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Per Johansson, Erik G. Almqvist, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensson
Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment
www.plosone.org
www.plosone.org
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(or)Tj
1.0998 0 Td
(acetylcho-)Tj
-32.9269 -1.2983 Td
(line)Tj
1.7064 0 Td
(esterase)Tj
3.3166 0 Td
(inhibitors.)Tj
-3.8268 -1.2982 Td
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3.3619 0 Td
(subjects)Tj
3.3789 0 Td
(were)Tj
2.1259 0 Td
(recruited)Tj
3.8551 0 Td
(contemporaneously)Tj
8.1353 0 Td
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2.2053 0 Td
(the)Tj
1.4684 0 Td
(same)Tj
2.262 0 Td
(geographical)Tj
5.3008 0 Td
(area)Tj
-33.2898 -1.3039 Td
(among)Tj
2.9934 0 Td
(spouses)Tj
3.2768 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(included)Tj
3.7134 0 Td
(patients)Tj
3.3675 0 Td
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1.7348 0 Td
(by)Tj
1.1792 0 Td
(advertisements)Tj
6.2304 0 Td
(in)Tj
1.0375 0 Td
(local)Tj
2.075 0 Td
(newspapers.)Tj
5.091 0 Td
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1.7801 0 Td
(con-)Tj
-34.9622 -1.2983 Td
(trols)Tj
2.0012 0 Td
(had)Tj
1.7122 0 Td
(no)Tj
1.2755 0 Td
(subjective)Tj
4.1613 0 Td
(symptoms)Tj
4.3596 0 Td
(of)Tj
1.0148 0 Td
(cognitive)Tj
3.8721 0 Td
(dysfunction)Tj
4.9719 0 Td
(but)Tj
1.5533 0 Td
(otherwise,)Tj
4.3087 0 Td
(inclusion)Tj
3.9174 0 Td
(and)Tj
1.7292 0 Td
(exclu-)Tj
-34.8772 -1.2983 Td
(sion)Tj
1.9049 0 Td
(criteria)Tj
3.0727 0 Td
(were)Tj
2.126 0 Td
(similar)Tj
2.982 0 Td
(as)Tj
1.0148 0 Td
(those)Tj
2.3414 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(patients.)Tj
3.5887 0 Td
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3.2427 0 Td
(60)Tj
1.1735 0 Td
(patients)Tj
3.3675 0 Td
(and)Tj
1.7292 0 Td
(20)Tj
1.1735 0 Td
(healthy)Tj
3.1294 0 Td
(controls)Tj
-33.3521 -1.3039 Td
(were)Tj
2.1203 0 Td
(recruited.)Tj
4.0819 0 Td
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4.0762 0 Td
(in)Tj
1.0374 0 Td
(this)Tj
1.6725 0 Td
(analysis,)Tj
3.5489 0 Td
(patients)Tj
3.3675 0 Td
(treated)Tj
2.999 0 Td
(with)Tj
1.9956 0 Td
(non-steroidal)Tj
5.6125 0 Td
(anti-inflamma-)Tj
-30.5118 -1.2983 Td
(tory)Tj
1.8482 0 Td
(drugs)Tj
2.4774 0 Td
(\(NSAIDs\))Tj
4.2293 0 Td
(were)Tj
2.126 0 Td
(excluded.)Tj
4.0081 0 Td
(Therefore,)Tj
4.3937 0 Td
(52)Tj
1.1678 0 Td
(patients)Tj
3.3732 0 Td
(\(29)Tj
1.508 0 Td
(men)Tj
2.0126 0 Td
(and)Tj
1.7291 0 Td
(23)Tj
1.1736 0 Td
(women\))Tj
3.5432 0 Td
(and)Tj
1.7292 0 Td
(18)Tj
-35.3194 -1.2982 Td
(healthy)Tj
3.1294 0 Td
(controls)Tj
3.4866 0 Td
(\(10)Tj
1.508 0 Td
(men)Tj
2.0126 0 Td
(and)Tj
1.7292 0 Td
(8)Tj
0.6973 0 Td
(women\))Tj
3.5433 0 Td
(were)Tj
2.1203 0 Td
(included)Tj
3.7132 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(present)Tj
3.1635 0 Td
(study.)Tj
-26.413 -1.3039 Td
(The)Tj
-0.012 Tc
1.7858 0 Td
(presence)Tj
3.6454 0 Td
(or)Tj
1.0828 0 Td
(absence)Tj
3.2882 0 Td
(of)Tj
0.9977 0 Td
(dementia)Tj
3.9005 0 Td
(was)Tj
1.6724 0 Td
(diagnosed)Tj
4.2122 0 Td
(according)Tj
4.1159 0 Td
(to)Tj
1.0091 0 Td
(the)Tj
1.4456 0 Td
(Diagnostic)Tj
