%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Dylan M. Nielson, Per B. Sederberg
MELD: Mixed effects for large datasets
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 8 0 R/Annots 9 0 R/Contents 10 0 R/TrimBox[0 0 612 792]>>
endobj
9 0 obj
[11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R]
endobj
11 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref004)>>
endobj
12 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref006)>>
endobj
13 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref007)>>
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref009)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref007)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref010)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref011)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref007)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref012)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref014)>>
endobj
21 0 obj
<>/Border[0 0 0]/A 22 0 R>>
endobj
22 0 obj
<>
endobj
10 0 obj
[23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R]
endobj
23 0 obj
<>stream
q
0.83 0.64 0.02 0 k
473.3858 706.337 m
478.148 706.337 l
h
f*
483.3638 706.337 m
488.0693 706.337 l
h
f*
384.2646 524.2961 m
389.0268 524.2961 l
h
f*
394.1858 524.2961 m
398.948 524.2961 l
h
f*
295.4268 498.3307 m
300.189 498.3307 l
h
f*
302.4567 498.3307 m
311.9244 498.3307 l
h
f*
203.4142 485.348 m
212.9386 485.348 l
h
f*
480.926 146.948 m
485.6882 146.948 l
h
f*
383.4709 81.9213 m
392.9953 81.9213 l
h
f*
398.1543 81.9213 m
407.6787 81.9213 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(in)Tj
1.0261 0 Td
(neural)Tj
2.7609 0 Td
(data)Tj
1.9106 0 Td
(significantly)Tj
5.0796 0 Td
(improves)Tj
3.9345 0 Td
(the)Tj
1.457 0 Td
(sensitivity)Tj
4.2122 0 Td
(of)Tj
1.0092 0 Td
(this)Tj
1.6667 0 Td
(approach)Tj
3.9401 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
2.5909 0 Td
(The)Tj
1.7688 0 Td
(power)Tj
2.7156 0 Td
(and)Tj
1.7234 0 Td
(sim-)Tj
-35.7956 -1.3039 Td
(plicity)Tj
2.6928 0 Td
(of)Tj
1.0148 0 Td
(nonparametric)Tj
6.1852 0 Td
(t-tests)Tj
2.6079 0 Td
(or)Tj
1.0998 0 Td
(ANOVAs)Tj
4.1272 0 Td
(with)Tj
1.9956 0 Td
(TFCE)Tj
2.5908 0 Td
(have)Tj
2.0636 0 Td
(led)Tj
1.4174 0 Td
(to)Tj
1.0261 0 Td
(its)Tj
1.1452 0 Td
(widespread)Tj
4.7565 0 Td
(use)Tj
1.5307 0 Td
(in)Tj
1.0375 0 Td
(neu-)Tj
-35.2911 -1.2982 Td
(roimaging)Tj
4.3653 0 Td
(and)Tj
1.7291 0 Td
(electrophysiology,)Tj
7.4437 0 Td
(but)Tj
1.5534 0 Td
(the)Tj
1.474 0 Td
(reliance)Tj
3.3562 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6724 0 Td
(approach)Tj
3.9515 0 Td
(on)Tj
1.2756 0 Td
(within-subject)Tj
5.9641 0 Td
(averages)Tj
-33.8001 -1.2983 Td
(and)Tj
1.7291 0 Td
(simple)Tj
2.8573 0 Td
(regression)Tj
4.3143 0 Td
(limits)Tj
2.4831 0 Td
(experimental)Tj
5.4595 0 Td
(designs)Tj
3.1691 0 Td
(and)Tj
1.7348 0 Td
(is)Tj
0.8447 0 Td
(unable)Tj
2.9084 0 Td
(to)Tj
1.0261 0 Td
(account)Tj
3.3789 0 Td
(for)Tj
1.3889 0 Td
(known)Tj
3.0047 0 Td
(sources)Tj
-34.2989 -1.2983 Td
(of)Tj
1.0147 0 Td
(trial)Tj
1.8369 0 Td
(level)Tj
2.0126 0 Td
(variance,)Tj
3.804 0 Td
(reducing)Tj
3.7758 0 Td
(its)Tj
1.1452 0 Td
(sensitivity.)Tj
-12.393 -1.3039 Td
(The)Tj
1.7858 0 Td
(standard)Tj
3.719 0 Td
(approach)Tj
3.9572 0 Td
(assumes)Tj
3.5036 0 Td
(that)Tj
1.7801 0 Td
(within)Tj
2.8119 0 Td
(each)Tj
2.0296 0 Td
(subject)Tj
3.0161 0 Td
(there)Tj
2.2677 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.6576 0 Td
(consistent)Tj
4.252 0 Td
(or)Tj
1.0998 0 Td
(fixed)Tj
-32.9213 -1.2982 Td
(effect)Tj
2.364 0 Td
(driving)Tj
3.1238 0 Td
(the)Tj
1.4683 0 Td
(difference)Tj
4.2009 0 Td
(between)Tj
3.532 0 Td
(classes)Tj
2.8289 0 Td
(of)Tj
1.0148 0 Td
(trials)Tj
2.1997 0 Td
(and)Tj
1.7291 0 Td
(that)Tj
1.7802 0 Td
(any)Tj
1.6554 0 Td
(trial)Tj
1.8368 0 Td
(level)Tj
2.0126 0 Td
(variance)Tj
3.5773 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
-34.9509 -1.2983 Td
(neglected)Tj
3.9968 0 Td
(because)Tj
3.3222 0 Td
(it)Tj
0.788 0 Td
(affects)Tj
2.7326 0 Td
(both)Tj
2.0579 0 Td
(classes)Tj
2.8346 0 Td
(of)Tj
1.0148 0 Td
(trials)Tj
2.194 0 Td
(equally.)Tj
3.2882 0 Td
(The)Tj
1.7801 0 Td
(within)Tj
2.812 0 Td
(subject)Tj
3.0217 0 Td
(effect)Tj
2.3641 0 Td
(is)Tj
0.8447 0 Td
(assessed)Tj
3.4753 0 Td
(by)Tj
-36.527 -1.3039 Td
(the)Tj
1.4683 0 Td
(first-level)Tj
3.9515 0 Td
(test,)Tj
1.8255 0 Td
(which)Tj
2.6475 0 Td
(may)Tj
1.9332 0 Td
(be)Tj
1.1509 0 Td
(as)Tj
1.0148 0 Td
(simple)Tj
2.8516 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(mean)Tj
2.4491 0 Td
(difference,)Tj
4.4277 0 Td
(or)Tj
1.0998 0 Td
(it)Tj
0.788 0 Td
(may)Tj
1.9276 0 Td
(be)Tj
1.1508 0 Td
(a)Tj
0.652 0 Td
(more)Tj
2.3414 0 Td
(complex)Tj
-33.3465 -1.2983 Td
(model)Tj
2.7439 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(GLM.)Tj
2.5909 0 Td
(The)Tj
1.7801 0 Td
(second-level)Tj
5.1591 0 Td
(test)Tj
1.5987 0 Td
(then)Tj
2.0182 0 Td
(assesses)Tj
3.3052 0 Td
(the)Tj
1.4684 0 Td
(significance)Tj
4.9379 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(subject)Tj
3.0217 0 Td
(level)Tj
-34.8375 -1.2983 Td
(effects)Tj
2.7269 0 Td
(only)Tj
1.9729 0 Td
(taking)Tj
2.7325 0 Td
(into)Tj
1.8369 0 Td
(account)Tj
3.3845 0 Td
(variance)Tj
3.5773 0 Td
(across)Tj
2.6759 0 Td
(subjects.)Tj
3.6057 0 Td
(If)Tj
0.8447 0 Td
(there)Tj
2.2677 0 Td
(are)Tj
1.4456 0 Td
(known)Tj
3.0048 0 Td
(confounds)Tj
4.4617 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
-35.4895 -1.3039 Td
(trial)Tj
1.8368 0 Td
(level,)Tj
2.2393 0 Td
(they)Tj
1.9219 0 Td
(must)Tj
2.228 0 Td
(be)Tj
1.1509 0 Td
(accounted)Tj
4.3313 0 Td
(for)Tj
1.389 0 Td
(via)Tj
1.3776 0 Td
(counterbalancing,)Tj
7.4154 0 Td
(significantly)Tj
5.091 0 Td
(complicating)Tj
5.4368 0 Td
(experi-)Tj
-34.418 -1.2982 Td
(mental)Tj
2.9876 0 Td
(design.)Tj
3.0388 0 Td
(Mixed)Tj
2.7949 0 Td
(effects)Tj
2.7269 0 Td
(models,)Tj
3.3335 0 Td
(such)Tj
2.058 0 Td
(as)Tj
1.0148 0 Td
(those)Tj
2.3357 0 Td
(implemented)Tj
5.5389 0 Td
(in)Tj
1.0318 0 Td
(linear)Tj
2.5115 0 Td
(mixed)Tj
2.7269 0 Td
(effects)Tj
2.7212 0 Td
(regres-)Tj
-34.8205 -1.2983 Td
(sion)Tj
1.9048 0 Td
(\(LMER\),)Tj
3.7474 0 Td
(avoid)Tj
2.4094 0 Td
(these)Tj
2.2507 0 Td
(issues)Tj
2.5228 0 Td
(by)Tj
1.1792 0 Td
(simultaneously)Tj
6.2476 0 Td
(modeling)Tj
4.0251 0 Td
(fixed)Tj
2.1884 0 Td
(effects)Tj
2.7269 0 Td
(and)Tj
1.7291 0 Td
(random)Tj
-30.9314 -1.3039 Td
(effects)Tj
2.7269 0 Td
(\(sources)Tj
3.5319 0 Td
(of)Tj
1.0148 0 Td
(variance\))Tj
3.9175 0 Td
(at)Tj
0.9524 0 Td
(multiple)Tj
3.566 0 Td
(levels)Tj
