%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Ying Xu, Yanfang Guo, Kaiqian Liu, Zheng Liu, Xiaobo Wang
E-Cigarette Awareness, Use, and Harm Perception among Adults: A Meta-Analysis of Observational Studies
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 9 0 R/Annots 10 0 R/Contents 11 0 R/TrimBox[0 0 612 792]>>
endobj
10 0 obj
[12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R]
endobj
12 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165938.ref001)>>
endobj
13 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165938.ref002)>>
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165938.ref001)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165938.ref003)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165938.ref006)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165938.ref007)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165938.ref008)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165938.ref009)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165938.ref010)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165938.ref011)>>
endobj
11 0 obj
[22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R]
endobj
22 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 633.9101 m
199.9998 633.9101 l
199.9998 634.4101 l
575.9997 634.4101 l
f*
0.83 0.64 0.02 0 k
321.2787 535.3512 m
326.0409 535.3512 l
h
f*
563.0173 470.3811 m
567.7795 470.3811 l
h
f*
546.0094 444.3591 m
550.7717 444.3591 l
h
f*
226.715 405.3543 m
231.4205 405.3543 l
h
f*
236.5228 405.3543 m
241.2283 405.3543 l
h
f*
477.8079 379.389 m
482.5134 379.389 l
h
f*
218.8913 340.3843 m
223.5969 340.3843 l
h
f*
375.3071 314.3622 m
380.0126 314.3622 l
h
f*
521.9717 275.3575 m
531.3827 275.3575 l
h
f*
486.5953 249.3921 m
496.0063 249.3921 l
h
f*
0 g
1 j
1 J
11.4998 0 0 11.4998 200.0125 706.3937 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusions)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 689.3858 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(E-cigarette)Tj
5.0008 0 Td
(awareness)Tj
5.0009 0 Td
(has)Tj
1.8142 0 Td
(been)Tj
2.4169 0 Td
(increasing,)Tj
4.9949 0 Td
(and)Tj
1.8679 0 Td
(e-cigarette)Tj
4.8875 0 Td
(use)Tj
1.8142 0 Td
(and)Tj
1.8679 0 Td
(perceived)Tj
4.4996 0 Td
(health)Tj
2.9062 0 Td
(risks)Tj
-37.071 -1.474 Td
(are)Tj
1.647 0 Td
(nearly)Tj
2.9063 0 Td
(invariable)Tj
4.4339 0 Td
(between)Tj
3.9566 0 Td
(2009)Tj
2.4169 0 Td
(and)Tj
1.8619 0 Td
(2014.)Tj
2.6974 0 Td
