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Oxidative stress caused by activation of NADPH oxidase 4 promotes contrast-induced acute kidney injury

Fig 6

Effects of Nox4 overexpression mediated by HA vector-based gene transfer on HK-2 cell apoptosis.

Virus expressing the HA vector was used as a control. (A) Western blot analysis of the effects of HA vector-Nox4 on p38, JNK, and ERK phosphorylation. (B) Effects of inhibitors of p38 (SB203580), JNK (SP600125), and ERK (PD98059) on cell apoptosis, as measured by caspase 3/7 activity assays. (C) Levels of Nox4 protein were measured after inhibition of p38 (SB203580), JNK (SP600125), and ERK (PD98059). The data are the mean ± SD (n = 5). **p < 0.01 versus the control and ###p < 0.001 versus iohexol treatment only.

Fig 6

doi: https://doi.org/10.1371/journal.pone.0191034.g006