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Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors

Fig 4

Distribution of Wfs1, D1, and D5 proteins in selected regions of the adult mouse brain.

Distribution of Wfs1, D1, and D5 proteins in selected regions of the adult mouse brain. Immunohistochemistry on coronal sections. The detected proteins are indicated above. In the cortex Wfs1, D1, and D5 are all present in layer I, upper part of layer II/III, and in layer V (images show somatosensory cortex; A-C); in the hippocampus Wfs1, D1, and D5 are simultaneously present in pyr and slm of CA1 (D-F); Wfs1, D1 and D5 are all present in Rt and Sth; in amygdala Wfs1 is strongly present in CeA, the lateral edge of BL, and medial and cortical nuclei (G-I), whereas D1 and D5 show only weak signal in CeA and BL (G-I); in the dorsolateral thalamus Wfs1, D1, and D5 are delineating dLG and VPM, note that strongly Wfs1-positive fibers are present in fi, but no D1 or D5 is seen there (J-L), in the substantia nigra Wfs1 has similar distribution with D1, but not with D5 (M-O). For abbreviations, see list. Scale bar is 100 μm in A-C, 1 mm in D-L, 500 μm in M-O.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0172825.g004