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Modulation of the endogenous omega-3 fatty acid and oxylipin profile in vivo—A comparison of the fat-1 transgenic mouse with C57BL/6 wildtype mice on an omega-3 fatty acid enriched diet

Fig 2

n6/n3 ratio in blood as well as tissues and %EPA+DHA in blood cells.

Shown is the n6/n3 ratio in blood (A) and in tissues (B), as well as %EPA+DHA in blood cells (C) in transgenic fat-1 mice and wild type animals (WT-STD) on a standard sunflower oil based diet, as well as in wild type mice on the same diet enriched with EPA and DHA (WT-STD+n3) after 30 days of feeding. The n6/n3 ratio was calculated as Ʃ%(C18:2 n6, C18:3 n6, C20:3 n6, C20:4 n6, C22:4n6)/ Ʃ%(C18:3 n3, C20:5 n3, C22:5 n3, C22:6 n3). Statistical differences were determined using one-way ANOVA followed by Tukey’s post test (*** p<0.001, **** p<0.0001).

Fig 2

doi: https://doi.org/10.1371/journal.pone.0184470.g002