A Conditioned Behavioral Paradigm for Assessing Onset and Lasting Tinnitus in Rats
Overall, exposed rats had higher silent trial licking rates compared to sham rats across a broad range of silent trial categories, especially at 1 and 2 weeks post-exposure. The higher licking rates are suggestive of tinnitus-like behavior. In exposed rats, the rate of silent trial licking, as well as the number of rats that exhibited elevated rates across a range of silent trial categories, tended to decrease over time. In sham-exposed rats, the rate of silent trial licking only slightly increased over time.