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A Rationally Designed TNF-α Epitope-Scaffold Immunogen Induces Sustained Antibody Response and Alleviates Collagen-Induced Arthritis in Mice

Fig 3

The stability of DTT and DTNF proteins.

(A) Thermal stability of DTT and DTNF proteins measured by DSC. Left panel, temperature dependent heat capacity of DTT and DTNF proteins. Right panel: melting temperatures of DTT and DTNF proteins. (B) SDS-PAGE analysis of the soluble fraction of DTT and DTNF proteins stored at 4°C for 2 days (Top) and 10 days (Bottom).

Fig 3

doi: https://doi.org/10.1371/journal.pone.0163080.g003