2.3754 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
2.5908 0 Td
(Mixed)Tj
2.8006 0 Td
(effects)Tj
2.7213 0 Td
(models)Tj
3.1067 0 Td
(are)Tj
1.4514 0 Td
(well)Tj
1.8198 0 Td
(established)Tj
-32.5755 -1.2983 Td
(in)Tj
1.0318 0 Td
(linguistics)Tj
4.2576 0 Td
(research,)Tj
3.7814 0 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.1089 0 Td
(utility)Tj
2.5796 0 Td
(for)Tj
1.3833 0 Td
(event)Tj
2.3697 0 Td
(related)Tj
2.9423 0 Td
(potential)Tj
3.7644 0 Td
(\(ERP\))Tj
2.6476 0 Td
(analysis)Tj
3.3278 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
-33.4656 -1.2982 Td
(pointed)Tj
3.3108 0 Td
(out)Tj
1.5477 0 Td
(repeatedly)Tj
4.3427 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(],)Tj
2.7779 0 Td
(but)Tj
1.5534 0 Td
(these)Tj
2.2563 0 Td
(analyses)Tj
3.4809 0 Td
(are)Tj
1.4457 0 Td
(rarely)Tj
2.5228 0 Td
(implemented)Tj
5.5332 0 Td
(in)Tj
1.0375 0 Td
(electrophysiology)Tj
-29.8089 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
2.0749 0 Td
(This)Tj
1.9899 0 Td
(is)Tj
0.8447 0 Td
(likely)Tj
2.3528 0 Td
(because)Tj
3.3222 0 Td
(mixed)Tj
2.7212 0 Td
(effects)Tj
2.7269 0 Td
(models)Tj
3.1068 0 Td
(take)Tj
1.8708 0 Td
(a)Tj
0.652 0 Td
(long)Tj
1.9899 0 Td
(time)Tj
2.0296 0 Td
(to)Tj
1.0261 0 Td
(solve)Tj
2.211 0 Td
(with)Tj
1.9956 0 Td
(iterative)Tj
3.4582 0 Td
(re-)Tj
-34.3726 -1.3039 Td
(stricted)Tj
3.1917 0 Td
(maximum)Tj
4.371 0 Td
(likelihood)Tj
4.235 0 Td
(techniques,)Tj
4.7565 0 Td
(making)Tj
3.2485 0 Td
(them)Tj
2.2903 0 Td
(computationally)Tj
6.7465 0 Td
(prohibitive)Tj
4.6317 0 Td
(for)Tj
1.3833 0 Td
(large)Tj
-34.8545 -1.2983 Td
(datasets.)Tj
3.5829 0 Td
(The)Tj
1.7802 0 Td
(computational)Tj
6.0491 0 Td
(cost)Tj
1.8085 0 Td
(is)Tj
0.8503 0 Td
(further)Tj
3.0274 0 Td
(exacerbated)Tj
4.9493 0 Td
(if)Tj
0.7767 0 Td
(one)Tj
1.7007 0 Td
(still)Tj
1.6385 0 Td
(wants)Tj
2.5455 0 Td
(to)Tj
1.0261 0 Td
(take)Tj
1.8709 0 Td
(advantage)Tj
4.2406 0 Td
(of)Tj
-35.8467 -1.2983 Td
(nonparametric)Tj
6.1851 0 Td
(resampling)Tj
4.6715 0 Td
(and)Tj
1.7291 0 Td
(TFCE.)Tj
2.8176 0 Td
(We)Tj
1.6101 0 Td
(have)Tj
2.0579 0 Td
(developed)Tj
4.2746 0 Td
(a)Tj
0.652 0 Td
(novel)Tj
2.3981 0 Td
(technique)Tj
4.1669 0 Td
(called)Tj
2.5228 0 Td
(Mixed)Tj
-33.0857 -1.3039 Td
(Effects)Tj
2.8686 0 Td
(for)Tj
1.389 0 Td
(Large)Tj
2.4491 0 Td
(Datasets)Tj
3.5659 0 Td
(\(MELD\))Tj
3.6397 0 Td
(that)Tj
1.7801 0 Td
(makes)Tj
2.7496 0 Td
(it)Tj
0.7881 0 Td
(easy)Tj
1.8935 0 Td
(to)Tj
1.0261 0 Td
(apply)Tj
2.3868 0 Td
(permutation)Tj
5.2327 0 Td
(testing,)Tj
3.1068 0 Td
(TFCE,)Tj
2.8176 0 Td
(and)Tj
-35.6936 -1.2982 Td
(LMER)Tj
2.8402 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(type)Tj
1.9162 0 Td
(of)Tj
1.0148 0 Td
(large)Tj
2.16 0 Td
(datasets)Tj
3.3562 0 Td
(commonly)Tj
4.5468 0 Td
(found)Tj
2.6191 0 Td
(in)Tj
1.0375 0 Td
(neuroimaging)Tj
5.862 0 Td
(research.)Tj
3.7814 0 Td
(Here)Tj
2.2054 0 Td
(we)Tj
-33.8341 -1.2983 Td
(explain)Tj
3.118 0 Td
(in)Tj
1.0375 0 Td
(detail)Tj
2.4151 0 Td
(how)Tj
1.9389 0 Td
(MELD)Tj
2.9594 0 Td
(works)Tj
2.6418 0 Td
(and)Tj
1.7292 0 Td
(compare)Tj
3.7133 0 Td
(its)Tj
1.1452 0 Td
(performance)Tj
5.3518 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(standard)Tj
3.719 0 Td
(approach)Tj
3.9571 0 Td
(of)Tj
-36.2208 -1.3039 Td
(t-tests)Tj
2.6078 0 Td
(with)Tj
2.0013 0 Td
(TFCE)Tj
2.5908 0 Td
(and)Tj
1.7291 0 Td
(permutation)Tj
5.2328 0 Td
(testing)Tj
2.8799 0 Td
(\(t+TFCE\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 360 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Linear)Tj
2.9575 0 Td
(mixed)Tj
2.8582 0 Td
(effects)Tj
3.1418 0 Td
(regression)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 342.9921 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(In)Tj
1.1055 0 Td
(both)Tj
2.0636 0 Td
(a)Tj
0.6519 0 Td
(typical)Tj
2.863 0 Td
(approach)Tj
3.9515 0 Td
(and)Tj
1.7291 0 Td
(in)Tj
1.0375 0 Td
(LMER,)Tj
3.067 0 Td
(one)Tj
1.6951 0 Td
(investigates)Tj
4.8246 0 Td
(the)Tj
1.4683 0 Td
(relationship)Tj
4.989 0 Td
(between)Tj
3.5319 0 Td
(indepen-)Tj
-32.978 -1.2982 Td
(dent)Tj
2.0182 0 Td
(variables)Tj
3.719 0 Td
(\(such)Tj
2.3981 0 Td
(as)Tj
1.0148 0 Td
(stimulus)Tj
3.6284 0 Td
(type)Tj
1.9162 0 Td
(or)Tj
1.0941 0 Td
(reaction)Tj
3.498 0 Td
(time\))Tj
2.364 0 Td
(and)Tj
1.7348 0 Td
(neural)Tj
2.7666 0 Td
(data)Tj
1.9162 0 Td
(\(dependent)Tj
4.8019 0 Td
(variables\))Tj
-32.8703 -1.2983 Td
(at)Tj
0.9524 0 Td
(each)Tj
2.0296 0 Td
(feature,)Tj
3.2088 0 Td
(where)Tj
2.6532 0 Td
(each)Tj
2.0239 0 Td
(time-point)Tj
4.5184 0 Td
(at)Tj
0.9524 0 Td
(each)Tj
2.0296 0 Td
(electrode)Tj
3.8665 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.6576 0 Td
(feature.)Tj
3.2088 0 Td
(The)Tj
1.7858 0 Td
(typical)Tj
2.8573 0 Td
(method)Tj
3.3279 0 Td
(for)Tj
-34.9169 -1.3039 Td
(applying)Tj
3.668 0 Td
(a)Tj
0.6576 0 Td
(general)Tj
3.1294 0 Td
(linear)Tj
2.5115 0 Td
(model)Tj
2.7439 0 Td
(to)Tj
1.0262 0 Td
(EEG)Tj
2.0749 0 Td
(data)Tj
1.9105 0 Td
(would)Tj
2.7156 0 Td
(be)Tj
1.1509 0 Td
(to)Tj
1.0261 0 Td
(fit)Tj
1.0715 0 Td
(the)Tj
1.4683 0 Td
(model)Tj
2.744 0 Td
(to)Tj
1.0261 0 Td
(each)Tj
2.0296 0 Td
(feature)Tj
2.9877 0 Td
(within)Tj
-33.9418 -1.2983 Td
(each)Tj
2.0295 0 Td
(subject)Tj
3.0161 0 Td
(and)Tj
1.7291 0 Td
(then)Tj
2.0183 0 Td
(to)Tj
1.0261 0 Td
(do)Tj
1.2529 0 Td
(a)Tj
0.6576 0 Td
(t-test)Tj
2.2451 0 Td
(on)Tj
1.2755 0 Td
(each)Tj
2.0296 0 Td
(term)Tj
2.1374 0 Td
(across)Tj
2.6758 0 Td
(subjects)Tj
3.3789 0 Td
(to)Tj
1.0262 0 Td
(determine)Tj
4.3199 0 Td
(which)Tj
2.6532 0 Td
(terms)Tj
2.4945 0 Td
(are)Tj
-35.9657 -1.2982 Td
(significantly)Tj
5.0853 0 Td
(different)Tj
3.6566 0 Td
(from)Tj
2.2054 0 Td
(zero)Tj
1.9389 0 Td
(across)Tj
2.6759 0 Td
(subjects.)Tj
3.6056 0 Td
(In)Tj
1.1055 0 Td
(LMER,)Tj
3.0671 0 Td
(a)Tj
0.6576 0 Td
(single)Tj
2.5285 0 Td
(model)Tj
2.7439 0 Td
(is)Tj
0.8504 0 Td
(fit)Tj
1.0715 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(data)Tj
1.9162 0 Td
(from)Tj
-35.6029 -1.3039 Td
(all)Tj
1.1451 0 Td
(trials)Tj
2.1997 0 Td
(and)Tj
1.7291 0 Td
(all)Tj
1.1452 0 Td
(subjects)Tj
3.3789 0 Td
(simultaneously.)Tj
6.4686 0 Td
(This)Tj
1.9843 0 Td
(is)Tj
0.8503 0 Td
(achieved)Tj
3.7021 0 Td
(by)Tj
1.1792 0 Td
(defining)Tj
3.5603 0 Td
(some)Tj
2.33 0 Td
(model)Tj
2.744 0 Td
(terms)Tj
2.4944 0 Td
(as)Tj
-34.9112 -1.2983 Td
(fixed)Tj
2.5851 0 Td
(effects,)Tj
3.3392 0 Td
(or)Tj
1.0999 0 Td
(invariant)Tj
3.8437 0 Td
(across)Tj
2.6759 0 Td
(subjects,)Tj
3.6056 0 Td
(and)Tj
1.7292 0 Td
(other)Tj
2.347 0 Td
(terms)Tj
2.4945 0 Td
(as)Tj
1.0148 0 Td
(random)Tj
3.8211 0 Td
(effects,)Tj
3.3449 0 Td
