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Thomas E. Besser, E. Frances Cassirer, Kathleen A. Potter, William J. Foreyt
Exposure of bighorn sheep to domestic goats colonized with Mycoplasma ovipneumoniae induces sub-lethal pneumonia
www.plosone.org
www.plosone.org
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(assay)Tj
2.2337 0 Td
(\(cELISA\))Tj
3.8834 0 Td
(serology)Tj
3.5093 0 Td
(and)Tj
1.7121 0 Td
(nasal)Tj
2.211 0 Td
(swab)Tj
2.1827 0 Td
(polymerase)Tj
4.7168 0 Td
(chain)Tj
2.3924 0 Td
(reac-)Tj
-35.5745 -1.2982 Td
(tion)Tj
1.8141 0 Td
(\(PCR\))Tj
2.7156 0 Td
(testing)Tj
2.8403 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
2.0466 0 Td
(Blood)Tj
2.5568 0 Td
(and)Tj
1.7121 0 Td
(nasal)Tj
2.2167 0 Td
(swab)Tj
2.1827 0 Td
(samples)Tj
3.3392 0 Td
(collected)Tj
3.685 0 Td
(from)Tj
2.1826 0 Td
(the)Tj
1.4514 0 Td
(six)Tj
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(experimental)Tj
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(ani-)Tj
-35.4271 -1.3039 Td
(mals)Tj
2.0579 0 Td
(on)Tj
1.2586 0 Td
(the)Tj
1.457 0 Td
(day)Tj
1.6157 0 Td
(of)Tj
1.0035 0 Td
(capture)Tj
3.1747 0 Td
(were)Tj
2.0977 0 Td
(also)Tj
1.7461 0 Td
(negative)Tj
3.4866 0 Td
(by)Tj
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1.1679 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.3039 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()11()18()4()6(\r)]TJ
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6.1511 0 Td
(cELISA)Tj
3.2145 0 Td
(and)Tj
1.7121 0 Td
(PCR)Tj
2.0466 0 Td
(tests.The)Tj
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2.0977 0 Td
(randomly)Tj
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(allocated)Tj
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(groups)Tj
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3.9458 0 Td
(or)Tj
-35.6936 -1.2983 Td
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(the)Tj
1.4513 0 Td
(bighorn)Tj
3.3732 0 Td
(sheep)Tj
2.4434 0 Td
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1.6838 0 Td
(conducted)Tj
4.371 0 Td
(under)Tj
2.5909 0 Td
(anesthesia)Tj
4.2406 0 Td
(\(butorphanol)Tj
5.4765 0 Td
(tartrate,)Tj
3.3222 0 Td
(azaperone)Tj
-32.1957 -1.3039 Td
(tartrate,)Tj
3.3221 0 Td
(and)Tj
1.7121 0 Td
(medetomidine)Tj
5.9981 0 Td
(hydrochloride,)Tj
6.0434 0 Td
(reversed)Tj
3.532 0 Td
(with)Tj
1.9729 0 Td
(atipamezole)Tj
4.9379 0 Td
(and)Tj
1.7121 0 Td
(naltrexone,)Tj
4.6432 0 Td
(BAM)Tj
2.3584 0 Td
(kit,)Tj
-36.2322 -1.2983 Td
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3.4015 0 Td
(Pharmaceuticals,)Tj
6.8995 0 Td
(Inc.)Tj
1.7348 0 Td
(Windsor)Tj
3.7247 0 Td
(CO\).)Tj
2.1713 0 Td
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1.4117 0 Td
(domestic)Tj
3.7984 0 Td
(goats)Tj
2.2563 0 Td
(were)Tj
2.0976 0 Td
(purchased)Tj
4.2803 0 Td
(from)Tj
2.1827 0 Td
(three)Tj
-33.9588 -1.2982 Td
(local)Tj
2.0466 0 Td
(private)Tj
2.9423 0 Td
(owners)Tj
3.0784 0 Td
(for)Tj
1.372 0 Td
(use)Tj
1.5137 0 Td
(in)Tj
1.0204 0 Td
(the)Tj
1.4513 0 Td
(experiments.)Tj
5.2951 0 Td
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4.0082 0 Td
(goats)Tj
2.2564 0 Td
(used)Tj
2.0352 0 Td
(in)Tj
1.0262 0 Td
(experiment)Tj
4.7168 0 Td
(1)Tj
0.6916 0 Td
(\(group)Tj
2.9084 0 Td
(1\))Tj
-36.3626 -1.3039 Td
(included)Tj
3.6623 0 Td
(a)Tj
0.6463 0 Td
(5+)Tj
1.2642 0 Td
(year)Tj
1.8822 0 Td
(Saanen)Tj
3.0501 0 Td
(wether)Tj
