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Meghna Verma, Samantha Erwin, Vida Abedi, Raquel Hontecillas, Stefan Hoops, Andrew Leber, Josep Bassaganya-Riera, Stanca M. Ciupe
Modeling the Mechanisms by Which HIV-Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa
www.plosone.org
www.plosone.org
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1 j
1 J
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11.9999 0 0 11.9999 200.0125 501.3921 cm
BT
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1 TL
-0.0033 Tc
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0 -1.4976 Td
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10 0 0 10 200.0125 466.4125 cm
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1 TL
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1.61 0 Td
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[()]TJ
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[()]TJ
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1.7291 0 Td
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3.515 0 Td
[( )]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 320.5417 412.7244 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
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10 0 0 10 326.211 414.4251 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
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(virions)Tj
2.999 0 Td
(throughout)Tj
4.7735 0 Td
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0.9524 0 Td
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1.7518 0 Td
()Tj
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(The)Tj
1.7858 0 Td
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2.1996 0 Td
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1.7518 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 421.9653 399.7417 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 427.6346 401.3858 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(per)Tj
1.5363 0 Td
(day.)Tj
1.8595 0 Td
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3.9798 0 Td
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4.6034 0 Td
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4.0933 0 Td
(\(ODE\))Tj
2.9536 0 Td
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4.32 0 Td
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Q
q
1 j
1 J
0 w
341.1213 364.8756 m
352.4598 364.8756 l
352.4598 364.4787 l
341.1213 364.4787 l
f*
10 0 0 10 341.1212 368.9574 cm
BT
/F13 1 Tf
1 TL
0 0 Td
[()]TJ
0.1587 -1.3662 Td
[()12()]TJ
/F14 1 Tf
1.2529 0.6859 Td
()Tj
/F11 1 Tf
1.0488 0 Td
[()]TJ
/F14 1 Tf
0.5556 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[()]TJ
/F14 1 Tf
1.355 0 Td
( )Tj
/F15 1 Tf
0.9921 0 Td
(b)Tj
/F13 1 Tf
[()-28()]TJ
/F16 1 Tf
(;)Tj
ET
Q
q
1 j
1 J
0 w
341.6315 338.0598 m
350.1354 338.0598 l
350.1354 337.663 l
341.6315 337.663 l
f*
10 0 0 10 341.6314 342.1417 cm
BT
/F13 1 Tf
1 TL
0 0 Td
[()]TJ
0.017 -1.3662 Td
[()12()]TJ
/F14 1 Tf
1.1111 0.6859 Td
()Tj
/F15 1 Tf
1.0488 0 Td
(b)Tj
/F13 1 Tf
[()-28()]TJ
/F14 1 Tf
2.0863 0 Td
( )Tj
/F15 1 Tf
0.9921 0 Td
(d)Tj
/F11 1 Tf
[()]TJ
/F16 1 Tf
0.8845 0 Td
(;)Tj
ET
Q
q
1 j
1 J
0 w
337.4362 311.2441 m
349.6252 311.2441 l
349.6252 310.8472 l
337.4362 310.8472 l
f*
10 0 0 10 337.4362 315.3259 cm
BT
/F13 1 Tf
1 TL
0 0 Td
[()]TJ
0.1984 -1.3662 Td
[()12()]TJ
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1.2982 0.6859 Td
()Tj
/F11 1 Tf
1.0488 0 Td
[( )]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 369.8645 306.0283 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 373.3795 308.5228 cm
BT
/F15 1 Tf
1 TL
0 0 Td
(d)Tj
/F11 1 Tf
[()]TJ
/F14 1 Tf
1.1055 0 Td
( )Tj
/F11 1 Tf
0.9977 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 398.1543 306.0283 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 401.6125 308.5228 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
/F16 1 Tf
0.754 0 Td
(;)Tj
/F14 1 Tf
15.4317 2.7779 Td
()Tj
/F6 1 Tf
(1)Tj
/F14 1 Tf
()Tj
/F6 1 Tf
-0.004 Tc
-36.3455 -5.5104 Td
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1.9956 0 Td
(initial)Tj
2.5511 0 Td
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4.4731 0 Td
[("#)]TJ
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1.9275 0 Td
(=)Tj
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0.7994 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 323.3763 279.5527 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0,)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 330.8031 281.1968 cm