(or)Tj
1.0941 0 Td
(variable)Tj
-32.995 -1.2983 Td
(across)Tj
2.6758 0 Td
(subjects)Tj
3.3789 0 Td
(or)Tj
1.0999 0 Td
(trials)Tj
2.194 0 Td
(or)Tj
1.0998 0 Td
(any)Tj
1.6554 0 Td
(other)Tj
2.3528 0 Td
(grouping)Tj
3.8891 0 Td
(factor.)Tj
2.7666 0 Td
(In)Tj
1.1055 0 Td
(a)Tj
0.6576 0 Td
(mixed)Tj
2.7212 0 Td
(effects)Tj
2.727 0 Td
(model,)Tj
2.9706 0 Td
(the)Tj
1.4684 0 Td
(random)Tj
-32.7626 -1.3039 Td
(effects)Tj
2.7269 0 Td
(are)Tj
1.4456 0 Td
(treated)Tj
2.9991 0 Td
(as)Tj
1.0148 0 Td
(if)Tj
0.771 0 Td
(they)Tj
1.9275 0 Td
(are)Tj
1.4457 0 Td
(drawn)Tj
2.7893 0 Td
(from)Tj
2.2053 0 Td
(a)Tj
0.652 0 Td
(distribution)Tj
4.9719 0 Td
(\(the)Tj
1.8085 0 Td
(shape)Tj
2.4831 0 Td
(of)Tj
1.0148 0 Td
(that)Tj
1.7802 0 Td
(distribution)Tj
4.9662 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
-36.629 -1.2983 Td
(specified,)Tj
3.9401 0 Td
(but)Tj
1.5534 0 Td
(most)Tj
2.2053 0 Td
(often)Tj
2.2904 0 Td
(it)Tj
0.7823 0 Td
(is)Tj
0.8504 0 Td
(assumed)Tj
3.6737 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(Gaussian\).)Tj
-16.2764 -1.2982 Td
(The)Tj
1.7858 0 Td
(strengths)Tj
3.8721 0 Td
(of)Tj
1.0148 0 Td
(LMER)Tj
2.8459 0 Td
(come)Tj
2.3925 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4683 0 Td
(fact)Tj
1.6668 0 Td
(that)Tj
1.7745 0 Td
(it)Tj
0.788 0 Td
(can)Tj
1.6271 0 Td
(simultaneously)Tj
6.2418 0 Td
(fit)Tj
1.0715 0 Td
(a)Tj
0.6577 0 Td
(model)Tj
2.7439 0 Td
(across)Tj
-33.3522 -1.3039 Td
(multiple)Tj
3.5659 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(data,)Tj
2.1373 0 Td
(and)Tj
1.7348 0 Td
(thereby)Tj
3.2258 0 Td
(account)Tj
3.3788 0 Td
(for)Tj
1.389 0 Td
(multiple)Tj
3.566 0 Td
(sources)Tj
3.1918 0 Td
(of)Tj
1.0148 0 Td
(variance)Tj
3.5773 0 Td
(within)Tj
2.8119 0 Td
(a)Tj
0.6577 0 Td
(single)Tj
-35.1097 -1.2983 Td
(framework.)Tj
4.8358 0 Td
(This)Tj
1.9843 0 Td
(allows)Tj
2.6929 0 Td
(LMER)Tj
2.8403 0 Td
(to)Tj
1.0204 0 Td
(perform)Tj
3.515 0 Td
(well)Tj
1.8141 0 Td
(in)Tj
1.0318 0 Td
(unbalanced)Tj
4.8359 0 Td
(designs.)Tj
3.3959 0 Td
(LMER)Tj
2.8403 0 Td
(can)Tj
1.6214 0 Td
(be)Tj
1.1452 0 Td
(more)Tj
2.3357 0 Td
(sen-)Tj
-35.909 -1.2983 Td
(sitive)Tj
2.2903 0 Td
(than)Tj
2.0296 0 Td
(individual)Tj
4.286 0 Td
(GLMs)Tj
2.7269 0 Td
(combined)Tj
4.2463 0 Td
(across)Tj
2.6759 0 Td
(subjects)Tj
3.3788 0 Td
(because)Tj
3.3222 0 Td
(in)Tj
1.0318 0 Td
(LMER,)Tj
3.0671 0 Td
(the)Tj
1.474 0 Td
(fit)Tj
1.0715 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(model)Tj
-34.0835 -1.2982 Td
(for)Tj
1.3832 0 Td
(each)Tj
2.0296 0 Td
(subject)Tj
3.0161 0 Td
(is)Tj
0.8504 0 Td
(informed)Tj
3.9741 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4684 0 Td
(models)Tj
3.1067 0 Td
(for)Tj
1.389 0 Td
(all)Tj
1.1452 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(other)Tj
2.3471 0 Td
(subjects)Tj
3.3789 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.6044 0 Td
(This)Tj
1.9842 0 Td
(is)Tj
0.8504 0 Td
(particularly)Tj
-32.19 -1.3039 Td
(true)Tj
1.8425 0 Td
(in)Tj
1.0318 0 Td
(situations)Tj
4.0932 0 Td
(where)Tj
2.6475 0 Td
(there)Tj
2.2677 0 Td
(are)Tj
1.4457 0 Td
(low)Tj
1.6554 0 Td
(numbers)Tj
3.7814 0 Td
(of)Tj
1.0148 0 Td
(subjects)Tj
3.3789 0 Td
(or)Tj
1.0998 0 Td
(low)Tj
1.6554 0 Td
(numbers)Tj
3.7757 0 Td
(of)Tj
1.0148 0 Td
(trials)Tj
2.1997 0 Td
(per)Tj
1.5307 0 Td
(subject.)Tj
-34.435 -1.2983 Td
(A)Tj
0.9014 0 Td
(general)Tj
3.1351 0 Td
(complication)Tj
5.4765 0 Td
(of)Tj
1.0148 0 Td
(using)Tj
2.3924 0 Td
(a)Tj
0.6519 0 Td
(mixed)Tj
2.7213 0 Td
(effects)Tj
2.7269 0 Td
(model)Tj
2.7439 0 Td
(is)Tj
0.8504 0 Td
(that,)Tj
2.0013 0 Td
(due)Tj
1.7007 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(complex)Tj
3.6227 0 Td
(error)Tj
2.262 0 Td
(struc-)Tj
-34.6958 -1.2983 Td
(ture,)Tj
2.0636 0 Td
(it)Tj
0.788 0 Td
(is)Tj
0.8447 0 Td
(unclear)Tj
3.1975 0 Td
(what)Tj
2.1656 0 Td
(the)Tj
1.4684 0 Td
(degrees)Tj
3.2144 0 Td
(of)Tj
1.0148 0 Td
(freedom)Tj
3.583 0 Td
(should)Tj
2.914 0 Td
(be)Tj
1.1508 0 Td
(for)Tj
1.389 0 Td
(testing)Tj
2.88 0 Td
(the)Tj
1.4683 0 Td
(significance)Tj
4.938 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
-34.0949 -1.3039 Td
(coefficient.)Tj
4.6034 0 Td
(There)Tj
2.5738 0 Td
(are)Tj
1.4514 0 Td
(different)Tj
3.6566 0 Td
(approaches)Tj
4.7339 0 Td
(to)Tj
1.0261 0 Td
(estimating)Tj
4.405 0 Td
(the)Tj
1.4683 0 Td
(degrees)Tj
3.2145 0 Td
(of)Tj
1.0148 0 Td
(freedom)Tj
3.583 0 Td
(that)Tj
1.7745 0 Td
(allow)Tj
2.3414 0 Td
(the)Tj
-35.8467 -1.2983 Td
(significance)Tj
4.9379 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
2.0239 0 Td
(coefficient)Tj
4.3823 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1452 0 Td
(assessed)Tj
3.4752 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(],)Tj
3.5433 0 Td
(but)Tj
1.5534 0 Td
(these)Tj
2.2563 0 Td
(methods)Tj
3.685 0 Td
(make)Tj
2.3925 0 Td
(assumptions)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 442.4881 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(MELD)Tj
2.7354 0 Td
(:)Tj
0.4961 0 Td
(Mixed)Tj
2.8488 0 Td
(effects)Tj
3.1181 0 Td
(for)Tj
1.3678 0 Td
(large)Tj
2.4024 0 Td
(datasets)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01827)Tj
4.089 0 Td
(97)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(22,)Tj
1.5874 0 Td
(2017)Tj
34.0302 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
24 0 obj
<>stream
endstream
endobj
25 0 obj
<>stream
endstream
endobj
26 0 obj
<>stream
endstream
endobj
27 0 obj
<>stream
endstream
endobj
28 0 obj
<>stream
endstream
endobj
29 0 obj
<>stream
endstream
endobj
30 0 obj
<>stream
endstream
endobj
31 0 obj
<>stream
endstream
endobj
32 0 obj
<>stream
BT
66.402 0 Td
(21)Tj
ET
Q
endstream
endobj
33 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 8 0 R/Annots 35 0 R/Contents 36 0 R/TrimBox[0 0 612 792]>>
endobj
35 0 obj
[37 0 R]
endobj
37 0 obj
<>/Border[0 0 0]/A 38 0 R>>
endobj
38 0 obj
<>
endobj
36 0 obj
[39 0 R 40 0 R 41 0 R]
endobj
39 0 obj
<>stream
q
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(that)Tj
1.7744 0 Td
(may)Tj
1.9332 0 Td
(not)Tj
1.5704 0 Td
(be)Tj
1.1509 0 Td
(always)Tj
2.8346 0 Td
(be)Tj
1.1509 0 Td
(supported.)Tj
4.4957 0 Td
(Permutation)Tj
5.2724 0 Td
(testing)Tj
2.8857 0 Td
(offers)Tj
2.4547 0 Td
(a)Tj
0.6577 0 Td
(more)Tj
2.3414 0 Td
(robust)Tj
2.7892 0 Td
(alternative)Tj
4.4221 0 Td
(for)Tj
-35.7333 -1.3039 Td
(determining)Tj
5.1816 0 Td
(the)Tj
1.4684 0 Td
(significance)Tj
4.9379 0 Td
(of)Tj
1.0148 0 Td
(coefficients,)Tj
4.9606 0 Td
(but)Tj
1.5534 0 Td
(permutation)Tj
5.2327 0 Td
(testing)Tj
2.8857 0 Td
(is)Tj
0.8447 0 Td