4.4447 0 Td
(and)Tj
1.7065 0 Td
(Statisti-)Tj
-34.503 -1.2983 Td
(cal)Tj
1.2983 0 Td
(Manual)Tj
3.2541 0 Td
(of)Tj
0.9978 0 Td
(Mental)Tj
3.016 0 Td
(Disorders,)Tj
4.2917 0 Td
(Fourth)Tj
2.931 0 Td
(Edition)Tj
3.1521 0 Td
(\(DSM-IV\))Tj
4.3255 0 Td
(criteria.)Tj
3.2315 0 Td
(Patients)Tj
3.3449 0 Td
(with)Tj
1.9615 0 Td
(dementia)Tj
3.9005 0 Td
(were)Tj
-35.7049 -1.2983 Td
(classified)Tj
3.736 0 Td
(as)Tj
0.9978 0 Td
(suffering)Tj
3.6907 0 Td
(of)Tj
0.9978 0 Td
(Alzheimer's)Tj
4.8869 0 Td
(disease)Tj
2.9594 0 Td
(\(AD\))Tj
2.2903 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(],)Tj
2.0352 0 Td
(vascular)Tj
3.4072 0 Td
(dementia)Tj
3.9005 0 Td
(\(VaD\))Tj
2.7269 0 Td
(according)Tj
4.1159 0 Td
(to)Tj
-35.7446 -1.2982 Td
(the)Tj
1.4457 0 Td
(requirements)Tj
5.4651 0 Td
(by)Tj
1.1679 0 Td
(NINDS-AIREN)Tj
6.4573 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(])Tj
1.8198 0 Td
(or)Tj
1.0828 0 Td
(the)Tj
1.4457 0 Td
(guidelines)Tj
4.1951 0 Td
(by)Tj
1.1679 0 Td
(Erkinjuntti)Tj
4.5808 0 Td
(et)Tj
0.9241 0 Td
(al.)Tj
1.1055 0 Td
(for)Tj
1.3606 0 Td
(the)Tj
1.4456 0 Td
(subcorti-)Tj
-33.6639 -1.3039 Td
(cal)Tj
1.2983 0 Td
(type)Tj
1.8822 0 Td
(of)Tj
0.9977 0 Td
(VaD)Tj
2.0637 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(],)Tj
2.0352 0 Td
(and)Tj
1.7065 0 Td
(dementia)Tj
3.9004 0 Td
(with)Tj
1.9616 0 Td
(Lewy)Tj
2.2904 0 Td
(bodies)Tj
2.7664 0 Td
(\(DLB\))Tj
2.71 0 Td
(as)Tj
1.0034 0 Td
(described)Tj
3.9798 0 Td
(previously)Tj
4.269 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
-0.004 Tc
-31.6684 -1.2983 Td
(All)Tj
1.4003 0 Td
(diagnoses)Tj
4.1159 0 Td
(were)Tj
2.1203 0 Td
(assessed)Tj
3.4696 0 Td
(by)Tj
1.1849 0 Td
(an)Tj
1.2018 0 Td
(independent)Tj
5.2724 0 Td
(specialized)Tj
4.524 0 Td
(physician)Tj
4.0252 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
0.652 0 Td
(university)Tj
4.1952 0 Td
(hospital)Tj
-34.3102 -1.2983 Td
(that)Tj
1.7745 0 Td
(was)Tj
1.7008 0 Td
(blinded)Tj
3.2711 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(results)Tj
2.8063 0 Td
(of)Tj
1.0148 0 Td
(CSF)Tj
1.8878 0 Td
(biomarkers,)Tj
5.0002 0 Td
(otherwise)Tj
4.0875 0 Td
(the)Tj
1.4684 0 Td
(specialist)Tj
3.8211 0 Td
(physician)Tj
4.0195 0 Td
(had)Tj
1.7064 0 Td
(access)Tj
-35.0529 -1.3039 Td
(to)Tj
1.0261 0 Td
(all)Tj
1.1452 0 Td
(clinical)Tj
3.0728 0 Td
(data)Tj
1.9162 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
2.0749 0 Td
(Mild)Tj
2.1543 0 Td
(cognitive)Tj
3.8778 0 Td
(impairment)Tj
4.9832 0 Td
(\(MCI\))Tj
2.8006 0 Td
(was)Tj
1.6951 0 Td
(diagnosed)Tj
4.286 0 Td
(in)Tj
1.0318 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
2.0012 0 Td
(cog-)Tj
-35.4327 -1.2983 Td
(nitive)Tj
2.4775 0 Td
(impairment)Tj
4.9889 0 Td
(that)Tj
1.7745 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5761 0 Td
(fulfil)Tj
2.0863 0 Td
(the)Tj
1.4683 0 Td
(criteria)Tj
3.0727 0 Td
(for)Tj
1.3889 0 Td
(dementia)Tj
3.9628 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(].)Tj
2.075 0 Td
(Patients)Tj
3.4129 0 Td
(with)Tj
1.9955 0 Td
(MCI)Tj
2.1147 0 Td
(were)Tj
2.1259 0 Td
(fol-)Tj
-36.062 -1.2982 Td
(lowed)Tj
2.6079 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9842 0 Td
