A Liver-Centric Multiscale Modeling Framework for Xenobiotics
Transfer between each of the three cell, or pseudo-cell, types is described by this transfer map. Subscripts indicate that there are multiple cells of each of the types and transfer is calculated between all pairs of cells that are in contact at a particular instant. The paired arrows represent passive transport that equilibrates across pairs of cell types if they are in contact. Looped arrows represent passive transport between adjacent cells of the same type. The single arrow labeled “Active Transport” represents the Michaelis-Menten modeled import of APAP from the serum into hepatocytes.