(made)Tj
2.4264 0 Td
(impractical)Tj
4.7225 0 Td
(by)Tj
-35.2287 -1.2982 Td
(another)Tj
3.3278 0 Td
(weakness)Tj
3.9515 0 Td
(of)Tj
1.0148 0 Td
(LMER.)Tj
3.067 0 Td
(Since)Tj
2.3584 0 Td
(LMERs)Tj
3.2032 0 Td
(are)Tj
1.4513 0 Td
(solved)Tj
2.7383 0 Td
(with)Tj
1.9955 0 Td
(an)Tj
1.2076 0 Td
(iterative)Tj
3.4582 0 Td
(restricted)Tj
3.9855 0 Td
(maximum)Tj
-31.7591 -1.2983 Td
(likelihood)Tj
4.2292 0 Td
(approach,)Tj
4.1783 0 Td
(it)Tj
0.7766 0 Td
(can)Tj
1.6271 0 Td
(take)Tj
1.8652 0 Td
(a)Tj
0.652 0 Td
(long)Tj
1.9842 0 Td
(time)Tj
2.0239 0 Td
(to)Tj
1.0205 0 Td
(fit)Tj
1.0715 0 Td
(a)Tj
0.652 0 Td
(complex)Tj
3.6169 0 Td
(mixed)Tj
2.7213 0 Td
(effects)Tj
2.7212 0 Td
(model.)Tj
2.965 0 Td
(This)Tj
1.9843 0 Td
(is)Tj
0.8447 0 Td
(partic-)Tj
-34.9339 -1.2983 Td
(ularly)Tj
2.5001 0 Td
(problematic)Tj
5.0343 0 Td
(when)Tj
2.4038 0 Td
(applying)Tj
3.668 0 Td
(LMER)Tj
2.8459 0 Td
(to)Tj
1.0205 0 Td
(each)Tj
2.0296 0 Td
(element)Tj
3.4072 0 Td
(or)Tj
1.0942 0 Td
(feature)Tj
2.9877 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(neural)Tj
2.7723 0 Td
(dataset)Tj
2.999 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
-35.4441 -1.3039 Td
(massive)Tj
3.3391 0 Td
(univariate)Tj
4.2463 0 Td
(approach,)Tj
4.1783 0 Td
(and)Tj
1.7291 0 Td
(then)Tj
2.0182 0 Td
(further)Tj
3.0274 0 Td
(compounded)Tj
5.5502 0 Td
(if)Tj
0.7767 0 Td
(using)Tj
2.3868 0 Td
(permutations.)Tj
5.8223 0 Td
(Conse-)Tj
-33.0744 -1.2982 Td
(quently,)Tj
3.4525 0 Td
(LMER)Tj
2.8403 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1509 0 Td
(orders)Tj
2.7779 0 Td
(of)Tj
1.0148 0 Td
(magnitude)Tj
4.5354 0 Td
(slower)Tj
2.8119 0 Td
(than)Tj
2.0296 0 Td
(the)Tj
1.4684 0 Td
(tests)Tj
1.9615 0 Td
(typically)Tj
3.5603 0 Td
(used)Tj
2.0636 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6577 0 Td
(massive)Tj
-32.9837 -1.2983 Td
(univariate)Tj
4.2462 0 Td
(approach,)Tj
4.1783 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(ANOVA,)Tj
3.9911 0 Td
(t-test,)Tj
2.4775 0 Td
(or)Tj
1.0942 0 Td
(GLM.)Tj
2.5965 0 Td
(The)Tj
1.7801 0 Td
(computational)Tj
6.0491 0 Td
(cost)Tj
1.8085 0 Td
(of)Tj
1.0148 0 Td
(element-)Tj
-33.5109 -1.3039 Td
(wise)Tj
1.9445 0 Td
(LMERs)Tj
3.1918 0 Td
(is)Tj
0.839 0 Td
(such)Tj
2.0466 0 Td
(that)Tj
1.7689 0 Td
(they)Tj
1.9162 0 Td
(are)Tj
1.44 0 Td
(infeasible)Tj
3.9741 0 Td
(for)Tj
1.3776 0 Td
(most)Tj
2.194 0 Td
(neural)Tj
2.761 0 Td
(datasets)Tj
3.3505 0 Td
(without)Tj
3.3165 0 Td
(use)Tj
1.525 0 Td
(of)Tj
1.0035 0 Td
(a)Tj
0.6463 0 Td
(supercom-)Tj
-33.2955 -1.2983 Td
(puter,)Tj
2.5851 0 Td
(massive)Tj
3.3392 0 Td
(downsampling,)Tj
6.3723 0 Td
(or)Tj
1.0941 0 Td
(both.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 563.6976 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(MELD:)Tj
3.3685 0 Td
(Mixed)Tj
3.0331 0 Td
(effects)Tj
3.4016 0 Td
(for)Tj
1.5401 0 Td
(large)Tj
2.589 0 Td
(datasets)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 546.6897 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Our)Tj
1.8651 0 Td
(goal)Tj
1.8709 0 Td
(for)Tj
1.389 0 Td
(MELD)Tj
2.9536 0 Td
(was)Tj
1.7008 0 Td
(to)Tj
1.0262 0 Td
(make)Tj
2.3924 0 Td
(it)Tj
0.7823 0 Td
(possible)Tj
3.4129 0 Td
(to)Tj
1.0262 0 Td
(analyze)Tj
3.1747 0 Td
(neural)Tj
2.7666 0 Td
(data)Tj
1.9162 0 Td
(or)Tj
1.0999 0 Td
(other)Tj
2.3471 0 Td
(large)Tj
2.1599 0 Td
(datasets)Tj
3.3562 0 Td
(with)Tj
-35.24 -1.2982 Td
(LMER)Tj
2.8402 0 Td
(without)Tj
3.3279 0 Td
(a)Tj
0.6576 0 Td
(supercomputer.)Tj
6.531 0 Td
(Again,)Tj
2.846 0 Td
(as)Tj
1.0148 0 Td
(with)Tj
2.0012 0 Td
(a)Tj
0.652 0 Td
(GLM)Tj
2.3641 0 Td
(or)Tj
1.0998 0 Td
(LMER,)Tj
3.0671 0 Td
(we)Tj
1.3266 0 Td
(are)Tj
1.4513 0 Td
(predicting)Tj
4.3257 0 Td
(values)Tj
2.6702 0 Td
(of)Tj
-36.1755 -1.2983 Td
(the)Tj
1.4683 0 Td
(dependent)Tj
4.4617 0 Td
(neural)Tj
2.7666 0 Td
(data)Tj
1.9162 0 Td
(\(e.g.,)Tj
2.126 0 Td
(combinations)Tj
5.7089 0 Td
(of)Tj
1.0148 0 Td
(time-point)Tj
4.5184 0 Td
(and)Tj
1.7291 0 Td
(electrode)Tj
3.8608 0 Td
(across)Tj
2.6815 0 Td
(events\))Tj
3.0671 0 Td
(with)Tj
-35.3194 -1.3039 Td
(independent)Tj
5.2724 0 Td
(variables)Tj
3.719 0 Td
(\(e.g.,)Tj
2.126 0 Td
(experimental)Tj
5.4595 0 Td
(condition)Tj
4.1102 0 Td
(or)Tj
1.0998 0 Td
(manipulation\).)Tj
6.2022 0 Td
(The)Tj
1.7801 0 Td
(primary)Tj
3.4583 0 Td
(obstacle)Tj
-33.2275 -1.2983 Td
(for)Tj
1.3832 0 Td
(this)Tj
1.6781 0 Td
(is)Tj
0.8448 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(required)Tj
3.6397 0 Td
(to)Tj
1.0261 0 Td
(run)Tj
1.6668 0 Td
(an)Tj
1.2018 0 Td
(LMER)Tj
2.846 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
2.0296 0 Td
(dimension)Tj
4.49 0 Td
(\(or)Tj
1.44 0 Td
(feature\))Tj
3.3222 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(dependent)Tj
-32.9383 -1.2982 Td
(data,)Tj
2.1373 0 Td
(which)Tj
2.6532 0 Td
(we)Tj
1.3266 0 Td
(circumvent)Tj
4.7792 0 Td
(by)Tj
1.1792 0 Td
(running)Tj
3.4979 0 Td
(the)Tj
1.4683 0 Td
(LMER)Tj
2.8403 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.474 0 Td
(dependent)Tj
4.4561 0 Td
(data)Tj
1.9162 0 Td
(after)Tj
2.0352 0 Td
(it)Tj
0.7824 0 Td
(has)Tj
1.542 0 Td
(been)Tj
-33.3635 -1.3039 Td
(transformed)Tj
5.1703 0 Td
(to)Tj
1.0205 0 Td
(a)Tj
0.6519 0 Td
(reduced)Tj
3.4469 0 Td
(space)Tj
2.3755 0 Td
(defined)Tj
3.2258 0 Td
(via)Tj
1.3776 0 Td
(a)Tj
0.652 0 Td
(singular)Tj
3.4412 0 Td
(value)Tj
2.3017 0 Td
(decomposition)Tj
6.1965 0 Td
(\(SVD\))Tj
2.8063 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(corre-)Tj
-35.1493 -1.2983 Td
(lation)Tj
2.5171 0 Td
(between)Tj
3.5319 0 Td
(the)Tj
1.4684 0 Td
(independent)Tj
5.2724 0 Td
(and)Tj
1.7348 0 Td
(dependent)Tj
4.456 0 Td
(data.)Tj
2.143 0 Td
(Taking)Tj
3.0387 0 Td
(the)Tj
1.4684 0 Td
(SVD)Tj
2.1316 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(correlation)Tj
4.6148 0 Td
(matrix)Tj
-34.8602 -1.2983 Td
(identifies)Tj
3.8891 0 Td
(components)Tj
5.176 0 Td
(that)Tj
1.7801 0 Td
(maximize)Tj
4.1273 0 Td
(the)Tj
1.4683 0 Td
(covariance)Tj
4.507 0 Td
(between)Tj
3.532 0 Td
(the)Tj
1.4683 0 Td
(independent)Tj
5.2724 0 Td
(and)Tj
1.7292 0 Td
(dependent)Tj
-32.9497 -1.3039 Td
(variables.)Tj
3.9401 0 Td
(We)Tj
1.6101 0 Td
(then)Tj
2.0182 0 Td
(take)Tj
1.8765 0 Td
(a)Tj
0.652 0 Td
(linear)Tj
2.5115 0 Td
(combination)Tj
5.3461 0 Td
(of)Tj
1.0148 0 Td
(dependent)Tj
4.4617 0 Td
(features)Tj
3.3448 0 Td
(weighted)Tj
3.8381 0 Td
(by)Tj
1.1792 0 Td
(each)Tj
2.0296 0 Td
(SVD)Tj
-33.8227 -1.2983 Td
(component,)Tj
5.0399 0 Td
(which)Tj
2.6476 0 Td
(turns)Tj
2.3244 0 Td
(MELD)Tj
2.9593 0 Td
(into)Tj
1.8425 0 Td
(multivariate,)Tj
