td
(18\))Tj
1.508 0 Td
(was)Tj
1.7008 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2053 0 Td
(predominant)Tj
5.4822 0 Td
(allele)Tj
2.2394 0 Td
(with)Tj
2.0012 0 Td
(the)Tj
1.4683 0 Td
(closest)Tj
2.8402 0 Td
(KPC-3)Tj
-32.1502 -1.3039 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7993 0 Td
(2\))Tj
1.0319 0 Td
(variant)Tj
3.033 0 Td
(detected)Tj
3.566 0 Td
(in)Tj
1.0318 0 Td
(only)Tj
1.9785 0 Td
(two)Tj
1.7065 0 Td
(isolates.)Tj
3.3448 0 Td
(The)Tj
1.7859 0 Td
(remaining)Tj
4.3596 0 Td
(carbapenemase)Tj
6.3438 0 Td
(genes)Tj
2.4435 0 Td
(encoded)Tj
-32.5131 -1.2983 Td
(three)Tj
2.262 0 Td
(different)Tj
3.6567 0 Td
(variants)Tj
3.3902 0 Td
(of)Tj
1.0148 0 Td
(NDM)Tj
2.5852 0 Td
(\(NDM-1,)Tj
/F13 1 Tf
3.9741 0 Td
[( )]TJ
/F8 1 Tf
0.7484 0 Td
(=)Tj
0.7993 0 Td
(16;)Tj
1.4003 0 Td
(NDM-7,)Tj
/F13 1 Tf
3.634 0 Td
[( )]TJ
/F8 1 Tf
0.7484 0 Td
(=)Tj
0.7993 0 Td
(2;)Tj
0.9241 0 Td
(and)Tj
1.7292 0 Td
(NDM-5,)Tj
/F13 1 Tf
3.6338 0 Td
[( )]TJ
/F8 1 Tf
0.7484 0 Td
(=)Tj
0.7994 0 Td
(1\),)Tj
1.2642 0 Td
(four)Tj
-34.1118 -1.2983 Td
(OXA-48-like)Tj
5.3858 0 Td
(\(OXA-48,)Tj
/F13 1 Tf
4.1726 0 Td
[( )]TJ
/F8 1 Tf
0.7483 0 Td
(=)Tj
0.7994 0 Td
(7;)Tj
0.924 0 Td
(OXA-181,)Tj
/F13 1 Tf
4.303 0 Td
[( )]TJ
/F8 1 Tf
0.7484 0 Td
(=)Tj
0.7993 0 Td
(2;)Tj
0.9241 0 Td
(OXA-245,)Tj
/F13 1 Tf
4.303 0 Td
[( )]TJ
/F8 1 Tf
0.7483 0 Td
(=)Tj
0.7994 0 Td
(2)Tj
0.6973 0 Td
(and)Tj
1.7291 0 Td
(OXA-162,)Tj
/F13 1 Tf
4.3086 0 Td
[( )]TJ
/F8 1 Tf
0.7483 0 Td
(=)Tj
0.7994 0 Td
(1\))Tj
1.0318 0 Td
(and)Tj
1.7348 0 Td
(four)Tj
-35.7049 -1.3039 Td
(VIM)Tj
2.1486 0 Td
(\(VIM-1,)Tj
/F13 1 Tf
3.5377 0 Td
[( )]TJ
/F8 1 Tf
0.7483 0 Td
(=)Tj
0.7994 0 Td
(3;)Tj
0.9184 0 Td
(VIM-27,)Tj
/F13 1 Tf
3.6737 0 Td
[( )]TJ
/F8 1 Tf
0.7483 0 Td
(=)Tj
0.7994 0 Td
(2;)Tj
0.9241 0 Td
(VIM-4,)Tj
/F13 1 Tf
3.1974 0 Td
[( )]TJ
/F8 1 Tf
0.7484 0 Td
(=)Tj
0.7993 0 Td
(1;)Tj
0.9184 0 Td
(and)Tj
1.7348 0 Td
(VIM-29,)Tj
/F13 1 Tf
3.6737 0 Td
[( )]TJ
/F8 1 Tf
0.7483 0 Td
(=)Tj
0.7994 0 Td
(1\).)Tj
1.2586 0 Td
(The)Tj
1.7858 0 Td
(single)Tj
2.5284 0 Td
(isolates)Tj
3.1181 0 Td
(with)Tj
/F13 1 Tf
-35.6085 -1.2982 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 211.9748 320.485 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(IMI)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 225.9212 322.1291 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
/F13 1 Tf
1.7347 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 255.2314 320.485 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(IMP)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 270.822 322.1291 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(encoded)Tj
3.5999 0 Td
(IMI-9)Tj
2.6192 0 Td
(and)Tj
1.7348 0 Td
(IMP-26,)Tj
3.5376 0 Td
(respectively.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 295.9937 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Bacterial)Tj
4.0582 0 Td
(population)Tj
4.767 0 Td
(structure)Tj
4.0725 0 Td
(and)Tj
1.8661 0 Td
(linkage)Tj
3.3402 0 Td
(to)Tj
1.0441 0 Td
(specific)Tj
3.515 0 Td
(carbapenemase)Tj
-22.6631 -1.1669 Td
(alleles)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 264.9826 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(MLST)Tj
2.7382 0 Td
(and)Tj
1.7291 0 Td
(cgMLST)Tj
3.6283 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8199 0 Td
(1)Tj
0 g
(\))Tj
1.0318 0 Td
(showed)Tj
3.2541 0 Td
(that)Tj
/F13 1 Tf
1.7745 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
5.0627 0 Td
(was)Tj
1.6951 0 Td
(dominated)Tj
4.5751 0 Td
(by)Tj
1.1848 0 Td
(KPC-producing)Tj
-29.5821 -1.2982 Td
(clonal)Tj
2.6248 0 Td
(group)Tj
2.6079 0 Td
(\(CG\))Tj
2.279 0 Td
(258,)Tj
1.8709 0 Td
(more)Tj
2.3414 0 Td
(specifically)Tj
4.5751 0 Td
(ST258)Tj
2.7325 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(15\))Tj
1.508 0 Td
(and)Tj
1.7348 0 Td
(its)Tj
1.1452 0 Td
(single)Tj
2.5285 0 Td
(locus)Tj
2.2847 0 Td
(variants)Tj
3.3902 0 Td
(\(SLV\))Tj
-33.5109 -1.2983 Td
(ST855)Tj
2.7325 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(1\))Tj
1.0375 0 Td
(and)Tj
1.7291 0 Td
(ST340)Tj
2.7326 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7993 0 Td
(1\).)Tj
1.2586 0 Td
(The)Tj
1.7858 0 Td
(CG258)Tj
3.0217 0 Td
(cluster)Tj
2.8743 0 Td
(comprised)Tj
4.4391 0 Td
(21)Tj
1.1678 0 Td
(isolates)Tj
3.1181 0 Td
(and)Tj
1.7292 0 Td
(included)Tj
3.7133 0 Td
(nearly)Tj
-35.1153 -1.3039 Td
(all)Tj
1.1451 0 Td
(KPC-producers)Tj
