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A Conditioned Behavioral Paradigm for Assessing Onset and Lasting Tinnitus in Rats

Fig 8

ABR hearing thresholds for tinnitus(+), tinnitus(-), and control rats prior to intense noise or sham exposure, and on post-exposure day 0 and post-exposure week 7.

Thresholds were elevated across all frequencies in tinnitus(+) and tinnitus(-) rats at post-exposure day 0, revealing immediate and significant hearing loss. By post-exposure week 7, however, thresholds recovered to pre-exposure levels. At all time points, thresholds were similar between tinnitus(+) and tinnitus(-) rats. There were no threshold elevations in control rats. Error bars represent standard error of the mean.

Fig 8

doi: https://doi.org/10.1371/journal.pone.0166346.g008