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Biophysical comparison of ATP-driven proton pumping mechanisms suggests a kinetic advantage for the rotary process depending on coupling ratio

Fig 1

Proton pumping by rotary and alternating access mechanisms.

H+ transport, against a transmembrane pH and electric potential (Δψ) gradient, is driven by the hydrolysis of ATP to ADP. (a) In the rotary mechanism, hydrolysis of ATP causes the rotation of the transmembrane ring which leads to proton transport across the membrane. (b) In the alternating access mechanism, ATP hydrolysis produces allosteric conformational changes that transport protons across the membrane.

Fig 1