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Marina Eloi, Daniela Vargas Horvath, João Carlos Ortega, Mônica Simon Prado, Luis Eduardo Coelho Andrade, Vera Lúcia Szejnfeld, Charlles Heldan de Moura Castro
25-Hydroxivitamin D Serum Concentration, Not Free and Bioavailable Vitamin D, Is Associated with Disease Activity in Systemic Lupus Erythematosus Patients
www.plosone.org
www.plosone.org
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485.0025 443.8905 l
575.9991 443.8905 l
f*
575.9991 409.6403 m
36 409.6403 l
36 410.1403 l
575.9991 410.1403 l
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(1.)Tj
1.2614 0 Td
(Demogra)Tj
4.2733 0 Td
(phic,)Tj
2.537 0 Td
(anthro)Tj
3.0685 0 Td
(pometric,)Tj
4.6631 0 Td
(clinical)Tj
3.5646 0 Td
(and)Tj
1.9842 0 Td
(labora)Tj
2.9552 0 Td
(torial)Tj
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(paramete)Tj
4.3725 0 Td
(rs)Tj
1.1409 0 Td
(in)Tj
1.1056 0 Td
(Systemic)Tj
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(Lupus)Tj
3.1961 0 Td
(Erythem)Tj
3.9402 0 Td
(atosus)Tj
3.3945 0 Td
(patients)Tj
4.004 0 Td
(and)Tj
1.9842 0 Td
(their)Tj
2.3528 0 Td
(healthy)Tj
-59.776 -1.1905 Td
(controls.)Tj
0 Tc
26.0364 -1.8496 Td
(Healthy)Tj
3.8197 0 Td
(controls)Tj
4.167 0 Td
(\(N)Tj
1.2756 0 Td
(=)Tj
0.8149 0 Td
(150\))Tj
9.8151 0 Td
(SLE)Tj
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(\(N)Tj
1.2756 0 Td
(=)Tj
0.8149 0 Td
(199\))Tj
/F15 1 Tf
11.3104 0 Td
(p)Tj
/F2 1 Tf
-61.5052 -1.6229 Td
(Sex,N\(%\))Tj
/F0 1 Tf
18.2836 -1.5661 Td
(Women)Tj
12.0756 0 Td
(135\(90\))Tj
16.9868 0 Td
(191\(96\))Tj
13.2237 0 Td
(0.231)Tj
-40.7909 -1.5591 Td
(Men)Tj
10.8568 0 Td
(15\(10\))Tj
17.5324 0 Td
(8\(4\))Tj
/F2 1 Tf
-48.168 -1.5662 Td
(Race,)Tj
2.8771 0 Td
(N\(%\))Tj
/F0 1 Tf
16.2923 -1.559 Td
(White)Tj
11.4662 0 Td
(93\(62\))Tj
16.2923 0 Td
(111\(55.7\))Tj
13.6418 0 Td
(0.238)Tj
-41.5066 -1.5662 Td
(Mixed)Tj
11.5725 0 Td
(52\(35\))Tj
16.5687 0 Td
(81\(40.7\))Tj
-27.9215 -1.559 Td
(Black)Tj
11.8985 0 Td
(5\(3\))Tj
16.5757 0 Td
(7\(3.6\))Tj
/F2 1 Tf
-47.757 -1.5662 Td
(Age)Tj
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2.1118 0 Td
(\(years\))Tj
27.7514 0 Td
(36.5)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(10.9)Tj
16.9867 0 Td
(37.2)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(11.1)Tj
13.7198 0 Td
(0.423)Tj
/F2 1 Tf
-60.5697 -1.5591 Td
(Weight)Tj
/F0 1 Tf
3.5645 0 Td
(\(kg\))Tj
26.2987 0 Td
(70.2)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(15.2)Tj
16.9867 0 Td
(69.8)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(16.2)Tj
13.7198 0 Td
(0.217)Tj
/F2 1 Tf
-60.5697 -1.5661 Td
(Height)Tj
/F0 1 Tf
3.3378 0 Td
(\(m\))Tj
26.5254 0 Td
(1.60)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(0.08)Tj
16.9867 0 Td
(1.59)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(0.08)Tj
13.7198 0 Td
(0.208)Tj
/F2 1 Tf
-60.5697 -1.5591 Td
(BMI)Tj
/F0 1 Tf
2.0551 0 Td
