The importance of mean time in therapeutic range for complication rates in warfarin therapy of patients with atrial fibrillation: A systematic review and meta-regression analysis
Fig 3
Association between mean time in therapeutic range and rate of major bleeding and stroke/systemic embolism, predicted from uni- and multivariable meta-regressions.
Predicted rates of major bleeding and stroke/systemic embolism based on meta-regression with mean TTR as predictor based on univariable (black lines) and multivariable (grey lines) meta-regression. For the predicted rates based on multivariable meta-regression, the unweighted mean values from studies were used for age, proportion with prior stroke/transient ischemic attack, and proportion females. Vertical lines indicate estimated 95% confidence intervals. MB: Major bleeding, SSE: Stroke/systemic embolism, TTR: Time in therapeutic range.