The authors have declared that no competing interests exist.
Conceived and designed the experiments: AA IKM JAGS. Performed the experiments: AA AW JM FJ. Analyzed the data: AA JAGS. Contributed reagents/materials/analysis tools: AA AW JM FJ IKM JAGS. Wrote the paper: AA JAGS.
In low-income countries, Surgical Site Infection (SSI) is a common form of hospital-acquired infection. Antibiotic prophylaxis is an effective method of preventing these infections, if given immediately before the start of surgery. Although several studies in Africa have compared pre-operative versus post-operative prophylaxis, there are no studies describing the implementation of policies to improve prescribing of surgical antibiotic prophylaxis in African hospitals.
We conducted SSI surveillance at a typical Government hospital in Kenya over a 16 month period between August 2010 and December 2011, using standard definitions of SSI and the extent of contamination of surgical wounds. As an intervention, we developed a hospital policy that advised pre-operative antibiotic prophylaxis and discouraged extended post-operative antibiotics use. We measured process, outcome and balancing effects of this intervention in using an interrupted time series design.
From a starting point of near-exclusive post-operative antibiotic use, after policy introduction in February 2011 there was rapid adoption of the use of pre-operative antibiotic prophylaxis (60% of operations at 1 week; 98% at 6 weeks) and a substantial decrease in the use of post-operative antibiotics (40% of operations at 1 week; 10% at 6 weeks) in Clean and Clean-Contaminated surgery. There was no immediate step-change in risk of SSI, but overall, there appeared to be a moderate reduction in the risk of superficial SSI across all levels of wound contamination. There were marked reductions in the costs associated with antibiotic use, the number of intravenous injections performed and nursing time spent administering these.
Implementation of a locally developed policy regarding surgical antibiotic prophylaxis is an achievable quality improvement target for hospitals in low-income countries, and can lead to substantial benefits for individual patients and the institution.
A World Health Organisation (WHO) systematic review in 2011 on hospital-acquired infections (HAI) highlighted the scarcity of studies from developing countries
Antibiotic prophylaxis in surgical patients is an effective means of reducing the risk of post-operative SSI
Achieving measureable and sustained improvements in the quality of healthcare is challenging in any setting, but in low-income countries examples of effectively introducing evidence-based practices are scanty
We report our experience of developing and implementing a Surgical Antibiotic Prophylaxis (AP) policy as an intervention to change healthcare practitioners’ prescribing behaviour in a Government hospital in Kenya.
During an 18-month period of SSI surveillance, we introduced a quality improvement intervention. We prospectively measured the effects of this intervention in terms of process, outcome and balancing measures, using various statistical methods to compare the time periods before and after this intervention.
Thika Level 5 Hospital is a 300-bed Government Hospital in the town of Thika, approximately 50 km NE of Nairobi, Kenya. Six consultant surgeons and a rotating pool of 16–20 junior doctors and clinical officers (clinically-trained healthcare professionals) carry out approximately 300 elective and emergency operations monthly. We conducted SSI surveillance at Thika Hospital from August 2010 to December 2011 for all patients undergoing surgical procedures involving overnight admission to Thika Hospital. Patients remained in SSI surveillance for 30 days after all operations, encompassing both inpatient and outpatient periods. After discharge from hospital, we contacted patients by phone to determine the occurrence of post-discharge SSI. Further examination of the methodological approaches used for this surveillance is described elsewhere
A team of hospital staff members (2 clinical officers and 4 support workers) conducted surveillance activities daily throughout the study period with on-site supervision by a clinical epidemiologist. Surgical wound class (Clean, Clean-Contaminated, Contaminated, Dirty) was assigned by the operating surgeon. No changes to surveillance methods or staff were made during this period. Surveillance staff, although not blinded to the introduction of the Antibiotic Prophylaxis policy, performed no role in its development or implementation.
We diagnosed SSI in accordance with CDC-NHSN definitions
As process indicators, we analysed the proportion of patients undergoing surgical procedures who were documented to receive AP within 60 minutes of the start of the operation, and the proportion of patients prescribed post-operative antibiotics. Using weekly datapoints (26 pre- and 40 post-intervention), we used segmented regression analysis
As outcome measures, the risk of different forms of SSI within 30 days of the operation were recorded. We examined a time series plot of monthly datapoints (6 pre- and 9 post-intervention) for SSI risk. We looked for a step-change associated with initial policy introduction and for overall trends in risk over time by performing linear regression analyses for the periods before (August 2010–January 2011) and after (March–November 2011) policy introduction. In the absence of a clear pattern in the month–to –month variation in SSI risk, the overall risk in these periods was compared in a before-and-after format by calculating a risk ratio. Patients whose surgery was classified as “Contaminated” or “Dirty” were considered separately as work in Thika Hospital
As balancing measures, we assessed financial costs and staff time requirements from the point of view of a hospital administrator. Costs were evaluated by comparing the average cost (per 100 operations) for purchasing and administering intravenous (iv) antibiotics based on usage in Thika Hospital during surveillance. The monetary values of drugs and other consumables were obtained from the awarded prices for medical products in Thika Hospital for 2011–12. We estimated the difference in nurse-hours based on an assumption of 10 minutes of nursing time per dose of intravenous medication being administered.