2.9083 0 Td
(previously)Tj
4.2916 0 Td
(used)Tj
2.0353 0 Td
(as)Tj
1.0035 0 Td
(a)Tj
0.6463 0 Td
(pack)Tj
2.0692 0 Td
(animal,)Tj
3.1521 0 Td
(a)Tj
0.652 0 Td
(1)Tj
0.686 0 Td
(year)Tj
1.8822 0 Td
(old)Tj
1.4796 0 Td
(mixed)Tj
2.6929 0 Td
(breed)Tj
-34.0041 -1.2983 Td
(wether)Tj
2.9139 0 Td
(intended)Tj
3.7361 0 Td
(for)Tj
1.3663 0 Td
(slaughter,)Tj
4.0422 0 Td
(and)Tj
1.7121 0 Td
(a)Tj
0.6463 0 Td
(1)Tj
0.6916 0 Td
(year)Tj
1.8765 0 Td
(old)Tj
1.4854 0 Td
(Boer)Tj
2.0749 0 Td
(wether)Tj
2.914 0 Td
(from)Tj
2.1827 0 Td
(a)Tj
0.6463 0 Td
(herd)Tj
2.0466 0 Td
(used)Tj
2.0353 0 Td
(for)Tj
1.3719 0 Td
(weed)Tj
2.2564 0 Td
(and)Tj
-33.9985 -1.2983 Td
(brush)Tj
2.4831 0 Td
(control.)Tj
3.2995 0 Td
(All)Tj
1.3776 0 Td
(were)Tj
2.0976 0 Td
(confirmed)Tj
4.3427 0 Td
(nasal)Tj
2.2167 0 Td
(carriers)Tj
3.1918 0 Td
(of)Tj
/F14 1 Tf
1.0034 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.3096 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()11()18()4()6(\r)]TJ
/F8 1 Tf
6.1455 0 Td
(based)Tj
2.4434 0 Td
(on)Tj
1.2643 0 Td
(PCR)Tj
2.0466 0 Td
(testing)Tj
-33.2218 -1.2982 Td
(of)Tj
1.0034 0 Td
(nasal)Tj
2.211 0 Td
(swab)Tj
2.1827 0 Td
(samples)Tj
3.3392 0 Td
(on)Tj
1.2642 0 Td
(at)Tj
0.9411 0 Td
(least)Tj
1.9559 0 Td
(two)Tj
1.6894 0 Td
(occasions)Tj
3.9969 0 Td
(prior)Tj
2.2223 0 Td
(to)Tj
1.0148 0 Td
(the)Tj
1.4513 0 Td
(study.)Tj
2.5796 0 Td
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4.0081 0 Td
(goats)Tj
2.2564 0 Td
(used)Tj
2.0352 0 Td
(in)Tj
1.0262 0 Td
(ex-)Tj
-35.1777 -1.3039 Td
(periments)Tj
4.1952 0 Td
(2)Tj
0.6916 0 Td
(and)Tj
1.7122 0 Td
(3)Tj
0.6859 0 Td
(\(group)Tj
2.914 0 Td
(2\))Tj
1.0262 0 Td
(included)Tj
3.6623 0 Td
(one)Tj
1.6838 0 Td
(yearling)Tj
3.3789 0 Td
(Boer)Tj
2.0806 0 Td
(female)Tj
2.8176 0 Td
(and)Tj
1.7121 0 Td
(two)Tj
1.6895 0 Td
(yearling)Tj
3.3845 0 Td
(LaMancha)Tj
-31.6344 -1.2983 Td
(wethers,)Tj
3.4865 0 Td
(all)Tj
1.1282 0 Td
(negative)Tj
3.4866 0 Td
(for)Tj
/F14 1 Tf
1.3663 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.3096 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()11()18()4()6(\r)]TJ
/F8 1 Tf
6.1455 0 Td
(by)Tj
1.1678 0 Td
(nasal)Tj
2.2167 0 Td
(swab)Tj
2.1827 0 Td
(PCR)Tj
2.0466 0 Td
(when)Tj
2.3754 0 Td
(purchased.)Tj
4.5014 0 Td
(Because)Tj
3.3505 0 Td
(they)Tj
-34.7638 -1.2983 Td
(originated)Tj
4.2689 0 Td
(in)Tj
1.0205 0 Td
(a)Tj
/F14 1 Tf
0.6463 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.3039 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()11()18()4()6(\r)]TJ
/F8 1 Tf
(positive)Tj
9.513 0 Td
(herd,)Tj
2.2677 0 Td
(group)Tj
2.5738 0 Td
(2)Tj
0.686 0 Td
(domestic)Tj
3.7984 0 Td
(goats)Tj
2.2564 0 Td
(were)Tj
2.0976 0 Td
(placed)Tj
2.7496 0 Td
(in)Tj
1.0261 0 Td
(isolation)Tj
-34.2082 -1.3039 Td
(from)Tj
2.1826 0 Td
(other)Tj
2.3187 0 Td
(small)Tj
2.2961 0 Td
(ruminants)Tj
4.3426 0 Td
(and)Tj
1.7122 0 Td
(were)Tj
2.0976 0 Td
(serially)Tj
2.9763 0 Td
(re-tested)Tj
3.6454 0 Td
(for)Tj
/F14 1 Tf
1.3663 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.3039 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()11()18()4()6(\r)]TJ
/F8 1 Tf
6.1511 0 Td
(nasal)Tj
2.211 0 Td
(carriage)Tj
3.3619 0 Td
(\(5)Tj
-35.9657 -1.2983 Td
(times)Tj
2.3584 0 Td
(over)Tj
1.9502 0 Td
(a)Tj
0.6519 0 Td
(4)Tj
0.686 0 Td
(week)Tj
2.228 0 Td
(period\))Tj
3.1295 0 Td
(to)Tj
1.0148 0 Td
(confirm)Tj
3.4015 0 Td
(their)Tj
2.0806 0 Td
(negative)Tj