(\(kg/m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 72.3968 549.9212 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 75.685 546.4062 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(\))Tj
25.1789 0 Td
(27.4)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(5.5)Tj
16.9867 0 Td
(27.7)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(6.0)Tj
13.4434 0 Td
(0.880)Tj
/F2 1 Tf
-60.5696 -1.5661 Td
(Disease)Tj
3.9756 0 Td
(duration)Tj
/F0 1 Tf
4.2306 0 Td
(\(years\))Tj
23.6908 0 Td
(-)Tj
15.5056 0 Td
(9.7)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(7.2)Tj
/F2 1 Tf
14.2442 0 Td
(-)Tj
-61.6468 -1.5591 Td
(25\(OH\)D)Tj
/F0 1 Tf
4.2095 0 Td
(\(ng/mL)Tj
3.0897 0 Td
(\))Tj
22.2875 0 Td
(28.79)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(7.82)Tj
17.6813 0 Td
(26)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(7.93)Tj
/F2 1 Tf
13.3016 0 Td
(0.009)Tj
/F7 1 Tf
-45.7373 -1.5661 Td
()Tj
/F2 1 Tf
(30)Tj
2.0976 0 Td
(ng/mL)Tj
3.2316 0 Td
(\(%\))Tj
/F0 1 Tf
10.6654 0 Td
(33.96)Tj
16.9867 0 Td
(28.64)Tj
/F3 1 Tf
12.1962 0 Td
[( )]TJ
/F2 1 Tf
(0.001)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 540.6236 512.4472 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(&)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 147.6283 496.4031 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(2030)Tj
2.9764 0 Td
(ng/mL)Tj
3.2315 0 Td
(\(%\))Tj
/F0 1 Tf
10.6654 0 Td
(59.43)Tj
16.9868 0 Td
(47.24)Tj
/F3 1 Tf
-32.7971 -1.5661 Td
[( )]TJ
/F2 1 Tf
(20)Tj
1.9134 0 Td
(ng/mL)Tj
3.2315 0 Td
(\(%\))Tj
/F0 1 Tf
10.9347 0 Td
(6.60)Tj
16.7175 0 Td
(24.12)Tj
/F2 1 Tf
-47.8137 -1.5591 Td
(DBP)Tj
/F0 1 Tf
2.3244 0 Td
(\(ng/mL\))Tj
/F6 1 Tf
[()]TJ
/F0 1 Tf
44.5255 0 Td
(1.91)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(0.89)Tj
/F2 1 Tf
-46.8499 -1.5661 Td
(Free)Tj
2.3244 0 Td
(vitamin)Tj
3.7205 0 Td
(D)Tj
/F0 1 Tf
0.9496 0 Td
(\(pg/mL)Tj
3.0898 0 Td
(\))Tj
/F6 1 Tf
[()]TJ
/F0 1 Tf
36.4963 0 Td
(11.10)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(5.)Tj
3.848 0 Td
(44)Tj
/F2 1 Tf
-50.4286 -1.5591 Td
(Bioavailab)Tj
4.9819 0 Td
(le)Tj
1.063 0 Td
(vitamin)Tj
3.7205 0 Td
(D)Tj
/F0 1 Tf
0.9426 0 Td
(\(ng/mL\))Tj
/F6 1 Tf
[()]TJ
/F0 1 Tf
36.1419 0 Td
(4.32)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(2.12)Tj
/F6 1 Tf
-46.8499 -2.3457 Td
[()]TJ
/F0 1 Tf
(N)Tj
1.4953 0 Td
(=)Tj
0.815 0 Td
(160)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 419.1874 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(&)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 42.1228 415.6157 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(ANOVA.)Tj
/F10 1 Tf
-0.005 Tc
-0.7653 -2.2464 Td
(doi:)Tj
-0.025 Tc
(10.137)Tj
4.0322 0 Td
(1/journal.pone.)Tj
5.556 0 Td
(0170323.t)Tj
3.7913 0 Td
(001)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 224.2525 m
576 224.2525 l
576 223.7525 l
36 223.7525 l
f*
119.6614 223.7525 m
119.6614 188.2525 l
119.1614 188.7525 l
