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Histological assessment of granulomas in natural and experimental Schistosoma mansoni infections using whole slide imaging

Fig 6

Confluent granulomas in livers and small and large intestines of Nectomys squamipes and Swiss mice infected with Schistosoma mansoni.

(A-H) General morphology of confluent granulomas in different organs. Graph I shows the proportions of confluent granulomas in livers and in intestines taken from naturally infected N. squamipes (at day one of capture after confirmation of the infection) and from experimentally infected Swiss mice at days 55 (acute phase) and 120 (chronic phase) of infection. Confluent granulomas were quantified using Pannoramic Viewer software. (***) indicates significant differences between the means (P < 0.001). Bar = 100 μm (A, D), 220 μm (B, C); 150 μm (E, F, G, H).

Fig 6

doi: https://doi.org/10.1371/journal.pone.0184696.g006