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A Rationally Designed TNF-α Epitope-Scaffold Immunogen Induces Sustained Antibody Response and Alleviates Collagen-Induced Arthritis in Mice

Fig 7

The cytokine levels in mice sera immunized with DTT or DTNF7.

Serum samples were collected from CIA mice on day 28 and 56 after the first injection with chicken type II collagen. The cytokine concentrations in sera were determined by Bio-Plex assay. The average of four mice with standard variation was plotted for each cytokine. Data are presented as the mean ± SD.

Fig 7

doi: https://doi.org/10.1371/journal.pone.0163080.g007