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Biophysical comparison of ATP-driven proton pumping mechanisms suggests a kinetic advantage for the rotary process depending on coupling ratio

Fig 4

Rotary mechanism is faster than other possible mechanisms across a wide range of driving conditions.

(a) Average rates for the different mechanisms showing that the rates are quantitatively similar to experiment (∼60 H+/s [1]), and that the rotary mechanism is faster on average. (b) Average ratio of H+/s relative to the rotary mechanism showing that the rotary mechanism is also faster across a wide range of conditions. (c) Average ratio for extensive and systematic variations in model assumptions showing that results are qualitatively similar. Results shown here for 3:1 coupling ratio are qualitatively similar for 2:1 coupling ratio (see S1 File). Average ratio is the geometric average of individual ratios of pumping rates relative to the rotary mechanism for each set of condition, i.e. the ratio is calculated for each condition and then averaged across all conditions. Error bars show standard error of the mean when sampling over a range of conditions.

Fig 4