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Joel Frohlich, Damla Senturk, Vidya Saravanapandian, Peyman Golshani, Lawrence T. Reiter, Raman Sankar, Ronald L. Thibert, Charlotte DiStefano, Scott Huberty, Edwin H. Cook, Shafali S. Jeste
A Quantitative Electrophysiological Biomarker of Duplication 15q11.2-q13.1 Syndrome
www.plosone.org
www.plosone.org
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497.9906 159.9307 m
507.515 159.9307 l
h
f*
342.2551 146.948 m
351.7228 146.948 l
h
f*
278.3622 133.9087 m
287.8299 133.9087 l
h
f*
0 g
1 j
1 J
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 612 cm
BT
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1 TL
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Q
q
1 j
1 J
0 w
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(exclusionary)Tj
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(\()Tj
/F11 1 Tf
[( )]TJ
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(2\),)Tj
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(15q11.2-q13.1)Tj
5.7089 0 Td
(region)Tj
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(\()Tj
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[( )]TJ
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1.0659 0 Td
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(\()Tj
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[( )]TJ
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1.0658 0 Td
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(2\).)Tj
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(16144)Tj
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(months)Tj
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(54)Tj
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(the)Tj
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(isodicentric)Tj
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(\()Tj
/F11 1 Tf
[( )]TJ
/F6 1 Tf
1.0659 0 Td
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(8\))Tj
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1.7008 0 Td
(interstitial)Tj
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(\()Tj
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[( )]TJ
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1.0658 0 Td
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0.7937 0 Td
(3\))Tj
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(biomarkers)Tj
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(groups:)Tj
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(\(1\))Tj
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(age)Tj
1.508 0 Td
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(IQ-matched)Tj
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(cohort)Tj
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-35.6879 -1.2983 Td
(non-syndromic)Tj
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(ASD)Tj
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(\()Tj
/F11 1 Tf
[( )]TJ
/F6 1 Tf
1.0715 0 Td
(=)Tj
0.7881 0 Td
(10\))Tj
1.4796 0 Td
(and)Tj
1.7008 0 Td
(\(2\))Tj
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(age-matched)Tj
5.2384 0 Td
(group)Tj
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(of)Tj
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(TD)Tj
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(\()Tj
/F11 1 Tf
[( )]TJ
/F6 1 Tf
1.0715 0 Td
(=)Tj
0.788 0 Td
(9\).)Tj
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(preschoolers)Tj
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(UCLA)Tj
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(early)Tj
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(intervention)Tj
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(program.)Tj
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(children)Tj
-32.3544 -1.2982 Td
(enter)Tj
2.2336 0 Td
(the)Tj
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(program)Tj
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0.6406 0 Td
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(ASD,)Tj
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(California)Tj
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(State)Tj
-33.6243 -1.2983 Td
(Regional)Tj
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(clinical)Tj
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(psychologists,)Tj
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(psychiatrist,)Tj
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(developmental)Tj
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4.303 0 Td
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(UCLA)Tj
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(psychologists)Tj
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(DSM-IV)Tj
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(criteria.)Tj
-32.7456 -1.2983 Td
(Non-syndromic)Tj
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2.0863 0 Td
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(normal)Tj
3.0841 0 Td
(clinical)Tj
2.999 0 Td
(chromosomal)Tj
5.6296 0 Td
(microarray)Tj
4.5751 0 Td
(testing,)Tj
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(but)Tj
1.525 0 Td
(most)Tj
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0 g
1 j
1 J
7.9999 0 0 7.9999 36 708.7181 cm
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(1.)Tj
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