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A Conditioned Behavioral Paradigm for Assessing Onset and Lasting Tinnitus in Rats

Fig 5

Licking rates over time for tinnitus(+), tinnitus(-), and control rats during silent trials (A-E).

Tinnitus(+) refers to rats that later exceeded 1 lick/trial for one or more silent trial categories over weeks 5 through 7 weeks following noise exposure; tinnitus(-) refers to noise-exposed rats that did not meet that criteria. Tinnitus(+) and tinnitus(-) rats exceeded 1 lick per each silent trial category immediately after noise exposure (D 0), except for one rat for 6–8 and another rat for 30–32 kHz silent trials. Eleven rats exceeded 1 lick per silent trial for one or more silent trial categories over at least 5 to 7 weeks post-exposure (Wk 5 –Wk 7). These increases in silent trial licking were significant relative to the last baseline training session (T16). Control rats show no significant increases in licking over time. The dashed line and gray-shaded area indicate the ≤ 1-lick/trial threshold.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0166346.g005