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Platform-Independent Genome-Wide Pattern of DNA Copy-Number Alterations Predicting Astrocytoma Survival and Response to Treatment Revealed by the GSVD Formulated as a Comparative Spectral Decomposition

Fig 4

Survival analyses of the LGA patients classified by the LGA pattern and by treatment.

(a) KM curves of the discovery set of 59 patients classified by the weights, or superposition coefficients of the LGA pattern in their tumor profiles, as listed in the second probelet (Fig 3). The 63-month KM median survival time of the group of patients with low coefficients is >3 times greater than that of the group of patients with high coefficients, with the corresponding log-rank test P-value <10−4. The univariate Cox proportional hazard ratio is >9. (b) Among the 29 patients in the discovery set treated by chemotherapy, the median survival time of the patients with low coefficients is ∼3.5 times greater than that of the patients with high coefficients. (c) Among the patients treated by radiation, the median survival times of patients with low and high coefficients are the same as among the chemotherapy-treated patients. (d) KM curves of the validation set of 74 patients classified by the Pearson correlation of the LGA pattern with their tumor profiles. The 73-month median survival time of the patients with low correlations is >3.5 times greater than that of the patients with high correlations, consistent with the median survival times of the patients in the discovery set. (e) The median survival times of the 46 chemotherapy-treated validation patients with low and high correlations are the same as those of the 74 validation patients, and consistent with those of the 27 chemotherapy-treated discovery patients. (f) The median survival times of the radiation-treated validation patients are the same as those of the validation patients, and consistent with those of the radiation-treated discovery patients.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0164546.g004