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Probing structural changes in single enveloped virus particles using nano-infrared spectroscopic imaging

Fig 1

s-SNOM experimental setup and near-field infrared spectral images of influenza virus at pH 7.4.

(a) schematic of the s-SNOM experiment, (b) topography of four viruses (scale bar is 100 nm), (c-e) near-field phase (φ3) spectral images at three different frequencies. Line profiles of topography (f) and phase (g) representing the red broken lines shown in the topography (b) and phase (c, e) images.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0199112.g001