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Spheroid Formation of Hepatocarcinoma Cells in Microwells: Experiments and Monte Carlo Simulations

Fig 9

Monte Carlo simulation of cell proliferation and spheroid formation in the microwells.

Cross sections of a well along the main axis at ϑ = 0.2 (a) and 0.4 (b) in the absence of cell-surface adhesion (ϵcs = 0). Cell diffusion is relatively rapid (pdiv = 10−4). In addition, the gravity is taken into account (ϵg = –0.03).

Fig 9

doi: https://doi.org/10.1371/journal.pone.0161915.g009