5.2838 0 Td
(rather)Tj
2.6475 0 Td
(than)Tj
2.0296 0 Td
(a)Tj
0.652 0 Td
(univariate,)Tj
4.473 0 Td
(method,)Tj
3.549 0 Td
(increasing)Tj
-33.4486 -1.2982 Td
(power)Tj
2.7212 0 Td
(while)Tj
2.3697 0 Td
(allowing)Tj
3.617 0 Td
(us)Tj
1.1112 0 Td
(to)Tj
1.0261 0 Td
(run)Tj
1.6668 0 Td
(one)Tj
1.6951 0 Td
(LMER)Tj
2.846 0 Td
(per)Tj
1.5307 0 Td
(component)Tj
4.8132 0 Td
(instead)Tj
3.0784 0 Td
(of)Tj
1.0148 0 Td
(one)Tj
1.7007 0 Td
(LMER)Tj
2.8403 0 Td
(per)Tj
1.5364 0 Td
(feature.)Tj
-33.5676 -1.2983 Td
(Prior)Tj
2.296 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(SVD,)Tj
2.3527 0 Td
(we)Tj
1.3266 0 Td
(select)Tj
2.3924 0 Td
(elements)Tj
3.7644 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(correlation)Tj
4.6148 0 Td
(matrix)Tj
2.8743 0 Td
(that)Tj
1.7802 0 Td
(are)Tj
1.4513 0 Td
(stable)Tj
2.4888 0 Td
(across)Tj
2.6759 0 Td
(subjects)Tj
3.3789 0 Td
(by)Tj
-36.3796 -1.3039 Td
(means)Tj
2.8062 0 Td
(of)Tj
1.0148 0 Td
(bootstrapping)Tj
5.8167 0 Td
(and)Tj
1.7291 0 Td
(TFCE)Tj
2.5965 0 Td
(to)Tj
1.0205 0 Td
(improve)Tj
3.583 0 Td
(the)Tj
1.4683 0 Td
(resilience)Tj
3.9741 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4741 0 Td
(SVD)Tj
2.1259 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(face)Tj
1.7858 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(large)Tj
-35.3988 -1.2983 Td
(numbers)Tj
3.7757 0 Td
(of)Tj
1.0148 0 Td
(noise)Tj
2.33 0 Td
(elements)Tj
3.7644 0 Td
(that)Tj
1.7745 0 Td
(are)Tj
1.4513 0 Td
(often)Tj
2.2847 0 Td
(present)Tj
3.1635 0 Td
(in)Tj
1.0375 0 Td
(neural)Tj
2.7722 0 Td
(datasets.)Tj
3.583 0 Td
(Since)Tj
2.3584 0 Td
(we)Tj
1.3266 0 Td
(are)Tj
1.4457 0 Td
(running)Tj
-32.0823 -1.2982 Td
(many)Tj
2.4774 0 Td
(fewer)Tj
2.4094 0 Td
(LMERs,)Tj
3.4299 0 Td
(the)Tj
1.4684 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(permutation)Tj
5.2327 0 Td
(testing)Tj
2.88 0 Td
(becomes)Tj
3.685 0 Td
(computationally)Tj
6.7521 0 Td
(feasible,)Tj
3.3959 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
-36.0054 -1.3039 Td
(ensure)Tj
2.8743 0 Td
(that)Tj
1.7801 0 Td
(our)Tj
1.6271 0 Td
(feature)Tj
2.982 0 Td
(selection)Tj
3.719 0 Td
(step)Tj
1.8199 0 Td
(has)Tj
1.542 0 Td
(not)Tj
1.5761 0 Td
(biassed)Tj
3.101 0 Td
(our)Tj
1.6271 0 Td
(results,)Tj
3.0331 0 Td
(we)Tj
1.3266 0 Td
(repeat)Tj
2.6872 0 Td
(the)Tj
1.474 0 Td
(same)Tj
2.2564 0 Td
(feature)Tj
-33.4259 -1.2983 Td
(selection)Tj
3.719 0 Td
(procedure)Tj
4.3086 0 Td
(for)Tj
1.389 0 Td
(each)Tj
2.0296 0 Td
(permutation.)Tj
5.4595 0 Td
(In)Tj
1.1055 0 Td
(MELD,)Tj
3.1804 0 Td
(the)Tj
1.474 0 Td
(strengths)Tj
3.8721 0 Td
(of)Tj
1.0148 0 Td
(permutation,)Tj
5.4595 0 Td
(TFCE,)Tj
-33.012 -1.2983 Td
(SVD,)Tj
2.3527 0 Td
(and)Tj
1.7291 0 Td
(LMER)Tj
2.8403 0 Td
(mitigate)Tj
3.4923 0 Td
(each)Tj
2.0296 0 Td
(other's)Tj
2.9253 0 Td
(weaknesses,)Tj
4.9606 0 Td
(producing)Tj
4.3767 0 Td
(a)Tj
0.6519 0 Td
(method)Tj
3.3222 0 Td
(that)Tj
1.7802 0 Td
(is)Tj
0.8503 0 Td
(more)Tj
2.3415 0 Td
(powerful)Tj
-33.6527 -1.3039 Td
(and)Tj
1.7291 0 Td
(more)Tj
2.3414 0 Td
(versatile)Tj
3.4979 0 Td
(than)Tj
2.0296 0 Td
(the)Tj
1.4683 0 Td
(standard)Tj
3.7247 0 Td
(approach)Tj
3.9515 0 Td
(to)Tj
1.0261 0 Td
(neural)Tj
2.7723 0 Td
(data)Tj
1.9105 0 Td
(analysis.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 272.9763 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(MELD)Tj
2.9716 0 Td
(in)Tj
0.9874 0 Td
(detail)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 256.0251 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(MELD)Tj
2.9536 0 Td
(consists)Tj
3.3506 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(following)Tj
3.9798 0 Td
(steps:)Tj
-12.7671 -1.9048 Td
(1.)Tj
1.2018 0 Td
(Correlate)Tj
3.9572 0 Td
(the)Tj
1.4683 0 Td
(independent)Tj
5.2724 0 Td
(and)Tj
1.7348 0 Td
(dependent)Tj
4.456 0 Td
(data.)Tj
-18.0905 -1.8992 Td
(2.)Tj
1.2018 0 Td
(Apply)Tj
2.6362 0 Td
(TFCE.)Tj
-3.838 -1.8992 Td
(3.)Tj
1.2018 0 Td
(Identify)Tj
3.3676 0 Td
(and)Tj
1.7291 0 Td
(mask)Tj
2.3301 0 Td
(unstable)Tj
3.5659 0 Td
(feature)Tj
2.9877 0 Td
(correlations.)Tj
-15.1822 -1.8992 Td
(4.)Tj
1.2018 0 Td
(Calculate)Tj
3.9118 0 Td
(the)Tj
1.474 0 Td
(SVD.)Tj
-6.5876 -1.8992 Td
(5.)Tj
1.2018 0 Td
(Reduce)Tj
3.1635 0 Td
(the)Tj
1.474 0 Td
(dimensionality)Tj
6.1908 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(dependent)Tj
4.4561 0 Td
(data.)Tj
-17.7391 -2.0013 Td
(a.)Tj
1.1622 0 Td
(Dot)Tj
1.7574 0 Td
(product)Tj
3.3959 0 Td
(of)Tj
1.0148 0 Td
(dependent)Tj
4.4561 0 Td
(data)Tj
1.9162 0 Td
(with)Tj
1.9955 0 Td
(right)Tj
2.1487 0 Td
(singular)Tj
3.4412 0 Td
(vectors.)Tj
-22.5182 -1.8992 Td
(6.)Tj
1.2018 0 Td
(Run)Tj
1.9162 0 Td
(LMER.)Tj
-1.9615 -2.0012 Td
(a.)Tj
1.1622 0 Td
(Predict)Tj
3.0897 0 Td
(the)Tj
1.4684 0 Td
(reduced)Tj
3.4469 0 Td
(dependent)Tj
4.456 0 Td
(data)Tj
1.9162 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(independent)Tj
5.2781 0 Td
(data.)Tj
-24.2814 -1.8992 Td
(b.)Tj
1.2359 0 Td
(Transform)Tj
4.5297 0 Td
(t-values)Tj
3.3165 0 Td
(back)Tj
2.0806 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(feature)Tj
2.9877 0 Td
(space)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 442.4881 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(MELD)Tj
2.7354 0 Td
(:)Tj
0.4961 0 Td
(Mixed)Tj
2.8488 0 Td
(effects)Tj
3.1181 0 Td
(for)Tj
1.3678 0 Td
(large)Tj
2.4024 0 Td
(datasets)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01827)Tj
4.089 0 Td
(97)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(22,)Tj
1.5874 0 Td
(2017)Tj
34.0302 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
BT
66.402 0 Td
(21)Tj
ET
Q
endstream
endobj
42 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 8 0 R/Annots 47 0 R/Contents 48 0 R/TrimBox[0 0 612 792]>>
endobj
47 0 obj
[49 0 R 50 0 R 51 0 R 52 0 R 53 0 R]
endobj
49 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.g001)>>
endobj
50 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref015)>>
endobj
51 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.ref007)>>
endobj
52 0 obj
<>/Border[0 0 0]/Dest(Rpone.0182797.g001)>>
endobj
53 0 obj
<>/Border[0 0 0]/A 54 0 R>>
endobj
54 0 obj
<>
endobj
48 0 obj
[55 0 R 56 0 R 57 0 R 58 0 R 59 0 R]
endobj
55 0 obj
<>stream
q
0.83 0.64 0.02 0 k
221.7827 583.3134 m
248.1449 583.3134 l
h
f*
332.2772 472.3654 m
341.8016 472.3654 l
h
f*
368.1071 472.3654 m
372.8693 472.3654 l
h
f*
509.8961 368.3906 m
535.2378 368.3906 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(7.)Tj
1.2018 0 Td
(Permutation)Tj
5.2724 0 Td
(test)Tj
1.5988 0 Td
(to)Tj
1.0261 0 Td