3.4866 0 Td
(status)Tj
2.4605 0 Td
(prior)Tj
2.228 0 Td
(to)Tj
1.0091 0 Td
(the)Tj
1.457 0 Td
(start)Tj
1.9503 0 Td
(of)Tj
1.0034 0 Td
(experiment)Tj
4.7168 0 Td
(2.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 308.0125 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Experimental)Tj
5.9858 0 Td
(design)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 291.0047 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
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2.5738 0 Td
(experiments)Tj
5.142 0 Td
(were)Tj
2.1203 0 Td
(conducted)Tj
4.4277 0 Td
(in)Tj
1.0375 0 Td
(which)Tj
2.6475 0 Td
(domestic)Tj
3.8494 0 Td
(goats)Tj
2.2847 0 Td
(\(DG\))Tj
2.3528 0 Td
(of)Tj
1.0148 0 Td
(known)Tj
/F14 1 Tf
3.0047 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.3153 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()]TJ
-31.7705 -1.2982 Td
[()18()4()6(\r)]TJ
/F8 1 Tf
1.8935 0 Td
(status)Tj
2.5001 0 Td
(were)Tj
2.1203 0 Td
(comingled)Tj
4.4504 0 Td
(with)Tj
1.9956 0 Td
(susceptible)Tj
4.5751 0 Td
(bighorn)Tj
3.4128 0 Td
(sheep)Tj
2.4775 0 Td
(\(BHS\).)Tj
2.948 0 Td
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1.1055 0 Td
(each)Tj
2.0296 0 Td
(experiment,)Tj
5.006 0 Td
(comin-)Tj
-34.5144 -1.3039 Td
(gled)Tj
1.8821 0 Td
(animals)Tj
3.3279 0 Td
(shared)Tj
2.8686 0 Td
(feed)Tj
1.8822 0 Td
(and)Tj
1.7292 0 Td
(water)Tj
2.4321 0 Td
(sources)Tj
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(\(pelleted)Tj
3.668 0 Td
(hay)Tj
1.6384 0 Td
(supplemented)Tj
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(with)Tj
2.0012 0 Td
(a)Tj
0.652 0 Td
(corn/oats/)Tj
-31.1242 -1.2983 Td
(barley)Tj
2.6532 0 Td
(mixture,)Tj
3.6226 0 Td
(free)Tj
1.7235 0 Td
(choice)Tj
2.7949 0 Td
(trace)Tj
2.1713 0 Td
(mineral)Tj
3.3279 0 Td
(salt,)Tj
1.7858 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.652 0 Td
(single)Tj
2.5342 0 Td
(frost-protected)Tj
6.1851 0 Td
(water)Tj
2.4321 0 Td
(source)Tj
2.8346 0 Td
(in)Tj
1.0375 0 Td
(each)Tj
-35.4838 -1.2983 Td
(pen\).)Tj
2.2733 0 Td
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2.6476 0 Td
(roofed)Tj
2.8459 0 Td
(shelters)Tj
3.2315 0 Td
(were)Tj
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(available)Tj
3.668 0 Td
(in)Tj
1.0375 0 Td
(each)Tj
2.0239 0 Td
(pen,)Tj
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(and)Tj
1.7291 0 Td
(plywood)Tj
3.6624 0 Td
(sheets)Tj
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(covered)Tj
3.3562 0 Td
(the)Tj
1.4683 0 Td
(pen)Tj
-34.6164 -1.3039 Td
(fences)Tj
2.6872 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4683 0 Td
(corners)Tj
3.2259 0 Td
(to)Tj
1.0261 0 Td
(provide)Tj
3.2882 0 Td
(windbreaks.)Tj
5.0683 0 Td
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1.3946 0 Td
(animals)Tj
3.3279 0 Td
(were)Tj
2.1259 0 Td
(observed)Tj
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(daily.)Tj
/F15 1 Tf
-27.1614 -1.2982 Td
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5.125 0 Td
(1.)Tj
/F8 1 Tf
1.542 0 Td
(BHS)Tj
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(group)Tj
2.6136 0 Td
(1)Tj
0.6916 0 Td
(\(BHS29,)Tj
3.5603 0 Td
(BHS32,)Tj
3.2201 0 Td
(and)Tj
1.7292 0 Td
(BHS33;)Tj
/F14 1 Tf
3.2201 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.3209 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()11()18()4()6(\r)]TJ
/F8 1 Tf
(negative\))Tj