6.497 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0885 0 Td
(=)Tj
0.7994 0 Td
(17\))Tj
1.5137 0 Td
(in)Tj
1.0318 0 Td
(addition)Tj
3.5999 0 Td
(to)Tj
1.0262 0 Td
(four)Tj
1.9105 0 Td
(ST11)Tj
2.262 0 Td
(isolates)Tj
3.1125 0 Td
(carrying)Tj
/F13 1 Tf
3.5603 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 487.4456 224.3338 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(NDM-1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 513.5244 225.9779 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0884 0 Td
(=)Tj
0.7994 0 Td
(2\))Tj
1.0375 0 Td
(or)Tj
/F13 1 Tf
-34.2762 -1.2982 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 211.9748 211.3511 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(OXA-245)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 243.0425 212.9952 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0884 0 Td
(=)Tj
0.7994 0 Td
(2\))Tj
1.0375 0 Td
(genes.)Tj
2.6645 0 Td
(Outside)Tj
3.3732 0 Td
(CG258,)Tj
/F13 1 Tf
3.2542 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 377.1779 211.3511 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(KPC)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 393.5622 212.9952 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(was)Tj
1.7007 0 Td
(only)Tj
1.9729 0 Td
(identified)Tj
4.0592 0 Td
(in)Tj
1.0375 0 Td
(one)Tj
1.7008 0 Td
(isolate)Tj
2.7552 0 Td
(belonging)Tj
4.1953 0 Td
(to)Tj
-36.7764 -1.2982 Td
(ST461.)Tj
2.9594 0 Td
(Among)Tj
3.2428 0 Td
(the)Tj
/F13 1 Tf
1.4683 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
5.0627 0 Td
(isolates)Tj
3.118 0 Td
(cgMLST)Tj
3.6226 0 Td
(identified)Tj
4.0592 0 Td
(two)Tj
1.7121 0 Td
(other)Tj
2.3471 0 Td
(clusters)Tj
3.2315 0 Td
(represented)Tj
-31.9122 -1.3039 Td
(by)Tj
1.1792 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(one)Tj
1.7008 0 Td
(isolate:)Tj
2.982 0 Td
(one)Tj
1.6951 0 Td
(representing)Tj
5.2441 0 Td
(CG147)Tj
3.0216 0 Td
(and)Tj
1.7348 0 Td
(including)Tj
4.0365 0 Td
(ST147)Tj
2.7383 0 Td
(with)Tj
/F13 1 Tf
1.9955 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 518.9669 185.3291 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(VIM-27)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 545.3291 186.9732 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0884 0 Td
(=)Tj
0.7994 0 Td
(2\))Tj
-36.4192 -1.2982 Td
(or)Tj
/F13 1 Tf
1.0942 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 222.9732 172.3464 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(NDM-1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 249.0519 173.9905 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0884 0 Td
(=)Tj
0.7994 0 Td
(1\))Tj
1.0318 0 Td
(and)Tj
1.7348 0 Td
(ST273)Tj
2.7326 0 Td
(with)Tj
/F13 1 Tf
1.9956 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 354.8409 172.3464 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(VIM-1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 377.6881 173.9905 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0828 0 Td
(=)Tj
0.805 0 Td
(1\),)Tj
1.2586 0 Td
(and)Tj
1.7291 0 Td
(one)Tj
1.7008 0 Td
(representing)Tj
5.2384 0 Td
(CG17)Tj
2.5511 0 Td
(including)Tj
-32.1332 -1.2982 Td
(ST17)Tj
2.2564 0 Td
(with)Tj
/F13 1 Tf
1.9955 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 254.5511 159.307 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(NDM-1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 280.6299 161.0078 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0884 0 Td
(=)Tj
0.7994 0 Td
(2\))Tj
1.0318 0 Td
(and)Tj
1.7348 0 Td
(ST336)Tj
2.7326 0 Td
(with)Tj
/F13 1 Tf
1.9956 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 386.4188 159.307 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(NDM-7)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 412.4976 161.0078 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\()Tj
/F13 1 Tf
[( )]TJ
/F8 1 Tf
1.0884 0 Td
(=)Tj
0.7994 0 Td
(1\).)Tj
1.2643 0 Td
(The)Tj
1.7801 0 Td
(remaining)Tj
/F13 1 Tf
4.3653 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0885 0 Td
[()11( )6()2(\n)12()6()11( )18()4()6()]TJ
/F8 1 Tf
-31.6343 -1.2982 Td
(isolates)Tj
3.1181 0 Td
(represented)Tj
4.9095 0 Td
(genetically)Tj
4.4504 0 Td
(diverse)Tj
3.0501 0 Td
(single)Tj
2.5285 0 Td
(strains)Tj
2.8629 0 Td
(harbouring)Tj
/F13 1 Tf
