Histological assessment of granulomas in natural and experimental Schistosoma mansoni infections using whole slide imaging
Path of Schistosoma mansoni eggs in the small (A, B) and large intestines (C, D) in the rodents Nectomys squamipes (A, C) and Swiss mice (B, D). The granulomatous inflammatory reaction (IR) produces a path which leads the translocation of parasite eggs (*) from the inner layers to the lumen of the intestines, as shown by the arrows. In (Ai), a S. mansoni egg is going out of the villi into the lumen of the small intestine. Liver and intestine fragments were taken from naturally infected N. squamipes (at day one of capture after confirmation of the infection) and from experimentally infected Swiss mice at days 55 (acute phase) and 120 (chronic phase) of infection. Bar = 160 μm (A); 120 μm (B, C, D); 80 μm (Ai).