BT
/F11 1 Tf
1 TL
-0.004 Tc
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[("#)]TJ
1.661 0 Td
[($)]TJ
0.8107 0 Td
[()]TJ
ET
Q
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1 j
1 J
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7.4999 0 0 6.6659 358.8094 279.5527 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(#)]TJ
/F6 1 Tf
(,)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 366.1795 281.1968 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
/F11 1 Tf
1.7291 0 Td
[("#)]TJ
2.0012 0 Td
[($)]TJ
0.8107 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 418.2236 279.5527 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(#)]TJ
/F6 1 Tf
(.)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 211.9748 268.2141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7858 0 Td
(effect)Tj
2.364 0 Td
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1.0148 0 Td
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3.05 0 Td
(transcriptase)Tj
5.3291 0 Td
(inhibitors)Tj
4.1386 0 Td
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1.0261 0 Td
()Tj
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0.7086 0 Td
(\(1-)Tj
/F18 1 Tf
1.3833 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 371.3952 253.5307 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(%)47()]TJ
ET
Q
q
1 j
1 J
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10 0 0 10 380.2393 255.1748 cm
BT
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1 TL
-0.004 Tc
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[()]TJ
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0.5385 0 Td
(and)Tj
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3.5546 0 Td
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4.1443 0 Td
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1.026 0 Td
[( )]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 396.4535 240.548 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 399.9685 242.1921 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\(1-)Tj
/F18 1 Tf
1.3832 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 418.6771 240.548 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(&)14()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 425.2535 242.1921 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
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(\).)Tj
0.7823 0 Td
(Here)Tj
2.2053 0 Td
(0)Tj
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0.6974 0 Td
()Tj
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-0.004 Tc
0.9921 0 Td
()Tj
ET
Q
q
1 j
1 J
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7.4999 0 0 6.6659 476.9007 240.548 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(%)47()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 485.7448 242.1921 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
/F18 1 Tf
0.4422 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 495.0425 240.548 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(&)14()]TJ
ET
Q
q
1 j
1 J
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BT
/F14 1 Tf
1 TL
0 0 Td
()Tj
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-0.004 Tc
0.9921 0 Td
(1)Tj
0.6973 0 Td
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1.4513 0 Td
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1.4684 0 Td
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-34.9849 -1.2982 Td
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3.8154 0 Td
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0.83 0.64 0.02 0 k
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(,)Tj
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1.7404 0 Td
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(].)Tj
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(the)Tj
1.4683 0 Td
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3.7134 0 Td
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1.0148 0 Td
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ET
Q
q
1 j
1 J
0 w
320.2016 192.6425 m
331.5402 192.6425 l
331.5402 192.2457 l
320.2016 192.2457 l
f*
10 0 0 10 320.2015 196.7811 cm
BT
/F13 1 Tf
1 TL
0 0 Td
[()]TJ
0.1587 -1.3662 Td
[()12()]TJ
/F14 1 Tf
1.2529 0.6859 Td
()Tj
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1.0488 0 Td