119.1614 223.7525 l
f*
119.6614 188.2525 m
36 188.2525 l
36 188.7525 l
119.1614 188.7525 l
f*
576 210.7525 m
119.6614 210.7525 l
119.6614 211.2525 l
576 211.2525 l
f*
209.0203 210.7525 m
209.0203 188.2525 l
208.5202 188.7525 l
208.5202 210.7525 l
f*
209.0203 188.2525 m
119.6614 188.2525 l
119.6614 188.7525 l
208.5202 188.7525 l
f*
289.5486 210.7525 m
289.5486 188.2525 l
289.0485 188.7525 l
289.0485 210.7525 l
f*
289.5486 188.2525 m
209.0203 188.2525 l
209.0203 188.7525 l
289.0485 188.7525 l
f*
392.4213 210.7525 m
392.4213 188.2525 l
391.9212 188.7525 l
391.9212 210.7525 l
f*
392.4213 188.2525 m
289.5486 188.2525 l
289.5486 188.7525 l
391.9212 188.7525 l
f*
480.6717 210.7525 m
480.6717 188.2525 l
480.1717 188.7525 l
480.1717 210.7525 l
f*
480.6717 188.2525 m
392.4213 188.2525 l
392.4213 188.7525 l
480.1717 188.7525 l
f*
576 188.2525 m
480.6717 188.2525 l
480.6717 188.7525 l
576 188.7525 l
f*
119.6614 188.2525 m
119.6614 175.7526 l
119.1614 176.2526 l
119.1614 188.2525 l
f*
119.6614 175.7526 m
36 175.7526 l
36 176.2526 l
119.1614 176.2526 l
f*
209.0203 188.2525 m
209.0203 175.7526 l
208.5202 176.2526 l
208.5202 188.2525 l
f*
209.0203 175.7526 m
119.6614 175.7526 l
119.6614 176.2526 l
208.5202 176.2526 l
f*
289.5486 188.2525 m
289.5486 175.7526 l
289.0485 176.2526 l
289.0485 188.2525 l
f*
289.5486 175.7526 m
209.0203 175.7526 l
209.0203 176.2526 l
289.0485 176.2526 l
f*
392.4213 188.2525 m
392.4213 175.7526 l
391.9212 176.2526 l
391.9212 188.2525 l
f*
392.4213 175.7526 m
289.5486 175.7526 l
289.5486 176.2526 l
391.9212 176.2526 l
f*
480.6717 188.2525 m
480.6717 175.7526 l
480.1717 176.2526 l
480.1717 188.2525 l
f*
480.6717 175.7526 m
392.4213 175.7526 l
392.4213 176.2526 l
480.1717 176.2526 l
f*
576 175.7526 m
480.6717 175.7526 l
480.6717 176.2526 l
576 176.2526 l
f*
119.6614 175.7526 m
119.6614 163.2526 l
119.1614 163.7527 l
119.1614 175.7526 l
f*
119.6614 163.2526 m
36 163.2526 l
36 163.7527 l
119.1614 163.7527 l
f*
209.0203 175.7526 m
209.0203 163.2526 l
208.5202 163.7527 l
208.5202 175.7526 l
f*
209.0203 163.2526 m
119.6614 163.2526 l
119.6614 163.7527 l
208.5202 163.7527 l
f*
289.5486 175.7526 m
289.5486 163.2526 l
289.0485 163.7527 l
289.0485 175.7526 l
f*
289.5486 163.2526 m
209.0203 163.2526 l
209.0203 163.7527 l
289.0485 163.7527 l
f*
392.4213 175.7526 m
392.4213 163.2526 l
391.9212 163.7527 l
391.9212 175.7526 l
f*
392.4213 163.2526 m
289.5486 163.2526 l
289.5486 163.7527 l
391.9212 163.7527 l
f*
480.6717 175.7526 m
480.6717 163.2526 l
480.1717 163.7527 l
480.1717 175.7526 l
f*
480.6717 163.2526 m
392.4213 163.2526 l
392.4213 163.7527 l
480.1717 163.7527 l
f*
576 163.2526 m
480.6717 163.2526 l
480.6717 163.7527 l
576 163.7527 l
f*
119.6614 163.2526 m
119.6614 150.7527 l
119.1614 151.2527 l
119.1614 163.2526 l
f*
119.6614 150.7527 m
36 150.7527 l
36 151.2527 l
119.1614 151.2527 l
f*
209.0203 163.2526 m
209.0203 150.7527 l
208.5202 151.2527 l