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(was)Tj
1.6951 0 Td
(comingled)Tj
4.4503 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.652 0 Td
(372)Tj
1.6497 0 Td
(m)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 303.0236 204.4346 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
-0.004 Tc
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(pen)Tj
1.7064 0 Td
(\(pen)Tj
2.0523 0 Td
(1\))Tj
1.0318 0 Td
(with)Tj
2.0012 0 Td
(group)Tj
2.6079 0 Td
(1)Tj
0.6973 0 Td
(DG)Tj
1.6668 0 Td
(\(DG1,)Tj
2.7155 0 Td
(DG2,)Tj
2.3754 0 Td
(and)Tj
1.7292 0 Td
(DG3;)Tj
/F14 1 Tf
2.3697 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
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1.321 0 Td
[()12(\n)-13()10()11()6(\r)2()]TJ
-33.1538 -1.3039 Td
[( )6()11()18()4()6(\r)]TJ
/F8 1 Tf
(positive\))Tj
6.8995 0 Td
(beginning)Tj
4.2632 0 Td
(February)Tj
3.8381 0 Td
(18,)Tj
1.3946 0 Td
(2014.)Tj
2.3471 0 Td
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3.1351 0 Td
(experiment)Tj
4.7792 0 Td
(1,)Tj
0.9241 0 Td
(BHS)Tj
2.0409 0 Td
(group)Tj
2.6079 0 Td
(2)Tj
0.6973 0 Td
(\(BHS27,)Tj
-32.927 -1.2982 Td
(BHS28,)Tj
3.2202 0 Td
(and)Tj
1.7291 0 Td
(BHS31;)Tj
/F14 1 Tf
3.2201 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.3153 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()11()18()4()6(\r)]TJ
/F8 1 Tf
(negativ)Tj
9.2295 0 Td
(e\))Tj
0.9807 0 Td
(were)Tj
2.126 0 Td
(housed)Tj
3.0898 0 Td
(in)Tj
1.0374 0 Td
(a)Tj
0.652 0 Td
(separate)Tj
3.4866 0 Td
(232)Tj
1.6441 0 Td
(m)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 525.5433 178.4692 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 531.2692 173.9905 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(pen)Tj
1.7121 0 Td
(\(pen)Tj
-34.8375 -1.2982 Td
(2\))Tj
1.0318 0 Td
(isolated)Tj
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0 Tc
3.2882 0 Td
(>)Tj
/F8 1 Tf
-0.004 Tc
(30)Tj
1.9445 0 Td
(m)Tj
1.0375 0 Td
(from)Tj
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(any)Tj
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(other)Tj
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(domestic)Tj
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(or)Tj
1.0998 0 Td
(wild)Tj
1.9445 0 Td
(sheep)Tj
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(or)Tj
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(goats.)Tj
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(animals)Tj
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(were)Tj
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(observed)Tj
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(signs)Tj
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(of)Tj
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(respiratory)Tj
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(disease)Tj
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(for)Tj
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(a)Tj
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(100)Tj
1.6384 0 Td
(day)Tj
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(period.)Tj
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(May)Tj
1.9956 0 Td
(30,)Tj
1.389 0 Td
(2014,)Tj
2.3414 0 Td
(BHS)Tj
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(group)Tj
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(1)Tj
0.686 0 Td
(ani-)Tj