[()]TJ
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0.5556 0 Td
( )Tj
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0.9921 0 Td
[()]TJ
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[()]TJ
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1.4117 0 Td
( )Tj
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1.3776 0 Td
(1)Tj
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0.7257 0 Td
( )Tj
/F12 1 Tf
0.9921 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 410.2299 187.4834 cm
BT
/F13 1 Tf
1 TL
0 0 Td
[()32()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 384.3212 189.9779 cm
BT
/F14 1 Tf
1 TL
0 0 Td
()Tj
3.3788 0 Td
()Tj
/F15 1 Tf
(b)Tj
/F13 1 Tf
[()-28()]TJ
/F16 1 Tf
(;)Tj
ET
Q
q
1 j
1 J
0 w
323.8866 165.8268 m
332.3906 165.8268 l
332.3906 165.4299 l
323.8866 165.4299 l
f*
10 0 0 10 323.8866 169.9653 cm
BT
/F13 1 Tf
1 TL
0 0 Td
[()]TJ
0.0113 -1.3662 Td
[()12()]TJ
/F14 1 Tf
1.1168 0.6859 Td
()Tj
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1.4344 0 Td
(1)Tj
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0.7199 0 Td
( )Tj
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0.9978 0 Td
()Tj
ET
Q
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1 j
1 J
0 w
5.9998 0 0 5.9998 371.5653 160.6677 cm
BT
/F13 1 Tf
1 TL
0 0 Td
[()32()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 345.6566 163.1622 cm
BT
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1 TL
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()Tj
3.3732 0 Td
()Tj
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(b)Tj
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/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(\()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 211.5779 572.0881 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
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(become)Tj
3.3165 0 Td
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(at)Tj
0.9411 0 Td
(the)Tj
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-35.9827 -1.2982 Td
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([)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(30)Tj
0 g
(].)Tj
1.7348 0 Td
(Therefore,)Tj
4.3937 0 Td
(both)Tj
/F11 1 Tf
2.0579 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 323.1496 557.4047 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 328.8188 559.1055 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
/F11 1 Tf
1.7291 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 352.1196 557.4047 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(\()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 357.8456 559.1055 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(cells)Tj
1.9162 0 Td
(are)Tj
1.4513 0 Td
(HPV)Tj
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-36.6687 -1.3039 Td
(the)Tj
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(epithelial)Tj
3.8721 0 Td
(cell)Tj
1.559 0 Td
(layer,)Tj
2.3754 0 Td
(wherein)Tj
/F11 1 Tf
3.464 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 333.411 544.422 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(\()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 339.0803 546.0661 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(cells)Tj
1.9218 0 Td
(are)Tj
1.4514 0 Td
(assumed)Tj
3.6736 0 Td
(to)Tj
1.0262 0 Td
(have)Tj
2.0579 0 Td
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2.8006 0 Td
(expression)Tj
4.4674 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(onco-)Tj
-33.7886 -1.2982 Td
(genes)Tj
/F11 1 Tf
2.4377 0 Td
[()]TJ
/F6 1 Tf
1.2359 0 Td
(and)Tj
/F11 1 Tf
1.7292 0 Td
[()]TJ
/F6 1 Tf
1.2359 0 Td
(compared)Tj
4.2462 0 Td
(to)Tj
/F11 1 Tf
1.0205 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 325.0771 531.4393 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 330.8031 533.0834 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
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1.6271 0 Td
(simplification,)Tj
5.9527 0 Td
(we)Tj
1.3323 0 Td
(assume)Tj
3.1464 0 Td
(that)Tj
1.7745 0 Td
(the)Tj
1.474 0 Td
(uninfected)Tj
4.4957 0 Td
(cells)Tj
-34.9565 -1.2982 Td
(and)Tj
1.7291 0 Td
(infected)Tj
3.4186 0 Td
(cells)Tj
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2.058 0 Td
(an)Tj
1.2019 0 Td
(equal)Tj
2.3584 0 Td
(probability)Tj
4.5976 0 Td
(of)Tj
1.0148 0 Td
(interaction)Tj
4.6091 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(HPV)Tj
