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Association of renal hyperfiltration with incident proteinuria - A nationwide registry study

Fig 2

A reverse J-shaped association between estimated glomerular filtration rate (eGFR) slope and the adjusted hazard ratio (aHR) for incident proteinuria.

aHR was calculated with a Cox regression model adjusted for age, sex, smoking status, regular exercise, regular alcohol consumption, known history of diabetes and/or hypertension medication, body mass index, systolic blood pressure, fasting serum glucose, serum triglycerides, and serum high-density lipoprotein-cholesterol in subjects who had undergone health screening five or more times. The relationship between the eGFR slope and the aHR was evaluated with a generalized additive model. The shaded area represents the 95% confidence interval.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0195784.g002