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(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(start)Tj
1.9842 0 Td
(of)Tj
1.0148 0 Td
(experiment)Tj
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(1.)Tj
0.9241 0 Td
(All)Tj
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(BHS)Tj
2.041 0 Td
(were)Tj
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(negative)Tj
3.532 0 Td
(for)Tj
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(carriage)Tj
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(\(PCR)Tj
2.4037 0 Td
(testing)Tj
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(of)Tj
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(nasal)Tj
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(swabs\))Tj
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(and)Tj
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(exposure)Tj
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(to)Tj
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1.0204 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.321 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()11()18()4()6(\r)]TJ
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6.2248 0 Td
(\(cELISA)Tj
3.5887 0 Td
(testing)Tj
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(of)Tj
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(serum)Tj
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(samples\))Tj
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(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7779 0 Td
(1)Tj
0 g
(\).)Tj
1.2529 0 Td
(DG)Tj
1.6668 0 Td
(were)Tj
2.1146 0 Td
(confirmed)Tj
4.388 0 Td
(as)Tj
1.0092 0 Td
(carriers)Tj
3.2371 0 Td
(of)Tj
/F14 1 Tf
1.0091 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.3096 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()11()18()4()6(\r)]TJ
/F8 1 Tf
6.2192 0 Td
(based)Tj
2.4661 0 Td
(on)Tj
1.2699 0 Td
(detec-)Tj
-35.1493 -1.2983 Td
(tion)Tj
1.8425 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(bacterium)Tj
4.2916 0 Td
(by)Tj
1.1792 0 Td
(PCR)Tj
2.0636 0 Td
(on)Tj
1.2756 0 Td
(repeated)Tj
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(nasal)Tj
2.245 0 Td
(swab)Tj
2.2053 0 Td
(samples.)Tj
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3.2598 0 Td
(pharyngeal)Tj
4.6431 0 Td
(Pasteurella-)Tj
-32.7342 -1.3039 Td
(ceae)Tj
1.9218 0 Td
(were)Tj
2.126 0 Td
(detected)Tj
3.566 0 Td
(in)Tj
1.0318 0 Td
(both)Tj
2.0636 0 Td
(BHS)Tj
2.0409 0 Td
(and)Tj
1.7291 0 Td
(DG)Tj
1.6725 0 Td
(during)Tj
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(experiment)Tj
4.7735 0 Td
(1)Tj
0.6973 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(1)Tj
0 g
(\).)Tj
1.2586 0 Td
(Group)Tj
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(1)Tj
0.6973 0 Td
(BHS)Tj
2.0466 0 Td
(\(BHS29,)Tj
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(BHS32,)Tj
3.2201 0 Td
(and)Tj
1.7291 0 Td
(BHS33\))Tj
3.3335 0 Td
(and)Tj
1.7292 0 Td
(group)Tj
2.6078 0 Td
(1)Tj
0.6973 0 Td
(DG)Tj
1.6725 0 Td
(\(DG1,)Tj
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(DG2,)Tj
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(and)Tj
1.7291 0 Td
(DG3\))Tj
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(were)Tj
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(commingled)Tj
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(in)Tj
1.0318 0 Td
(pen)Tj
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(1)Tj