(Given)Tj
2.8048 0 Td
(the)Tj
1.5933 0 Td
(substantial)Tj
4.9413 0 Td
(heterogenei)Tj
5.2157 0 Td
(ty)Tj
0.9906 0 Td
(in)Tj
0.9847 0 Td
(the)Tj
-36.4504 -1.468 Td
(prevalence)Tj
5.0486 0 Td
(rate)Tj
1.9216 0 Td
(estimates,)Tj
4.7383 0 Td
(there)Tj
2.4766 0 Td
(is)Tj
0.9309 0 Td
(a)Tj
0.7698 0 Td
(need)Tj
2.411 0 Td
(for)Tj
1.3785 0 Td
(more)Tj
2.4766 0 Td
(accurate)Tj
4.0162 0 Td
(and)Tj
1.8679 0 Td
(comparable)Tj
5.3828 0 Td
(prevalence)Tj
-33.4188 -1.474 Td
(estimates)Tj
4.4578 0 Td
(for)Tj
1.3785 0 Td
(e-cigarettes)Tj
5.3828 0 Td
(across)Tj
3.139 0 Td
(the)Tj
1.5934 0 Td
(world.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 605.4803 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 588.4724 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(electronic)Tj
4.1556 0 Td
(cigarette)Tj
3.6226 0 Td
(\(e-cigarette\),)Tj
5.3064 0 Td
(first)Tj
1.8029 0 Td
(developed)Tj
4.2746 0 Td
(in)Tj
1.0318 0 Td
(China)Tj
2.6645 0 Td
(in)Tj
1.0318 0 Td
(2003,)Tj
2.3471 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(battery-powered)Tj
-29.5198 -1.3039 Td
(nicotine)Tj
3.5035 0 Td
(delivery)Tj
3.3903 0 Td
(device)Tj
2.7382 0 Td
(that)Tj
1.7802 0 Td
(provides)Tj
3.6453 0 Td
(inhaled)Tj
3.1975 0 Td
(doses)Tj
2.398 0 Td
(of)Tj
1.0148 0 Td
(vaporized)Tj
4.1386 0 Td
(nicotine)Tj
3.5036 0 Td
(solution)Tj
3.4809 0 Td
(and)Tj
1.7291 0 Td
(is)Tj
-34.52 -1.2982 Td
(designed)Tj
3.7643 0 Td
(to)Tj
1.0262 0 Td
(look)Tj
1.9729 0 Td
(and)Tj
1.7291 0 Td
(feel)Tj
1.6044 0 Td
(like)Tj
1.6554 0 Td
(a)Tj
0.652 0 Td
(traditional)Tj
4.4163 0 Td
(cigarette.)Tj
3.8551 0 Td
(E-cigarettes)Tj
4.9039 0 Td
(have)Tj
2.058 0 Td
(become)Tj
3.3278 0 Td
(increasingly)Tj
-30.9654 -1.2983 Td
(popular,)Tj
3.5659 0 Td
(for)Tj
1.3833 0 Td
(example,)Tj
3.7757 0 Td
(it)Tj
0.7881 0 Td
(was)Tj
1.6951 0 Td
(reported)Tj
3.6623 0 Td
(that)Tj
1.7802 0 Td
(e-cigarettes)Tj
4.7565 0 Td
(sales)Tj
2.0466 0 Td
(have)Tj
2.0579 0 Td
(doubled)Tj
3.4866 0 Td
(every)Tj
2.3527 0 Td
(year)Tj
1.8992 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
-34.2876 -1.3039 Td
(United)Tj
3.0217 0 Td
(States)Tj
2.5114 0 Td
(\(US\))Tj
2.109 0 Td
(since)Tj
2.245 0 Td
(2008[)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
3.5036 0 Td
(This)Tj
1.9843 0 Td
(increasing)Tj
4.3313 0 Td
(trend)Tj
2.3924 0 Td
(might)Tj
2.5965 0 Td
(be)Tj
1.1509 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
1.0261 0 Td
(e-cigarette)Tj
4.3994 0 Td
(product)Tj
-32.9667 -1.2983 Td
(promotional)Tj