(assess)Tj
2.5228 0 Td
(feature)Tj
2.9877 0 Td
(level)Tj
2.0126 0 Td
(significance.)Tj
-15.392 -2.0012 Td
(a.)Tj
1.1622 0 Td
(Dependent)Tj
4.6658 0 Td
(data)Tj
1.9162 0 Td
(is)Tj
0.8447 0 Td
(reshuffled)Tj
4.2066 0 Td
(within)Tj
2.8119 0 Td
(subjects.)Tj
-15.6811 -1.8992 Td
(b.)Tj
1.2359 0 Td
(Repeat)Tj
2.9367 0 Td
(steps)Tj
/F11 1 Tf
2.1826 0 Td
(1)Tj
/F5 1 Tf
0.7143 0 Td
(through)Tj
/F11 1 Tf
3.4469 0 Td
(6)Tj
/F5 1 Tf
0.7144 0 Td
(for)Tj
1.3889 0 Td
(each)Tj
2.024 0 Td
(permutation.)Tj
-14.604 -1.8992 Td
(For)Tj
1.627 0 Td
(the)Tj
1.4684 0 Td
(sake)Tj
1.9389 0 Td
(of)Tj
1.0148 0 Td
(demonstration,)Tj
6.3552 0 Td
(we)Tj
1.3266 0 Td
(imagined)Tj
3.9741 0 Td
(a)Tj
0.652 0 Td
(simplified)Tj
4.2066 0 Td
(experiment)Tj
4.7792 0 Td
(in)Tj
1.0375 0 Td
(which)Tj
2.6475 0 Td
(a)Tj
0.652 0 Td
(3)Tj
0.6973 0 Td
(electrode)Tj
-33.5733 -1.3039 Td
(x)Tj
0.6859 0 Td
(5)Tj
0.6917 0 Td
(timepoint)Tj
4.1669 0 Td
(set)Tj
1.3039 0 Td
(of)Tj
1.0148 0 Td
(neural)Tj
2.7723 0 Td
(data)Tj
1.9162 0 Td
(was)Tj
1.6951 0 Td
(collected)Tj
3.7417 0 Td
(in)Tj
1.0375 0 Td
(each)Tj
2.0239 0 Td
(of)Tj
1.0148 0 Td
(10)Tj
1.1735 0 Td
(trials)Tj
2.1997 0 Td
(for)Tj
1.3833 0 Td
(three)Tj
2.2677 0 Td
(subjects.)Tj
3.6 0 Td
(Different)Tj
-32.6889 -1.2983 Td
(items)Tj
2.3867 0 Td
(were)Tj
2.126 0 Td
(presented)Tj
4.1102 0 Td
(in)Tj
1.0375 0 Td
(each)Tj
2.0296 0 Td
(trial)Tj
1.8368 0 Td
(so)Tj
1.0885 0 Td
(that)Tj
1.7801 0 Td
(no)Tj
1.2756 0 Td
(subject)Tj
3.0161 0 Td
(saw)Tj
1.7007 0 Td
(the)Tj
1.4684 0 Td
(same)Tj
2.2563 0 Td
(item)Tj
2.0296 0 Td
(twice.)Tj
2.5399 0 Td
(Trials)Tj
2.5114 0 Td
(were)Tj
-33.1934 -1.2982 Td
(evenly)Tj
2.7722 0 Td
(split)Tj
1.9106 0 Td
(between)Tj
3.5262 0 Td
(two)Tj
1.7065 0 Td
(behavioral)Tj
4.3937 0 Td
(conditions,)Tj
4.6998 0 Td
(A)Tj
0.907 0 Td
(and)Tj
1.7292 0 Td
(B,)Tj
1.0261 0 Td
(and)Tj
1.7291 0 Td
(there)Tj
2.2677 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.652 0 Td
(continuous)Tj
4.7395 0 Td
(variable)Tj
-32.9043 -1.304 Td
(with)Tj
1.9955 0 Td
(a)Tj
0.652 0 Td
(different)Tj
3.6567 0 Td
(random)Tj
3.4299 0 Td
(value)Tj
2.3073 0 Td
(in)Tj
1.0319 0 Td
(each)Tj
2.0295 0 Td
(trial)Tj
1.8369 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(mock)Tj
2.4718 0 Td
(neural)Tj
2.7666 0 Td
(data)Tj
1.9162 0 Td
(corresponding)Tj
6.0604 0 Td
(to)Tj
1.0262 0 Td
(each)Tj
-35.0303 -1.2982 Td
(trial)Tj
1.8368 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1A)Tj
0 g
(\).)Tj
1.9446 0 Td
(We)Tj
1.61 0 Td
(predict)Tj
3.0501 0 Td
(the)Tj
1.4683 0 Td
(neural)Tj
2.7723 0 Td
(data)Tj
1.9105 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(following)Tj
3.9798 0 Td
(mixed)Tj
2.7213 0 Td
(effects)Tj
2.7269 0 Td
(model:)Tj
/F6 1 Tf
0 Tc
-21.4808 -2.143 Td
[()6()2()12()]TJ
1.8085 0 Td
[()11()]TJ
/F12 1 Tf
1.0261 0 Td
()Tj
/F6 1 Tf
1.0488 0 Td
[()4()15( )]TJ
/F12 1 Tf
1.5988 0 Td
()Tj
/F6 1 Tf
0.9978 0 Td
[(\n)7()11()]TJ
1.3606 0 Td
[()]TJ
/F12 1 Tf
0.5669 0 Td
()Tj
0.9921 0 Td
()Tj
/F6 1 Tf
[()4()15( )]TJ
/F12 1 Tf
1.9899 0 Td
()Tj
/F6 1 Tf
0.9921 0 Td
[(\n)7()11()22()]TJ
/F12 1 Tf
1.7065 0 Td
(j)Tj
/F6 1 Tf
[()10()14()11(\r)]TJ
1.8595 0 Td
[()7(\n)-4()]TJ
/F12 1 Tf
1.1112 0 Td
()Tj
0.6009 0 Td
()Tj
0.9978 0 Td
()Tj
/F13 1 Tf
(1)Tj
/F12 1 Tf
(j)Tj
/F6 1 Tf
[()14()]TJ
1.7178 0 Td
[()2()]TJ
/F12 1 Tf
()Tj
/F5 1 Tf
-0.004 Tc
-27.0083 -3.7474 Td
(This)Tj
1.9899 0 Td
(model)Tj
2.7439 0 Td
(indicates)Tj
3.77 0 Td
(that)Tj
1.7802 0 Td
(we)Tj
1.3266 0 Td
(are)Tj
1.4457 0 Td
(fitting)Tj
2.6532 0 Td
(fixed)Tj
2.194 0 Td
(effects)Tj
2.7269 0 Td
(representing)Tj
5.2384 0 Td
(the)Tj
1.4683 0 Td
(mean)Tj
2.4491 0 Td
(effects)Tj
2.7213 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-34.7185 -1.3039 Td
(behavioral)Tj
4.3936 0 Td
(condition)Tj
4.1102 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4684 0 Td
(continuous)Tj
4.7338 0 Td
(variable,)Tj
3.583 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(allowing)Tj
3.6226 0 Td
(the)Tj
1.4684 0 Td
(magnitude)Tj
4.5297 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
-34.5087 -1.2983 Td
(effects)Tj
2.7269 0 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.1089 0 Td
(intercepts)Tj
4.1499 0 Td
(to)Tj
1.0262 0 Td
(vary)Tj
1.9332 0 Td
(across)Tj
2.6759 0 Td
(subjects.)Tj
3.6056 0 Td
(The)Tj
1.7858 0 Td
(intercept)Tj
3.7871 0 Td
(is)Tj
0.8504 0 Td
(additionally)Tj
4.9776 0 Td
(allowed)Tj
3.2882 0 Td
(to)Tj
1.0261 0 Td
(vary)Tj
-35.6709 -1.2982 Td
(across)Tj
2.6758 0 Td
(individual)Tj
4.286 0 Td
(items.)Tj
2.6192 0 Td
(Careful)Tj
3.1748 0 Td
(consideration)Tj
5.7032 0 Td
(should)Tj
2.914 0 Td
(be)Tj
1.1509 0 Td
(given)Tj
2.3811 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(specification)Tj
5.244 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(ran-)Tj
-35.1323 -1.304 Td
(dom)Tj
2.0749 0 Td
(effects.)Tj
2.948 0 Td
(We)Tj
1.6101 0 Td
(refer)Tj
2.0976 0 Td
(readers)Tj
3.1351 0 Td
(to)Tj
1.0205 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(])Tj
1.8538 0 Td
(and)Tj
1.7291 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(])Tj
1.3777 0 Td
(for)Tj
1.3833 0 Td
(discussion)Tj
4.371 0 Td
(of)Tj
1.0148 0 Td
(random)Tj
3.4299 0 Td
(effects)Tj
2.7269 0 Td
(specification.)Tj
5.4708 0 Td
(In)Tj
-36.2435 -1.2982 Td
(the)Tj
1.4683 0 Td
(following)Tj
3.9798 0 Td
(description)Tj
4.7338 0 Td
(of)Tj
1.0148 0 Td
(our)Tj
1.6214 0 Td
(technique)Tj
4.1669 0 Td
(we)Tj
1.3323 0 Td
(provide)Tj
3.2882 0 Td
(the)Tj
1.4683 0 Td
(dimensions)Tj
4.8529 0 Td
(of)Tj
1.0148 0 Td
(matrices)Tj
3.617 0 Td
(our)Tj
1.6271 0 Td
(analysis)Tj
-34.1856 -1.2983 Td
(would)Tj
2.7099 0 Td
(produce)Tj
3.5206 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2755 0 Td
(this)Tj
1.6725 0 Td
(small)Tj
2.33 0 Td
(dataset.)Tj
-12.7841 -1.3039 Td
(The)Tj
1.7858 0 Td
(trial)Tj
1.8368 0 Td
(information)Tj
5.074 0 Td
(is)Tj
0.8504 0 Td
(collected)Tj
3.736 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6576 0 Td
(matrix)Tj
/F6 1 Tf
2.8743 0 Td
[()]TJ
/F5 1 Tf
0.8504 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6576 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(rows)Tj
2.143 0 Td
(equal)Tj
2.3584 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(number)Tj
-33.9815 -1.2983 Td
(of)Tj
1.0147 0 Td
(trials)Tj
2.194 0 Td
(per)Tj
1.5364 0 Td
(subject)Tj
3.0161 0 Td
(\(10)Tj
1.5137 0 Td
(trials)Tj
2.194 0 Td
(per)Tj
1.5363 0 Td
(subject)Tj
3.0161 0 Td
(=)Tj
0.7993 0 Td
(10)Tj
1.1679 0 Td
(rows)Tj
2.1486 0 Td
(per)Tj
1.5307 0 Td
(subject\))Tj
3.3562 0 Td
(and)Tj
1.7292 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(columns)Tj
