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Liver fibrosis staging with a new 2D-shear wave elastography using comb-push technique: Applicability, reproducibility, and diagnostic performance

Fig 5

When applying the cutoff values from our study, the live stiffness (LS) values obtained by the 2D comb-push shear wave elastography (2D CP-SWE) could predict histologic fibrosis staging.

A)The median LS value of 5.98kPa was achieved by the 2D CP-SWE in a 64-year-old man, which was greater than the cutoff value of F2 (5.33kPa) and less than the cutoff value of F3 (6.84kPa). The patient underwent surgical resection for hepatocellular carcinoma (HCC), after which the fibrosis staging was histologically confirmed to be F2. B) The median LS value of 7.38kPa was measured by the 2D CP-SWE in a 66-year-old man, which was greater than the cutoff value of F3 (6.84kPa) and less than the cutoff value of F4 (7.59kPa). The patient underwent surgical resection for HCC, after which the fibrosis stage was histologically confirmed as F3. C) Despite massive ascites, reliable LS values were successfully measured by 2D CP-SWE in a 57-year-old woman. The median LS value of 13.45kPa was greater than the cutoff value of F4 (7.59kPa). The patient underwent liver transplantation. The fibrosis stage was histologically proven to be F4, and the macronodular cirrhosis was associated with alcohol consumption. D) Reliable LS values were successfully measured by 2D CP-SWE in a 49-year-old obese man with a body mass index of 31.33kg/m2. The median LS value of 8.14kPa was greater than the value of F4 (7.59kPa). The patient underwent liver transplantation. The fibrosis stage was histologically proven to be F4, and macronodular cirrhosis was associated with hepatitis B virus infection and alcohol consumption.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0177264.g005