2.2394 0 Td
(virions)Tj
2.9933 0 Td
(irrespective)Tj
4.8246 0 Td
(of)Tj
-36.4362 -1.3039 Td
(the)Tj
1.4683 0 Td
(spatial)Tj
2.7779 0 Td
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5.0117 0 Td
(of)Tj
1.0148 0 Td
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4.7622 0 Td
(model)Tj
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(which)Tj
2.6533 0 Td
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2.228 0 Td
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1.8425 0 Td
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(one)Tj
1.7007 0 Td
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(spatial)Tj
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1.9162 0 Td
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3.6567 0 Td
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(extensive)Tj
3.8892 0 Td
(knowledge)Tj
4.541 0 Td
(of)Tj
1.0148 0 Td
(numerous)Tj
4.303 0 Td
(parameters,)Tj
4.9039 0 Td
(which)Tj
-0.014 Tc
-33.9077 -1.3039 Td
(are)Tj
1.4173 0 Td
(currently)Tj
3.7984 0 Td
(unknown.)Tj
4.2236 0 Td
(We)Tj
1.5874 0 Td
(assume)Tj
3.0896 0 Td
(that)Tj
1.7405 0 Td
(the)Tj
1.44 0 Td
(infection)Tj
3.6963 0 Td
(is)Tj
0.8334 0 Td
(density)Tj
3.0274 0 Td
(dependent)Tj
4.371 0 Td
(with)Tj
/F11 1 Tf
1.9559 0 Td
[(+)]TJ
/F6 1 Tf
0.7823 0 Td
(representing)Tj
-31.9631 -1.2982 Td
(the)Tj
1.44 0 Td
(uninfected)Tj
4.3936 0 Td
(cell)Tj
1.5194 0 Td
(concentration)Tj
5.6919 0 Td
(where)Tj
2.6021 0 Td
(the)Tj
1.44 0 Td
(infection)Tj
3.6964 0 Td
(is)Tj
0.8333 0 Td
(half-maximal.)Tj
5.6466 0 Td
(We)Tj
1.5874 0 Td
(assume)Tj
3.0898 0 Td
(that)Tj
1.7348 0 Td
(infected)Tj
-33.6753 -1.2983 Td
(cell)Tj
1.5193 0 Td
(populations)Tj
/F11 1 Tf
4.8416 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 269.5181 440.3905 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 275.074 442.0913 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
(and)Tj
/F11 1 Tf
1.7007 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 298.0346 440.3905 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(\()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 303.5905 442.0913 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
(differ)Tj
2.3243 0 Td
(in)Tj
1.0148 0 Td
(terms)Tj
2.4435 0 Td
(of)Tj
0.9978 0 Td
(the)Tj
1.44 0 Td
(oncogene)Tj
3.9855 0 Td
(expression)Tj
4.3653 0 Td
(such)Tj
2.0182 0 Td
(that)Tj
1.7405 0 Td
(the)Tj
/F11 1 Tf
1.44 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 527.1874 440.3905 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(\()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 532.8 442.0913 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
(\(located)Tj
3.3391 0 Td
(in)Tj
-36.6176 -1.2982 Td
(the)Tj
1.44 0 Td
(suprabasal)Tj
4.3143 0 Td
(epithelial)Tj
3.7701 0 Td
(layer\))Tj
2.4264 0 Td
(have)Tj
2.0239 0 Td
(higher)Tj
2.744 0 Td
(oncogene)Tj
3.9854 0 Td
(expression)Tj
4.3654 0 Td
(compared)Tj
4.1612 0 Td
(to)Tj
/F11 1 Tf
1.0091 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 508.3086 427.4078 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 513.8645 429.1086 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
(cells)Tj
1.8708 0 Td
(\(located)Tj
3.3392 0 Td
(in)Tj
-36.5949 -1.3039 Td
(the)Tj
1.4399 0 Td
(basal)Tj
2.1487 0 Td
(epithelial)Tj
3.7757 0 Td
(layer\))Tj
2.4265 0 Td
([)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(].)Tj
2.0295 0 Td
(The)Tj
1.7518 0 Td
(rate)Tj
1.7065 0 Td
(of)Tj
0.9921 0 Td
(oncogene)Tj
3.9912 0 Td
(expression)Tj
4.3653 0 Td
(of)Tj
0.9921 0 Td
(the)Tj
1.44 0 Td
(HPV)Tj
2.211 0 Td
(type)Tj
1.8765 0 Td
(present)Tj
3.0897 0 Td
(in)Tj
1.0205 0 Td
(an)Tj
-35.257 -1.2982 Td
(infected)Tj
3.3391 0 Td
(cell,)Tj
1.7348 0 Td
(given)Tj
2.3301 0 Td
(by)Tj
/F12 1 Tf
1.1622 0 Td
()Tj
/F6 1 Tf
0.6973 0 Td
(controls)Tj
3.4016 0 Td
(the)Tj
1.44 0 Td
(conversion)Tj
4.5297 0 Td
(of)Tj
/F11 1 Tf
0.9978 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 402.2362 401.4425 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 405.6377 403.0866 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
(,)Tj
0.4308 0 Td
(into)Tj
1.8028 0 Td
(the)Tj
1.44 0 Td
(transit-amplifying)Tj
7.2794 0 Td
(infected)Tj
3.3391 0 Td
(cells,)Tj
/F11 1 Tf
-34.8544 -1.2982 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 205.9086 388.4031 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(\()]TJ
/F6 1 Tf