This study is reported in accordance with ORION guidelines
SSI Surveillance at Thika Hospital was approved by the Kenya Medical Research Institute National Ethics Review Committee. All patients gave written consent to participation in surveillance, which included contact by phone after discharge from hospital.
We conducted SSI surveillance at Thika Hospital for all operations performed between the 16th August 2010 and the 20th November 2011 for patients who spent at least one post-operative night in hospital. We followed all patients for a 30-day post-operative period, with contact by telephone after discharge. A total of 3,343 patients were followed up in surveillance over this time (see
Variable | Total number |
Age (years) | |
≤14 | 84 |
15–39 | 2,936 |
40–65 | 289 |
65+ | 34 |
Sex | |
Male | 307 |
Female | 3,036 |
Type of surgery | |
Caesarean section | 2,594 |
General Surgery | 327 |
Orthopaedic/Neurosurgery | 125 |
Gynaecological | 297 |
Surgeon grade |
|
Consultant | 525 |
Medical Officer | 1,616 |
Medical Officer Intern | 1,164 |
Registered Clinical Officer | 38 |
Total operations followed up | 3,343 |
Medical Officer = junior doctor; Medical Officer Intern = junior doctor in first year after qualification; Registered Clinical Officer = vocationally-trained medical professional.
As our intervention, we developed an Antibiotic Prophylaxis (AP) policy for Thika Hospital over a series of multi-disciplinary seminars held between November 2010 and January 2011. This was based on reviewing African
Following extensive training of medical, nursing and theatre staff, this AP policy was implemented in Thika Hospital from the 7th February 2011 onwards. Following an initial evaluation meeting, a patient information poster was used (
In the pre-intervention phase of this study (prior to Feb 2011), less than 2% of patients were given pre-operative antibiotic prophylaxis – this was only used for patients having orthopaedic procedures involving implanted material – whilst over 99% of surgical patients were prescribed post-operative antibiotic regimes, typically a combination of penicillin, gentamicin and metronidazole given intravenously (iv) for three to five days, followed by a course of oral antibiotics. The implementation of the AP policy is illustrated in
Over the surveillance period, the monthly risk of developing any form of SSI (superficial, deep or organ-space) ranged between 3 and 13% in patients whose surgery was classified as Clean or Clean-Contaminated (see
Evaluation of the effects of the AP policy on SSI risk in a before-and-after comparison showed reduction in the risk of superficial SSI in both Clean/Clean-Contaminated surgery (RR 0.66; 95% CI 0.49–0.91; p = 0.01) and in Contaminated/Dirty surgery (RR 0.17; 95% CI 0.04–0.74; p = 0.005) – see
Surgical Site Infections | Post-operative antibiotics only (%) | Pre-operative AP +/− post-operative antibiotics (%) | Risk Ratio (95% CI) | p-valuea |
number of operations | 1,130 (100) | 2,046 (100) | – | |
superficial | 69 (6.1) | 83 (4.1) | 0.66 (0.49–0.91) | 0.01 |
Deep | 10 (0.9) | 13 (0.6) | 0.72 (0.32–1.63) | 0.43 |
organ-space | 3 (0.3) | 6 (0.3) | 1.10 (0.28–4.41) | 0.89 |
totalb | 82 (7.3) | 102 (5.0) | – | |
number of operations | 76 (100) | 91 (100) | – | |
Superficial | 10 (13.2) | 2 (2.2) | 0.17 (0.04–0.74) | 0.006 |
Deep | 6 (7.9) | 13 (14.3) | 1.81 (0.72–4.53) | 0.20 |
organ-space | 2 (2.6) | 2 (2.2) | 0.83 (0.12–5.79) | 0.86 |
totalb | 18 (23.7) | 17 (18.7) | – |
a = p-value from χ2-test with 1 degree of freedom.
b = no RR calculated for all SSI combined as these represent diverse forms of infection.
The financial and time impacts associated with the introduction of the AP policy in Thika Hospital, based on recorded usage before and after AP policy introduction are given in
Item | Baseline August2010–Jan 2011 | Intervention April2011–Nov 2011 | Change associated with AP policy(% change from baseline) |
All iv antibiotic agents used |
394.21 | 293.14 | −101.07 (b−26) |
Consumables for iv administration | 223.01 | 71.02 | −151.99 (−68) |
Total costs | 617.22 | 364.16 | −253.06 (−41) |
Doses of iv medications (number) | 1221 | 367 | −854 (−70) |
Nursing time giving iv antibiotics (hrs) |
204 | 61 | −143 (−70) |
Exchange rate of Ksh85 = US$1 used.
based on documented prescriptions and number of doses administered in these time-periods.
= based on an assumption of 10 mins nursing time/dose of iv antibiotics.