4.7451 0 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 468.6236 146.3244 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(NDM-1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 494.7023 148.0251 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\(ST37)Tj
2.6021 0 Td
(and)Tj
1.7292 0 Td
(ST101\),)Tj
/F13 1 Tf
-33.8 -1.3039 Td
[()10()4()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 211.9748 133.3417 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(NDM-1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 238.0535 134.9858 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
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(.)Tj
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1.1744 0 Td
(stuartii)Tj
/F0 1 Tf
13.566 0 Td
(-)Tj
14.8943 0 Td
(NDM-1)Tj
-42.0992 -1.6441 Td
(1)Tj
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12.4645 0 Td
(P)Tj
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(.)Tj
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1.1744 0 Td
(mirabilis)Tj
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13.566 0 Td
(-)Tj
14.8943 0 Td
(NDM-1)Tj
-42.0992 -1.6441 Td
(1)Tj
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(Citrobacter)Tj
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5.1106 0 Td
(sp.)Tj
9.6298 0 Td
(-)Tj
14.8943 0 Td
(NDM-1)Tj
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(Spain)Tj
21.981 0 Td
(1)Tj
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(K)Tj
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(.)Tj
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(pneumoniae)Tj
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13.566 0 Td
(ST11)Tj
14.8943 0 Td
(OXA-245)Tj
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(1)Tj
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(K)Tj
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(.)Tj
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(quasipneumoniae)Tj
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13.566 0 Td
(ST1466)Tj
14.8943 0 Td
(VIM-1)Tj
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(1)Tj
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(E)Tj
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(complex)Tj
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(ST635)Tj
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(IMI-9)Tj
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(Morocco)Tj
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(1)Tj
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(K)Tj
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(ST405)Tj
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(OXA-48)Tj
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(K)Tj
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(ST11)Tj
14.8943 0 Td
(OXA-245)Tj
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(Thailand)Tj
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(1)Tj
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(E)Tj
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(coli)Tj
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(OXA-48)Tj
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(1)Tj
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(E)Tj
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(.)Tj
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(coli)Tj
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13.566 0 Td
(ST6355)Tj
14.8943 0 Td
(VIM-29)Tj
-64.0802 -1.636 Td
(Brazil)Tj
21.981 0 Td
(1)Tj
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12.4645 0 Td
(K)Tj
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(.)Tj
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(pneumoniae)Tj
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13.566 0 Td
(ST855)Tj
14.8943 0 Td
(KPC-2)Tj
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(United)Tj
3.1101 0 Td
(Arab)Tj
2.3406 0 Td
(Emirates)Tj
16.5303 0 Td
(1)Tj
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(K)Tj
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(.)Tj
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(pneumoniae)Tj
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13.566 0 Td
(ST336)Tj
14.8943 0 Td
(NDM-7)Tj
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(Syria/Jordan)Tj
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(1)Tj
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(E)Tj