208.5202 163.2526 l
f*
209.0203 150.7527 m
119.6614 150.7527 l
119.6614 151.2527 l
208.5202 151.2527 l
f*
289.5486 163.2526 m
289.5486 150.7527 l
289.0485 151.2527 l
289.0485 163.2526 l
f*
289.5486 150.7527 m
209.0203 150.7527 l
209.0203 151.2527 l
289.0485 151.2527 l
f*
392.4213 163.2526 m
392.4213 150.7527 l
391.9212 151.2527 l
391.9212 163.2526 l
f*
392.4213 150.7527 m
289.5486 150.7527 l
289.5486 151.2527 l
391.9212 151.2527 l
f*
480.6717 163.2526 m
480.6717 150.7527 l
480.1717 151.2527 l
480.1717 163.2526 l
f*
480.6717 150.7527 m
392.4213 150.7527 l
392.4213 151.2527 l
480.1717 151.2527 l
f*
576 150.7527 m
480.6717 150.7527 l
480.6717 151.2527 l
576 151.2527 l
f*
119.6614 150.7527 m
119.6614 128.7527 l
119.1614 129.2528 l
119.1614 150.7527 l
f*
119.6614 128.7527 m
36 128.7527 l
36 129.2528 l
119.1614 129.2528 l
f*
209.0203 150.7527 m
209.0203 128.7527 l
208.5202 129.2528 l
208.5202 150.7527 l
f*
209.0203 128.7527 m
119.6614 128.7527 l
119.6614 129.2528 l
208.5202 129.2528 l
f*
289.5486 150.7527 m
289.5486 128.7527 l
289.0485 129.2528 l
289.0485 150.7527 l
f*
289.5486 128.7527 m
209.0203 128.7527 l
209.0203 129.2528 l
289.0485 129.2528 l
f*
392.4213 150.7527 m
392.4213 128.7527 l
391.9212 129.2528 l
391.9212 150.7527 l
f*
392.4213 128.7527 m
289.5486 128.7527 l
289.5486 129.2528 l
391.9212 129.2528 l
f*
480.6717 150.7527 m
480.6717 128.7527 l
480.1717 129.2528 l
480.1717 150.7527 l
f*
480.6717 128.7527 m
392.4213 128.7527 l
392.4213 129.2528 l
480.1717 129.2528 l
f*
576 128.7527 m
480.6717 128.7527 l
480.6717 129.2528 l
576 129.2528 l
f*
576 95.0026 m
36 95.0026 l
36 95.5026 l
576 95.5026 l
f*
0 g
7.9999 0 0 7.9999 36 238.5637 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(2.)Tj
1.2614 0 Td
(Serum)Tj
3.2882 0 Td
(25\(OH\)D)Tj
4.167 0 Td
(\(ng/mL\),)Tj
4.1244 0 Td
(D)Tj
0.9284 0 Td
(binding)Tj
3.8126 0 Td
(protein)Tj
3.5717 0 Td
(\(DBP\))Tj
2.9551 0 Td
(\(ng/mL\),)Tj
4.1245 0 Td
(free)Tj
2.0197 0 Td
(\(pg/mL\))Tj
3.848 0 Td
(and)Tj
1.9772 0 Td
(bioavailable)Tj
5.8749 0 Td
(\(ng/mL\))Tj
3.848 0 Td
(vitamin)Tj
3.678 0 Td
(D)Tj
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(in)Tj
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(Lupus)Tj
3.1961 0 Td
(Erythem)Tj
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(a-)Tj
-65.991 -1.1834 Td
(tosus)Tj
2.8559 0 Td
(patient)Tj
3.2315 0 Td
(s,)Tj
1.0417 0 Td
(according)Tj
4.9394 0 Td
(to)Tj
1.1552 0 Td
(disease)Tj
3.8339 0 Td
(activity)Tj
3.6071 0 Td
(measured)Tj
4.8685 0 Td
(by)Tj
1.3748 0 Td
(Systemic)Tj
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(Lupus)Tj
3.1961 0 Td
(Erythem)Tj
3.9402 0 Td
(atosus)Tj
3.4016 0 Td
(Disease)Tj
3.9331 0 Td
(Activity)Tj
3.7701 0 Td
(Index)Tj
2.7992 0 Td
(\(SLEDAI\).)Tj
0 Tc
-17.2985 -1.8567 Td
(Disease)Tj
3.9827 0 Td
(Activity)Tj
-27.2341 -1.6229 Td
(InactiveSL)Tj
4.9819 0 Td
(EDAI)Tj
2.6079 0 Td
(0)Tj
-5.2796 -1.1905 Td
(\(N)Tj
1.2756 0 Td
(=)Tj
0.815 0 Td