We believe this is the first report of the implementation of a quality improvement intervention in antibiotic use accompanied by process, outcome and balancing measures reported from sub-Saharan Africa. It is also the largest single-institution study of SSI risk in this region.
Our intervention, a locally-developed surgical antibiotic prophylaxis policy, rationalised clinicians’ prescribing, substantially reduced the use of intravenous antibiotics and saved both money and nursing time. Furthermore, there was some evidence of a modest reduction in risk of superficial SSI across all levels of wound contamination (RR 0.66 in Clean/Clean-Contaminated surgery; RR 0.17 in Contaminated/Dirty surgery).
We note that there was marked month-to-month variation in the overall risk of SSI during surveillance, principally due to changes in the recorded risk of superficial SSI. The highest overall risk of SSI was seen in the month of February 2011: this was both the month of the AP policy implementation and also the month that the annual intake of newly qualified junior doctors commenced work in Thika Hospital in 2011. This may have obscured the immediate effect of the changeover in AP use and may also account for the spike in SSI cases that occurred that month. Junior doctors (who perform the majority of uncomplicated Caesarean sections) rotated between hospital departments on a 3-monthly basis throughout the surveillance period; no other changes in staffing levels, equipment, facilities or operative techniques took place in Thika Hospital during this period.
Surgical Site Infections are inherently difficult to measure as they must be detected over a prolonged post-discharge period and largely rely on clinical judgement for diagnosis: these represent potential sources of classification error or bias. Although this study represents the largest report of SSI surveillance in a single institution in sub-Saharan Africa, it still remains relatively small in comparison to SSI surveillance studies in high-income settings. The study was almost certainly too small to detect changes in the risk of deep or organ-space SSI, which both occurred rarely. There are insufficient data points in this surveillance to discern cyclical patterns to SSI risk which could relate to hospital crowding or changes in levels of staff experience. Some circumstantial evidence, as described above, suggests that the latter could be important. This could be contributing bias to this study, though this would probably lead to underestimation of the effectiveness of the intervention as junior doctors were, on average, less experienced in the period after policy introduction.
Selection of antibiotics for use in the AP policy in Thika Hospital was difficult. Gentamicin was not used due to concerns about possible interactions with long-acting muscle relaxants. Co-amoxiclav might have been a better agent
Inappropriate antibiotic use is a multi-dimensional problem. What barriers existed to prevent this change in timing of antibiotic prophylaxis being implemented in Thika Hospital prior to 2011, when both research evidence and national guidelines supported such a change? Firstly, there was very limited awareness of national clinical policy documents, resulting in a marked policy-to-practice gap. Secondly, there was poor access to appropriate medicines for surgical prophylaxis – for example, although the Kenya Essential Medicines List describes ampicillin as “essential” for Government hospitals, in practice, this antibiotic was never received from official suppliers. Thirdly, amongst clinicians there was a marked concern about negative outcomes, especially regarding nosocomial infections, that hindered changes in antibiotic usage. The belief that prolonged post-operative antibiotic use mitigated the risk of HAI (in turn mainlyattributed to overcrowding and poor hygiene) was widespread. Finally, there was a lack of awareness amongst hospital management of the overall potential for cost-savings associated with such a policy change.
Why did this AP policy intervention succeed in changing local practice and sustaining this throughout the study period? Contributing factors to success may have been:
A strong evidence base and national infection control guidelines to support the policy.
“Buy-in” from senior clinicians and hospital management.
Multi-disciplinary and cross-departmental policy development.
Locally-relevant training materials for both staff and patients.
Extensive staff and patient sensitization prior to and after implementation.
Data collection for both process and outcome measures with timely feedback, including personalized feedback to persistent policy non-compliers.
Upgrade of SSI microbiology services as part of surveillance.
An appreciable saving of nurse-time and resources as a result of policy implementation.
Informal feedback from staff at Thika Hospital suggested that factors 5 and 8 were judged to have been most important, but all other factors played a contributing role. The change in practice with regard to use of surgical prophylaxis was reported to have been sustained as of August 2012, although no further data were collected.
Antibiotic stewardship, evidence-based practice and infection control are all important issues in healthcare. Achieving lasting improvements in any one of these fields is difficult – but this intervention made an improvement in a typical Government hospital in Kenya in all three areas whilst also saving both nursing-time and resources. Many factors contributed to achieving successful implementation of policy – most importantly, local engagement with clinicians and support of the process of change.
Our report demonstrates that changing from the outdated practice of post-operative prophylaxis is an achievable quality improvement intervention for hospitals in low-income settings. The looming threat of widespread antibiotic resistance means that there is a pressing need to improve antimicrobial use in low-resource settings
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The authors wish to thank the Thika Hospital staff and patients for their involvement in surveillance and the SSI Surveillance team for their diligent work on data collection and entry. We also wish to thank Andy Hall, Neal Alexander and Hajo Grundmann for their assistance with designing and conducting SSI surveillance and Peter Davey and Andrea Patton for advice on conducting an Interrupted Time Series analysis. This study is published with the permission of the Director of Kenya Medical Research Institute.