5.244 0 Td
(campaigns)Tj
4.4901 0 Td
(conducted)Tj
4.4277 0 Td
(on)Tj
1.2755 0 Td
(multiple)Tj
3.566 0 Td
(mainstream)Tj
4.9946 0 Td
(marketing)Tj
4.3427 0 Td
(channels,)Tj
3.9628 0 Td
(including)Tj
-32.3034 -1.2982 Td
(television,)Tj
4.2406 0 Td
(print,)Tj
2.4491 0 Td
(radio,)Tj
2.5511 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.474 0 Td
(Internet.)Tj
3.6963 0 Td
(Kornfield)Tj
4.0705 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1282 0 Td
(reported)Tj
3.6624 0 Td
(that)Tj
1.7744 0 Td
(promotional)Tj
5.2441 0 Td
(spending)Tj
-32.961 -1.2983 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(US)Tj
1.4286 0 Td
(was)Tj
1.7008 0 Td
(minimal)Tj
3.6226 0 Td
(through)Tj
3.447 0 Td
(mid-2010)Tj
4.0875 0 Td
(and)Tj
1.7291 0 Td
(has)Tj
1.542 0 Td
(since)Tj
2.2451 0 Td
(rapidly)Tj
3.0387 0 Td
(increased,)Tj
4.2236 0 Td
(reaching)Tj
3.6793 0 Td
(US$12)Tj
-33.2501 -1.3039 Td
(million)Tj
3.118 0 Td
(in)Tj
1.0375 0 Td
(2011)Tj
2.126 0 Td
(and)Tj
1.7291 0 Td
(US$22)Tj
2.8573 0 Td
(million)Tj
3.1238 0 Td
(in)Tj
1.0318 0 Td
(2012.)Tj
2.347 0 Td
(For)Tj
1.6271 0 Td
(the)Tj
1.4684 0 Td
(second)Tj
3.016 0 Td
(quarter)Tj
3.1521 0 Td
(of)Tj
1.0148 0 Td
(2013)Tj
2.1203 0 Td
(alone,)Tj
2.6079 0 Td
(expenditures)Tj
-32.3771 -1.2983 Td
(reached)Tj
3.3505 0 Td
(US$28)Tj
2.8573 0 Td
(million,)Tj
3.3505 0 Td
(over)Tj
1.9729 0 Td
(eight)Tj
2.2054 0 Td
(times)Tj
2.3867 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(spending)Tj
3.8778 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(second)Tj
3.0104 0 Td
(quarter)Tj
3.1521 0 Td
(of)Tj
1.0148 0 Td
(2012[)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
-34.0552 -1.2983 Td
(Luo)Tj
1.7914 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1282 0 Td
(systematically)Tj
5.743 0 Td
(assessed)Tj
3.4696 0 Td
(196)Tj
1.6497 0 Td
(unique)Tj
3.0217 0 Td
(videos)Tj
2.7609 0 Td
(and)Tj
1.7292 0 Td
(found)Tj
2.6192 0 Td
(that)Tj
1.7744 0 Td
(94%)Tj
1.9333 0 Td
(\(n)Tj
1.1055 0 Td
(=)Tj
0.7993 0 Td
(185\))Tj
1.9899 0 Td
(were)Tj
2.1203 0 Td
(pro)Tj
-34.5767 -1.3039 Td
(e-cigarettes)Tj
4.7565 0 Td
(and)Tj
1.7347 0 Td
(4%)Tj
1.4514 0 Td
(\(n)Tj
1.1055 0 Td
(=)Tj
0.7993 0 Td
(8\))Tj
1.0375 0 Td
(were)Tj
2.126 0 Td
(neutral,)Tj
3.2938 0 Td
(while)Tj
2.3698 0 Td
(only)Tj
1.9729 0 Td
(2%)Tj
1.4513 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7993 0 Td
(3\))Tj
1.0375 0 Td
(were)Tj
2.1203 0 Td
(anti)Tj
2.5512 0 Td
(e-cigarettes[)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
