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Ezh2 is not required for cardiac regeneration in neonatal mice

Fig 1

Ezh2-deficient cardiomyocytes have reduced levels of H3K27me3.

(A) Relative expression of Ezh2 mRNA in whole ventricles of control (Ezh2fl/fl) and mutant (Ezh2fl/fl;Myh6-Cre) mice. (B) Immunofluorescence of H3K27me3 (red) in sections of hearts from P14 control and mutant mice. Cardiomyocytes (CMs) are evidenced by α-actinin (green), nuclei were counterstained with DAPI (blue). Arrowheads point to non-cardiomyocytes. Arrows point to cardiomyocytes. (C) Quantification of H3K27me3-positive (+) CMs and non-CMs. Scale bar = 50 μm. Bars represent the mean +/- SEM.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0192238.g001