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Figure 1.

Temperature curves.

Mice (n = 14 mice for each of the four F. tularensis infection groups) infected in round 1 and round 2 with F. tularensis groups (A1a, A1b, A2 and type B) are shown. Mice were infected with F. tularensis and temperature was monitored every 1–2 hours until mice expired.

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Figure 2.

A representative mouse subcutaneous temperature curve in response to infection with F. tularensis type B is shown.

P1, P2 and P3 represent phase 1 (normal phase), phase 2 (febrile phase) and phase 3 (hypothermic phase), respectively. Black dots on the temperature curve labeled CP1 and CP2 represent change point 1 and change point 2, respectively.

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Table 1.

Length of infection phase for mice infected with each F. tularensis group (A1a, A1b, A2 and type B).

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Table 2.

Number of mice in each phase over time.

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Figure 3.

Predicted time of death (based on change point 2) versus observed time of death.

A) The correlation between predicted time of death and observed time of death are shown for all mice (black dots) infected with F. tularensis groups (A1a, A1b, A2 and type B) in both round 1 and round 2. The solid black line represents 100% correlation. B) The observed time of death minus the predicted times of death are shown for all mice (black dots) infected with F. tularensis groups (A1a, A1b, A2 and type B) in both round 1 and round 2.

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Figure 4.

Comparison of fitted survival curves.

A) Survival curves (fitted for all data from round 1 and round 2) are shown for mice infected with F. tularensis groups (A1a, A1b, A2 and type B) using drop point (solid lines) and observed time of death (dashed lines). The time at which each mouse expired (solid circles) or reached drop point (open circles) was reached is shown below the graph. B) Survival curve comparison between two infections performed at different times using the same A1b strain MA00-2987. The first MA00-2987 infection is denoted as (••• — •••). During this infection, mice were allowed to expire and drop point was subsequently identified and used as the endpoint for generating the survival curve. The second MA00-2987 infection is denoted as (——). Mice were euthanized at drop point during this infection for generation of the survival curve. The time at which each mouse reached drop point is shown below the graph as squares (1st round) or circles (2nd round).

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