-0.01 Tc
-28.522 -1.2982 Td
(However,)Tj
4.0308 0 Td
(there)Tj
2.2337 0 Td
(is)Tj
0.839 0 Td
(insufficient)Tj
4.6545 0 Td
(scientific)Tj
3.7304 0 Td
(evidence)Tj
3.6623 0 Td
(concerning)Tj
4.6885 0 Td
(the)Tj
1.4513 0 Td
(health)Tj
2.6419 0 Td
(benefits)Tj
3.2882 0 Td
(of)Tj
1.0034 0 Td
(e-ciga-)Tj
-33.4202 -1.2983 Td
(rettes,)Tj
2.5795 0 Td
(possible)Tj
3.3618 0 Td
(adverse)Tj
3.1748 0 Td
(effects,)Tj
2.9027 0 Td
(the)Tj
1.4513 0 Td
(efficiency)Tj
3.9685 0 Td
(of)Tj
1.0034 0 Td
(cigarette)Tj
3.566 0 Td
(cessation)Tj
3.7927 0 Td
(attempts)Tj
3.6227 0 Td
(and)Tj
1.7121 0 Td
(cigarette)Tj
3.5716 0 Td
(absti-)Tj
-34.7071 -1.3039 Td
(nence[)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
4.8925 0 Td
(Consequently,)Tj
5.879 0 Td
(approaches)Tj
4.6772 0 Td
(to)Tj
1.0148 0 Td
(regulation)Tj
4.2462 0 Td
(vary)Tj
1.9106 0 Td
(widely.)Tj
3.0104 0 Td
(Some)Tj
2.4207 0 Td
(states)Tj
2.3584 0 Td
(have)Tj
2.0353 0 Td
(labeled)Tj
2.9877 0 Td
(e-)Tj
-35.4328 -1.2983 Td
(cigarettes)Tj
3.9231 0 Td
(as)Tj
1.0034 0 Td
(tobacco)Tj
3.2769 0 Td
(products,)Tj
3.9288 0 Td
(while)Tj
2.3357 0 Td
(others)Tj
2.6759 0 Td
(have)Tj
2.0352 0 Td
(passed)Tj
2.8063 0 Td
(measures)Tj
3.8948 0 Td
(that)Tj
1.7575 0 Td
(define)Tj
2.6589 0 Td
(them)Tj
2.2677 0 Td
(as)Tj
1.0034 0 Td
(some-)Tj
-33.5676 -1.2982 Td
(thing)Tj
2.2847 0 Td
(else,)Tj
1.8651 0 Td
(such)Tj
2.024 0 Td
(as)Tj
0.9978 0 Td
(alternative)Tj
4.7281 0 Td
(nicotine)Tj
3.4469 0 Td
(products)Tj
4.0819 0 Td
(or)Tj
1.0828 0 Td
(vapor)Tj
2.8517 0 Td
(products)Tj
4.0818 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.5647 0 Td
(In)Tj
1.0885 0 Td
(a)Tj
0.6407 0 Td
(revised)Tj
2.999 0 Td
(European)Tj
-33.7377 -1.304 Td
(Union)Tj
2.7836 0 Td
(Tobacco)Tj
3.5829 0 Td
(Product)Tj
3.3846 0 Td
(Directive,)Tj
4.0421 0 Td
(e-cigarettes)Tj
4.6772 0 Td
(have)Tj
2.0239 0 Td
(been)Tj
2.092 0 Td
(regulated)Tj
3.8721 0 Td
(as)Tj
0.9921 0 Td
(tobacco)Tj
3.2655 0 Td
(products)Tj
3.6963 0 Td
(or)Tj
1.0772 0 Td
(med-)Tj
-35.4895 -1.2982 Td
(ical)Tj
1.5647 0 Td
(devices,)Tj
3.2768 0 Td
(depending)Tj
4.4163 0 Td
(on)Tj
1.2643 0 Td
(the)Tj
1.4513 0 Td
(nicotine)Tj
3.4583 0 Td
(concentrations)Tj
6.0944 0 Td
(\(up)Tj
1.5874 0 Td
(to)Tj
1.0148 0 Td
(20)Tj
1.1565 0 Td
(mg/ml)Tj
2.8743 0 Td
(or)Tj
1.0829 0 Td
(more)Tj
2.3187 0 Td
(than)Tj
2.0069 0 Td
(that)Tj
1.7518 0 Td
(or)Tj
-35.3194 -1.2983 Td
(not)Tj
1.5533 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(]\).)Tj
1.9106 0 Td
(Some)Tj
2.4264 0 Td
