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Biophysical comparison of ATP-driven proton pumping mechanisms suggests a kinetic advantage for the rotary process depending on coupling ratio

Fig 2

Minimalistic kinetic models of possible ATP-driven H+ pump mechanisms.

Coupling ratio of 3:1 H+:ATP is shown here. See S1 File for 2:1 coupling ratio. Two possible proton transport mechanisms, (a) rotary and (b) alternating access, based on one of six possible sequences of reactions (event orders) for nucleotide and phosphate binding/unbinding in the ATP-driven proton pumping cycle. Results are qualitatively similar for other event orders. See S1 File and Fig 4(b).

Fig 2