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A Rationally Designed TNF-α Epitope-Scaffold Immunogen Induces Sustained Antibody Response and Alleviates Collagen-Induced Arthritis in Mice

Fig 2

Antibody responses induced by DTT and DTNF proteins.

(A) Anti-DTT antibody titers in sera of mice immunized with DTT or DTNF proteins on day 49. (B) Anti-mTNF-α antibody titers in sera of mice immunized with DTT or DTNF proteins on day 49, serum samples were diluted 1:100. (C) Serum anti-mTNF-α and anti-hTNF-α titers measured by ELISA. Serum samples were diluted 1:100. Data are presented as the mean ± SD. (D) Average anti-mTNF-α antibody titers in sera of mice immunized with DTNF7 on day 49. (E) Analysis of antibody subclass in the sera of DTNF7 immunized mice. (F) The persistent antibody response against mTNF-α and DTT in mice immunized with DTNF7. Data are presented as the mean ± SD.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0163080.g002