0.6917 0 Td
(to)Tj
-35.121 -1.2982 Td
(begin)Tj
2.4321 0 Td
(the)Tj
1.4683 0 Td
(experiment,)Tj
5.0003 0 Td
(while)Tj
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(group)Tj
2.6079 0 Td
(2)Tj
0.6973 0 Td
(BHS)Tj
2.0409 0 Td
(\(BHS27,)Tj
3.5603 0 Td
(BHS28,)Tj
3.2202 0 Td
(and)Tj
1.7291 0 Td
(BHS31\))Tj
3.3392 0 Td
(were)Tj
2.1203 0 Td
(maintained)Tj
4.7905 0 Td
(in)Tj
-35.3761 -1.304 Td
(isolation)Tj
3.6566 0 Td
(in)Tj
1.0318 0 Td
(pen)Tj
1.7121 0 Td
(2.)Tj
0.9185 0 Td
(Beginning)Tj
4.3369 0 Td
(23)Tj
1.6895 0 Td
(weeks)Tj
2.6078 0 Td
(after)Tj
2.0353 0 Td
(commingling,)Tj
5.8223 0 Td
(all)Tj
1.1452 0 Td
(group)Tj
2.6079 0 Td
(1)Tj
0.6973 0 Td
(BHS)Tj
2.0409 0 Td
(began)Tj
2.6022 0 Td
(showing)Tj
-32.9043 -1.2982 Td
(signs)Tj
2.2223 0 Td
(of)Tj
1.0148 0 Td
(respiratory)Tj
4.5978 0 Td
(disease,)Tj
3.2428 0 Td
(including)Tj
4.0422 0 Td
(increased)Tj
3.9968 0 Td
(nasal)Tj
2.245 0 Td
(discharge)Tj
4.0195 0 Td
(and)Tj
1.7291 0 Td
(coughing)Tj
3.9572 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.9184 0 Td
(S1)Tj
-33.8057 -1.2983 Td
(Table)Tj
0 g
(\).)Tj
3.0047 0 Td
(Clinical)Tj
3.3165 0 Td
(signs)Tj
2.2223 0 Td
(of)Tj
1.0148 0 Td
(middle)Tj
3.0331 0 Td
(ear)Tj
1.4513 0 Td
(involvement)Tj
5.21 0 Td
(\(head)Tj
2.4718 0 Td
(shaking,)Tj
3.5433 0 Td
(ear)Tj
1.4514 0 Td
(droop\))Tj
2.9876 0 Td
(were)Tj
2.126 0 Td
(rarely)Tj
2.5228 0 Td
(seen.)Tj
-34.3556 -1.2983 Td
(After)Tj
2.2847 0 Td
(70)Tj
1.1678 0 Td
(days)Tj
2.0013 0 Td
(of)Tj
1.0148 0 Td
(illness,)Tj
2.897 0 Td
(group)Tj
2.6078 0 Td
(1)Tj
0.6973 0 Td
(BHS)Tj
2.041 0 Td
(exhibited)Tj
3.9288 0 Td
(decreasing)Tj
4.4673 0 Td
(clinical)Tj
3.0728 0 Td
(signs)Tj
2.2223 0 Td
(of)Tj
1.0148 0 Td
(respiratory)Tj
4.5978 0 Td
(tract)Tj
2.0466 0 Td
(dis-)Tj
-36.0621 -1.3039 Td
(ease,)Tj
2.0862 0 Td
(and)Tj
1.7292 0 Td
(group)Tj
2.6078 0 Td
(1)Tj
0.6973 0 Td
(DG)Tj
1.6725 0 Td
(remained)Tj
4.0365 0 Td
(clinically)Tj
3.7757 0 Td
(normal)Tj
3.1464 0 Td
(throughout)Tj
4.7792 0 Td
(the)Tj
1.4684 0 Td
(experiment.)Tj
5.0059 0 Td
(Group)Tj
2.8573 0 Td
(1)Tj
0.6917 0 Td
(BHS)Tj
-34.5541 -1.2982 Td
(were)Tj
2.1203 0 Td
(euthanized)Tj
4.6147 0 Td
(and)Tj
1.7291 0 Td
(necropsied)Tj
4.5865 0 Td
(after)Tj
2.0352 0 Td
(100)Tj
1.6498 0 Td
(days)Tj
1.9956 0 Td
(of)Tj
1.0148 0 Td
(commingling.)Tj
5.8223 0 Td
(Uncommingled)Tj
6.5537 0 Td
(group)Tj
2.6078 0 Td
(2)Tj
0.6973 0 Td
(BHS)Tj
-35.4271 -1.2983 Td
(remained)Tj
4.0365 0 Td
(healthy)Tj
3.1294 0 Td
(in)Tj
1.0375 0 Td
(pen)Tj
1.7064 0 Td
(2)Tj
0.6973 0 Td
(throughout)Tj
4.7792 0 Td
(experiment)Tj
4.7792 0 Td
(1.)Tj
0.9184 0 Td
(At)Tj
1.2019 0 Td
(the)Tj
1.4683 0 Td
(end)Tj
1.7235 0 Td
(of)Tj
1.0148 0 Td
(experiment)Tj
4.7792 0 Td
(1,)Tj
0.9184 0 Td
(the)Tj
/F14 1 Tf
1.4683 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.321 0 Td
[()12(\n)-13()10()]TJ
-34.9793 -1.3039 Td
[()6(\r)2()12( )6()11()18()4()6(\r)]TJ
/F8 1 Tf
(negative)Tj
8.226 0 Td
(status)Tj
2.5002 0 Td
(of)Tj
1.0148 0 Td
(group)Tj
2.6078 0 Td
(2)Tj
0.6974 0 Td
(BHS)Tj
2.0409 0 Td
(was)Tj
1.7008 0 Td
(re-confirmed)Tj
5.5445 0 Td
(by)Tj
1.1792 0 Td
(PCR)Tj
2.0636 0 Td
(and)Tj
1.7291 0 Td
(cELISA)Tj
3.2542 0 Td
(serology.)Tj
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(BHS27)Tj
2.9933 0 Td
(subsequently)Tj
5.4085 0 Td
(died)Tj
1.9615 0 Td
(from)Tj
2.2054 0 Td
(aspiration)Tj
4.2293 0 Td
(pneumonia,)Tj
5.0399 0 Td
(the)Tj
1.4684 0 Td
