Erythrocyte Inosine triphosphatase activity: A potential biomarker for adverse events during combination antiretroviral therapy for HIV
The effect of ITPA genotype wt/wt versus the other ITPA genotypes on the occurrence of regimen associated adverse events (renal adverse events for tenofovir and gastro-intestinal and skin related adverse events for abacavir) is plotted. Other ITPA genotypes than wt/wt were wt/c.124+21A>C, wt/c.94C>A, c.124+21A>C/c.124+21A>C, c.94C>A/c.94C>A or c.124+21a>C/c.94C>C. Odds ratio with 95% confidential interval and matching p-values are displayed. The analyses were conducted with repeated statement, adjusted for cumulative total duration of cART, cumulative duration of purine analogue therapy of all prior regimens and duration of the current regimen.