(countries,)Tj
4.1102 0 Td
(such)Tj
2.0353 0 Td
(as)Tj
1.0034 0 Td
(Brazil)Tj
2.4945 0 Td
(and)Tj
1.7121 0 Td
(France,)Tj
3.1351 0 Td
(have)Tj
2.0353 0 Td
(banned)Tj
3.1748 0 Td
(the)Tj
1.4513 0 Td
(sale,)Tj
1.8765 0 Td
(import,)Tj
3.1861 0 Td
(and)Tj
1.7122 0 Td
(advertis-)Tj
-33.8171 -1.2983 Td
(ing)Tj
1.4796 0 Td
(of)Tj
1.0035 0 Td
(e-cigarettes,)Tj
4.9096 0 Td
(while)Tj
2.3357 0 Td
(other)Tj
2.3187 0 Td
(countries)Tj
3.8948 0 Td
(such)Tj
2.0353 0 Td
(as)Tj
1.0034 0 Td
(Finland)Tj
3.2768 0 Td
(have)Tj
2.041 0 Td
(treated)Tj
2.9537 0 Td
(e-cigarettes)Tj
4.6884 0 Td
(as)Tj
1.0035 0 Td
(medicinal)Tj
-32.944 -1.3039 Td
(products)Tj
3.702 0 Td
(and)Tj
1.7178 0 Td
(banned)Tj
3.1691 0 Td
(only)Tj
1.9559 0 Td
(their)Tj
2.0749 0 Td
(advertising)Tj
4.5751 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
1.5761 0 Td
(In)Tj
1.0998 0 Td
(addition,)Tj
3.7644 0 Td
(some)Tj
2.3074 0 Td
(local)Tj
2.0466 0 Td
(governments)Tj
5.3801 0 Td
(in)Tj
1.0205 0 Td
(the)Tj
1.4513 0 Td
(US)Tj
-35.841 -1.2982 Td
(have)Tj
2.0352 0 Td
(taken)Tj
2.3924 0 Td
(action)Tj
2.6589 0 Td
(to)Tj
1.0148 0 Td
(prohibit)Tj
3.4356 0 Td
(sales)Tj
2.0126 0 Td
(to)Tj
1.0148 0 Td
(minors)Tj
3.0614 0 Td
(or)Tj
1.0828 0 Td
(otherwise)Tj
4.0308 0 Td
(restrict)Tj
2.9877 0 Td
(e-cigarettes)Tj
4.6885 0 Td
(use.)Tj
1.7348 0 Td
(The)Tj
1.7631 0 Td
(World)Tj
-33.9134 -1.2983 Td
(Health)Tj
2.8799 0 Td
(Organization)Tj
5.4482 0 Td
(\(WHO\))Tj
3.3505 0 Td
(has)Tj
1.525 0 Td
(called)Tj
2.4832 0 Td
(for)Tj
1.3719 0 Td
(regulations)Tj
4.6035 0 Td
(that)Tj
1.7518 0 Td
(impede)Tj
3.1634 0 Td
(the)Tj
1.4513 0 Td
(promotion)Tj
4.5128 0 Td
(of)Tj
1.0034 0 Td
(e-ciga-)Tj
-33.5449 -1.3039 Td
(rettes,)Tj
2.5795 0 Td
(minimize)Tj
3.9968 0 Td
(their)Tj
2.0806 0 Td
(potential)Tj
3.702 0 Td
(health)Tj
2.6419 0 Td
(risks,)Tj
2.2677 0 Td
(and)Tj
1.7121 0 Td
(prohibit)Tj
3.4356 0 Td
(unproven)Tj
4.0705 0 Td
(health)Tj
2.6419 0 Td
(claims)Tj
2.7382 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
-30.6706 -1.2983 Td
(To)Tj
1.3266 0 Td
(face)Tj
1.7688 0 Td
(this)Tj
1.6497 0 Td
(new)Tj
1.8595 0 Td
(challenge,)Tj
4.1216 0 Td
(more)Tj
2.3187 0 Td
(and)Tj
1.7121 0 Td
(more)Tj
2.3188 0 Td
(scientific)Tj
3.7247 0 Td
(research)Tj
3.5092 0 Td
(has)Tj
1.5251 0 Td
(been)Tj
2.0976 0 Td
(conducted)Tj
4.371 0 Td
(to)Tj
1.0148 0 Td
(identify)Tj
-34.5144 -1.2983 Td
(the)Tj
1.4513 0 Td
(safety)Tj
2.4434 0 Td
(and)Tj
1.7121 0 Td
(efficacy)Tj
3.1748 0 Td
(of)Tj
1.0035 0 Td
(e-cigarettes)Tj