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(.)Tj
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(coli)Tj
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13.566 0 Td
(ST410)Tj
14.8943 0 Td
(VIM-4)Tj
-64.0802 -1.6441 Td
(Jamaica)Tj
21.981 0 Td
(1)Tj
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12.4645 0 Td
(E)Tj
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(.)Tj
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(cloacae)Tj
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(complex)Tj
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(ST456)Tj
14.8943 0 Td
(KPC-2)Tj
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(Pakistan)Tj
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(1)Tj
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(E)Tj
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(.)Tj
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(coli)Tj
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(ST617)Tj
14.8943 0 Td
(NDM-1)Tj
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(Romania)Tj
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(1)Tj
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(K)Tj
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(.)Tj
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(pneumoniae)Tj
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(ST525)Tj
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(NDM-1+OXA-)Tj
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(181)Tj
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(Sri)Tj
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(Lanka)Tj
20.5313 0 Td
(1)Tj
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12.4645 0 Td
(K)Tj
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(.)Tj
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1.1744 0 Td
(pneumoniae)Tj
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13.566 0 Td
(ST101)Tj
14.8943 0 Td
(NDM-1)Tj
-64.0802 -1.6441 Td
(USA)Tj
21.981 0 Td
(1)Tj
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12.4645 0 Td
(K)Tj
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(.)Tj
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1.1744 0 Td
(pneumoniae)Tj
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13.566 0 Td
(ST258)Tj
14.8943 0 Td
(KPC-3)Tj
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(Unknown)Tj
21.981 0 Td
(1)Tj
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12.4645 0 Td
(K)Tj
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(.)Tj
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1.1744 0 Td
(pneumoniae)Tj
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13.566 0 Td
(ST187)Tj
14.8943 0 Td
(OXA-48)Tj
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(2)Tj
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12.4645 0 Td
(E)Tj
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(.)Tj
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1.1744 0 Td
(coli)Tj
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13.566 0 Td
(ST38)Tj
14.8943 0 Td
(OXA-48)Tj
-42.0992 -1.6442 Td
(1)Tj
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12.4645 0 Td
(E)Tj
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(.)Tj
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1.1744 0 Td
(coli)Tj
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13.566 0 Td
(ST95)Tj
14.8943 0 Td
(IMP-26)Tj
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(Norway)Tj
3.6122 0 Td
(\(no)Tj
1.6684 0 Td
(reported)Tj
3.9443 0 Td
(overseas)Tj
4.2764 0 Td
(travel\))Tj
8.4797 0 Td
(9)Tj
ET
Q
q
1 j
1 J
0 w
5.2497 0 0 4.6661 193.7763 306.9921 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(c,)Tj
1.0799 0 Td
(d)Tj
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 277.1149 303.874 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(K)Tj
/F0 1 Tf
(.)Tj
/F7 1 Tf
1.1743 0 Td
(pneumoniae)Tj
/F0 1 Tf
13.5661 0 Td
(ST258)Tj
14.8943 0 Td
(KPC-2)Tj
-42.0992 -1.6441 Td
(1)Tj
/F7 1 Tf
12.4645 0 Td
(K)Tj
/F0 1 Tf
(.)Tj
/F7 1 Tf
1.1743 0 Td
(pneumoniae)Tj
/F0 1 Tf
13.5661 0 Td
(ST14)Tj
14.8943 0 Td
(OXA-162)Tj
-42.0992 -1.636 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
5.2497 0 0 4.6661 193.7763 284.0314 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(a)Tj
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 277.1149 280.9133 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(K)Tj
