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Alteration of the α1β22β1 subunit interface contributes to the increased hemoglobin-oxygen affinity of high-altitude deer mice

Fig 4

Difference in interface area between highland and lowland hemoglobin and human oxygenated and deoxygenated hemoglobin.

Interface area of lowland hemoglobin and two highland hemoglobin tetramers were calculated by the PISA webserver. The values on the graph show the surface area in Å2. The blue line is a result from one highland hemoglobin, which consists of chains A, B, C and D. The dotted dark line is a result from another highland hemoglobin (chains E, F, G and H). The lowland hemoglobin result is depicted by the red line. The intradimeric interface area of human hemoglobin was calculated using the following structures; deoxygenated structure (2DN2, orange) and oxygenated structure (2DN1, black)

Fig 4