4.6885 0 Td
(worldwide.)Tj
4.6204 0 Td
(A)Tj
0.9014 0 Td
(bibliometric)Tj
5.0513 0 Td
(analysis)Tj
3.2769 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(])Tj
1.8311 0 Td
(indicated)Tj
3.8835 0 Td
(that)Tj
1.7518 0 Td
(the)Tj
-35.79 -1.3039 Td
(number)Tj
3.3788 0 Td
(of)Tj
1.0035 0 Td
(published)Tj
4.0705 0 Td
(articles)Tj
2.999 0 Td
(in)Tj
1.0262 0 Td
(the)Tj
1.4513 0 Td
(PubMed)Tj
3.617 0 Td
(database)Tj
3.5943 0 Td
(on)Tj
1.2642 0 Td
(this)Tj
1.6498 0 Td
(topic)Tj
2.2053 0 Td
(has)Tj
1.5194 0 Td
(grown)Tj
2.7666 0 Td
(exponentially,)Tj
-30.5459 -1.2982 Td
(from)Tj
2.1826 0 Td
(less)Tj
1.5874 0 Td
(than)Tj
2.0013 0 Td
(100)Tj
1.6327 0 Td
(in)Tj
1.0205 0 Td
(2012)Tj
2.0976 0 Td
(to)Tj
1.0148 0 Td
(more)Tj
2.3187 0 Td
(than)Tj
2.0069 0 Td
(200)Tj
1.6271 0 Td
(in)Tj
1.0205 0 Td
(2013)Tj
2.1033 0 Td
(to)Tj
1.0091 0 Td
(more)Tj
2.3187 0 Td
(than)Tj
2.0069 0 Td
(800)Tj
1.6271 0 Td
(in)Tj
1.0261 0 Td
(2014.)Tj
2.3131 0 Td
(WHO)Tj
2.6872 0 Td
(is)Tj
0.8334 0 Td
(cur-)Tj
-34.435 -1.2983 Td
(rently)Tj
2.5284 0 Td
(reviewing)Tj
4.0706 0 Td
(the)Tj
1.4513 0 Td
(existing)Tj
3.2655 0 Td
(evidence)Tj
3.668 0 Td
(on)Tj
1.2586 0 Td
(e-cigarettes)Tj
4.6884 0 Td
(to)Tj
1.0148 0 Td
(understand)Tj
4.7282 0 Td
(their)Tj
2.0806 0 Td
(impact)Tj
2.9424 0 Td
(on)Tj
1.2642 0 Td
(health)Tj
-32.961 -1.2983 Td
(\(Statement)Tj
4.507 0 Td
(revised)Tj
2.999 0 Td
(on)Tj
1.2529 0 Td
(3)Tj
0.6804 0 Td
(June)Tj
2.0125 0 Td
(2014)Tj
2.092 0 Td
(in)Tj
1.0148 0 Td
(GENEVA\).)Tj
4.6941 0 Td
(This)Tj
1.9503 0 Td
(study)Tj
2.3527 0 Td
(aimed)Tj
2.6532 0 Td
(to)Tj
1.0035 0 Td
(review)Tj
2.7949 0 Td
(the)Tj
1.4457 0 Td
(increasing)Tj
4.2576 0 Td
(pub-)Tj
-35.7106 -1.3039 Td
(lished)Tj
2.5341 0 Td
(literature)Tj
3.8211 0 Td
(related)Tj
2.9026 0 Td
(to)Tj
1.0148 0 Td
(e-cigarettes)Tj
4.6885 0 Td
(awareness,)Tj
4.4277 0 Td
(use,)Tj
1.7348 0 Td
(and)Tj
1.7121 0 Td
(perceived)Tj
3.9968 0 Td
(harmfulness)Tj
5.0627 0 Td
(among)Tj
2.965 0 Td
(adults)Tj
-34.8602 -1.2982 Td
(and)Tj
1.7121 0 Td
(to)Tj
1.0148 0 Td
(combine)Tj
3.6736 0 Td
(these)Tj
2.2224 0 Td
(results)Tj
2.7666 0 Td
(using)Tj
2.3584 0 Td
(meta-analysis.)Tj
5.794 0 Td
(In)Tj
1.0998 0 Td
(this)Tj
1.6498 0 Td
(case,)Tj
2.0579 0 Td
(evidence-based)Tj
6.2305 0 Td
(decision-making)Tj
-30.5799 -1.2983 Td
(might)Tj
2.5681 0 Td
(inform)Tj
2.9821 0 Td
(efforts)Tj
2.7155 0 Td
(to)Tj
1.0148 0 Td
(determine)Tj
4.269 0 Td
(appropriate)Tj
4.8132 0 Td
(public)Tj
2.6759 0 Td
(health)Tj
2.6362 0 Td
(policy)Tj