3.6567 0 Td
(equal)Tj
-34.8432 -1.2982 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(independent)Tj
5.2724 0 Td
(variables)Tj
3.719 0 Td
(\(2)Tj
1.0375 0 Td
(independent)Tj
5.2724 0 Td
(variables)Tj
3.719 0 Td
(=)Tj
0.7994 0 Td
(2)Tj
0.6973 0 Td
(columns\).)Tj
4.2179 0 Td
(The)Tj
1.7802 0 Td
(neural)Tj
-33.4429 -1.2983 Td
(data)Tj
1.9105 0 Td
(are)Tj
1.4513 0 Td
(flattened)Tj
3.7077 0 Td
(and)Tj
1.7291 0 Td
(stacked)Tj
3.1862 0 Td
(to)Tj
1.0261 0 Td
(produce)Tj
3.5149 0 Td
(the)Tj
1.474 0 Td
(matrix)Tj
/F6 1 Tf
2.8743 0 Td
[()]TJ
/F5 1 Tf
0.8221 0 Td
(with)Tj
1.9956 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(rows)Tj
2.143 0 Td
(equal)Tj
2.3584 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(num-)Tj
-35.121 -1.3039 Td
(ber)Tj
1.5193 0 Td
(of)Tj
1.0148 0 Td
(trials)Tj
2.1997 0 Td
(per)Tj
1.5307 0 Td
(subject)Tj
3.016 0 Td
(\(10)Tj
1.5137 0 Td
(trials)Tj
2.1997 0 Td
(per)Tj
1.5307 0 Td
(subject)Tj
3.016 0 Td
(=)Tj
0.7994 0 Td
(10)Tj
1.1735 0 Td
(rows)Tj
2.143 0 Td
(per)Tj
1.5307 0 Td
(subject\))Tj
3.3562 0 Td
(and)Tj
1.7348 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(columns)Tj
-32.7116 -1.2983 Td
(equal)Tj
2.3584 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(features)Tj
3.3449 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(neural)Tj
2.7722 0 Td
(data)Tj
1.9106 0 Td
(\(15)Tj
1.5137 0 Td
(features)Tj
3.3448 0 Td
(=)Tj
0.8051 0 Td
(15)Tj
1.1678 0 Td
(columns\))Tj
3.9968 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8199 0 Td
(1B)Tj
0 g
(\).)Tj
/F11 1 Tf
-31.2716 -1.2982 Td
(Step)Tj
2.0409 0 Td
(1:)Tj
0.9638 0 Td
(Correlate)Tj
4.1669 0 Td
(the)Tj
1.542 0 Td
(independent)Tj
5.4708 0 Td
(and)Tj
1.7972 0 Td
(dependent)Tj
4.6261 0 Td
(data.)Tj
/F5 1 Tf
2.863 0 Td
(In)Tj
1.1055 0 Td
(order)Tj
2.4264 0 Td
(to)Tj
1.0205 0 Td
(calculate)Tj
3.6793 0 Td
(the)Tj
1.4684 0 Td
(correla-)Tj
-34.367 -1.304 Td
(tion)Tj
1.8425 0 Td
(between)Tj
3.5262 0 Td
(the)Tj
1.4684 0 Td
(independent)Tj
5.278 0 Td
(and)Tj
1.7292 0 Td
(dependent)Tj
4.456 0 Td
(variables,)Tj
3.9458 0 Td
(the)Tj
1.4683 0 Td
(columns)Tj
3.6567 0 Td
(of)Tj
1.0148 0 Td
(matrices)Tj
/F6 1 Tf
3.617 0 Td
[()]TJ
/F5 1 Tf
0.8504 0 Td
(and)Tj
/F6 1 Tf
1.7291 0 Td
[()]TJ
/F5 1 Tf
0.8221 0 Td
(are)Tj
-35.4045 -1.2982 Td
(normalized)Tj
4.7678 0 Td
(within)Tj
2.8063 0 Td
(subject)Tj
3.0104 0 Td
(so)Tj
1.0771 0 Td
(that)Tj
1.7745 0 Td
(the)Tj
1.457 0 Td
(mean)Tj
2.4378 0 Td
(of)Tj
1.0091 0 Td
(each)Tj
2.0182 0 Td
(column)Tj
3.2882 0 Td
(is)Tj
0.8391 0 Td
(0)Tj
0.6859 0 Td
(and)Tj
1.7235 0 Td
(the)Tj
1.4627 0 Td
(sum)Tj
1.9218 0 Td
(of)Tj
1.0035 0 Td
(the)Tj
1.4627 0 Td
(squared)Tj
3.3618 0 Td
(val-)Tj
-36.1074 -1.3096 Td
(ues)Tj
1.5306 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(column)Tj
3.2938 0 Td
(is)Tj
0.8504 0 Td
(1.)Tj
0.9184 0 Td
(The)Tj
1.7802 0 Td
(dot)Tj
1.5534 0 Td
(product)Tj
3.3958 0 Td
(of)Tj
/F6 1 Tf
0 Tc
1.0148 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 375.0803 320.9952 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()]TJ
-0.085 -1.0677 Td
[()6()11()-9()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 390.0472 317.3669 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
/F6 1 Tf
1.7291 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 413.348 315.6661 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()6()11()-9()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 431.4897 317.3669 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(for)Tj
1.3889 0 Td
(each)Tj
2.0296 0 Td
(subject)Tj
3.0161 0 Td
(then)Tj
2.0182 0 Td
(produces)Tj
3.8778 0 Td
(cor-)Tj
-35.4781 -1.3379 Td
(relations)Tj
3.6737 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(matrix)Tj
/F6 1 Tf
2.8743 0 Td
[()]TJ
/F5 1 Tf
(,)Tj
1.0375 0 Td
(which)Tj
2.6532 0 Td
(has)Tj
1.542 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(rows)Tj
2.1429 0 Td
(equal)Tj
2.3584 0 Td
(to)Tj
1.0204 0 Td
(the)Tj
1.474 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(independent)Tj
-30.149 -1.2983 Td
(variables)Tj
3.719 0 Td
(per)Tj
1.5307 0 Td
(subject)Tj
3.0161 0 Td
(\(2)Tj
1.0374 0 Td
(independent)Tj
5.2724 0 Td
(variables)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 382.9606 294.633 cm
BT
/F12 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 388.6866 291.0047 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(3)Tj
0.6916 0 Td
(subjects)Tj
3.3789 0 Td
(=)Tj
0.805 0 Td
(6)Tj
0.6917 0 Td
(rows\))Tj
2.4831 0 Td
(and)Tj
1.7291 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(columns)Tj
-33.08 -1.2982 Td
(equal)Tj
2.3584 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(features)Tj
3.3449 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(neural)Tj
2.7722 0 Td
(data)Tj
1.9105 0 Td
(\(15)Tj
1.5137 0 Td
(features)Tj
3.3448 0 Td
(=)Tj
0.8051 0 Td
(15)Tj
1.1678 0 Td
(columns\).)Tj
/F11 1 Tf
-25.4548 -1.3039 Td
(Step)Tj
2.0409 0 Td
(2:)Tj
0.9638 0 Td
(Apply)Tj
2.7666 0 Td
(TFCE.)Tj
/F5 1 Tf
3.4866 0 Td
(TFCE)Tj
2.5965 0 Td
(improves)Tj
3.9401 0 Td
(sensitivity)Tj
4.2179 0 Td
(for)Tj
1.3889 0 Td
(contiguous)Tj
4.6545 0 Td
(signals)Tj
2.9026 0 Td
(\(in)Tj
1.372 0 Td
(both)Tj
2.0636 0 Td
(space)Tj
2.3754 0 Td
(and)Tj
-35.9656 -1.2983 Td
(time\),)Tj
2.5908 0 Td
(so)Tj
1.0885 0 Td
(we)Tj
1.3266 0 Td
(enhance)Tj
3.549 0 Td
(the)Tj
1.474 0 Td
(values)Tj
2.6645 0 Td
(in)Tj
/F6 1 Tf
1.0375 0 Td
[()]TJ
/F5 1 Tf
0.8107 0 Td
(prior)Tj
2.2507 0 Td
(to)Tj
1.0261 0 Td
(feature)Tj
2.9876 0 Td
(selection)Tj
3.7191 0 Td
(in)Tj
1.0374 0 Td
(Step)Tj
1.9333 0 Td
(3.)Tj
0.9184 0 Td
(First,)Tj
2.2733 0 Td
(we)Tj
1.3267 0 Td
(convert)Tj
3.2484 0 Td
(the)Tj
-35.2626 -1.2983 Td
(correlation)Tj
4.6147 0 Td
(coefficients)Tj
4.7395 0 Td
(in)Tj
/F6 1 Tf
1.0375 0 Td
[()]TJ
/F5 1 Tf
0.8107 0 Td
(to)Tj
/F6 1 Tf
1.0262 0 Td
[()]TJ
/F5 1 Tf
(s)Tj
0.9921 0 Td
(with)Tj
1.9955 0 Td
(Fisher's)Tj
3.2769 0 Td
(z-transformation)Tj
7.0354 0 Td
(to)Tj
1.0262 0 Td
(normalize)Tj
4.2519 0 Td
(the)Tj
1.4683 0 Td
(distribution.)Tj
-32.2749 -1.3039 Td
(Then)Tj
2.33 0 Td
(we)Tj
1.3266 0 Td
(apply)Tj
2.3925 0 Td
(TFCE)Tj
2.5908 0 Td
(to)Tj
1.0261 0 Td
(each)Tj
2.024 0 Td
(row)Tj
1.7858 0 Td
(of)Tj
/F6 1 Tf
1.0148 0 Td
[()]TJ
/F5 1 Tf
0.8107 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4683 0 Td
(connectivity)Tj
5.1363 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(features)Tj
3.3505 0 Td
(in)Tj
1.0318 0 Td
(features)Tj
-32.5187 -1.2982 Td
(space,)Tj
2.6022 0 Td
(producing)Tj
4.3766 0 Td
(cluster)Tj
2.8743 0 Td
(enhanced)Tj
