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Spheroid Formation of Hepatocarcinoma Cells in Microwells: Experiments and Monte Carlo Simulations

Fig 8

Monte Carlo simulation of cell proliferation and spheroid formation in the microwells.

Cross sections of a microwell along the main axis at ϑ = 0.2 (a) and 0.4 (b) in the presence of adhesion (ϵcs = –1.2) of cells to the bottom and side area of the microwell. The adhesion to the top boundary is neglected because in reality the corresponding plane crosses the solution. The diffusion of cells is relatively rapid (pdiv = 10−4). The well and cells are represented by black and red circles, respectively.

Fig 8

doi: https://doi.org/10.1371/journal.pone.0161915.g008