/F0 1 Tf
(.)Tj
/F7 1 Tf
1.1743 0 Td
(pneumoniae)Tj
/F0 1 Tf
13.5661 0 Td
(ST37)Tj
14.8943 0 Td
(NDM-1)Tj
-42.0992 -1.6441 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
5.2497 0 0 4.6661 193.7763 272.5228 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(e)Tj
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 277.1149 269.4047 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(K)Tj
/F0 1 Tf
(.)Tj
/F7 1 Tf
1.1743 0 Td
(pneumoniae)Tj
/F0 1 Tf
13.5661 0 Td
(ST147)Tj
14.8943 0 Td
(VIM-27)Tj
-42.0992 -1.6441 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
5.2497 0 0 4.6661 193.7763 261.0141 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(c)Tj
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 277.1149 257.896 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(K)Tj
/F0 1 Tf
(.)Tj
/F7 1 Tf
1.1743 0 Td
(pneumoniae)Tj
/F0 1 Tf
13.5661 0 Td
(ST461)Tj
14.8943 0 Td
(KPC-2)Tj
-42.0992 -1.6441 Td
(1)Tj
/F7 1 Tf
12.4645 0 Td
(K)Tj
/F0 1 Tf
(.)Tj
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1.1743 0 Td
(pneumoniae)Tj
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13.5661 0 Td
(ST2134)Tj
14.8943 0 Td
(VIM-1)Tj
-42.0992 -1.6441 Td
(1)Tj
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12.4645 0 Td
(E)Tj
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(.)Tj
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1.1743 0 Td
(coli)Tj
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13.5661 0 Td
(ST410)Tj
14.8943 0 Td
(OXA-181)Tj
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(1)Tj
/F7 1 Tf
12.4645 0 Td
(E)Tj
/F0 1 Tf
(.)Tj
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1.1743 0 Td
(coli)Tj
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13.5661 0 Td
(ST636)Tj
14.8943 0 Td
(NDM-5)Tj
-42.0992 -1.636 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
5.2497 0 0 4.6661 193.7763 214.9795 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(f)Tj
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 277.1149 211.9181 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(E)Tj
/F0 1 Tf
(.)Tj
/F7 1 Tf
1.1743 0 Td
(coli)Tj
/F0 1 Tf
13.5661 0 Td
(ST681)Tj
14.8943 0 Td
(NDM-1)Tj
-42.0992 -1.6441 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
5.2497 0 0 4.6661 193.7763 203.5275 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(f)Tj
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 277.1149 200.4094 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(E)Tj
/F0 1 Tf
(.)Tj
/F7 1 Tf
1.1743 0 Td
(cloacae)Tj
/F0 1 Tf
3.6608 0 Td
(complex)Tj
9.9053 0 Td
(ST92)Tj
14.8943 0 Td
(NDM-1)Tj
-42.0992 -1.6441 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
5.2497 0 0 4.6661 193.7763 192.0188 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(c)Tj
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 277.1149 188.9007 cm
BT
/F7 1 Tf
1 TL
0 0 Td
(E)Tj
/F0 1 Tf
(.)Tj
/F7 1 Tf
1.1743 0 Td
(cloacae)Tj
/F0 1 Tf
3.6608 0 Td
(complex)Tj
9.9053 0 Td
(ST484)Tj
14.8943 0 Td
(KPC-2)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 173.707 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(a)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 170.1354 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Two)Tj
/F7 1 Tf
2.1118 0 Td
(bla)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 68.5984 168.8314 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(NDM-1)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 87.4771 170.1354 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(-positive)Tj
/F7 1 Tf
3.926 0 Td
(K)Tj
/F0 1 Tf
(.)Tj
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(pneumon)Tj
4.1315 0 Td
(iae)Tj
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(isolates,)Tj
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(one)Tj
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(ST147)Tj
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(and)Tj
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(one)Tj
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(ST37,)Tj
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(from)Tj
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(the)Tj
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(same)Tj
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(patient.)Tj
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(isolates)Tj
