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Oxidative stress caused by activation of NADPH oxidase 4 promotes contrast-induced acute kidney injury

Fig 4

Effects of Nox4 on iohexol-induced ROS generation.

Cells were exposed to iohexol for 0, 1, or 2 h with and without Nox4 knockdown and GKT137831. (A) Confocal microscopic images of cells subjected to DHE staining. Original magnification, ×200; scale bar, 20 μm. (B) H2O2, a product of Nox4, was measured by Amplex red assay. The data are the mean ± SD. **p < 0.01, ***p < 0.001versus the control and ##p < 0.01, ###p < 0.001 versus iohexol treatment only.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0191034.g004