(annually)Tj
3.6567 0 Td
(for)Tj
1.389 0 Td
(a)Tj
0.6519 0 Td
(median)Tj
3.2428 0 Td
(of)Tj
1.0148 0 Td
(3)Tj
0.6917 0 Td
(\(range)Tj
2.8063 0 Td
(17\))Tj
2.0295 0 Td
(years)Tj
2.262 0 Td
(to)Tj
1.0261 0 Td
(evaluate)Tj
3.464 0 Td
(whether)Tj
3.4752 0 Td
(they)Tj
1.9219 0 Td
(later)Tj
-33.1764 -1.3039 Td
(developed)Tj
4.269 0 Td
(dementia.)Tj
4.1895 0 Td
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3.1351 0 Td
(the)Tj
1.4684 0 Td
(follow-up)Tj
4.0932 0 Td
(visits,)Tj
2.4548 0 Td
(11)Tj
1.1734 0 Td
(patients)Tj
3.3675 0 Td
(remained)Tj
4.0365 0 Td
(stable)Tj
2.4888 0 Td
(in)Tj
1.0375 0 Td
(MCI)Tj
2.1146 0 Td
(\(SMCI\).)Tj
-33.8283 -1.2983 Td
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2.948 0 Td
(progressed,)Tj
4.7735 0 Td
(during)Tj
2.9254 0 Td
(the)Tj
1.474 0 Td
(follow-up)Tj
4.0932 0 Td
(period,)Tj
3.0557 0 Td
(to)Tj
1.026 0 Td
(dementia)Tj
3.9628 0 Td
(and)Tj
1.7292 0 Td
(were)Tj
2.1259 0 Td
(diagnosed)Tj
4.2803 0 Td
(with)Tj
1.9956 0 Td
(AD)Tj
-34.3896 -1.2983 Td
(\(n)Tj
1.1055 0 Td
(=)Tj
0.7994 0 Td
(6\))Tj
1.0374 0 Td
(or)Tj
1.0999 0 Td
(VaD)Tj
2.0863 0 Td
(\(n)Tj
1.1055 0 Td
(=)Tj
0.7993 0 Td
(3\).)Tj
1.2643 0 Td
(MCI)Tj
2.1146 0 Td
(patients)Tj
3.3676 0 Td
(diagnosed)Tj
4.2802 0 Td
(with)Tj
2.0012 0 Td
(AD)Tj
1.6384 0 Td
(on)Tj
1.2756 0 Td
(follow-up)Tj
4.0932 0 Td
(visits)Tj
2.228 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5761 0 Td
(differ)Tj
2.3868 0 Td
(in)Tj
-35.8013 -1.2982 Td
(CSF)Tj
1.8879 0 Td
(concentrations)Tj
6.1795 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(AD)Tj
1.6384 0 Td
(biomarkers)Tj
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4.7792 0 Td
()Tj
/F6 1 Tf
(-amyloid)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 410.6267 354.7275 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1-42)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 426.1039 356.4283 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
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(\(A)Tj
/F10 1 Tf
()Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 441.2409 354.7275 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(142)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 455.7543 356.4283 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
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(\),)Tj
0.788 0 Td
(total-tau)Tj
3.6113 0 Td
(\(T-tau\))Tj
3.1238 0 Td
(or)Tj
1.0998 0 Td
(phos-)Tj
-34.1969 -1.3039 Td
(phorylated)Tj
4.5241 0 Td
(tau)Tj
1.4853 0 Td
(protein)Tj
3.1522 0 Td
(\(P-tau\))Tj
3.067 0 Td
(from)Tj
2.2054 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
2.0012 0 Td
(established)Tj
4.5978 0 Td
(AD)Tj
1.6383 0 Td
(at)Tj
0.9525 0 Td
(baseline)Tj
3.4299 0 Td
(\(data)Tj
2.2563 0 Td
(not)Tj
1.5704 0 Td
(shown\).)Tj
-34.2479 -1.2982 Td
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3.2429 0 Td
(the)Tj
1.4683 0 Td
(study)Tj
2.3924 0 Td
(population)Tj
4.5864 0 Td
(consisted)Tj
3.9402 0 Td
(of)Tj
1.0148 0 Td
(AD)Tj
1.6384 0 Td
(dementia)Tj
3.9628 0 Td
(or)Tj
1.0998 0 Td
(MCI)Tj
2.1147 0 Td
(diagnosed)Tj
4.2802 0 Td
(with)Tj
2.0012 0 Td
(AD)Tj
