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A Rationally Designed TNF-α Epitope-Scaffold Immunogen Induces Sustained Antibody Response and Alleviates Collagen-Induced Arthritis in Mice

Fig 6

DTNF7 inhibits joint inflammation.

Tissue sections of ankle joints from DTNF7 and DTT immunized mice on day 56 were stained with hematoxylin-eosin staining (A) and Safranin O staining (B). The arrows indicate synovial hyperplasia (green) cell infiltration (black), cartilage destruction (orange), and bone erosion (blue).

Fig 6

doi: https://doi.org/10.1371/journal.pone.0163080.g006