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(21)Tj
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(months)Tj
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(the)Tj
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(first)Tj
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(detection)Tj
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(importation)Tj
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(,)Tj
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(but)Tj
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(not)Tj
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1.3961 0 Td
(the)Tj
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(second)Tj
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(detection)Tj
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(.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 149.7259 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(b)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 146.1543 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(All)Tj
1.3322 0 Td
(four)Tj
/F7 1 Tf
1.9418 0 Td
(bla)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 77.896 144.7937 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(NDM-1)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 96.8314 146.1543 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(-positive)Tj
3.926 0 Td
(isolates)Tj
3.5929 0 Td
(were)Tj
2.3811 0 Td
(isolated)Tj
3.6426 0 Td
(from)Tj
2.2252 0 Td
(the)Tj
1.6087 0 Td
(same)Tj
2.6646 0 Td
(patient.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 137.707 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(c)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 40.8188 134.1354 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Six)Tj
/F7 1 Tf
1.6157 0 Td
(K)Tj
/F0 1 Tf
(.)Tj
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1.1693 0 Td
(pneumoniae)Tj
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(ST258,)Tj
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(pneum)Tj
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(ST461)Tj
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(and)Tj
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(one)Tj
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(.)Tj
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(ST484,)Tj
3.4442 0 Td
(all)Tj
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(bla)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 379.1055 132.8314 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(KPC-2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 396.737 134.1354 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(-positive,)Tj
4.2094 0 Td
(were)Tj
2.3741 0 Td
(associated)Tj
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(with)Tj
1.9984 0 Td
(a)Tj
0.7796 0 Td
(long-term)Tj
-59.4287 -1.4952 Td
(outbreak)Tj
4.0961 0 Td
([)Tj
0.83 0.64 0.02 0 k
(50)Tj
0 g
(].)Tj
2.1685 0 Td
(The)Tj
1.9417 0 Td
(first)Tj
1.8426 0 Td
(case)Tj
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(\()Tj
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(K)Tj
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(.)Tj
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1.5095 0 Td
(pneumo)Tj
3.5787 0 Td
(niae)Tj
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2.1048 0 Td
(ST258)Tj
3.1535 0 Td
(with)Tj
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1.9985 0 Td
(bla)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 244.2897 120.8125 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(KPC-2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 261.9212 122.1732 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(\))Tj
0.5598 0 Td
(of)Tj
1.063 0 Td
(the)Tj
1.6087 0 Td
(outbreak)Tj
4.089 0 Td
(were)Tj
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(associated)Tj
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(with)Tj
1.9985 0 Td
(import)Tj
2.9906 0 Td
(from)Tj
2.2252 0 Td
(Greece.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 113.7259 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(d)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 110.1543 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(One)Tj
/F7 1 Tf
2.1118 0 Td
(bla)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 68.5984 108.7937 cm
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