Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction
For definition of the age-specific criteria of impaired relaxation and increased filling pressure, see Methods. The analyses accounted for cohort and family cluster and were adjusted for sex, age, body mass index, mean arterial pressure, pulse pressure, heart rate, total cholesterol, plasma glucose, left ventricular mass index, alcohol intake and antihypertensive drug treatment. Horizontal bars denote the 95% confidence interval. For each entry, the number of people with diastolic LV dysfunction vs. normal function are given.