(onset)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(which)Tj
2.6475 0 Td
(followed)Tj
3.651 0 Td
(the)Tj
1.4683 0 Td
(anes-)Tj
-34.4463 -1.2982 Td
(thesia)Tj
2.5284 0 Td
(conducted)Tj
4.4277 0 Td
(to)Tj
1.0262 0 Td
(permit)Tj
2.9196 0 Td
(sampling)Tj
3.8778 0 Td
(after)Tj
2.0353 0 Td
(experiment)Tj
4.7791 0 Td
(1;)Tj
0.9185 0 Td
(at)Tj
0.9524 0 Td
(necropsy,)Tj
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(BHS27)Tj
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(was)Tj
1.7008 0 Td
(also)Tj
1.7688 0 Td
(PCR-)Tj
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(and)Tj
1.7291 0 Td
(ELISA-negative)Tj
6.4913 0 Td
(for)Tj
/F14 1 Tf
1.3889 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.3153 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()11()18()4()6(\r)]TJ
/F8 1 Tf
(.)Tj
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(All)Tj
1.4003 0 Td
(BHS)Tj
2.0409 0 Td
(ewes)Tj
2.1146 0 Td
(lambed)Tj
3.1748 0 Td
(during)Tj
2.931 0 Td
(experiment)Tj
4.7792 0 Td
(1.)Tj
0.9184 0 Td
(All)Tj
1.3947 0 Td
(lambs)Tj
2.5908 0 Td
(born)Tj
2.1543 0 Td
(to)Tj
1.0262 0 Td
(group)Tj
2.6078 0 Td
(1)Tj
0.6917 0 Td
(\(goat-commingled,)Tj
/F14 1 Tf
-29.0209 -1.2983 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F14 1 Tf
1.3152 0 Td
[()12(\n)-13()10()11()6(\r)2()12( )6()11()18()4()6(\r)]TJ
/F8 1 Tf
(positive\))Tj
9.9949 0 Td
(BHS)Tj
2.0409 0 Td
(died)Tj
1.9673 0 Td
(at)Tj
0.9524 0 Td
(less)Tj
1.6101 0 Td
(than)Tj
2.0296 0 Td
(7)Tj
0.6916 0 Td
(days)Tj
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(of)Tj
1.0148 0 Td
(age,)Tj
1.7688 0 Td
(with)Tj
1.9956 0 Td
(signs)Tj
2.2223 0 Td
(of)Tj
1.0148 0 Td
(ocular,)Tj
2.9537 0 Td
(systemic)Tj
-33.5733 -1.3039 Td
(and/or)Tj
2.9366 0 Td
(gastrointestinal)Tj
6.3496 0 Td
(tract)Tj
2.0466 0 Td
(disease)Tj
3.016 0 Td
(\(BHS29L,)Tj
4.0989 0 Td
(BHS32L,)Tj
3.7587 0 Td
(and)Tj
1.7291 0 Td
(BHS33L;)Tj
0.83 0.64 0.02 0 k
3.7588 0 Td
(Table)Tj
2.4434 0 Td
(2)Tj
0 g
(\).)Tj
1.2586 0 Td
(At)Tj
1.2019 0 Td
(necropsy,)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
35.9997 340.2516 m
575.9997 340.2516 l
575.9997 339.7516 l
35.9997 339.7516 l
f*
89.996 339.7516 m
89.996 314.7517 l
89.496 314.7517 l
89.496 339.7516 l
f*
89.496 314.7517 m
35.9997 314.7517 l
35.9997 315.2517 l
89.496 315.2517 l
f*
135.0303 339.7516 m
135.0303 314.7517 l
134.5303 314.7517 l
134.5303 339.7516 l
f*
134.5303 314.7517 m
89.996 314.7517 l
89.996 315.2517 l
134.5303 315.2517 l
f*
187.1257 339.7516 m
187.1257 314.7517 l
186.6257 314.7517 l
186.6257 339.7516 l
f*
186.6257 314.7517 m
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186.6257 315.2517 l
f*
294.774 339.7516 m
294.774 314.7517 l
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294.2739 339.7516 l
f*
294.2739 314.7517 m
187.1257 314.7517 l
187.1257 315.2517 l
294.2739 315.2517 l
f*
453.496 339.7516 m
453.496 327.2516 l
452.9959 327.2516 l
452.9959 339.7516 l
f*
452.9959 327.2516 m
294.774 327.2516 l
294.774 327.7517 l
452.9959 327.7517 l
f*
575.9991 314.7517 m
453.496 314.7517 l
453.496 315.2517 l
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f*
362.0957 327.2516 m
362.0957 314.7517 l
361.5956 314.7517 l
361.5956 327.2516 l
f*
361.5956 314.7517 m
294.774 314.7517 l
294.774 315.2517 l
361.5956 315.2517 l
f*
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452.9959 314.7517 l
452.9959 327.2516 l
f*
452.9959 314.7517 m
