DNase-capture reveals differential transcription factor binding modalities
The plots show enrichment over the DNase-capture baseline. The bottom panel shows a normal accessibility profile of a transcription factor, with a characteristic dip in the center and a rise on both sides. The top panel shows a novel CTCF accessibility profile, where the left side has the characteristic difference between the forward and reverse strands, but the right side does not. The 95% confidence bounds are calculated through bootstrapping.