(.)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 213.0519 390.1039 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
(Cells,)Tj
/F11 1 Tf
2.33 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 242.2488 388.4031 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(\()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 245.5937 390.1039 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
(,)Tj
0.4365 0 Td
(grow)Tj
2.211 0 Td
(at)Tj
0.9298 0 Td
(rate)Tj
/F11 1 Tf
1.7064 0 Td
[(\n)]TJ
/F12 1 Tf
()Tj
/F6 1 Tf
(,)Tj
1.2642 0 Td
(proportional)Tj
5.1931 0 Td
(to)Tj
1.0034 0 Td
(their)Tj
2.058 0 Td
(own)Tj
1.9275 0 Td
(density)Tj
3.0331 0 Td
(and)Tj
1.7008 0 Td
(die)Tj
1.4059 0 Td
(at)Tj
0.9355 0 Td
(rate)Tj
/F11 1 Tf
1.7064 0 Td
[(,)]TJ
/F6 1 Tf
(.)Tj
0.9354 0 Td
(Due)Tj
1.8766 0 Td
(to)Tj
1.0034 0 Td
(higher)Tj
-33.885 -1.3039 Td
(expression)Tj
4.3653 0 Td
(of)Tj
0.992 0 Td
(oncogenes,)Tj
4.5524 0 Td
(the)Tj
1.44 0 Td
(transit-amplifying)Tj
7.2793 0 Td
(cells,)Tj
/F11 1 Tf
2.0863 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 413.0645 375.4204 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(\()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 418.6771 377.0645 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
(divide)Tj
2.6248 0 Td
(more)Tj
2.3017 0 Td
(before)Tj
2.6816 0 Td
(death,)Tj
2.5965 0 Td
(compared)Tj
4.1612 0 Td
(to)Tj
-36.2321 -1.2982 Td
(the)Tj
1.44 0 Td
(basal)Tj
2.1487 0 Td
(infected)Tj
3.3448 0 Td
(cells)Tj
/F11 1 Tf
1.8652 0 Td
[(')]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 293.9527 362.4377 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 297.2976 364.0818 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
(.)Tj
0.4365 0 Td
(Since,)Tj
2.5228 0 Td
(both)Tj
2.0239 0 Td
(infected)Tj
3.3392 0 Td
(cell)Tj
1.5194 0 Td
(population)Tj
4.49 0 Td
(have)Tj
2.0183 0 Td
(an)Tj
1.1849 0 Td
(expression)Tj
4.3653 0 Td
(of)Tj
0.9921 0 Td
(oncogene,)Tj
-32.6208 -1.2982 Td
(as)Tj
0.9921 0 Td
(in)Tj
1.0148 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(],)Tj
2.0296 0 Td
(both)Tj
2.0183 0 Td
(types)Tj
2.228 0 Td
(of)Tj
0.9921 0 Td
(infected)Tj
3.3391 0 Td
(cells)Tj
1.8709 0 Td
(produce)Tj
3.4525 0 Td
(free)Tj
1.6838 0 Td
(virions)Tj
2.9253 0 Td
(\()Tj
/F11 1 Tf
[(\))4()]TJ
/F6 1 Tf
(,)Tj
2.0126 0 Td
(at)Tj
0.9298 0 Td
(production)Tj
4.6148 0 Td
(rates)Tj
/F11 1 Tf
2.0579 0 Td
[(-)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 526.2236 349.3984 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 531.7795 351.0992 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
(and)Tj
/F11 1 Tf
1.7007 0 Td
[(-)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 553.3228 349.3984 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(\()]TJ
/F6 1 Tf
(,)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 560.5228 351.0992 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
(that)Tj
-36.0507 -1.3039 Td
(are)Tj
1.4173 0 Td
(released)Tj
3.3505 0 Td
(through)Tj
3.3732 0 Td
(bursting.)Tj
3.702 0 Td
(For)Tj
1.5988 0 Td
(simplicity,)Tj
4.2576 0 Td
(we)Tj
1.3096 0 Td
(consider)Tj
3.5659 0 Td
(an)Tj
1.1849 0 Td
(equal)Tj
2.3074 0 Td
(virion)Tj
2.5738 0 Td
(production)Tj
4.6205 0 Td
(rate)Tj
1.7064 0 Td
(of)Tj
/F11 1 Tf
0.9921 0 Td
[(-)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 564.2078 336.4157 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 569.7637 338.0598 cm
BT
/F11 1 Tf
1 TL
-0.014 Tc
0 0 Td
[($)]TJ
-36.9748 -1.2982 Td
[(-)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 204.548 323.433 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(\()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 210.1039 325.0771 cm
BT
/F11 1 Tf
1 TL
-0.014 Tc
0 0 Td
[($)]TJ
0.805 0 Td
[(-)]TJ
/F6 1 Tf
(.)Tj
0.8901 0 Td
(The)Tj
1.7518 0 Td
(HPV)Tj
2.211 0 Td
(virions)Tj
2.9253 0 Td
(are)Tj
1.4173 0 Td
(cleared)Tj
3.0047 0 Td
(at)Tj
0.9298 0 Td
(rate)Tj
/F11 1 Tf
1.7064 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 370.148 323.433 cm
BT
/F11 1 Tf
1 TL
-0.0186 Tc
0 0 Td
[(\()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 375.7039 325.0771 cm
BT
/F6 1 Tf
1 TL
-0.014 Tc
0 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
2.0295 0 Td
(The)Tj
/F11 1 Tf
1.7518 0 Td
[()]TJ
ET
Q
q
1 j
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2000 Adobe Systems Incorporated. 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