362.0957 314.7517 l
362.0957 315.2517 l
452.9959 315.2517 l
f*
89.996 314.7517 m
89.996 289.7518 l
89.496 289.7518 l
89.496 314.7517 l
f*
89.496 289.7518 m
35.9997 289.7518 l
35.9997 290.2518 l
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f*
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134.5303 289.7518 l
134.5303 314.7517 l
f*
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89.996 289.7518 l
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f*
187.1257 314.7517 m
187.1257 302.2517 l
186.6257 302.2517 l
186.6257 314.7517 l
f*
186.6257 302.2517 m
135.0303 302.2517 l
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186.6257 302.7518 l
f*
294.774 314.7517 m
294.774 302.2517 l
294.2739 302.2517 l
294.2739 314.7517 l
f*
294.2739 302.2517 m
187.1257 302.2517 l
187.1257 302.7518 l
294.2739 302.7518 l
f*
362.0957 314.7517 m
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361.5956 314.7517 l
f*
361.5956 302.2517 m
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f*
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f*
452.9959 302.2517 m
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f*
575.9991 302.2517 m
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f*
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187.1257 289.7518 l
186.6257 289.7518 l
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f*
186.6257 289.7518 m
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f*
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f*
294.2739 289.7518 m
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f*
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f*
361.5956 289.7518 m
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f*
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f*
452.9959 289.7518 m
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f*
575.9991 289.7518 m
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f*
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89.996 264.7519 l
89.496 264.7519 l
89.496 289.7518 l
f*
89.496 264.7519 m
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89.496 265.252 l
f*
135.0303 289.7518 m
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f*
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f*
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f*
186.6257 277.2519 m
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f*
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f*
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f*
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f*
361.5956 277.2519 m
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f*
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f*
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f*
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f*
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f*
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f*
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f*
294.2739 264.7519 m
187.1257 264.7519 l
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f*
362.0957 277.2519 m
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f*
361.5956 264.7519 m
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f*
453.496 277.2519 m
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f*
452.9959 264.7519 m
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