4.0762 0 Td
(matrix)Tj
/F6 1 Tf
2.8743 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 373.9464 211.3511 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 379.1055 212.9952 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(with)Tj
1.9955 0 Td
(the)Tj
1.4684 0 Td
(same)Tj
2.2563 0 Td
(dimensions)Tj
4.8529 0 Td
(as)Tj
/F6 1 Tf
1.0148 0 Td
[()]TJ
/F5 1 Tf
(.)Tj
/F11 1 Tf
-28.3008 -1.2982 Td
(Step)Tj
2.0409 0 Td
(3:)Tj
0.9638 0 Td
(Identify)Tj
3.5546 0 Td
(and)Tj
1.7915 0 Td
(mask)Tj
2.4151 0 Td
(unstable)Tj
3.753 0 Td
(feature)Tj
3.1747 0 Td
(correlations.)Tj
/F5 1 Tf
6.0548 0 Td
(Neural)Tj
2.9593 0 Td
(datasets)Tj
3.3619 0 Td
(typically)Tj
3.5603 0 Td
(have)Tj
2.0579 0 Td
(a)Tj
-36.884 -1.3039 Td
(large)Tj
2.16 0 Td
(proportion)Tj
4.6317 0 Td
(of)Tj
1.0148 0 Td
(features)Tj
3.3449 0 Td
(where)Tj
2.6532 0 Td
(the)Tj
1.4683 0 Td
(correlation)Tj
4.6204 0 Td
(between)Tj
3.5263 0 Td
(dependent)Tj
4.456 0 Td
(data)Tj
1.9162 0 Td
(and)Tj
1.7291 0 Td
(any)Tj
1.6611 0 Td
(given)Tj
-33.182 -1.2983 Td
(dimension)Tj
4.49 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(independent)Tj
5.2724 0 Td
(data)Tj
1.9162 0 Td
(is)Tj
0.8504 0 Td
(not)Tj
1.5703 0 Td
(stable)Tj
2.4887 0 Td
(across)Tj
2.6816 0 Td
(subjects.)Tj
3.6 0 Td
(The)Tj
1.7858 0 Td
(goal)Tj
1.8709 0 Td
(of)Tj
1.0147 0 Td
(this)Tj
1.6725 0 Td
(step)Tj
1.8198 0 Td
(is)Tj
0.8504 0 Td
(to)Tj
-34.3669 -1.2983 Td
(remove)Tj
3.2201 0 Td
(these)Tj
2.2507 0 Td
(unstable)Tj
3.566 0 Td
(feature)Tj
2.9877 0 Td
(correlations)Tj
4.9776 0 Td
(to)Tj
1.026 0 Td
(improve)Tj
3.583 0 Td
(the)Tj
1.4683 0 Td
(performance)Tj
5.3461 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(SVD)Tj
2.1316 0 Td
(in)Tj
/F11 1 Tf
1.0318 0 Td
(Step)Tj
2.0409 0 Td
(4)Tj
/F5 1 Tf
(.)Tj
-36.113 -1.2982 Td
(Taking)Tj
3.0387 0 Td
(the)Tj
1.474 0 Td
(SVD)Tj
2.126 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(feature)Tj
2.9877 0 Td
(correlations)Tj
4.9776 0 Td
(identifies)Tj
3.889 0 Td
(the)Tj
1.474 0 Td
(transformation)Tj
6.2702 0 Td
(that)Tj
1.7802 0 Td
(reduces)Tj
3.2768 0 Td
(the)Tj
-33.7773 -1.3039 Td
(dimensionality)Tj
6.1908 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(dependent)Tj
4.4561 0 Td
(data)Tj
1.9162 0 Td
(while)Tj
2.3697 0 Td
(maintaining)Tj
5.1193 0 Td
(the)Tj
1.4683 0 Td
(relationships)Tj
5.3518 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.4683 0 Td
(depen-)Tj
-34.3499 -1.2983 Td
(dent)Tj
2.0182 0 Td
(and)Tj
1.7291 0 Td
(independent)Tj
5.2725 0 Td
(data.)Tj
2.1429 0 Td
(If)Tj
0.8448 0 Td
(we)Tj
1.3266 0 Td
(did)Tj
1.5477 0 Td
(not)Tj
1.5704 0 Td
(mask)Tj
2.3299 0 Td
(unstable)Tj
3.566 0 Td
(feature)Tj
2.9877 0 Td
(correlations,)Tj
5.2044 0 Td
(the)Tj
1.4683 0 Td
(SVD)Tj
2.126 0 Td
(would)Tj
-34.1345 -1.2983 Td
(give)Tj
1.8311 0 Td
(each)Tj
2.024 0 Td
(unstable)Tj
3.5716 0 Td
(feature)Tj
2.982 0 Td
(correlation)Tj
4.6205 0 Td
(very)Tj
1.9218 0 Td
(little)Tj
2.0012 0 Td
(weight,)Tj
3.1124 0 Td
(but)Tj
1.5534 0 Td
(neural)Tj
2.7723 0 Td
(datasets)Tj
3.3562 0 Td
(have)Tj
2.0579 0 Td
(so)Tj
1.0885 0 Td
(many)Tj
-32.8929 -1.3039 Td
(unstable)Tj
3.5659 0 Td
(feature)Tj
2.9877 0 Td
(correlations)Tj
4.9776 0 Td
(that)Tj
1.7745 0 Td
(their)Tj
2.109 0 Td
(cumulative)Tj
4.643 0 Td
(effect)Tj
2.3641 0 Td
(would)Tj
2.7156 0 Td
(drown)Tj
2.8573 0 Td
(out)Tj
1.5533 0 Td
(the)Tj
1.4684 0 Td
(signal)Tj
2.5455 0 Td
(in)Tj
1.0318 0 Td
(our)Tj
-34.5937 -1.2983 Td
(transformed)Tj
5.1703 0 Td
(data.)Tj
2.1373 0 Td
(It)Tj
0.8618 0 Td
(is)Tj
0.8447 0 Td
(important)Tj
4.2803 0 Td
(to)Tj
1.0261 0 Td
(note)Tj
2.0013 0 Td
(that)Tj
1.7743 0 Td
(we)Tj
1.3266 0 Td
(are)Tj
1.4514 0 Td
(determining)Tj
5.1817 0 Td
(the)Tj
1.4683 0 Td
(across)Tj
2.6759 0 Td
(subject)Tj
3.0217 0 Td
(stability)Tj
3.3505 0 Td
(of)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 442.4881 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(MELD)Tj
2.7354 0 Td
(:)Tj
0.4961 0 Td
(Mixed)Tj
2.8488 0 Td
(effects)Tj
3.1181 0 Td
(for)Tj
1.3678 0 Td
(large)Tj
2.4024 0 Td
(datasets)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01827)Tj
4.089 0 Td
(97)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(22,)Tj
1.5874 0 Td
(2017)Tj
34.0302 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
BT
66.402 0 Td
(21)Tj
ET
Q
endstream
endobj
60 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 8 0 R/Annots 62 0 R/Contents 63 0 R/TrimBox[0 0 612 792]>>
endobj
61 0 obj
<>stream
xyV;Α)*Re#!2d̢R*C$RyV:88ٿk_^k}{Xkzkߟl_B+I'c+" " " " " " " " " " " " " "O?ԱcDŽ?w_!" " " " " " " " " " " " " "?xM6IVf%)SXV@5jTÆ
UW^JHe˶~ĥa"lڴ~V@/rQ';
+" " " " " " " " " " " " " "<˗_ve+Rksw\tiV" " " " " " " " " " " " " " q|駭[NI&ڵ^?#HW^yUVYeԨQ[YW" " " " " " " " " " " " " " v|G
ܶm[V(HD@D@D@D@D@D@D@D@D@D@D@D@D@D@'`f͚*
y
Ν|~/K0k?eJD@D@D@D@D@D@D@D@D@D@D@D@D@D@$v=mi8뭷?~W\" " " " " " " " " " " " " " vg
P" " " " " " " " " " " " " " I0aBf0 s1K,I KD@D@D@D@D@D@D@D@D@D@D@D@D@DW_}}Yo/P*_." " " " " " " " " " " " " "$x Ki8Hk̘1IAq"3{u{N@2̙ӦMUW]GMED@D@D@D@D@D@D@D@D@D@D@D@D@D#Gf/
)x㍥r" " " " " " " " " " " " " " 7h`Zibh۶s=@1?ޢE7mwW{gz]wy1(" " " " " " " " " " " " " " .YmܸY>&M8Gr饗&PE!" " " " " " " " " " " " " "PE,loֽ{wHڴi3sy_ǏoԨ۵kLvm묳s<-(Nsqt7d~8osT'p?X<"" " " " " " " " " " " " " "NW^c=%ۇi\SNQzʔ)al:ȘgUɉ@pW{˘˘y%-I4h,37'Ghc8p`nl:Ȍ'|5]ܿ;',JHD@D@D@D@D@D@ Ν;vػ+[NtҪ&Pϟ?Vov&@|ͳf*WΕ$HOvs7n̳/bwW^qn:Ȇ |v ֭[6T*" " " " " " "Pg榧knΜ9,1bl:蠲d[@~m:?]ta}n~XS\uw}wn:Ȇĉ}=zdO"" " " " " " N ucqV,}>,V" SO=Y;.?3rKF=餓g˗/o?r믿s"P-Z8g*--" " " "PK2.==2?s)E@2 :²+
wiyeK⦛nѰ]l ܹs:tx[X}՛V_&M[oI&m}"PWo)" " " " !6[s5=|7rH40dܬY78nVwgyfQl" :109!
'iӦm62.駂o?hW]u.`:)" I_1+}}VJ-UG@pU2," " " "OgRca>dO~uFDH.WeI.y[!|u93䪫jذs+@FuÚRE HTE ?yZ%:&)cVpA=kU.RURE^V<>[j5ybYYܷaEO>Y,rz# uj\r:\.JW&px{>8iiP@U;i f/JpB"PޥgI>袋{у9nݺYҚ0a[8~k u '8G{!r]" u[2:\FJZR%:κw;駱=E." " HVʴvˇ'[MrU,ɿ:ur5CZ؍;W70LnkKS*W"f{ロ^$N qux6:uj:8RE(E@pKp~.]8H'[Y|o\mڴ)PeѢEL#8'ѲeiӦ%[j&" UJ@pV-UG@pU2,p<4:l YD@D@*@0OɖQp<T2Y:%msZ]w]~/Tzg:'z*@=:\2@%:\ <@AUqT,4FO_E:,O&UG@pLpgIۜV>-9wݸqcڶm$0" "Pvt"P9WN]('",Tl" " N
uN| ]p0T#5Y:%msZfm,ڶhb$.ٳsBoIlRmRk~U:R+.Hdy*6
':k| ]p0T#5Y:%mCZ駟+;cC>l焸q=$ùXD@ꐀ:tYB@pY+QȀ + !:\e>}\>,urڌr"e! u,ITpgIېO?N;(_~!%q.ݼy{/~@:\o5@{>f+WΕa3]1+!C%u8)GrU,KΒ!g}v
7tV5j4qDCK_~ѰaCs{$Z""u~{x]wU"PL;[W[m;68"P{^D" " Ì<~%RjrU,KΒv{y?sai쨲l2R*jRU}R$/u8Kb1Zk,6i+yHws
4߿?%_E@D H*VE@D@D URSūE@D@*@_W]RKgD H.WIΒ,iLkɒ%;vtViSOu|r-⋂I06?|2c{キFe u*IH@0ڵ[pg{"PgI^po>*q
\$7/qNԏ>hT@D@j:ܣG,x+_믿PD@D@DH*SE@D@|d|$JE H.W
JΒ,iJ+,n6s͏|a9'6i)uCe7#:lCIaD@D@j@0-[|W}I{EH.W%JΒ,i秅m:8` 7AfƏkKgD@DߥCS)Yヾ|k~-DQ~7P79-oU}nb᧟~Zt7|q1S+ە/Ew3Zd^Me|WlQD@D@ :~E:۱S{0eR,
\c hOAYRg/&;y7YF#jWi4`Mg&?3~a' >oBJ