1.6384 0 Td
(dementia)Tj
-33.3805 -1.2983 Td
(upon)Tj
2.3188 0 Td
(follow-up)Tj
4.0932 0 Td
(\(n)Tj
1.1111 0 Td
(=)Tj
0.7994 0 Td
(30\),)Tj
1.7348 0 Td
(other)Tj
2.3471 0 Td
(dementias)Tj
4.3256 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7994 0 Td
(11\),)Tj
1.7347 0 Td
(SMCI)Tj
2.5909 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7993 0 Td
(11\),)Tj
1.7347 0 Td
(and)Tj
1.7291 0 Td
(healthy)Tj
3.1351 0 Td
(controls)Tj
-31.4756 -1.3039 Td
(\(n)Tj
1.1055 0 Td
(=)Tj
0.7994 0 Td
(18\).)Tj
1.7405 0 Td
(The)Tj
1.7801 0 Td
(distribution)Tj
4.9663 0 Td
(of)Tj
1.0204 0 Td
(diagnoses)Tj
4.1103 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(other)Tj
2.347 0 Td
(dementia)Tj
3.9629 0 Td
(group)Tj
2.6077 0 Td
(were)Tj
2.126 0 Td
(VaD)Tj
2.0863 0 Td
(or)Tj
1.0941 0 Td
(MCI)Tj
2.1147 0 Td
(diag-)Tj
-34.367 -1.2983 Td
(nosed)Tj
2.5852 0 Td
(with)Tj
2.0013 0 Td
(VaD)Tj
2.0806 0 Td
(upon)Tj
2.3244 0 Td
(follow-up)Tj
4.0932 0 Td
(\(n)Tj
1.1055 0 Td
(=)Tj
0.7993 0 Td
(7\))Tj
1.0375 0 Td
(and)Tj
1.7291 0 Td
(DLB)Tj
2.075 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7993 0 Td
(4\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 262.7149 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Ethical)Tj
3.1842 0 Td
(considerations)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 245.707 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(study)Tj
2.3924 0 Td
(was)Tj
1.6951 0 Td
(approved)Tj
3.9742 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(ethical)Tj
2.8403 0 Td
(committee)Tj
4.5014 0 Td
(at)Tj
0.9524 0 Td
(University)Tj
4.3994 0 Td
(of)Tj
1.0147 0 Td
(Gothenburg)Tj
5.1137 0 Td
(\(ethical)Tj
-31.3169 -1.2982 Td
(approval)Tj
3.702 0 Td
(number)Tj
3.4185 0 Td
(49699,)Tj
3.3392 0 Td
(T)Tj
0.8277 0 Td
(45205\).)Tj
3.6851 0 Td
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1.7801 0 Td
(specialist)Tj
3.8211 0 Td
(physician)Tj
4.0195 0 Td
(\(P.J.\))Tj
2.2393 0 Td
(gave)Tj
1.9956 0 Td
(written)Tj
3.1124 0 Td
(information)Tj
-31.9405 -1.3039 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(study)Tj
2.3924 0 Td
(and)Tj
1.7291 0 Td
(explained)Tj
4.0706 0 Td
(the)Tj
1.4683 0 Td
(study)Tj
2.3924 0 Td
(protocol)Tj
3.5943 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.474 0 Td
(controls)Tj
3.4809 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(patients)Tj
3.3675 0 Td
(and)Tj
1.7292 0 Td
(care-)Tj
-35.5519 -1.2983 Td
(taker)Tj
2.245 0 Td
(if)Tj
0.771 0 Td
(available.)Tj
3.8948 0 Td
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1.3946 0 Td
(participants)Tj
4.9606 0 Td
(provided)Tj
3.8154 0 Td
(both)Tj
2.058 0 Td
(oral)Tj
1.7801 0 Td
(and)Tj
1.7291 0 Td
(written)Tj
3.1124 0 Td
(informed)Tj
3.9742 0 Td
(consent.)Tj
3.5546 0 Td
(A)Tj
0.9014 0 Td
(next)Tj
1.9559 0 Td
(of)Tj
-36.1471 -1.2983 Td
(kin,)Tj
1.7574 0 Td
(caretaker)Tj
3.8948 0 Td
(or)Tj
1.0998 0 Td
(guardian)Tj
3.7928 0 Td
(consented)Tj
4.2803 0 Td
(on)Tj
1.2755 0 Td
(behalf)Tj
2.6476 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3675 0 Td
(if)Tj
0.7767 0 Td
(the)Tj
1.4683 0 Td
(capacity)Tj
3.4753 0 Td
(to)Tj
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