(30\))Tj
6.626 1.1905 Td
(MildSLEDA)Tj
5.3788 0 Td
(I)Tj
0.5103 0 Td
(1-5)Tj
-3.9898 -1.1905 Td
(\(N)Tj
1.2827 0 Td
(=)Tj
0.8078 0 Td
(69\))Tj
5.9883 1.1905 Td
(Moderate)Tj
4.4221 0 Td
(SLEDAI)Tj
3.8835 0 Td
(6-10)Tj
-4.9182 -1.1905 Td
(\(N)Tj
1.2756 0 Td
(=)Tj
0.815 0 Td
(42\))Tj
7.2922 1.1905 Td
(HighSLEDA)Tj
5.5984 0 Td
(I)Tj
0.5103 0 Td
(11-19)Tj
-3.5505 -1.1905 Td
(\(N)Tj
1.2827 0 Td
(=)Tj
0.8079 0 Td
(40\))Tj
6.789 1.1905 Td
(SevereSLED)Tj
5.9103 0 Td
(AI)Tj
/F7 1 Tf
()Tj
/F2 1 Tf
(20)Tj
-3.2811 -1.1905 Td
(\(N)Tj
1.2756 0 Td
(=)Tj
0.815 0 Td
(18\))Tj
-61.8737 -1.6229 Td
(25\(OH\)D)Tj
/F6 1 Tf
[()]TJ
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13.5355 0 Td
(28.45)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(6.8)Tj
4.4008 0 Td
(3)Tj
6.215 0 Td
(27.70)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(7.8)Tj
4.4008 0 Td
(1)Tj
7.0655 0 Td
(25.16)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(6.)Tj
3.848 0 Td
(38)Tj
8.093 0 Td
(26.98)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(9.93)Tj
10.956 0 Td
(22.22)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(6.9)Tj
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(6)Tj
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[()]TJ
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-62.9154 -1.5591 Td
(DBP)Tj
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12.0473 0 Td
(1.80)Tj
/F5 1 Tf
[( )]TJ
/F0 1 Tf
(0.92)Tj
4.4008 0 Td
(\(N)Tj
1.2827 0 Td
(=)Tj
0.8079 0 Td
(27\))Tj
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324.9113 658.8893 l
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407.9446 671.3892 m
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494.8807 658.3893 m
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576 658.3893 m
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176.2115 658.3893 m
176.2115 645.8893 l
175.7115 646.3894 l
175.7115 658.3893 l
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247.2809 645.8893 m
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325.4114 658.3893 m
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324.9113 646.3894 l
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f*
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q
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W* n
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BT
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0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(4.)Tj
1.2614 0 Td
(Serum)Tj
3.2882 0 Td
(25\(OH\)D)Tj
4.167 0 Td
(\(mean)Tj
/F3 1 Tf
3.1181 0 Td
[( )]TJ
/F2 1 Tf
0.7583 0 Td
(SD\))Tj
1.9205 0 Td
(and)Tj
1.9772 0 Td
(vitamin)Tj
3.6779 0 Td
(D)Tj
0.9284 0 Td
(status)Tj
3.1181 0 Td
(\(deficien)Tj
4.0536 0 Td
(cy:)Tj
1.6441 0 Td
(25\(OH\))Tj
3.2245 0 Td
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2000 Adobe Systems Incorporated. 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