2.6021 0 Td
(and)Tj
1.7122 0 Td
(regulatory)Tj
4.2576 0 Td
(action.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 131.0173 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methods)Tj
/F0 1 Tf
0 -1.5023 Td
(Search)Tj
3.3543 0 Td
(strategy)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 95.9811 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(We)Tj
1.61 0 Td
(searched)Tj
3.7077 0 Td
(the)Tj
1.474 0 Td
(electronic)Tj
4.1499 0 Td
(databases)Tj
4.0025 0 Td
(PubMed)Tj
3.6567 0 Td
(\(2003)Tj
2.4604 0 Td
(to)Tj
1.0262 0 Td
(Feb)Tj
1.6781 0 Td
(2015\))Tj
2.4604 0 Td
(and)Tj
1.7348 0 Td
(Scopus)Tj
3.0274 0 Td
(\(2003)Tj
2.4661 0 Td
(to)Tj
1.0262 0 Td
(Feb)Tj
-34.4804 -1.2982 Td
(2015\))Tj
2.4604 0 Td
(using)Tj
2.3924 0 Td
(the)Tj
1.4684 0 Td
(following)Tj
3.9798 0 Td
(broad)Tj
2.5682 0 Td
(set)Tj
1.2982 0 Td
(of)Tj
1.0148 0 Td
(search)Tj
2.7609 0 Td
(terms)Tj
2.4945 0 Td
(for)Tj
1.389 0 Td
(article)Tj
2.6815 0 Td
(titles:)Tj
2.3414 0 Td
(electronic)Tj
4.5468 0 Td
(cigarette)Tj
3.6226 0 Td
(OR)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 486.7653 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(E-Cigarett)Tj
4.422 0 Td
(e)Tj
0.7654 0 Td
(among)Tj
3.2315 0 Td
(Adults)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0165)Tj
3.5434 0 Td
(938)Tj
2.6362 0 Td
(November)Tj
4.7622 0 Td
(18,)Tj
1.5874 0 Td
(2016)Tj
36.7515 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
23 0 obj
<>stream
endstream
endobj
24 0 obj
<>stream
endstream
endobj
25 0 obj
<>stream
endstream
endobj
26 0 obj
<>stream
endstream
endobj
27 0 obj
<>stream
endstream
endobj
28 0 obj
<>stream
endstream
endobj
29 0 obj
<>stream
endstream
endobj
30 0 obj
<>stream
endstream
endobj
31 0 obj
<>stream
endstream
endobj
32 0 obj
<>stream
endstream
endobj
33 0 obj
<>stream
endstream
endobj
34 0 obj
<>stream
BT
66.402 0 Td
(18)Tj
ET
Q
endstream
endobj
35 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 9 0 R/Annots 38 0 R/Contents 39 0 R/TrimBox[0 0 612 792]>>
endobj
36 0 obj
<>
endobj
40 0 obj
<>stream
/CIDInit/ProcSet findresource begin
12 dict begin begincmap
/CMapName/Adobe-Identity-UCS def
/CIDSystemInfo<>def
/CMapType 2 def
1 begincodespacerange
<0000>
endcodespacerange
1 beginbfchar
<0121><03C7>
endbfchar
endcmap
CMapName currentdict /CMap defineresource pop end end
endstream
endobj
41 0 obj
<>/FontDescriptor 42 0 R/DW 250/W[289[514]]>>
endobj
42 0 obj
<>
endobj
43 0 obj
<>stream
cvt f6 fpgm2Msf bglyf_ |heado 6hhea1 $hmtx&O